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Protein

Sorting nexin-11

Gene

Snx11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei85Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei99Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-11
Gene namesi
Name:Snx11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921729 Snx11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138571 – 271Sorting nexin-11Add BLAST271

Proteomic databases

MaxQBiQ91WL6
PaxDbiQ91WL6
PRIDEiQ91WL6

PTM databases

iPTMnetiQ91WL6
PhosphoSitePlusiQ91WL6
SwissPalmiQ91WL6

Expressioni

Gene expression databases

BgeeiENSMUSG00000020876
CleanExiMM_SNX11
ExpressionAtlasiQ91WL6 baseline and differential
GenevisibleiQ91WL6 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021246

Structurei

3D structure databases

ProteinModelPortaliQ91WL6
SMRiQ91WL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 132PXPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 139Important for membrane traffickingBy similarity5

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2527 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00650000093174
HOGENOMiHOG000231108
HOVERGENiHBG054994
InParanoidiQ91WL6
KOiK17924
OMAiSCCFLPR
OrthoDBiEOG091G0NL7
PhylomeDBiQ91WL6
TreeFamiTF332117

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR028655 SNX11
PANTHERiPTHR10555:SF36 PTHR10555:SF36, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLWYRMLEN QDLEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT
60 70 80 90 100
AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG GSDEFIEKRR
110 120 130 140 150
QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRGAMTVSDA
160 170 180 190 200
ILSYAMSNCG WAQEERQSTS HLAKGDQLNS CCFLPRSGRR SSPSPPLSEE
210 220 230 240 250
KEQLETWAPV MDSEGPSSES PTLLPSSSLP ACWDPARPEE GLSVSQPARR
260 270
AVAADQAGPM EPTQLDTAWD K
Length:271
Mass (Da):30,431
Last modified:December 1, 2001 - v1
Checksum:iD1921CBD70477456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042409 mRNA Translation: BAE20632.1
AK076332 mRNA Translation: BAC36302.1
BC014719 mRNA Translation: AAH14719.1
CCDSiCCDS25302.1
RefSeqiNP_001156861.1, NM_001163389.1
NP_083241.1, NM_028965.4
XP_006534438.1, XM_006534375.3
XP_011247591.1, XM_011249289.2
UniGeneiMm.270781

Genome annotation databases

EnsembliENSMUST00000021246; ENSMUSP00000021246; ENSMUSG00000020876
ENSMUST00000107661; ENSMUSP00000103288; ENSMUSG00000020876
GeneIDi74479
KEGGimmu:74479
UCSCiuc007lci.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSNX11_MOUSE
AccessioniPrimary (citable) accession number: Q91WL6
Secondary accession number(s): Q3V3A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health