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Q91WL0 (ES8L3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 3

Short name=EPS8-like protein 3
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 3
Short name=EPS8-related protein 3
Gene names
Name:Eps8l3
Synonyms:Eps8r3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Interacts with FASLG By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Detected in embryonic gut. Detected in adult testis, placenta, adrenal gland and intestine. Ref.4

Sequence similarities

Belongs to the EPS8 family.

Contains 1 SH3 domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainSH3 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Epidermal growth factor receptor kinase substrate 8-like protein 3
PRO_0000239088

Regions

Domain457 – 51660SH3
Compositional bias170 – 24273Pro-rich
Compositional bias273 – 28513Lys-rich

Sequences

Sequence LengthMass (Da)Tools
Q91WL0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4AD0F34FCCCCDD39

FASTA60068,216
        10         20         30         40         50         60 
MSRPSSRAIY LHRKEYSQSM ASEPTLLQHR VEHLMTCKLG TQRVREPKDA LQKLQEMDAQ 

        70         80         90        100        110        120 
GRVWSQDLFL QVRDGWLHLL DIETKEELDS YRLDNIKAID VALNTCSYNS ILSVTVQESG 

       130        140        150        160        170        180 
LPGISTLLFQ CQEVGAEQLR TSLQKALEEE LEERPRFGVH HPSQDRWKGP PLERPLPIQQ 

       190        200        210        220        230        240 
APPLEQRFSP EHRFPPEQPH NMTSERSISP SSRSLTHYPS AREPNGFTLP PPPRRAPSPE 

       250        260        270        280        290        300 
DPERDEEVLN HVLRDIELFA GKLKEVQARN SHKKTKLGRK KKKSKNGITQ AEYIDCFQKI 

       310        320        330        340        350        360 
KLSFNLLGKL ALRMQETSAP EFVGLIFQTL KFILSQCPEA GLPAKVISPL LTPKAIDLLQ 

       370        380        390        400        410        420 
SCLSPPEDTL WKSLGTSWTT SWADWTGSEP PPYQPTFYDG WQIPQPRSMM PITNQDSISL 

       430        440        450        460        470        480 
RGSRMRSSLH FPRDEPYNHN PEYEDSNLPL SSPSPGRAAL KMQVLYEFEA RNAQELTVAQ 

       490        500        510        520        530        540 
GEILEVLDQS KRWWLVKNEA GLTGYIPSNI LEPLPAGAPR GHRQPSFRAP MLRLSSKPEE 

       550        560        570        580        590        600 
VTAWLQAENF STVTVRTLGS LMGSQLLHMR PGELQMLCPQ EAPRIQARLD AVRRMLGMTH 

« Hide

References

« Hide 'large scale' references
[1]"In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."
Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C.
Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-278.
[4]"The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."
Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., Di Fiore P.P., Scita G.
Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC014734 mRNA. Translation: AAH14734.1.
AY074932 mRNA. Translation: AAL76121.1.
AK167630 mRNA. Translation: BAE39681.1.
RefSeqNP_598628.1. NM_133867.2.
UniGeneMm.108491.

3D structure databases

ProteinModelPortalQ91WL0.
SMRQ91WL0. Positions 28-148, 454-514, 516-582.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91WL0.

Proteomic databases

PaxDbQ91WL0.
PRIDEQ91WL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037375; ENSMUSP00000042004; ENSMUSG00000040600.
GeneID99662.
KEGGmmu:99662.
UCSCuc008qxo.2. mouse.

Organism-specific databases

CTD79574.
MGIMGI:2139743. Eps8l3.

Phylogenomic databases

eggNOGNOG277915.
GeneTreeENSGT00390000003646.
HOGENOMHOG000112393.
HOVERGENHBG099838.
InParanoidQ91WL0.
KOK17277.
OMAWLQAENF.
OrthoDBEOG7TMZR9.
PhylomeDBQ91WL0.
TreeFamTF313069.

Gene expression databases

BgeeQ91WL0.
CleanExMM_EPS8L3.
GenevestigatorQ91WL0.

Family and domain databases

InterProIPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio354051.
PROQ91WL0.
SOURCESearch...

Entry information

Entry nameES8L3_MOUSE
AccessionPrimary (citable) accession number: Q91WL0
Secondary accession number(s): Q3TJ14
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot