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Protein

Solute carrier family 7 member 13

Gene

Slc7a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.8.8. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 7 member 13
Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
X-amino acid transporter 2
Gene namesi
Name:Slc7a13
Synonyms:Agt1, Xat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921337. Slc7a13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence analysisAdd
BLAST
Transmembranei15 – 3521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini36 – 4712ExtracellularSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini69 – 8921CytoplasmicSequence analysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini111 – 12919ExtracellularSequence analysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini151 – 16313CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini185 – 20824ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini230 – 24213CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini264 – 28825ExtracellularSequence analysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini310 – 33829CytoplasmicSequence analysisAdd
BLAST
Transmembranei339 – 35921Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini360 – 3601ExtracellularSequence analysis
Transmembranei361 – 38121Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini382 – 39514CytoplasmicSequence analysisAdd
BLAST
Transmembranei396 – 41621Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini417 – 4237ExtracellularSequence analysis
Transmembranei424 – 44421Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini445 – 47834CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Solute carrier family 7 member 13PRO_0000330726Add
BLAST

Proteomic databases

PaxDbiQ91WN3.
PRIDEiQ91WN3.

PTM databases

PhosphoSiteiQ91WN3.

Expressioni

Tissue specificityi

Expressed in the kidney.2 Publications

Gene expression databases

BgeeiQ91WN3.
GenevisibleiQ91WN3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036228.

Structurei

3D structure databases

ProteinModelPortaliQ91WN3.
SMRiQ91WN3. Positions 27-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ91WN3.
KOiK13870.
OMAiLVWFEKM.
OrthoDBiEOG7Z3F48.
PhylomeDBiQ91WN3.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDSKKEIR LKRELGYFWG TNFLIINIIG AGIFVSPKGV LQHSSMNVGV
60 70 80 90 100
SLCVWAVCAV LTLTSALCSA EIGITFPYSG AHYYFLKRCF GPLVAFLRLW
110 120 130 140 150
TSLFLGPGLI ASQALLLAEY GVQPFYPSCS APILPRKCLA LAMLWIVGIL
160 170 180 190 200
NSRGVKELSW LQTVSSVLKV GILGVISLSG LFLLVRGKKE NVQRLQNAFD
210 220 230 240 250
AEFPEVSQLI EAIFQGYFAF SGGGCFTCIA GELKKPSKTI PRCIFTGLPL
260 270 280 290 300
VTVVYLLANI SYLTVLTPQE MLSSDAVALT WTDRVIPQFT WTVPFAISAS
310 320 330 340 350
LFINLVINVL ETSRVLYIAS ENGQLPLLFC ALNVHSSPFI AVLLIISMAS
360 370 380 390 400
ILIVLTNLID LINYLYFVVS IWTALSIIGI LKLRYQEPNL HRPYKVFLPF
410 420 430 440 450
TFIALGITLS LVLIPLVKSP KLHYIYVFLF LLSGLVFYVP LIHFKVKFVW
460 470
FQKLTCYLQL LFNICIPDVS DDHIHEES
Length:478
Mass (Da):53,233
Last modified:December 1, 2001 - v1
Checksum:iAF9B82699ED66AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417662 mRNA. Translation: CAD10394.1.
AB072352 mRNA. Translation: BAC00494.1.
AK143768 mRNA. Translation: BAE25532.1.
BX470225 Genomic DNA. Translation: CAM28013.1.
BC014684 mRNA. Translation: AAH14684.1.
CCDSiCCDS17993.1.
RefSeqiNP_083022.1. NM_028746.3.
UniGeneiMm.173833.

Genome annotation databases

EnsembliENSMUST00000035890; ENSMUSP00000036228; ENSMUSG00000041052.
GeneIDi74087.
KEGGimmu:74087.
UCSCiuc008scf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417662 mRNA. Translation: CAD10394.1.
AB072352 mRNA. Translation: BAC00494.1.
AK143768 mRNA. Translation: BAE25532.1.
BX470225 Genomic DNA. Translation: CAM28013.1.
BC014684 mRNA. Translation: AAH14684.1.
CCDSiCCDS17993.1.
RefSeqiNP_083022.1. NM_028746.3.
UniGeneiMm.173833.

3D structure databases

ProteinModelPortaliQ91WN3.
SMRiQ91WN3. Positions 27-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036228.

Protein family/group databases

TCDBi2.A.3.8.8. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiQ91WN3.

Proteomic databases

PaxDbiQ91WN3.
PRIDEiQ91WN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035890; ENSMUSP00000036228; ENSMUSG00000041052.
GeneIDi74087.
KEGGimmu:74087.
UCSCiuc008scf.2. mouse.

Organism-specific databases

CTDi157724.
MGIiMGI:1921337. Slc7a13.

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ91WN3.
KOiK13870.
OMAiLVWFEKM.
OrthoDBiEOG7Z3F48.
PhylomeDBiQ91WN3.
TreeFamiTF313355.

Miscellaneous databases

PROiQ91WN3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WN3.
GenevisibleiQ91WN3. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2."
    Blondeau J.-P.
    Gene 286:241-248(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Kidney.
  2. "Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains."
    Matsuo H., Kanai Y., Kim J.Y., Chairoungdua A., Kim D.K., Inatomi J., Shigeta Y., Ishimine H., Chaekuntode S., Tachampa K., Choi H.W., Babu E., Fukuda J., Endou H.
    J. Biol. Chem. 277:21017-21026(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: ICR.
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiS7A13_MOUSE
AccessioniPrimary (citable) accession number: Q91WN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.