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Protein

Diacylglycerol kinase gamma

Gene

Dgkg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi185 – 1961PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi230 – 2412PROSITE-ProRule annotationAdd BLAST12
Zinc fingeri268 – 318Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri333 – 380Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-114508. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.107)
Short name:
DAG kinase gamma
Alternative name(s):
88 kDa diacylglycerol kinase
Diglyceride kinase gamma
Short name:
DGK-gamma
Gene namesi
Name:Dgkg
Synonyms:Dagk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:105060. Dgkg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002184601 – 788Diacylglycerol kinase gammaAdd BLAST788

Proteomic databases

EPDiQ91WG7.
MaxQBiQ91WG7.
PaxDbiQ91WG7.
PRIDEiQ91WG7.

PTM databases

iPTMnetiQ91WG7.
PhosphoSitePlusiQ91WG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022861.
CleanExiMM_DGKG.
ExpressionAtlasiQ91WG7. baseline and differential.
GenevisibleiQ91WG7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087371.

Structurei

3D structure databases

ProteinModelPortaliQ91WG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 207EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini217 – 252EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini427 – 561DAGKcPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 318Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri333 – 380Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1169. Eukaryota.
ENOG410XQVB. LUCA.
GeneTreeiENSGT00760000119050.
HOVERGENiHBG051345.
InParanoidiQ91WG7.
KOiK00901.
OMAiCYQSVTA.
OrthoDBiEOG091G04A5.
TreeFamiTF313104.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProiIPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF47473. SSF47473. 3 hits.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEQWVSLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LRQYDPHKPI
60 70 80 90 100
SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRQETPDH PKEGASSSEP
110 120 130 140 150
NVSDYNSDNA AKADEACAPD TESKTTKTQA PSKELEAAAP WEDPGALASS
160 170 180 190 200
SDAPVVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENG LLDQAEMDQI
210 220 230 240 250
VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YDKDGFVSLQ EWINGGMTTI
260 270 280 290 300
PLLVLLGMDD SGSKGDGRHA WTLKHFKKPT YCNFCRAMLM GVGKQGLCCI
310 320 330 340 350
YCKYTVHQRC VSKTIHGCVK TNSKAKRSGE VMQHAWVEGN SSVKCDRCHK
360 370 380 390 400
SIKCYQSVTA RHCVWCRMTF HRKCELSTVC DGGELKDHIL LPTSICPVSG
410 420 430 440 450
DRQGGKSDGS VAAKGELVTQ YKIIPSPGTH PLLVLVNPKS GGRQGERILR
460 470 480 490 500
KFHYLLNPEQ VFNLDNGGPT PGLNFFHDTP DFRVLACGGD GTVGWILDCI
510 520 530 540 550
DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV
560 570 580 590 600
MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHMMREKHP
610 620 630 640 650
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE
660 670 680 690 700
GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ
710 720 730 740 750
LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTNKL LPMQVDGEPW
760 770 780
MQPQCTIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD
Length:788
Mass (Da):88,523
Last modified:December 1, 2001 - v1
Checksum:i969298DFD144F5DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015278 mRNA. Translation: AAH15278.1.
CCDSiCCDS28068.1.
RefSeqiNP_619591.1. NM_138650.2.
UniGeneiMm.194986.
Mm.448158.

Genome annotation databases

EnsembliENSMUST00000089925; ENSMUSP00000087371; ENSMUSG00000022861.
GeneIDi110197.
KEGGimmu:110197.
UCSCiuc007ysg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015278 mRNA. Translation: AAH15278.1.
CCDSiCCDS28068.1.
RefSeqiNP_619591.1. NM_138650.2.
UniGeneiMm.194986.
Mm.448158.

3D structure databases

ProteinModelPortaliQ91WG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087371.

PTM databases

iPTMnetiQ91WG7.
PhosphoSitePlusiQ91WG7.

Proteomic databases

EPDiQ91WG7.
MaxQBiQ91WG7.
PaxDbiQ91WG7.
PRIDEiQ91WG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089925; ENSMUSP00000087371; ENSMUSG00000022861.
GeneIDi110197.
KEGGimmu:110197.
UCSCiuc007ysg.2. mouse.

Organism-specific databases

CTDi1608.
MGIiMGI:105060. Dgkg.

Phylogenomic databases

eggNOGiKOG1169. Eukaryota.
ENOG410XQVB. LUCA.
GeneTreeiENSGT00760000119050.
HOVERGENiHBG051345.
InParanoidiQ91WG7.
KOiK00901.
OMAiCYQSVTA.
OrthoDBiEOG091G04A5.
TreeFamiTF313104.

Enzyme and pathway databases

ReactomeiR-MMU-114508. Effects of PIP2 hydrolysis.

Miscellaneous databases

ChiTaRSiDgkg. mouse.
PROiQ91WG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022861.
CleanExiMM_DGKG.
ExpressionAtlasiQ91WG7. baseline and differential.
GenevisibleiQ91WG7. MM.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProiIPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF47473. SSF47473. 3 hits.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGKG_MOUSE
AccessioniPrimary (citable) accession number: Q91WG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.