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Protein

U3 small nucleolar RNA-interacting protein 2

Gene

Rrp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-interacting protein 2
Alternative name(s):
RRP9 homolog
U3 small nucleolar ribonucleoprotein-associated 55 kDa protein
Short name:
U3 snoRNP-associated 55 kDa protein
Short name:
U3-55K
Gene namesi
Name:Rrp9
Synonyms:Rnu3ip2, U3-55k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2384313. Rrp9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475U3 small nucleolar RNA-interacting protein 2PRO_0000051314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei51 – 511PhosphoserineCombined sources
Modified residuei53 – 531PhosphoserineCombined sources
Modified residuei57 – 571PhosphoserineBy similarity
Modified residuei470 – 4701PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91WM3.
MaxQBiQ91WM3.
PaxDbiQ91WM3.
PeptideAtlasiQ91WM3.
PRIDEiQ91WM3.

PTM databases

iPTMnetiQ91WM3.
PhosphoSiteiQ91WM3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041506.
ExpressionAtlasiQ91WM3. baseline and differential.
GenevisibleiQ91WM3. MM.

Interactioni

Subunit structurei

Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif. The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif (By similarity).By similarity

Protein-protein interaction databases

BioGridi205694. 3 interactions.
IntActiQ91WM3. 2 interactions.
MINTiMINT-4139075.
STRINGi10090.ENSMUSP00000038580.

Structurei

3D structure databases

ProteinModelPortaliQ91WM3.
SMRiQ91WM3. Positions 87-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati144 – 18340WD 1Add
BLAST
Repeati197 – 23640WD 2Add
BLAST
Repeati239 – 27840WD 3Add
BLAST
Repeati281 – 32040WD 4Add
BLAST
Repeati322 – 36039WD 5Add
BLAST
Repeati374 – 41340WD 6Add
BLAST
Repeati419 – 46042WD 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi8 – 4033Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 10559Glu-richAdd
BLAST

Domaini

The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding.By similarity

Sequence similaritiesi

Belongs to the WD repeat RRP9 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0299. Eukaryota.
ENOG410XP9U. LUCA.
GeneTreeiENSGT00840000129872.
HOGENOMiHOG000188732.
HOVERGENiHBG079296.
InParanoidiQ91WM3.
KOiK14793.
OMAiAITGLDC.
OrthoDBiEOG091G0CZJ.
PhylomeDBiQ91WM3.
TreeFamiTF105828.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAVATRKR AKPAPGPGAA PVAGKRRRKV DSAADRGKSK GGGKMNEEIS
60 70 80 90 100
SDSESESLAP RKTEEEEEEE LEETAQEKKL RLAKLYLEQL RQQEEEKAEA
110 120 130 140 150
RAFEEDQVAG RLKEDVLEQR GRLQKSVAKE IQAPAPTDIR VLRGHQLSIT
160 170 180 190 200
CLVITPDDLA IFSAAKDCTI IKWSVETGRK LHVIPRAKKG AQGQPAGHSS
210 220 230 240 250
HVLCMAISSD GKYLASGDRS KLILIWEAQS CQHLYTFTGH RDAVSGLAFR
260 270 280 290 300
KGTHQLYSTS HDRSVKVWNA AENSYVETLF GHQDAVAALD ALSRECCVTA
310 320 330 340 350
GGRDGTVRVW KIPEESQLVF YGHQGSIDCI HLINEEHMVS GADDGSVALW
360 370 380 390 400
GLSKKRPLAL QREAHGLHGE PGLEQPFWVS SVAALLNTDL VATGSHNARV
410 420 430 440 450
RLWQCGEGFR QLDPLCDIPL VGFINSLKFS SAGDFLVAGV GQEHRLGRWW
460 470
RIKEARNSVC IIPLRRLPVS PVAGS
Length:475
Mass (Da):52,107
Last modified:December 1, 2001 - v1
Checksum:iEF7E2B2D9CD68F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368232 mRNA. Translation: AAN62792.1.
AF368234 Genomic DNA. Translation: AAN62794.1.
AK076113 mRNA. Translation: BAC36193.1.
BC014703 mRNA. Translation: AAH14703.1.
CCDSiCCDS23481.1.
RefSeqiNP_663595.1. NM_145620.4.
UniGeneiMm.239997.

Genome annotation databases

EnsembliENSMUST00000047721; ENSMUSP00000038580; ENSMUSG00000041506.
GeneIDi27966.
KEGGimmu:27966.
UCSCiuc009rkb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368232 mRNA. Translation: AAN62792.1.
AF368234 Genomic DNA. Translation: AAN62794.1.
AK076113 mRNA. Translation: BAC36193.1.
BC014703 mRNA. Translation: AAH14703.1.
CCDSiCCDS23481.1.
RefSeqiNP_663595.1. NM_145620.4.
UniGeneiMm.239997.

3D structure databases

ProteinModelPortaliQ91WM3.
SMRiQ91WM3. Positions 87-465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205694. 3 interactions.
IntActiQ91WM3. 2 interactions.
MINTiMINT-4139075.
STRINGi10090.ENSMUSP00000038580.

PTM databases

iPTMnetiQ91WM3.
PhosphoSiteiQ91WM3.

Proteomic databases

EPDiQ91WM3.
MaxQBiQ91WM3.
PaxDbiQ91WM3.
PeptideAtlasiQ91WM3.
PRIDEiQ91WM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047721; ENSMUSP00000038580; ENSMUSG00000041506.
GeneIDi27966.
KEGGimmu:27966.
UCSCiuc009rkb.1. mouse.

Organism-specific databases

CTDi9136.
MGIiMGI:2384313. Rrp9.

Phylogenomic databases

eggNOGiKOG0299. Eukaryota.
ENOG410XP9U. LUCA.
GeneTreeiENSGT00840000129872.
HOGENOMiHOG000188732.
HOVERGENiHBG079296.
InParanoidiQ91WM3.
KOiK14793.
OMAiAITGLDC.
OrthoDBiEOG091G0CZJ.
PhylomeDBiQ91WM3.
TreeFamiTF105828.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ91WM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041506.
ExpressionAtlasiQ91WM3. baseline and differential.
GenevisibleiQ91WM3. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiU3IP2_MOUSE
AccessioniPrimary (citable) accession number: Q91WM3
Secondary accession number(s): Q8CFB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.