Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91WL0

- ES8L3_MOUSE

UniProt

Q91WL0 - ES8L3_MOUSE

Protein

Epidermal growth factor receptor kinase substrate 8-like protein 3

Gene

Eps8l3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epidermal growth factor receptor kinase substrate 8-like protein 3
    Short name:
    EPS8-like protein 3
    Alternative name(s):
    Epidermal growth factor receptor pathway substrate 8-related protein 3
    Short name:
    EPS8-related protein 3
    Gene namesi
    Name:Eps8l3
    Synonyms:Eps8r3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2139743. Eps8l3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Epidermal growth factor receptor kinase substrate 8-like protein 3PRO_0000239088Add
    BLAST

    Proteomic databases

    MaxQBiQ91WL0.
    PaxDbiQ91WL0.
    PRIDEiQ91WL0.

    PTM databases

    PhosphoSiteiQ91WL0.

    Expressioni

    Tissue specificityi

    Detected in embryonic gut. Detected in adult testis, placenta, adrenal gland and intestine.1 Publication

    Gene expression databases

    BgeeiQ91WL0.
    CleanExiMM_EPS8L3.
    GenevestigatoriQ91WL0.

    Interactioni

    Subunit structurei

    Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Interacts with FASLG By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WL0.
    SMRiQ91WL0. Positions 28-148, 454-514, 516-582.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini457 – 51660SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi170 – 24273Pro-richAdd
    BLAST
    Compositional biasi273 – 28513Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EPS8 family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG277915.
    GeneTreeiENSGT00390000003646.
    HOGENOMiHOG000112393.
    HOVERGENiHBG099838.
    InParanoidiQ91WL0.
    KOiK17277.
    OMAiWLQAENF.
    OrthoDBiEOG7TMZR9.
    PhylomeDBiQ91WL0.
    TreeFamiTF313069.

    Family and domain databases

    InterProiIPR013625. PTB.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91WL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRPSSRAIY LHRKEYSQSM ASEPTLLQHR VEHLMTCKLG TQRVREPKDA    50
    LQKLQEMDAQ GRVWSQDLFL QVRDGWLHLL DIETKEELDS YRLDNIKAID 100
    VALNTCSYNS ILSVTVQESG LPGISTLLFQ CQEVGAEQLR TSLQKALEEE 150
    LEERPRFGVH HPSQDRWKGP PLERPLPIQQ APPLEQRFSP EHRFPPEQPH 200
    NMTSERSISP SSRSLTHYPS AREPNGFTLP PPPRRAPSPE DPERDEEVLN 250
    HVLRDIELFA GKLKEVQARN SHKKTKLGRK KKKSKNGITQ AEYIDCFQKI 300
    KLSFNLLGKL ALRMQETSAP EFVGLIFQTL KFILSQCPEA GLPAKVISPL 350
    LTPKAIDLLQ SCLSPPEDTL WKSLGTSWTT SWADWTGSEP PPYQPTFYDG 400
    WQIPQPRSMM PITNQDSISL RGSRMRSSLH FPRDEPYNHN PEYEDSNLPL 450
    SSPSPGRAAL KMQVLYEFEA RNAQELTVAQ GEILEVLDQS KRWWLVKNEA 500
    GLTGYIPSNI LEPLPAGAPR GHRQPSFRAP MLRLSSKPEE VTAWLQAENF 550
    STVTVRTLGS LMGSQLLHMR PGELQMLCPQ EAPRIQARLD AVRRMLGMTH 600
    Length:600
    Mass (Da):68,216
    Last modified:December 1, 2001 - v1
    Checksum:i4AD0F34FCCCCDD39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC014734 mRNA. Translation: AAH14734.1.
    AY074932 mRNA. Translation: AAL76121.1.
    AK167630 mRNA. Translation: BAE39681.1.
    CCDSiCCDS38594.1.
    RefSeqiNP_598628.1. NM_133867.2.
    UniGeneiMm.108491.

    Genome annotation databases

    EnsembliENSMUST00000037375; ENSMUSP00000042004; ENSMUSG00000040600.
    GeneIDi99662.
    KEGGimmu:99662.
    UCSCiuc008qxo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC014734 mRNA. Translation: AAH14734.1 .
    AY074932 mRNA. Translation: AAL76121.1 .
    AK167630 mRNA. Translation: BAE39681.1 .
    CCDSi CCDS38594.1.
    RefSeqi NP_598628.1. NM_133867.2.
    UniGenei Mm.108491.

    3D structure databases

    ProteinModelPortali Q91WL0.
    SMRi Q91WL0. Positions 28-148, 454-514, 516-582.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91WL0.

    Proteomic databases

    MaxQBi Q91WL0.
    PaxDbi Q91WL0.
    PRIDEi Q91WL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037375 ; ENSMUSP00000042004 ; ENSMUSG00000040600 .
    GeneIDi 99662.
    KEGGi mmu:99662.
    UCSCi uc008qxo.2. mouse.

    Organism-specific databases

    CTDi 79574.
    MGIi MGI:2139743. Eps8l3.

    Phylogenomic databases

    eggNOGi NOG277915.
    GeneTreei ENSGT00390000003646.
    HOGENOMi HOG000112393.
    HOVERGENi HBG099838.
    InParanoidi Q91WL0.
    KOi K17277.
    OMAi WLQAENF.
    OrthoDBi EOG7TMZR9.
    PhylomeDBi Q91WL0.
    TreeFami TF313069.

    Miscellaneous databases

    NextBioi 354051.
    PROi Q91WL0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91WL0.
    CleanExi MM_EPS8L3.
    Genevestigatori Q91WL0.

    Family and domain databases

    InterProi IPR013625. PTB.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."
      Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C.
      Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-278.
    4. "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."
      Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., Di Fiore P.P., Scita G.
      Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiES8L3_MOUSE
    AccessioniPrimary (citable) accession number: Q91WL0
    Secondary accession number(s): Q3TJ14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3