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Q91WQ3

- SYYC_MOUSE

UniProt

Q91WQ3 - SYYC_MOUSE

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Protein
Tyrosine--tRNA ligase, cytoplasmic
Gene
Yars
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity.

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Tyrosine By similarity
Binding sitei166 – 1661Tyrosine By similarity
Binding sitei170 – 1701Tyrosine By similarity
Binding sitei173 – 1731Tyrosine By similarity
Binding sitei188 – 1881Tyrosine By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tRNA binding Source: UniProtKB-KW
  3. tyrosine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tyrosyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligase, cytoplasmic (EC:6.1.1.1)
Alternative name(s):
Tyrosyl-tRNA synthetase
Short name:
TyrRS
Cleaved into the following chain:
Gene namesi
Name:Yars
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2147627. Yars.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Tyrosine--tRNA ligase, cytoplasmic
PRO_0000055674Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 528527Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
PRO_0000423286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei2 – 21N-acetylglycine; in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed By similarity
Modified residuei197 – 1971N6-acetyllysine By similarity
Modified residuei206 – 2061N6-acetyllysine By similarity
Modified residuei474 – 4741N6-acetyllysine By similarity
Modified residuei482 – 4821N6-acetyllysine By similarity
Modified residuei490 – 4901N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ91WQ3.
PaxDbiQ91WQ3.
PRIDEiQ91WQ3.

PTM databases

PhosphoSiteiQ91WQ3.

Expressioni

Gene expression databases

ArrayExpressiQ91WQ3.
BgeeiQ91WQ3.
CleanExiMM_YARS.
GenevestigatoriQ91WQ3.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

BioGridi223230. 1 interaction.
IntActiQ91WQ3. 2 interactions.
MINTiMINT-1855454.

Structurei

3D structure databases

ProteinModelPortaliQ91WQ3.
SMRiQ91WQ3. Positions 4-342, 360-528.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini364 – 468105tRNA-binding
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 529"HIGH" region
Motifi222 – 2265"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0162.
GeneTreeiENSGT00750000117748.
HOGENOMiHOG000228237.
HOVERGENiHBG080113.
InParanoidiQ91WQ3.
KOiK01866.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR002307. Tyr-tRNA-ligase.
[Graphical view]
PfamiPF00579. tRNA-synt_1b. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01040. TRNASYNTHTYR.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00234. tyrS. 1 hit.
PROSITEiPS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WQ3-1 [UniParc]FASTAAdd to Basket

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MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKVYW GTATTGKPHV    50
AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRTSYYENV 100
IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDAKKAGA 150
EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGVDQRK IFTFAEKYLP 200
ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC 250
EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT VYLELEKDFA 300
AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPP 350
AKGPAKNSEP EEVIPSRLDI RVGKILSVEK HPDADSLYVE KIDVGEAEPR 400
TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVDSQGML LCASVEGVSR 450
QVEPLDPPAG SAPGERVFVQ GYEKGQPDEE LKPKKKVFEK LQADFKISEE 500
CIAQWKQTNF MTKLGFVSCK SLKGGNIS 528
Length:528
Mass (Da):59,105
Last modified:January 23, 2007 - v3
Checksum:i39D852D4C5701D0B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111L → M in BAC26120. 1 Publication
Sequence conflicti29 – 291E → K in BAE24073. 1 Publication
Sequence conflicti195 – 1951A → S in BAC36424. 1 Publication
Sequence conflicti294 – 2941E → Q in BAC36424. 1 Publication
Sequence conflicti320 – 3201L → W in BAC36424. 1 Publication
Sequence conflicti377 – 3771S → R in BAC36424. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028785 mRNA. Translation: BAC26120.1.
AK043837 mRNA. Translation: BAC31674.1.
AK076634 mRNA. Translation: BAC36424.1.
AK139579 mRNA. Translation: BAE24073.1.
AK145356 mRNA. Translation: BAE26384.1.
AK151880 mRNA. Translation: BAE30766.1.
AK169708 mRNA. Translation: BAE41320.1.
BC013552 mRNA. Translation: AAH13552.1.
BC022143 mRNA. Translation: AAH22143.1.
BC026615 mRNA. Translation: AAH26615.1.
RefSeqiNP_598912.4. NM_134151.4.
UniGeneiMm.145488.

Genome annotation databases

EnsembliENSMUST00000001365; ENSMUSP00000001365; ENSMUSG00000028811.
GeneIDi107271.
KEGGimmu:107271.
UCSCiuc008uwk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028785 mRNA. Translation: BAC26120.1 .
AK043837 mRNA. Translation: BAC31674.1 .
AK076634 mRNA. Translation: BAC36424.1 .
AK139579 mRNA. Translation: BAE24073.1 .
AK145356 mRNA. Translation: BAE26384.1 .
AK151880 mRNA. Translation: BAE30766.1 .
AK169708 mRNA. Translation: BAE41320.1 .
BC013552 mRNA. Translation: AAH13552.1 .
BC022143 mRNA. Translation: AAH22143.1 .
BC026615 mRNA. Translation: AAH26615.1 .
RefSeqi NP_598912.4. NM_134151.4.
UniGenei Mm.145488.

3D structure databases

ProteinModelPortali Q91WQ3.
SMRi Q91WQ3. Positions 4-342, 360-528.
ModBasei Search...

Protein-protein interaction databases

BioGridi 223230. 1 interaction.
IntActi Q91WQ3. 2 interactions.
MINTi MINT-1855454.

PTM databases

PhosphoSitei Q91WQ3.

Proteomic databases

MaxQBi Q91WQ3.
PaxDbi Q91WQ3.
PRIDEi Q91WQ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001365 ; ENSMUSP00000001365 ; ENSMUSG00000028811 .
GeneIDi 107271.
KEGGi mmu:107271.
UCSCi uc008uwk.2. mouse.

Organism-specific databases

CTDi 8565.
MGIi MGI:2147627. Yars.

Phylogenomic databases

eggNOGi COG0162.
GeneTreei ENSGT00750000117748.
HOGENOMi HOG000228237.
HOVERGENi HBG080113.
InParanoidi Q91WQ3.
KOi K01866.

Miscellaneous databases

NextBioi 358652.
PROi Q91WQ3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91WQ3.
Bgeei Q91WQ3.
CleanExi MM_YARS.
Genevestigatori Q91WQ3.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.620. 1 hit.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR002307. Tyr-tRNA-ligase.
[Graphical view ]
Pfami PF00579. tRNA-synt_1b. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
PRINTSi PR01040. TRNASYNTHTYR.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00234. tyrS. 1 hit.
PROSITEi PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Brain cortex, Egg, Embryo, Skin, Testis and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Liver.

Entry informationi

Entry nameiSYYC_MOUSE
AccessioniPrimary (citable) accession number: Q91WQ3
Secondary accession number(s): Q3TEC8
, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi