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Protein

Epidermal growth factor receptor kinase substrate 8-like protein 3

Gene

Eps8l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 3
Short name:
EPS8-like protein 3
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 3
Short name:
EPS8-related protein 3
Gene namesi
Name:Eps8l3
Synonyms:Eps8r3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2139743. Eps8l3.

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Epidermal growth factor receptor kinase substrate 8-like protein 3PRO_0000239088Add
BLAST

Proteomic databases

MaxQBiQ91WL0.
PaxDbiQ91WL0.
PRIDEiQ91WL0.

PTM databases

PhosphoSiteiQ91WL0.

Expressioni

Tissue specificityi

Detected in embryonic gut. Detected in adult testis, placenta, adrenal gland and intestine.1 Publication

Gene expression databases

BgeeiQ91WL0.
CleanExiMM_EPS8L3.
GenevestigatoriQ91WL0.

Interactioni

Subunit structurei

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Interacts with FASLG (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91WL0.
SMRiQ91WL0. Positions 28-148, 454-514, 516-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini457 – 51660SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 24273Pro-richAdd
BLAST
Compositional biasi273 – 28513Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the EPS8 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG277915.
GeneTreeiENSGT00390000003646.
HOGENOMiHOG000112393.
HOVERGENiHBG099838.
InParanoidiQ91WL0.
KOiK17277.
OMAiWLQAENF.
OrthoDBiEOG7TMZR9.
PhylomeDBiQ91WL0.
TreeFamiTF313069.

Family and domain databases

InterProiIPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPSSRAIY LHRKEYSQSM ASEPTLLQHR VEHLMTCKLG TQRVREPKDA
60 70 80 90 100
LQKLQEMDAQ GRVWSQDLFL QVRDGWLHLL DIETKEELDS YRLDNIKAID
110 120 130 140 150
VALNTCSYNS ILSVTVQESG LPGISTLLFQ CQEVGAEQLR TSLQKALEEE
160 170 180 190 200
LEERPRFGVH HPSQDRWKGP PLERPLPIQQ APPLEQRFSP EHRFPPEQPH
210 220 230 240 250
NMTSERSISP SSRSLTHYPS AREPNGFTLP PPPRRAPSPE DPERDEEVLN
260 270 280 290 300
HVLRDIELFA GKLKEVQARN SHKKTKLGRK KKKSKNGITQ AEYIDCFQKI
310 320 330 340 350
KLSFNLLGKL ALRMQETSAP EFVGLIFQTL KFILSQCPEA GLPAKVISPL
360 370 380 390 400
LTPKAIDLLQ SCLSPPEDTL WKSLGTSWTT SWADWTGSEP PPYQPTFYDG
410 420 430 440 450
WQIPQPRSMM PITNQDSISL RGSRMRSSLH FPRDEPYNHN PEYEDSNLPL
460 470 480 490 500
SSPSPGRAAL KMQVLYEFEA RNAQELTVAQ GEILEVLDQS KRWWLVKNEA
510 520 530 540 550
GLTGYIPSNI LEPLPAGAPR GHRQPSFRAP MLRLSSKPEE VTAWLQAENF
560 570 580 590 600
STVTVRTLGS LMGSQLLHMR PGELQMLCPQ EAPRIQARLD AVRRMLGMTH
Length:600
Mass (Da):68,216
Last modified:December 1, 2001 - v1
Checksum:i4AD0F34FCCCCDD39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014734 mRNA. Translation: AAH14734.1.
AY074932 mRNA. Translation: AAL76121.1.
AK167630 mRNA. Translation: BAE39681.1.
CCDSiCCDS38594.1.
RefSeqiNP_598628.1. NM_133867.2.
XP_006502527.2. XM_006502464.2.
UniGeneiMm.108491.

Genome annotation databases

EnsembliENSMUST00000037375; ENSMUSP00000042004; ENSMUSG00000040600.
GeneIDi99662.
KEGGimmu:99662.
UCSCiuc008qxo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014734 mRNA. Translation: AAH14734.1.
AY074932 mRNA. Translation: AAL76121.1.
AK167630 mRNA. Translation: BAE39681.1.
CCDSiCCDS38594.1.
RefSeqiNP_598628.1. NM_133867.2.
XP_006502527.2. XM_006502464.2.
UniGeneiMm.108491.

3D structure databases

ProteinModelPortaliQ91WL0.
SMRiQ91WL0. Positions 28-148, 454-514, 516-582.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ91WL0.

Proteomic databases

MaxQBiQ91WL0.
PaxDbiQ91WL0.
PRIDEiQ91WL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037375; ENSMUSP00000042004; ENSMUSG00000040600.
GeneIDi99662.
KEGGimmu:99662.
UCSCiuc008qxo.2. mouse.

Organism-specific databases

CTDi79574.
MGIiMGI:2139743. Eps8l3.

Phylogenomic databases

eggNOGiNOG277915.
GeneTreeiENSGT00390000003646.
HOGENOMiHOG000112393.
HOVERGENiHBG099838.
InParanoidiQ91WL0.
KOiK17277.
OMAiWLQAENF.
OrthoDBiEOG7TMZR9.
PhylomeDBiQ91WL0.
TreeFamiTF313069.

Miscellaneous databases

NextBioi354051.
PROiQ91WL0.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WL0.
CleanExiMM_EPS8L3.
GenevestigatoriQ91WL0.

Family and domain databases

InterProiIPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."
    Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C.
    Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-278.
  4. "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."
    Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., Di Fiore P.P., Scita G.
    Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiES8L3_MOUSE
AccessioniPrimary (citable) accession number: Q91WL0
Secondary accession number(s): Q3TJ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.