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Protein

Fibroblast growth factor receptor substrate 3

Gene

Frs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor substrate 3
Short name:
FGFR substrate 3
Alternative name(s):
FRS2-beta
Gene namesi
Name:Frs3
Synonyms:Frs2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2135965. Frs3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 492491Fibroblast growth factor receptor substrate 3PRO_0000087347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Post-translational modificationi

Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB. Phosphorylated by ULK2 in vitro.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ91WJ0.
PaxDbiQ91WJ0.
PRIDEiQ91WJ0.

PTM databases

iPTMnetiQ91WJ0.
PhosphoSiteiQ91WJ0.

Expressioni

Gene expression databases

BgeeiQ91WJ0.
CleanExiMM_FRS3.
ExpressionAtlasiQ91WJ0. baseline and differential.
GenevisibleiQ91WJ0. MM.

Interactioni

Subunit structurei

Binds NGFR, GRB2, PTPN11 and ERK2 (By similarity). Binds FGFR1 and NTRK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91WJ0. 1 interaction.
STRINGi10090.ENSMUSP00000108921.

Structurei

3D structure databases

ProteinModelPortaliQ91WJ0.
SMRiQ91WJ0. Positions 6-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 115103IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00510000046707.
HOGENOMiHOG000290694.
HOVERGENiHBG062705.
InParanoidiQ91WJ0.
OMAiRHCLQPL.
PhylomeDBiQ91WJ0.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCWSCLDR DSVPHNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH
60 70 80 90 100
QREAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEDIFNL
110 120 130 140 150
LQDLMQCNSI NVTEEPVIIT RSSHPPELDL PRGPPQPAGY TVSGFSNGFP
160 170 180 190 200
GCPGEGPRFS SAPRRPSTSS LRHPSPGEES THTLIASEEQ SHTYVNTPTG
210 220 230 240 250
DEDGRSRHCL QPLPEGRVPL PAQTQGSDQR DPQVLLQPGQ VKFVLGPTPA
260 270 280 290 300
RRQVMKCQSL CPGMQDPPHH NNNEGPSECP AQPKCTYENV SGGLQQGAGW
310 320 330 340 350
RLSPEERGWS GLAHRRAALL HYENLPPLPP VWESQGQQPG GEAGDDGDSR
360 370 380 390 400
DGLTPSSNGF PDGEEDETPL QKPTSTRASA RSHSGFPVPL TRRRGSPRVF
410 420 430 440 450
NFDFRRQGPE PPRQLNYIQV ELKGWGTARP KGPQNPSVSG APGPTPHPVR
460 470 480 490
SSDSYAVIDL KKTAAMSDLQ RALPRDDGAV RKTRHNSTDL PL
Length:492
Mass (Da):53,976
Last modified:January 23, 2007 - v3
Checksum:iC0A895B9173394E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456480 Genomic DNA. Translation: AAO15529.1.
BC014819 mRNA. Translation: AAH14819.1.
CCDSiCCDS28854.1.
RefSeqiNP_659188.1. NM_144939.2.
XP_006523531.1. XM_006523468.1.
XP_006523532.1. XM_006523469.2.
UniGeneiMm.392206.

Genome annotation databases

EnsembliENSMUST00000113296; ENSMUSP00000108921; ENSMUSG00000023266.
GeneIDi107971.
KEGGimmu:107971.
UCSCiuc008cvz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456480 Genomic DNA. Translation: AAO15529.1.
BC014819 mRNA. Translation: AAH14819.1.
CCDSiCCDS28854.1.
RefSeqiNP_659188.1. NM_144939.2.
XP_006523531.1. XM_006523468.1.
XP_006523532.1. XM_006523469.2.
UniGeneiMm.392206.

3D structure databases

ProteinModelPortaliQ91WJ0.
SMRiQ91WJ0. Positions 6-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91WJ0. 1 interaction.
STRINGi10090.ENSMUSP00000108921.

PTM databases

iPTMnetiQ91WJ0.
PhosphoSiteiQ91WJ0.

Proteomic databases

MaxQBiQ91WJ0.
PaxDbiQ91WJ0.
PRIDEiQ91WJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113296; ENSMUSP00000108921; ENSMUSG00000023266.
GeneIDi107971.
KEGGimmu:107971.
UCSCiuc008cvz.1. mouse.

Organism-specific databases

CTDi10817.
MGIiMGI:2135965. Frs3.

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00510000046707.
HOGENOMiHOG000290694.
HOVERGENiHBG062705.
InParanoidiQ91WJ0.
OMAiRHCLQPL.
PhylomeDBiQ91WJ0.
TreeFamiTF324994.

Enzyme and pathway databases

ReactomeiR-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

NextBioi359797.
PROiQ91WJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WJ0.
CleanExiMM_FRS3.
ExpressionAtlasiQ91WJ0. baseline and differential.
GenevisibleiQ91WJ0. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes."
    Zhou L., McDougall K., Kubu C.J., Verdi J.M., Meakin S.O.
    Mol. Biol. Rep. 30:15-25(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors."
    Ong S.-H., Guy G.R., Hadari Y.R., Laks S., Gotoh N., Schlessinger J., Lax I.
    Mol. Cell. Biol. 20:979-989(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR1 AND NTRK1.
  4. "UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3."
    Avery A.W., Figueroa C., Vojtek A.B.
    Cell. Signal. 19:177-184(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY ULK2.

Entry informationi

Entry nameiFRS3_MOUSE
AccessioniPrimary (citable) accession number: Q91WJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.