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Q91WL5

- CP4CA_MOUSE

UniProt

Q91WL5 - CP4CA_MOUSE

Protein

Cytochrome P450 4A12A

Gene

Cyp4a12a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Curated

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei319 – 3191Heme (covalent; via 1 link)By similarity
    Metal bindingi455 – 4551Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. alkane 1-monooxygenase activity Source: MGI
    2. aromatase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro
    5. monooxygenase activity Source: UniProtKB

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4A12A (EC:1.14.14.1)
    Alternative name(s):
    CYPIVA12
    Gene namesi
    Name:Cyp4a12a
    Synonyms:Cyp4a12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:88612. Cyp4a12a.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Cytochrome P450 4A12APRO_0000051817Add
    BLAST

    Proteomic databases

    PaxDbiQ91WL5.
    PRIDEiQ91WL5.

    PTM databases

    PhosphoSiteiQ91WL5.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

    Gene expression databases

    BgeeiQ91WL5.
    GenevestigatoriQ91WL5.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1864052.
    STRINGi10090.ENSMUSP00000081370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WL5.
    SMRiQ91WL5. Positions 70-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00740000115505.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiA2A973.
    KOiK07425.
    OMAiANSACKL.
    OrthoDBiEOG7CNZFK.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91WL5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASALSSIR FPGSISEYLQ VASVLSLLLL LFKTAQLYLH RQWLLSSTQQ    50
    FPSPPSHWLF GHKILKDQDL QDILTRIKNF PSACPQWLWG SKVRIQVYDP 100
    DYMKLILGRS DPKANGSYRF LAPWIGRGLL MLDGQTWFQH RRMLTPAFHY 150
    DILKPYTEIM ADSVRVMLDK WEQIVGQDST LEIFRHITLM TLDTIMKCAF 200
    SHEGSVQLDR KYKSYIQAVE DLNDLVFSRV RNIFHQNDII YRVSSNGCKA 250
    NSACKLAHDH TDQVIKSRRI QLQDEEELEK LKKKRRLDFL DILLFARMEN 300
    GKSLSDKDLR AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ 350
    SLLGDGTSIT WNDLDKMPYT TMCIKEALRI YPPVPSVSRE LSSPVTFPDG 400
    RSLPKGIHVM LSFYGLHHNP TVWPNPEVFD PSRFAPGSSR HSHSFLPFSG 450
    GARNCIGKQF AMNELKVAVA LTLLRFELLP DPTRVPIPIP RIVLKSKNGI 500
    HLHLKKLQ 508
    Length:508
    Mass (Da):58,350
    Last modified:July 27, 2011 - v2
    Checksum:i0F6C78665E78DF4F
    GO

    Sequence cautioni

    The sequence BAE25803.1 differs from that shown. Reason: Frameshift at position 492.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581W → C in BAE25803. (PubMed:16141072)Curated
    Sequence conflicti131 – 1311M → L in AAH14721. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311M → L in AAH25936. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311M → L in AAH26582. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311M → L in AAH31141. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311M → L in AAH33924. (PubMed:15489334)Curated
    Sequence conflicti288 – 2881D → G in BAE25803. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK144260 mRNA. Translation: BAE25803.1. Frameshift.
    AL627227, AL627182 Genomic DNA. Translation: CAM18400.1.
    AL627182, AL627227 Genomic DNA. Translation: CAM21083.1.
    CH466552 Genomic DNA. Translation: EDL30651.1.
    BC014721 mRNA. Translation: AAH14721.1.
    BC025936 mRNA. Translation: AAH25936.1.
    BC026582 mRNA. Translation: AAH26582.1.
    BC031141 mRNA. Translation: AAH31141.1.
    BC033924 mRNA. Translation: AAH33924.1.
    CCDSiCCDS18489.1.
    RefSeqiNP_803125.2. NM_177406.3.
    UniGeneiMm.276106.

    Genome annotation databases

    EnsembliENSMUST00000084343; ENSMUSP00000081370; ENSMUSG00000066071.
    GeneIDi277753.
    KEGGimmu:277753.
    UCSCiuc008uer.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK144260 mRNA. Translation: BAE25803.1 . Frameshift.
    AL627227 , AL627182 Genomic DNA. Translation: CAM18400.1 .
    AL627182 , AL627227 Genomic DNA. Translation: CAM21083.1 .
    CH466552 Genomic DNA. Translation: EDL30651.1 .
    BC014721 mRNA. Translation: AAH14721.1 .
    BC025936 mRNA. Translation: AAH25936.1 .
    BC026582 mRNA. Translation: AAH26582.1 .
    BC031141 mRNA. Translation: AAH31141.1 .
    BC033924 mRNA. Translation: AAH33924.1 .
    CCDSi CCDS18489.1.
    RefSeqi NP_803125.2. NM_177406.3.
    UniGenei Mm.276106.

    3D structure databases

    ProteinModelPortali Q91WL5.
    SMRi Q91WL5. Positions 70-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1864052.
    STRINGi 10090.ENSMUSP00000081370.

    PTM databases

    PhosphoSitei Q91WL5.

    Proteomic databases

    PaxDbi Q91WL5.
    PRIDEi Q91WL5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084343 ; ENSMUSP00000081370 ; ENSMUSG00000066071 .
    GeneIDi 277753.
    KEGGi mmu:277753.
    UCSCi uc008uer.1. mouse.

    Organism-specific databases

    CTDi 277753.
    MGIi MGI:88612. Cyp4a12a.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00740000115505.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi A2A973.
    KOi K07425.
    OMAi ANSACKL.
    OrthoDBi EOG7CNZFK.
    TreeFami TF105088.

    Enzyme and pathway databases

    Reactomei REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 393827.
    PROi Q91WL5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91WL5.
    Genevestigatori Q91WL5.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: Gall bladderImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: KidneyImported and LiverImported.

    Entry informationi

    Entry nameiCP4CA_MOUSE
    AccessioniPrimary (citable) accession number: Q91WL5
    Secondary accession number(s): A2A973
    , Q3UNE4, Q6P931, Q8N7N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3