Reviewed, UniProtKB/Swiss-Prot Q91WR8 (GPX6_MOUSE)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 6
    EC=1.11.1.9

Gene names

Name:

Gpx6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Subcellular location	SecretedBy similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 221	202	Glutathione peroxidase 6		PRO_0000013082
Sites
	Active site	73	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91WR8-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 15308DC6E4BA996A	FASTA	221	24,845
	10 20 30 40 50 60 MAQKLWGSCL FSLFMAALAQ ETLNPQKSKV DCNKGVTGTV YEYGANTIDG GGFVNFQQYA 70 80 90 100 110 120 GKHILFVNVA SFCGLTATYP ELNTLQEELK PFNVTVLGFP CNQFGKQEPG KNSEILLGLK 130 140 150 160 170 180 YVRPGGGYVP NFQLFEKGDV NGDNEQKVFS FLKNSCPPTS ELFGSPEHLF WDPMKIHDIR 190 200 210 220 WNFEKFLVGP DGVPVMRWFH HTPVRIVQSD IMEYLNQTST Q

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC013526 mRNA. Translation: AAH13526.1.
UniGene	Mm.46195
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	3719. MmGPx06.
Genome annotation databases
Ensembl	ENSMUSG00000004341. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:1922762. Gpx6.
Phylogenomic databases
HOGENOM	Q91WR8.
HOVERGEN	Q91WR8.
Gene expression databases
ArrayExpress	Q91WR8.
CleanEx	MM_GPX6.
GermOnline	ENSMUSG00000004341. Mus musculus.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

GPX6_MOUSE

Accession

Primary (citable) accession number: Q91WR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	December 1, 2001
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)