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Protein

Ankyrin repeat domain-containing protein 54

Gene

Ankrd54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.1 Publication

GO - Molecular functioni

  • protein kinase regulator activity Source: MGI

GO - Biological processi

  • nucleocytoplasmic transport Source: MGI
  • positive regulation of erythrocyte differentiation Source: MGI
  • regulation of intracellular signal transduction Source: MGI
  • regulation of protein kinase activity Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 54
Alternative name(s):
Lyn-interacting ankyrin repeat protein
Gene namesi
Name:Ankrd54
Synonyms:Liar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2444209 Ankrd54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98R → A: Increases the cytoplasmic protein content; when associated with A-99. 1 Publication1
Mutagenesisi99R → A: Increases the cytoplasmic protein content; when associated with A-98. 1 Publication1
Mutagenesisi289L → A: Accumulation within the nucleus; when associated with A-291. 1 Publication1
Mutagenesisi291L → A: Accumulation within the nucleus; when associated with A-289. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002744942 – 299Ankyrin repeat domain-containing protein 54Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei62PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91WK7
MaxQBiQ91WK7
PaxDbiQ91WK7
PRIDEiQ91WK7

PTM databases

iPTMnetiQ91WK7
PhosphoSitePlusiQ91WK7

Expressioni

Tissue specificityi

Expressed in a variety of hemopoietic cell lines and tissue with high levels in testis. Highly expressed in ciliated cells.2 Publications

Developmental stagei

Expressed in brachial arches, maxillary process, fore and hind limb buds and in the developing gastrointestinal tract of day 10 embryos.

Gene expression databases

BgeeiENSMUSG00000033055
CleanExiMM_ANKRD54
ExpressionAtlasiQ91WK7 baseline and differential
GenevisibleiQ91WK7 MM

Interactioni

Subunit structurei

Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.1 Publication

Protein-protein interaction databases

IntActiQ91WK7, 2 interactors
STRINGi10090.ENSMUSP00000047042

Structurei

3D structure databases

ProteinModelPortaliQ91WK7
SMRiQ91WK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati108 – 137ANK 1Add BLAST30
Repeati141 – 170ANK 2Add BLAST30
Repeati174 – 203ANK 3Add BLAST30
Repeati207 – 239ANK 4Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 240LYN-bindingAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi98 – 116Nuclear localization signal (NLS)Add BLAST19
Motifi282 – 292Nuclear export signal (NES)Add BLAST11

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00910000144039
HOGENOMiHOG000008674
HOVERGENiHBG080858
InParanoidiQ91WK7
KOiK21442
OMAiWQQDAEP
OrthoDBiEOG091G0WXS
PhylomeDBiQ91WK7
TreeFamiTF330790

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATGGGADD ESRSGRSSSD GECAVAPEPL AEAGGLVSFA DFGVSLGSGA
60 70 80 90 100
GLPGRSVGRA QSSLRYLQVL WQQDVEPRDE LRCKIPAGRL RRAARPHRRL
110 120 130 140 150
GPTGKEVHAL KRLRDSANAN DVETVQQLLE DGADPCAADD KGRTALHFAS
160 170 180 190 200
CNGNDQIVQL LLDHGADPNQ QDGLGNTPLH LAACTNHVPV ITTLLRGGAR
210 220 230 240 250
VDALDRAGRT PLHLAKSKLN ILQEGHSQCL EAVRLEVKQI IHMLREYLER
260 270 280 290
LGRHEQRERL DDLCTRLQMT STKEQVDEVT DLLASFTSLS LQMQSMEKR
Length:299
Mass (Da):32,486
Last modified:December 1, 2001 - v1
Checksum:i88E91A10F1953AC3
GO

Sequence cautioni

The sequence BAE25471 differs from that shown. Reason: Frameshift at position 291.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173G → N in BAE21840 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133785 mRNA Translation: BAE21840.1
AK143625 mRNA Translation: BAE25471.1 Frameshift.
BC014743 mRNA Translation: AAH14743.1
CCDSiCCDS37139.1
RefSeqiNP_659098.1, NM_144849.1
UniGeneiMm.24262

Genome annotation databases

EnsembliENSMUST00000040676; ENSMUSP00000047042; ENSMUSG00000033055
GeneIDi223690
KEGGimmu:223690
UCSCiuc007wsi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiANR54_MOUSE
AccessioniPrimary (citable) accession number: Q91WK7
Secondary accession number(s): Q3UPC5, Q3UZL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health