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Protein

Fibroblast growth factor receptor substrate 3

Gene

Frs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor substrate 3
Short name:
FGFR substrate 3
Alternative name(s):
FRS2-beta
Gene namesi
Name:Frs3
Synonyms:Frs2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2135965 Frs3

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00000873472 – 492Fibroblast growth factor receptor substrate 3Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB. Phosphorylated by ULK2 in vitro.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ91WJ0
PaxDbiQ91WJ0
PeptideAtlasiQ91WJ0
PRIDEiQ91WJ0

PTM databases

iPTMnetiQ91WJ0
PhosphoSitePlusiQ91WJ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000023266
CleanExiMM_FRS3
ExpressionAtlasiQ91WJ0 baseline and differential
GenevisibleiQ91WJ0 MM

Interactioni

Subunit structurei

Binds NGFR, GRB2, PTPN11 and ERK2 (By similarity). Binds FGFR1 and NTRK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91WJ0, 1 interactor
STRINGi10090.ENSMUSP00000108921

Structurei

3D structure databases

ProteinModelPortaliQ91WJ0
SMRiQ91WJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 115IRS-type PTBPROSITE-ProRule annotationAdd BLAST103

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00510000046707
HOGENOMiHOG000290694
HOVERGENiHBG062705
InParanoidiQ91WJ0
OMAiRHCLQPL
OrthoDBiEOG091G06AV
PhylomeDBiQ91WJ0
TreeFamiTF324994

Family and domain databases

CDDicd01202 PTB_FRS2, 1 hit
InterProiView protein in InterPro
IPR038742 FRS2_PTB
IPR002404 IRS_PTB
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCWSCLDR DSVPHNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH
60 70 80 90 100
QREAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEDIFNL
110 120 130 140 150
LQDLMQCNSI NVTEEPVIIT RSSHPPELDL PRGPPQPAGY TVSGFSNGFP
160 170 180 190 200
GCPGEGPRFS SAPRRPSTSS LRHPSPGEES THTLIASEEQ SHTYVNTPTG
210 220 230 240 250
DEDGRSRHCL QPLPEGRVPL PAQTQGSDQR DPQVLLQPGQ VKFVLGPTPA
260 270 280 290 300
RRQVMKCQSL CPGMQDPPHH NNNEGPSECP AQPKCTYENV SGGLQQGAGW
310 320 330 340 350
RLSPEERGWS GLAHRRAALL HYENLPPLPP VWESQGQQPG GEAGDDGDSR
360 370 380 390 400
DGLTPSSNGF PDGEEDETPL QKPTSTRASA RSHSGFPVPL TRRRGSPRVF
410 420 430 440 450
NFDFRRQGPE PPRQLNYIQV ELKGWGTARP KGPQNPSVSG APGPTPHPVR
460 470 480 490
SSDSYAVIDL KKTAAMSDLQ RALPRDDGAV RKTRHNSTDL PL
Length:492
Mass (Da):53,976
Last modified:January 23, 2007 - v3
Checksum:iC0A895B9173394E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456480 Genomic DNA Translation: AAO15529.1
BC014819 mRNA Translation: AAH14819.1
CCDSiCCDS28854.1
RefSeqiNP_659188.1, NM_144939.2
XP_006523531.1, XM_006523468.1
XP_006523532.1, XM_006523469.3
UniGeneiMm.392206

Genome annotation databases

EnsembliENSMUST00000113296; ENSMUSP00000108921; ENSMUSG00000023266
GeneIDi107971
KEGGimmu:107971
UCSCiuc008cvz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFRS3_MOUSE
AccessioniPrimary (citable) accession number: Q91WJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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