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Q91WL5

- CP4CA_MOUSE

UniProt

Q91WL5 - CP4CA_MOUSE

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Protein
Cytochrome P450 4A12A
Gene
Cyp4a12a, Cyp4a12
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei319 – 3191Heme (covalent; via 1 link) By similarityBy similarity
Metal bindingi455 – 4551Iron (heme axial ligand) By similarityBy similarity

GO - Molecular functioni

  1. alkane 1-monooxygenase activity Source: MGI
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4A12A (EC:1.14.14.1)
Alternative name(s):
CYPIVA12
Gene namesi
Name:Cyp4a12a
Synonyms:Cyp4a12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:88612. Cyp4a12a.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Cytochrome P450 4A12A
PRO_0000051817Add
BLAST

Proteomic databases

PaxDbiQ91WL5.
PRIDEiQ91WL5.

PTM databases

PhosphoSiteiQ91WL5.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiQ91WL5.
GenevestigatoriQ91WL5.

Interactioni

Protein-protein interaction databases

MINTiMINT-1864052.
STRINGi10090.ENSMUSP00000081370.

Structurei

3D structure databases

ProteinModelPortaliQ91WL5.
SMRiQ91WL5. Positions 70-508.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00740000115505.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiA2A973.
KOiK07425.
OMAiANSACKL.
OrthoDBiEOG7CNZFK.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WL5-1 [UniParc]FASTAAdd to Basket

« Hide

MSASALSSIR FPGSISEYLQ VASVLSLLLL LFKTAQLYLH RQWLLSSTQQ    50
FPSPPSHWLF GHKILKDQDL QDILTRIKNF PSACPQWLWG SKVRIQVYDP 100
DYMKLILGRS DPKANGSYRF LAPWIGRGLL MLDGQTWFQH RRMLTPAFHY 150
DILKPYTEIM ADSVRVMLDK WEQIVGQDST LEIFRHITLM TLDTIMKCAF 200
SHEGSVQLDR KYKSYIQAVE DLNDLVFSRV RNIFHQNDII YRVSSNGCKA 250
NSACKLAHDH TDQVIKSRRI QLQDEEELEK LKKKRRLDFL DILLFARMEN 300
GKSLSDKDLR AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ 350
SLLGDGTSIT WNDLDKMPYT TMCIKEALRI YPPVPSVSRE LSSPVTFPDG 400
RSLPKGIHVM LSFYGLHHNP TVWPNPEVFD PSRFAPGSSR HSHSFLPFSG 450
GARNCIGKQF AMNELKVAVA LTLLRFELLP DPTRVPIPIP RIVLKSKNGI 500
HLHLKKLQ 508
Length:508
Mass (Da):58,350
Last modified:July 27, 2011 - v2
Checksum:i0F6C78665E78DF4F
GO

Sequence cautioni

The sequence BAE25803.1 differs from that shown. Reason: Frameshift at position 492.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581W → C in BAE25803. 1 Publication
Sequence conflicti131 – 1311M → L in AAH14721. 1 Publication
Sequence conflicti131 – 1311M → L in AAH25936. 1 Publication
Sequence conflicti131 – 1311M → L in AAH26582. 1 Publication
Sequence conflicti131 – 1311M → L in AAH31141. 1 Publication
Sequence conflicti131 – 1311M → L in AAH33924. 1 Publication
Sequence conflicti288 – 2881D → G in BAE25803. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK144260 mRNA. Translation: BAE25803.1. Frameshift.
AL627227, AL627182 Genomic DNA. Translation: CAM18400.1.
AL627182, AL627227 Genomic DNA. Translation: CAM21083.1.
CH466552 Genomic DNA. Translation: EDL30651.1.
BC014721 mRNA. Translation: AAH14721.1.
BC025936 mRNA. Translation: AAH25936.1.
BC026582 mRNA. Translation: AAH26582.1.
BC031141 mRNA. Translation: AAH31141.1.
BC033924 mRNA. Translation: AAH33924.1.
CCDSiCCDS18489.1.
RefSeqiNP_803125.2. NM_177406.3.
UniGeneiMm.276106.

Genome annotation databases

EnsembliENSMUST00000084343; ENSMUSP00000081370; ENSMUSG00000066071.
GeneIDi277753.
KEGGimmu:277753.
UCSCiuc008uer.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK144260 mRNA. Translation: BAE25803.1 . Frameshift.
AL627227 , AL627182 Genomic DNA. Translation: CAM18400.1 .
AL627182 , AL627227 Genomic DNA. Translation: CAM21083.1 .
CH466552 Genomic DNA. Translation: EDL30651.1 .
BC014721 mRNA. Translation: AAH14721.1 .
BC025936 mRNA. Translation: AAH25936.1 .
BC026582 mRNA. Translation: AAH26582.1 .
BC031141 mRNA. Translation: AAH31141.1 .
BC033924 mRNA. Translation: AAH33924.1 .
CCDSi CCDS18489.1.
RefSeqi NP_803125.2. NM_177406.3.
UniGenei Mm.276106.

3D structure databases

ProteinModelPortali Q91WL5.
SMRi Q91WL5. Positions 70-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1864052.
STRINGi 10090.ENSMUSP00000081370.

PTM databases

PhosphoSitei Q91WL5.

Proteomic databases

PaxDbi Q91WL5.
PRIDEi Q91WL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084343 ; ENSMUSP00000081370 ; ENSMUSG00000066071 .
GeneIDi 277753.
KEGGi mmu:277753.
UCSCi uc008uer.1. mouse.

Organism-specific databases

CTDi 277753.
MGIi MGI:88612. Cyp4a12a.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00740000115505.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi A2A973.
KOi K07425.
OMAi ANSACKL.
OrthoDBi EOG7CNZFK.
TreeFami TF105088.

Enzyme and pathway databases

Reactomei REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi 393827.
PROi Q91WL5.
SOURCEi Search...

Gene expression databases

Bgeei Q91WL5.
Genevestigatori Q91WL5.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Gall bladder.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Liver.

Entry informationi

Entry nameiCP4CA_MOUSE
AccessioniPrimary (citable) accession number: Q91WL5
Secondary accession number(s): A2A973
, Q3UNE4, Q6P931, Q8N7N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi