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Q91WN4

- KMO_MOUSE

UniProt

Q91WN4 - KMO_MOUSE

Protein

Kynurenine 3-monooxygenase

Gene

Kmo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.UniRule annotation

    Catalytic activityi

    L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.By similarityUniRule annotation

    Cofactori

    FAD.By similarityUniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    2. kynurenine 3-monooxygenase activity Source: UniProtKB
    3. NAD(P)H oxidase activity Source: Ensembl

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. NAD metabolic process Source: UniProtKB
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. response to salt stress Source: Ensembl
    6. tryptophan catabolic process to kynurenine Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00328.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
    Alternative name(s):
    Kynurenine 3-hydroxylaseUniRule annotation
    Gene namesi
    Name:KmoImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2138151. Kmo.

    Subcellular locationi

    Mitochondrion outer membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrial outer membrane Source: UniProtKB
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Kynurenine 3-monooxygenaseCuratedPRO_0000229743Add
    BLAST

    Proteomic databases

    MaxQBiQ91WN4.
    PaxDbiQ91WN4.
    PRIDEiQ91WN4.

    PTM databases

    PhosphoSiteiQ91WN4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91WN4.
    BgeeiQ91WN4.
    GenevestigatoriQ91WN4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WN4.
    SMRiQ91WN4. Positions 11-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei385 – 40420HelicalUniRule annotationAdd
    BLAST
    Transmembranei425 – 44521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0654.
    GeneTreeiENSGT00390000000747.
    HOGENOMiHOG000251788.
    HOVERGENiHBG057213.
    InParanoidiQ91WN4.
    KOiK00486.
    OMAiQPMISVK.
    PhylomeDBiQ91WN4.
    TreeFamiTF312990.

    Family and domain databases

    HAMAPiMF_01971. Kynurenine_monooxygenase.
    InterProiIPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view]
    PfamiPF01494. FAD_binding_3. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q91WN4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSDTQGKR VAVIGGGLVG ALNACFLAKR NFQVDVYEAR EDIRVAKSAR    50
    GRSINLALSY RGRQALKAIG LEDQIVSKGV PMKARMIHSL SGKKSAIPYG 100
    NKSQYILSIS RENLNKDLLT AVESYANAKV HFGHKLSKCI PEEGVLTVLG 150
    PDKVPRDVTC DLVVGCDGAY STVRAHLMKK PRFDYTQQYI PHGYMELTIP 200
    PKNGEYAMEP NCLHIWPRNA YMMIALPNMD KSFTCTLFMP FEEFERLPTR 250
    SDVLDFFQKN FPDAIPLMGE QALMRDFFLL PAQPMISVKC SPFHLKSHCV 300
    LMGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFNNNLSM CLPEFSRFRI 350
    PDDHAISDLS MYNYIEMRAH VNSRWFLFQK LLDKFLHAIM PSTFIPLYTM 400
    VAFTRIRYHE AVLRWHWQKK VINRGLFVLG SLIAIGGTYL LVHHLSLRPL 450
    EFLRRPAWMG TTGYWTRSTD ISLQVPWSY 479
    Length:479
    Mass (Da):54,532
    Last modified:December 1, 2001 - v1
    Checksum:iE880997DBC9C8163
    GO
    Isoform 21 Publication (identifier: Q91WN4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         367-400: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:445
    Mass (Da):50,396
    Checksum:iE2B58D64DDF95BCC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei367 – 40034Missing in isoform 2. 1 PublicationVSP_051974Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129011 mRNA. No translation available.
    BC014683 mRNA. Translation: AAH14683.1.
    CCDSiCCDS15548.1. [Q91WN4-1]
    RefSeqiNP_598570.1. NM_133809.1. [Q91WN4-1]
    UniGeneiMm.27217.

    Genome annotation databases

    EnsembliENSMUST00000040250; ENSMUSP00000038914; ENSMUSG00000039783. [Q91WN4-1]
    ENSMUST00000097458; ENSMUSP00000095067; ENSMUSG00000039783. [Q91WN4-2]
    GeneIDi98256.
    KEGGimmu:98256.
    UCSCiuc007dto.1. mouse. [Q91WN4-1]
    uc011wxd.1. mouse. [Q91WN4-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129011 mRNA. No translation available.
    BC014683 mRNA. Translation: AAH14683.1 .
    CCDSi CCDS15548.1. [Q91WN4-1 ]
    RefSeqi NP_598570.1. NM_133809.1. [Q91WN4-1 ]
    UniGenei Mm.27217.

    3D structure databases

    ProteinModelPortali Q91WN4.
    SMRi Q91WN4. Positions 11-367.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91WN4.

    Proteomic databases

    MaxQBi Q91WN4.
    PaxDbi Q91WN4.
    PRIDEi Q91WN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040250 ; ENSMUSP00000038914 ; ENSMUSG00000039783 . [Q91WN4-1 ]
    ENSMUST00000097458 ; ENSMUSP00000095067 ; ENSMUSG00000039783 . [Q91WN4-2 ]
    GeneIDi 98256.
    KEGGi mmu:98256.
    UCSCi uc007dto.1. mouse. [Q91WN4-1 ]
    uc011wxd.1. mouse. [Q91WN4-2 ]

    Organism-specific databases

    CTDi 8564.
    MGIi MGI:2138151. Kmo.

    Phylogenomic databases

    eggNOGi COG0654.
    GeneTreei ENSGT00390000000747.
    HOGENOMi HOG000251788.
    HOVERGENi HBG057213.
    InParanoidi Q91WN4.
    KOi K00486.
    OMAi QPMISVK.
    PhylomeDBi Q91WN4.
    TreeFami TF312990.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00328 .

    Miscellaneous databases

    NextBioi 353386.
    PROi Q91WN4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91WN4.
    Bgeei Q91WN4.
    Genevestigatori Q91WN4.

    Family and domain databases

    HAMAPi MF_01971. Kynurenine_monooxygenase.
    InterProi IPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view ]
    Pfami PF01494. FAD_binding_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/NImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiKMO_MOUSE
    AccessioniPrimary (citable) accession number: Q91WN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3