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Q91WL0

- ES8L3_MOUSE

UniProt

Q91WL0 - ES8L3_MOUSE

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Protein

Epidermal growth factor receptor kinase substrate 8-like protein 3

Gene

Eps8l3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 3
Short name:
EPS8-like protein 3
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 3
Short name:
EPS8-related protein 3
Gene namesi
Name:Eps8l3
Synonyms:Eps8r3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2139743. Eps8l3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Epidermal growth factor receptor kinase substrate 8-like protein 3PRO_0000239088Add
BLAST

Proteomic databases

MaxQBiQ91WL0.
PaxDbiQ91WL0.
PRIDEiQ91WL0.

PTM databases

PhosphoSiteiQ91WL0.

Expressioni

Tissue specificityi

Detected in embryonic gut. Detected in adult testis, placenta, adrenal gland and intestine.1 Publication

Gene expression databases

BgeeiQ91WL0.
CleanExiMM_EPS8L3.
GenevestigatoriQ91WL0.

Interactioni

Subunit structurei

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Interacts with FASLG By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91WL0.
SMRiQ91WL0. Positions 28-148, 454-514, 516-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini457 – 51660SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 24273Pro-richAdd
BLAST
Compositional biasi273 – 28513Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the EPS8 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG277915.
GeneTreeiENSGT00390000003646.
HOGENOMiHOG000112393.
HOVERGENiHBG099838.
InParanoidiQ91WL0.
KOiK17277.
OMAiWLQAENF.
OrthoDBiEOG7TMZR9.
PhylomeDBiQ91WL0.
TreeFamiTF313069.

Family and domain databases

InterProiIPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRPSSRAIY LHRKEYSQSM ASEPTLLQHR VEHLMTCKLG TQRVREPKDA
60 70 80 90 100
LQKLQEMDAQ GRVWSQDLFL QVRDGWLHLL DIETKEELDS YRLDNIKAID
110 120 130 140 150
VALNTCSYNS ILSVTVQESG LPGISTLLFQ CQEVGAEQLR TSLQKALEEE
160 170 180 190 200
LEERPRFGVH HPSQDRWKGP PLERPLPIQQ APPLEQRFSP EHRFPPEQPH
210 220 230 240 250
NMTSERSISP SSRSLTHYPS AREPNGFTLP PPPRRAPSPE DPERDEEVLN
260 270 280 290 300
HVLRDIELFA GKLKEVQARN SHKKTKLGRK KKKSKNGITQ AEYIDCFQKI
310 320 330 340 350
KLSFNLLGKL ALRMQETSAP EFVGLIFQTL KFILSQCPEA GLPAKVISPL
360 370 380 390 400
LTPKAIDLLQ SCLSPPEDTL WKSLGTSWTT SWADWTGSEP PPYQPTFYDG
410 420 430 440 450
WQIPQPRSMM PITNQDSISL RGSRMRSSLH FPRDEPYNHN PEYEDSNLPL
460 470 480 490 500
SSPSPGRAAL KMQVLYEFEA RNAQELTVAQ GEILEVLDQS KRWWLVKNEA
510 520 530 540 550
GLTGYIPSNI LEPLPAGAPR GHRQPSFRAP MLRLSSKPEE VTAWLQAENF
560 570 580 590 600
STVTVRTLGS LMGSQLLHMR PGELQMLCPQ EAPRIQARLD AVRRMLGMTH
Length:600
Mass (Da):68,216
Last modified:December 1, 2001 - v1
Checksum:i4AD0F34FCCCCDD39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC014734 mRNA. Translation: AAH14734.1.
AY074932 mRNA. Translation: AAL76121.1.
AK167630 mRNA. Translation: BAE39681.1.
CCDSiCCDS38594.1.
RefSeqiNP_598628.1. NM_133867.2.
UniGeneiMm.108491.

Genome annotation databases

EnsembliENSMUST00000037375; ENSMUSP00000042004; ENSMUSG00000040600.
GeneIDi99662.
KEGGimmu:99662.
UCSCiuc008qxo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC014734 mRNA. Translation: AAH14734.1 .
AY074932 mRNA. Translation: AAL76121.1 .
AK167630 mRNA. Translation: BAE39681.1 .
CCDSi CCDS38594.1.
RefSeqi NP_598628.1. NM_133867.2.
UniGenei Mm.108491.

3D structure databases

ProteinModelPortali Q91WL0.
SMRi Q91WL0. Positions 28-148, 454-514, 516-582.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91WL0.

Proteomic databases

MaxQBi Q91WL0.
PaxDbi Q91WL0.
PRIDEi Q91WL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037375 ; ENSMUSP00000042004 ; ENSMUSG00000040600 .
GeneIDi 99662.
KEGGi mmu:99662.
UCSCi uc008qxo.2. mouse.

Organism-specific databases

CTDi 79574.
MGIi MGI:2139743. Eps8l3.

Phylogenomic databases

eggNOGi NOG277915.
GeneTreei ENSGT00390000003646.
HOGENOMi HOG000112393.
HOVERGENi HBG099838.
InParanoidi Q91WL0.
KOi K17277.
OMAi WLQAENF.
OrthoDBi EOG7TMZR9.
PhylomeDBi Q91WL0.
TreeFami TF313069.

Miscellaneous databases

NextBioi 354051.
PROi Q91WL0.
SOURCEi Search...

Gene expression databases

Bgeei Q91WL0.
CleanExi MM_EPS8L3.
Genevestigatori Q91WL0.

Family and domain databases

InterProi IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."
    Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C.
    Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-278.
  4. "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."
    Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., Di Fiore P.P., Scita G.
    Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiES8L3_MOUSE
AccessioniPrimary (citable) accession number: Q91WL0
Secondary accession number(s): Q3TJ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3