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Protein

Cytochrome P450 4A12A

Gene

Cyp4a12a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Curated

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei319 – 3191Heme (covalent; via 1 link)By similarity
Metal bindingi455 – 4551Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_300263. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_331519. Fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4A12A (EC:1.14.14.1)
Alternative name(s):
CYPIVA12
Gene namesi
Name:Cyp4a12a
Synonyms:Cyp4a12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88612. Cyp4a12a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 508507Cytochrome P450 4A12APRO_0000051817Add
BLAST

Proteomic databases

PaxDbiQ91WL5.
PRIDEiQ91WL5.

PTM databases

PhosphoSiteiQ91WL5.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiQ91WL5.
ExpressionAtlasiQ91WL5. baseline and differential.
GenevisibleiQ91WL5. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1864052.
STRINGi10090.ENSMUSP00000081370.

Structurei

3D structure databases

ProteinModelPortaliQ91WL5.
SMRiQ91WL5. Positions 90-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ91WL5.
KOiK07425.
OMAiCKANSAC.
OrthoDBiEOG7CNZFK.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASALSSIR FPGSISEYLQ VASVLSLLLL LFKTAQLYLH RQWLLSSTQQ
60 70 80 90 100
FPSPPSHWLF GHKILKDQDL QDILTRIKNF PSACPQWLWG SKVRIQVYDP
110 120 130 140 150
DYMKLILGRS DPKANGSYRF LAPWIGRGLL MLDGQTWFQH RRMLTPAFHY
160 170 180 190 200
DILKPYTEIM ADSVRVMLDK WEQIVGQDST LEIFRHITLM TLDTIMKCAF
210 220 230 240 250
SHEGSVQLDR KYKSYIQAVE DLNDLVFSRV RNIFHQNDII YRVSSNGCKA
260 270 280 290 300
NSACKLAHDH TDQVIKSRRI QLQDEEELEK LKKKRRLDFL DILLFARMEN
310 320 330 340 350
GKSLSDKDLR AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ
360 370 380 390 400
SLLGDGTSIT WNDLDKMPYT TMCIKEALRI YPPVPSVSRE LSSPVTFPDG
410 420 430 440 450
RSLPKGIHVM LSFYGLHHNP TVWPNPEVFD PSRFAPGSSR HSHSFLPFSG
460 470 480 490 500
GARNCIGKQF AMNELKVAVA LTLLRFELLP DPTRVPIPIP RIVLKSKNGI

HLHLKKLQ
Length:508
Mass (Da):58,350
Last modified:July 27, 2011 - v2
Checksum:i0F6C78665E78DF4F
GO

Sequence cautioni

The sequence BAE25803.1 differs from that shown. Reason: Frameshift at position 492. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581W → C in BAE25803 (PubMed:16141072).Curated
Sequence conflicti131 – 1311M → L in AAH14721 (PubMed:15489334).Curated
Sequence conflicti131 – 1311M → L in AAH25936 (PubMed:15489334).Curated
Sequence conflicti131 – 1311M → L in AAH26582 (PubMed:15489334).Curated
Sequence conflicti131 – 1311M → L in AAH31141 (PubMed:15489334).Curated
Sequence conflicti131 – 1311M → L in AAH33924 (PubMed:15489334).Curated
Sequence conflicti288 – 2881D → G in BAE25803 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144260 mRNA. Translation: BAE25803.1. Frameshift.
AL627227, AL627182 Genomic DNA. Translation: CAM18400.1.
AL627182, AL627227 Genomic DNA. Translation: CAM21083.1.
CH466552 Genomic DNA. Translation: EDL30651.1.
BC014721 mRNA. Translation: AAH14721.1.
BC025936 mRNA. Translation: AAH25936.1.
BC026582 mRNA. Translation: AAH26582.1.
BC031141 mRNA. Translation: AAH31141.1.
BC033924 mRNA. Translation: AAH33924.1.
CCDSiCCDS18489.1.
RefSeqiNP_803125.2. NM_177406.3.
UniGeneiMm.276106.

Genome annotation databases

EnsembliENSMUST00000084343; ENSMUSP00000081370; ENSMUSG00000066071.
GeneIDi277753.
KEGGimmu:277753.
UCSCiuc008uer.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144260 mRNA. Translation: BAE25803.1. Frameshift.
AL627227, AL627182 Genomic DNA. Translation: CAM18400.1.
AL627182, AL627227 Genomic DNA. Translation: CAM21083.1.
CH466552 Genomic DNA. Translation: EDL30651.1.
BC014721 mRNA. Translation: AAH14721.1.
BC025936 mRNA. Translation: AAH25936.1.
BC026582 mRNA. Translation: AAH26582.1.
BC031141 mRNA. Translation: AAH31141.1.
BC033924 mRNA. Translation: AAH33924.1.
CCDSiCCDS18489.1.
RefSeqiNP_803125.2. NM_177406.3.
UniGeneiMm.276106.

3D structure databases

ProteinModelPortaliQ91WL5.
SMRiQ91WL5. Positions 90-497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1864052.
STRINGi10090.ENSMUSP00000081370.

PTM databases

PhosphoSiteiQ91WL5.

Proteomic databases

PaxDbiQ91WL5.
PRIDEiQ91WL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084343; ENSMUSP00000081370; ENSMUSG00000066071.
GeneIDi277753.
KEGGimmu:277753.
UCSCiuc008uer.1. mouse.

Organism-specific databases

CTDi277753.
MGIiMGI:88612. Cyp4a12a.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ91WL5.
KOiK07425.
OMAiCKANSAC.
OrthoDBiEOG7CNZFK.
TreeFamiTF105088.

Enzyme and pathway databases

ReactomeiREACT_300263. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_331519. Fatty acids.

Miscellaneous databases

NextBioi393827.
PROiQ91WL5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WL5.
ExpressionAtlasiQ91WL5. baseline and differential.
GenevisibleiQ91WL5. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Gall bladderImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: KidneyImported and LiverImported.

Entry informationi

Entry nameiCP4CA_MOUSE
AccessioniPrimary (citable) accession number: Q91WL5
Secondary accession number(s): A2A973
, Q3UNE4, Q6P931, Q8N7N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.