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Protein

Glutathione peroxidase 6

Gene

Gpx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3719. MmGPx06.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 6 (EC:1.11.1.9)
Short name:
GPx-6
Short name:
GSHPx-6
Gene namesi
Name:Gpx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1922762. Gpx6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 221202Glutathione peroxidase 6PRO_0000013082Add
BLAST

Proteomic databases

MaxQBiQ91WR8.
PaxDbiQ91WR8.
PRIDEiQ91WR8.

Expressioni

Gene expression databases

CleanExiMM_GPX6.
GenevisibleiQ91WR8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004453.

Structurei

3D structure databases

ProteinModelPortaliQ91WR8.
SMRiQ91WR8. Positions 38-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiQ91WR8.
KOiK00432.
OMAiFQQYAGK.
OrthoDBiEOG7KQ23C.
TreeFamiTF105318.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKLWGSCL FSLFMAALAQ ETLNPQKSKV DCNKGVTGTV YEYGANTIDG
60 70 80 90 100
GEFVNFQQYA GKHILFVNVA SFCGLTATYP ELNTLQEELK PFNVTVLGFP
110 120 130 140 150
CNQFGKQEPG KNSEILLGLK YVRPGGGYVP NFQLFEKGDV NGDNEQKVFS
160 170 180 190 200
FLKNSCPPTS ELFGSPEHLF WDPMKVHDIR WNFEKFLVGP DGVPVMRWFH
210 220
HTPVRIVQSD IMEYLNQTST Q
Length:221
Mass (Da):24,903
Last modified:October 3, 2012 - v2
Checksum:i39577A18B4C99BCA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521E → G in AAH13526 (PubMed:15489334).Curated
Sequence conflicti176 – 1761V → I in AAH13526 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124460 Genomic DNA. No translation available.
BC013526 mRNA. Translation: AAH13526.1.
CCDSiCCDS26271.1.
RefSeqiNP_663426.2. NM_145451.3.
UniGeneiMm.46195.

Genome annotation databases

EnsembliENSMUST00000004453; ENSMUSP00000004453; ENSMUSG00000004341.
GeneIDi75512.
KEGGimmu:75512.
UCSCiuc007pqa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124460 Genomic DNA. No translation available.
BC013526 mRNA. Translation: AAH13526.1.
CCDSiCCDS26271.1.
RefSeqiNP_663426.2. NM_145451.3.
UniGeneiMm.46195.

3D structure databases

ProteinModelPortaliQ91WR8.
SMRiQ91WR8. Positions 38-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004453.

Protein family/group databases

PeroxiBasei3719. MmGPx06.

Proteomic databases

MaxQBiQ91WR8.
PaxDbiQ91WR8.
PRIDEiQ91WR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004453; ENSMUSP00000004453; ENSMUSG00000004341.
GeneIDi75512.
KEGGimmu:75512.
UCSCiuc007pqa.1. mouse.

Organism-specific databases

CTDi257202.
MGIiMGI:1922762. Gpx6.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiQ91WR8.
KOiK00432.
OMAiFQQYAGK.
OrthoDBiEOG7KQ23C.
TreeFamiTF105318.

Miscellaneous databases

PROiQ91WR8.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPX6.
GenevisibleiQ91WR8. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGPX6_MOUSE
AccessioniPrimary (citable) accession number: Q91WR8
Secondary accession number(s): F2Z3U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.