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Protein

Sorting nexin-11

Gene

Snx11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Phosphatidylinositol 3-phosphateBy similarity
Binding sitei85 – 851Phosphatidylinositol 3-phosphateBy similarity
Binding sitei99 – 991Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-11
Gene namesi
Name:Snx11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921729. Snx11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Sorting nexin-11PRO_0000213857Add
BLAST

Proteomic databases

MaxQBiQ91WL6.
PaxDbiQ91WL6.
PRIDEiQ91WL6.

PTM databases

iPTMnetiQ91WL6.
PhosphoSiteiQ91WL6.

Expressioni

Gene expression databases

BgeeiQ91WL6.
CleanExiMM_SNX11.
ExpressionAtlasiQ91WL6. baseline and differential.
GenevisibleiQ91WL6. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021246.

Structurei

3D structure databases

ProteinModelPortaliQ91WL6.
SMRiQ91WL6. Positions 15-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 132117PXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1395Important for membrane traffickingBy similarity

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ91WL6.
KOiK17924.
OMAiSCCFLPR.
OrthoDBiEOG73Z2TQ.
PhylomeDBiQ91WL6.
TreeFamiTF332117.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLWYRMLEN QDLEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT
60 70 80 90 100
AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG GSDEFIEKRR
110 120 130 140 150
QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRGAMTVSDA
160 170 180 190 200
ILSYAMSNCG WAQEERQSTS HLAKGDQLNS CCFLPRSGRR SSPSPPLSEE
210 220 230 240 250
KEQLETWAPV MDSEGPSSES PTLLPSSSLP ACWDPARPEE GLSVSQPARR
260 270
AVAADQAGPM EPTQLDTAWD K
Length:271
Mass (Da):30,431
Last modified:December 1, 2001 - v1
Checksum:iD1921CBD70477456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042409 mRNA. Translation: BAE20632.1.
AK076332 mRNA. Translation: BAC36302.1.
BC014719 mRNA. Translation: AAH14719.1.
CCDSiCCDS25302.1.
RefSeqiNP_001156861.1. NM_001163389.1.
NP_083241.1. NM_028965.4.
XP_006534438.1. XM_006534375.2.
XP_011247591.1. XM_011249289.1.
UniGeneiMm.270781.

Genome annotation databases

EnsembliENSMUST00000021246; ENSMUSP00000021246; ENSMUSG00000020876.
ENSMUST00000107661; ENSMUSP00000103288; ENSMUSG00000020876.
GeneIDi74479.
KEGGimmu:74479.
UCSCiuc007lci.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042409 mRNA. Translation: BAE20632.1.
AK076332 mRNA. Translation: BAC36302.1.
BC014719 mRNA. Translation: AAH14719.1.
CCDSiCCDS25302.1.
RefSeqiNP_001156861.1. NM_001163389.1.
NP_083241.1. NM_028965.4.
XP_006534438.1. XM_006534375.2.
XP_011247591.1. XM_011249289.1.
UniGeneiMm.270781.

3D structure databases

ProteinModelPortaliQ91WL6.
SMRiQ91WL6. Positions 15-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021246.

PTM databases

iPTMnetiQ91WL6.
PhosphoSiteiQ91WL6.

Proteomic databases

MaxQBiQ91WL6.
PaxDbiQ91WL6.
PRIDEiQ91WL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021246; ENSMUSP00000021246; ENSMUSG00000020876.
ENSMUST00000107661; ENSMUSP00000103288; ENSMUSG00000020876.
GeneIDi74479.
KEGGimmu:74479.
UCSCiuc007lci.2. mouse.

Organism-specific databases

CTDi29916.
MGIiMGI:1921729. Snx11.

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ91WL6.
KOiK17924.
OMAiSCCFLPR.
OrthoDBiEOG73Z2TQ.
PhylomeDBiQ91WL6.
TreeFamiTF332117.

Miscellaneous databases

ChiTaRSiSnx11. mouse.
PROiQ91WL6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WL6.
CleanExiMM_SNX11.
ExpressionAtlasiQ91WL6. baseline and differential.
GenevisibleiQ91WL6. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiSNX11_MOUSE
AccessioniPrimary (citable) accession number: Q91WL6
Secondary accession number(s): Q3V3A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.