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Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene

Atp4a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transportUniRule annotation, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, Potassium

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alphaUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:Atp4aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88113. Atp4a.

Subcellular locationi

  • Membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei106 – 128HelicalUniRule annotationAdd BLAST23
Transmembranei140 – 159HelicalUniRule annotationAdd BLAST20
Transmembranei301 – 327HelicalUniRule annotationAdd BLAST27
Transmembranei333 – 354HelicalUniRule annotationAdd BLAST22
Transmembranei791 – 811HelicalUniRule annotationAdd BLAST21
Transmembranei914 – 936HelicalUniRule annotationAdd BLAST23
Transmembranei956 – 975HelicalUniRule annotationAdd BLAST20
Transmembranei987 – 1003HelicalUniRule annotationAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000005553.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131964.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 126Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKAENYELY SVELGSGPGG DMTAKMSKKK AGGGGGKKKE KLENMKKEME
60 70 80 90 100
INDHQLSVSE LEQKYQTSAT KGLKASLAAE LLLRDGPNAL RPPRGTPEYV
110 120 130 140 150
KFARQLAGGL QCLMWVAAAI CLIAFAIQAS EGDLTTDDNL YLAVALIAVV
160 170 180 190 200
VVTGCFGYYQ EFKSTNIIAS FKNLVPQQAT VIRDGDKFQI NADQLVVGDL
210 220 230 240 250
VEMKGGDRVP ADIRILSAQG CKVDNSSLTG ESEPQTRSPE CTHESPLETR
260 270 280 290 300
NIAFFSTMCL EGTAQGLVVS TGDRTIIGRI ASLASGVENE KTPIAIEIEH
310 320 330 340 350
FVDIIAGLAI LFGATFFVVA MCIGYTFLRA MVFFMAIVVA YVPEGLLATV
360 370 380 390 400
TVCLSLTAKR LASKNCVVKN LEAVETLGST SVICSDKTGT LTQNRMTVSH
410 420 430 440 450
LWFDNHIHTA DTTEDQSGQT FDQSSETWRA LCRVLTLCNR AAFKSGQDAV
460 470 480 490 500
PVPKRIVIGD ASETALLKFS ELTLGNAMGY RDRFPKVCEI PFNSINKFQL
510 520 530 540 550
SIHTLEDPRD SRHLLVMKGA PERVLERCSS ILIKGQELPL DEQWREAFQT
560 570 580 590 600
AYLSLGGLGE RVLGFCQLYL NEKDYPPGYA FDVEAMNFPS SGLCFAGLVS
610 620 630 640 650
MIDPPRATVP DAVLKCRTAG IRVIMVTGDH PITAKAIAAS VGIISEGSET
660 670 680 690 700
VEDIAARLRM PVDQVNRKDA RACVINGMQL KDMDPSELVE ALRTHPEMVF
710 720 730 740 750
ARTSPQQKLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI
760 770 780 790 800
LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP YLIYITVSVP
810 820 830 840 850
LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP KRDRLVNEPL
860 870 880 890 900
AAYSYFQIGA IQSFAGFADY FTAMAQEGWF PLLCVGLRPQ WEDHHLQDLQ
910 920 930 940 950
DSYGQEWTFG QRLYQQYTCY TVFFISIEMC QIADVLIRKT RRLSVFQQGF
960 970 980 990 1000
FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPMPFGLLI
1010 1020
FVYDEIRKLG VRCCPGSWWD QELYY
Length:1,025
Mass (Da):113,037
Last modified:December 1, 2001 - v1
Checksum:iDB931B2F346E05A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC167978 Genomic DNA. No translation available.
BC015262 mRNA. Translation: AAH15262.1.
RefSeqiNP_061201.2. NM_018731.3.
UniGeneiMm.12821.

Genome annotation databases

EnsembliENSMUST00000170371; ENSMUSP00000131964; ENSMUSG00000005553.
GeneIDi11944.
UCSCiuc009gfy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC167978 Genomic DNA. No translation available.
BC015262 mRNA. Translation: AAH15262.1.
RefSeqiNP_061201.2. NM_018731.3.
UniGeneiMm.12821.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170371; ENSMUSP00000131964; ENSMUSG00000005553.
GeneIDi11944.
UCSCiuc009gfy.2. mouse.

Organism-specific databases

CTDi495.
MGIiMGI:88113. Atp4a.

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOVERGENiHBG004298.

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005553.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91WH7_MOUSE
AccessioniPrimary (citable) accession number: Q91WH7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.