Q91WJ0 (FRS3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor receptor substrate 3
Short name=FGFR substrate 3

Alternative name(s):
FRS2-beta

Gene names

Name:	Frs3
Synonyms:	Frs2b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Subunit structure	Binds NGFR, GRB2, PTPN11 and ERK2 By similarity. Binds FGFR1 and NTRK1.
Subcellular location	Membrane; Lipid-anchor.
Post-translational modification	Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB. Phosphorylated by ULK2 in vitro. Ref.4
Sequence similarities	Contains 1 IRS-type PTB domain.

Ontologies

Keywords
Cellular component	Membrane
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	insulin receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 492	491	Fibroblast growth factor receptor substrate 3		PRO_0000087347
Regions
	Domain	13 – 115	103	IRS-type PTB
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q91WJ0 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C0A895B9173394E6	FASTA	492	53,976
	10 20 30 40 50 60 MGSCWSCLDR DSVPHNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH QREAVRWPYL 70 80 90 100 110 120 CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEDIFNL LQDLMQCNSI NVTEEPVIIT 130 140 150 160 170 180 RSSHPPELDL PRGPPQPAGY TVSGFSNGFP GCPGEGPRFS SAPRRPSTSS LRHPSPGEES 190 200 210 220 230 240 THTLIASEEQ SHTYVNTPTG DEDGRSRHCL QPLPEGRVPL PAQTQGSDQR DPQVLLQPGQ 250 260 270 280 290 300 VKFVLGPTPA RRQVMKCQSL CPGMQDPPHH NNNEGPSECP AQPKCTYENV SGGLQQGAGW 310 320 330 340 350 360 RLSPEERGWS GLAHRRAALL HYENLPPLPP VWESQGQQPG GEAGDDGDSR DGLTPSSNGF 370 380 390 400 410 420 PDGEEDETPL QKPTSTRASA RSHSGFPVPL TRRRGSPRVF NFDFRRQGPE PPRQLNYIQV 430 440 450 460 470 480 ELKGWGTARP KGPQNPSVSG APGPTPHPVR SSDSYAVIDL KKTAAMSDLQ RALPRDDGAV 490 RKTRHNSTDL PL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes." Zhou L., McDougall K., Kubu C.J., Verdi J.M., Meakin S.O. Mol. Biol. Rep. 30:15-25(2003) [PubMed: 12688531] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
[3]	"FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors." Ong S.-H., Guy G.R., Hadari Y.R., Laks S., Gotoh N., Schlessinger J., Lax I. Mol. Cell. Biol. 20:979-989(2000) [PubMed: 10629055] [Abstract] Cited for: INTERACTION WITH FGFR1 AND NTRK1.
[4]	"UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3." Avery A.W., Figueroa C., Vojtek A.B. Cell. Signal. 19:177-184(2007) [PubMed: 16887332] [Abstract] Cited for: PHOSPHORYLATION BY ULK2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF456480 Genomic DNA. Translation: AAO15529.1. BC014819 mRNA. Translation: AAH14819.1.
IPI	IPI00128179.
RefSeq	NP_659188.1. NM_144939.2.
UniGene	Mm.392206.
3D structure databases
ProteinModelPortal	Q91WJ0.
SMR	Q91WJ0. Positions 6-120.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q91WJ0. 1 interaction.
STRING	Q91WJ0.
PTM databases
PhosphoSite	Q91WJ0.
Proteomic databases
PRIDE	Q91WJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000024034; ENSMUSP00000024034; ENSMUSG00000023266. ENSMUST00000113296; ENSMUSP00000108921; ENSMUSG00000023266.
GeneID	107971.
KEGG	mmu:107971.
UCSC	uc008cvz.1. mouse.
Organism-specific databases
CTD	10817.
MGI	MGI:2135965. Frs3.
Phylogenomic databases
eggNOG	roNOG04045.
GeneTree	ENSGT00510000046707.
HOGENOM	HBG446324.
HOVERGEN	HBG062705.
InParanoid	Q91WJ0.
OMA	PSECPAQ.
PhylomeDB	Q91WJ0.
Gene expression databases
ArrayExpress	Q91WJ0.
Bgee	Q91WJ0.
CleanEx	MM_FRS3.
Genevestigator	Q91WJ0.
GermOnline	ENSMUSG00000023266. Mus musculus.
Family and domain databases
InterPro	IPR002404. Insln_rcpt_S1. IPR011993. PH_type. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF02174. IRS. 1 hit. [Graphical view]
SMART	SM00310. PTBI. 1 hit. [Graphical view]
PROSITE	PS51064. IRS_PTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	359797.
SOURCE	Search...

Entry information

Entry name

FRS3_MOUSE

Accession

Primary (citable) accession number: Q91WJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	January 23, 2007
Last modified:	October 19, 2011
This is version 66 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program