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Protein

Solute carrier family 7 member 13

Gene

Slc7a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.8.8. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 7 member 13
Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
X-amino acid transporter 2
Gene namesi
Name:Slc7a13
Synonyms:Agt1, Xat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921337. Slc7a13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini36 – 47ExtracellularSequence analysisAdd BLAST12
Transmembranei48 – 68Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini69 – 89CytoplasmicSequence analysisAdd BLAST21
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 129ExtracellularSequence analysisAdd BLAST19
Transmembranei130 – 150Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini151 – 163CytoplasmicSequence analysisAdd BLAST13
Transmembranei164 – 184Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini185 – 208ExtracellularSequence analysisAdd BLAST24
Transmembranei209 – 229Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini230 – 242CytoplasmicSequence analysisAdd BLAST13
Transmembranei243 – 263Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini264 – 288ExtracellularSequence analysisAdd BLAST25
Transmembranei289 – 309Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini310 – 338CytoplasmicSequence analysisAdd BLAST29
Transmembranei339 – 359Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini360ExtracellularSequence analysis1
Transmembranei361 – 381Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini382 – 395CytoplasmicSequence analysisAdd BLAST14
Transmembranei396 – 416Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini417 – 423ExtracellularSequence analysis7
Transmembranei424 – 444Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini445 – 478CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003307261 – 478Solute carrier family 7 member 13Add BLAST478

Proteomic databases

PaxDbiQ91WN3.
PRIDEiQ91WN3.

PTM databases

PhosphoSitePlusiQ91WN3.

Expressioni

Tissue specificityi

Expressed in the kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000041052.
GenevisibleiQ91WN3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036228.

Structurei

3D structure databases

ProteinModelPortaliQ91WN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ91WN3.
KOiK13870.
OMAiLVWFEKM.
OrthoDBiEOG091G05K3.
PhylomeDBiQ91WN3.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDSKKEIR LKRELGYFWG TNFLIINIIG AGIFVSPKGV LQHSSMNVGV
60 70 80 90 100
SLCVWAVCAV LTLTSALCSA EIGITFPYSG AHYYFLKRCF GPLVAFLRLW
110 120 130 140 150
TSLFLGPGLI ASQALLLAEY GVQPFYPSCS APILPRKCLA LAMLWIVGIL
160 170 180 190 200
NSRGVKELSW LQTVSSVLKV GILGVISLSG LFLLVRGKKE NVQRLQNAFD
210 220 230 240 250
AEFPEVSQLI EAIFQGYFAF SGGGCFTCIA GELKKPSKTI PRCIFTGLPL
260 270 280 290 300
VTVVYLLANI SYLTVLTPQE MLSSDAVALT WTDRVIPQFT WTVPFAISAS
310 320 330 340 350
LFINLVINVL ETSRVLYIAS ENGQLPLLFC ALNVHSSPFI AVLLIISMAS
360 370 380 390 400
ILIVLTNLID LINYLYFVVS IWTALSIIGI LKLRYQEPNL HRPYKVFLPF
410 420 430 440 450
TFIALGITLS LVLIPLVKSP KLHYIYVFLF LLSGLVFYVP LIHFKVKFVW
460 470
FQKLTCYLQL LFNICIPDVS DDHIHEES
Length:478
Mass (Da):53,233
Last modified:December 1, 2001 - v1
Checksum:iAF9B82699ED66AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417662 mRNA. Translation: CAD10394.1.
AB072352 mRNA. Translation: BAC00494.1.
AK143768 mRNA. Translation: BAE25532.1.
BX470225 Genomic DNA. Translation: CAM28013.1.
BC014684 mRNA. Translation: AAH14684.1.
CCDSiCCDS17993.1.
RefSeqiNP_083022.1. NM_028746.3.
UniGeneiMm.173833.

Genome annotation databases

EnsembliENSMUST00000035890; ENSMUSP00000036228; ENSMUSG00000041052.
GeneIDi74087.
KEGGimmu:74087.
UCSCiuc008scf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417662 mRNA. Translation: CAD10394.1.
AB072352 mRNA. Translation: BAC00494.1.
AK143768 mRNA. Translation: BAE25532.1.
BX470225 Genomic DNA. Translation: CAM28013.1.
BC014684 mRNA. Translation: AAH14684.1.
CCDSiCCDS17993.1.
RefSeqiNP_083022.1. NM_028746.3.
UniGeneiMm.173833.

3D structure databases

ProteinModelPortaliQ91WN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036228.

Protein family/group databases

TCDBi2.A.3.8.8. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitePlusiQ91WN3.

Proteomic databases

PaxDbiQ91WN3.
PRIDEiQ91WN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035890; ENSMUSP00000036228; ENSMUSG00000041052.
GeneIDi74087.
KEGGimmu:74087.
UCSCiuc008scf.2. mouse.

Organism-specific databases

CTDi157724.
MGIiMGI:1921337. Slc7a13.

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ91WN3.
KOiK13870.
OMAiLVWFEKM.
OrthoDBiEOG091G05K3.
PhylomeDBiQ91WN3.
TreeFamiTF313355.

Miscellaneous databases

PROiQ91WN3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041052.
GenevisibleiQ91WN3. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS7A13_MOUSE
AccessioniPrimary (citable) accession number: Q91WN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.