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Q91WG7

- DGKG_MOUSE

UniProt

Q91WG7 - DGKG_MOUSE

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Protein

Diacylglycerol kinase gamma

Gene
Dgkg, Dagk3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi185 – 196121 Reviewed predictionAdd
BLAST
Calcium bindingi230 – 241122 Reviewed predictionAdd
BLAST
Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. diacylglycerol kinase activity Source: UniProtKB-EC
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. neuron development Source: Ensembl
  3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_219232. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.107)
Short name:
DAG kinase gamma
Alternative name(s):
88 kDa diacylglycerol kinase
Diglyceride kinase gamma
Short name:
DGK-gamma
Gene namesi
Name:Dgkg
Synonyms:Dagk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:105060. Dgkg.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 788788Diacylglycerol kinase gammaPRO_0000218460Add
BLAST

Proteomic databases

MaxQBiQ91WG7.
PaxDbiQ91WG7.
PRIDEiQ91WG7.

PTM databases

PhosphoSiteiQ91WG7.

Expressioni

Gene expression databases

ArrayExpressiQ91WG7.
BgeeiQ91WG7.
CleanExiMM_DGKG.
GenevestigatoriQ91WG7.

Structurei

3D structure databases

ProteinModelPortaliQ91WG7.
SMRiQ91WG7. Positions 1-245, 262-310.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 20736EF-hand 1Add
BLAST
Domaini217 – 25236EF-hand 2Add
BLAST
Domaini427 – 561135DAGKcAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 2 EF-hand domains.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00750000117569.
HOVERGENiHBG051345.
InParanoidiQ91WG7.
KOiK00901.
OMAiCYQSVTA.
OrthoDBiEOG75XGK8.
TreeFamiTF313104.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WG7-1 [UniParc]FASTAAdd to Basket

« Hide

MSEEQWVSLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LRQYDPHKPI    50
SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRQETPDH PKEGASSSEP 100
NVSDYNSDNA AKADEACAPD TESKTTKTQA PSKELEAAAP WEDPGALASS 150
SDAPVVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENG LLDQAEMDQI 200
VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YDKDGFVSLQ EWINGGMTTI 250
PLLVLLGMDD SGSKGDGRHA WTLKHFKKPT YCNFCRAMLM GVGKQGLCCI 300
YCKYTVHQRC VSKTIHGCVK TNSKAKRSGE VMQHAWVEGN SSVKCDRCHK 350
SIKCYQSVTA RHCVWCRMTF HRKCELSTVC DGGELKDHIL LPTSICPVSG 400
DRQGGKSDGS VAAKGELVTQ YKIIPSPGTH PLLVLVNPKS GGRQGERILR 450
KFHYLLNPEQ VFNLDNGGPT PGLNFFHDTP DFRVLACGGD GTVGWILDCI 500
DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV 550
MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHMMREKHP 600
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE 650
GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ 700
LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTNKL LPMQVDGEPW 750
MQPQCTIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD 788
Length:788
Mass (Da):88,523
Last modified:December 1, 2001 - v1
Checksum:i969298DFD144F5DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC015278 mRNA. Translation: AAH15278.1.
CCDSiCCDS28068.1.
RefSeqiNP_619591.1. NM_138650.2.
UniGeneiMm.194986.
Mm.448158.

Genome annotation databases

EnsembliENSMUST00000089925; ENSMUSP00000087371; ENSMUSG00000022861.
GeneIDi110197.
KEGGimmu:110197.
UCSCiuc007ysg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC015278 mRNA. Translation: AAH15278.1 .
CCDSi CCDS28068.1.
RefSeqi NP_619591.1. NM_138650.2.
UniGenei Mm.194986.
Mm.448158.

3D structure databases

ProteinModelPortali Q91WG7.
SMRi Q91WG7. Positions 1-245, 262-310.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91WG7.

Proteomic databases

MaxQBi Q91WG7.
PaxDbi Q91WG7.
PRIDEi Q91WG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089925 ; ENSMUSP00000087371 ; ENSMUSG00000022861 .
GeneIDi 110197.
KEGGi mmu:110197.
UCSCi uc007ysg.2. mouse.

Organism-specific databases

CTDi 1608.
MGIi MGI:105060. Dgkg.

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00750000117569.
HOVERGENi HBG051345.
InParanoidi Q91WG7.
KOi K00901.
OMAi CYQSVTA.
OrthoDBi EOG75XGK8.
TreeFami TF313104.

Enzyme and pathway databases

Reactomei REACT_219232. Effects of PIP2 hydrolysis.

Miscellaneous databases

NextBioi 363515.
PROi Q91WG7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91WG7.
Bgeei Q91WG7.
CleanExi MM_DGKG.
Genevestigatori Q91WG7.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDGKG_MOUSE
AccessioniPrimary (citable) accession number: Q91WG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi