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Protein

Serine protease inhibitor A3N

Gene

Serpina3n

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei381 – 382Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Acute phase

Protein family/group databases

MEROPSiI04.078.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor A3N
Short name:
Serpin A3N
Gene namesi
Name:Serpina3n
Synonyms:Spi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105045. Serpina3n.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003241921 – 418Serine protease inhibitor A3NAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91WP6.
PaxDbiQ91WP6.
PeptideAtlasiQ91WP6.
PRIDEiQ91WP6.

PTM databases

iPTMnetiQ91WP6.
PhosphoSitePlusiQ91WP6.

Expressioni

Tissue specificityi

Expressed at high levels in brain, heart, liver, lung, spleen, testis and thymus, and at low levels in bone marrow, kidney and skeletal muscle.2 Publications

Inductioni

Expression is induced by bacterial lipopolysaccharide (LPS).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021506.

Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi48 – 65Combined sources18
Beta strandi71 – 73Combined sources3
Helixi75 – 86Combined sources12
Helixi91 – 100Combined sources10
Turni105 – 107Combined sources3
Helixi110 – 124Combined sources15
Beta strandi131 – 142Combined sources12
Helixi149 – 159Combined sources11
Beta strandi162 – 166Combined sources5
Helixi171 – 185Combined sources15
Turni186 – 188Combined sources3
Beta strandi189 – 191Combined sources3
Beta strandi203 – 212Combined sources10
Beta strandi214 – 217Combined sources4
Helixi221 – 223Combined sources3
Beta strandi225 – 229Combined sources5
Beta strandi237 – 254Combined sources18
Turni255 – 258Combined sources4
Beta strandi259 – 277Combined sources19
Helixi282 – 287Combined sources6
Helixi291 – 300Combined sources10
Beta strandi302 – 312Combined sources11
Beta strandi314 – 321Combined sources8
Helixi323 – 328Combined sources6
Helixi333 – 335Combined sources3
Helixi342 – 345Combined sources4
Beta strandi346 – 348Combined sources3
Beta strandi354 – 363Combined sources10
Beta strandi365 – 369Combined sources5
Beta strandi389 – 391Combined sources3
Beta strandi396 – 402Combined sources7
Turni403 – 405Combined sources3
Beta strandi409 – 415Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXAX-ray2.10A/B21-418[»]
ProteinModelPortaliQ91WP6.
SMRiQ91WP6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91WP6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni367 – 392RCLAdd BLAST26

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ91WP6.
PhylomeDBiQ91WP6.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFIAALGLL MAGICPAVLC FPDGTLGMDA AVQEDHDNGT QLDSLTLASI
60 70 80 90 100
NTDFAFSLYK ELVLKNPDKN IVFSPLSISA ALAVMSLGAK GNTLEEILEG
110 120 130 140 150
LKFNLTETSE ADIHQGFGHL LQRLNQPKDQ VQISTGSALF IEKRQQILTE
160 170 180 190 200
FQEKAKTLYQ AEAFTADFQQ PRQAKKLIND YVRKQTQGMI KELVSDLDKR
210 220 230 240 250
TLMVLVNYIY FKAKWKVPFD PLDTFKSEFY AGKRRPVIVP MMSMEDLTTP
260 270 280 290 300
YFRDEELSCT VVELKYTGNA SALFILPDQG RMQQVEASLQ PETLRKWKNS
310 320 330 340 350
LKPRMIDELH LPKFSISTDY SLEDVLSKLG IREVFSTQAD LSAITGTKDL
360 370 380 390 400
RVSQVVHKAV LDVAETGTEA AAATGVKFVP MSAKLYPLTV YFNRPFLIMI
410
FDTETEIAPF IAKIANPK
Length:418
Mass (Da):46,718
Last modified:December 1, 2001 - v1
Checksum:i4BF21BBE10A81F6C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231A → C in AAA40130 (PubMed:1718822).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64086 mRNA. Translation: AAA40130.1.
BC013651 mRNA. Translation: AAH13651.1.
CCDSiCCDS26152.1.
PIRiJH0494.
UniGeneiMm.482074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64086 mRNA. Translation: AAA40130.1.
BC013651 mRNA. Translation: AAH13651.1.
CCDSiCCDS26152.1.
PIRiJH0494.
UniGeneiMm.482074.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXAX-ray2.10A/B21-418[»]
ProteinModelPortaliQ91WP6.
SMRiQ91WP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021506.

Protein family/group databases

MEROPSiI04.078.

PTM databases

iPTMnetiQ91WP6.
PhosphoSitePlusiQ91WP6.

Proteomic databases

MaxQBiQ91WP6.
PaxDbiQ91WP6.
PeptideAtlasiQ91WP6.
PRIDEiQ91WP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:105045. Serpina3n.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ91WP6.
PhylomeDBiQ91WP6.

Miscellaneous databases

EvolutionaryTraceiQ91WP6.
PROiQ91WP6.
SOURCEiSearch...

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPA3N_MOUSE
AccessioniPrimary (citable) accession number: Q91WP6
Secondary accession number(s): Q62258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.