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Q91WG7 (DGKG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Diacylglycerol kinase gamma

Short name=DAG kinase gamma
EC=2.7.1.107
Alternative name(s):
88 kDa diacylglycerol kinase
Diglyceride kinase gamma
Short name=DGK-gamma
Gene names
Name:Dgkg
Synonyms:Dagk3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length788 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Sequence similarities

Belongs to the eukaryotic diacylglycerol kinase family.

Contains 1 DAGKc domain.

Contains 2 EF-hand domains.

Contains 2 phorbol-ester/DAG-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 788788Diacylglycerol kinase gamma
PRO_0000218460

Regions

Domain172 – 20736EF-hand 1
Domain217 – 25236EF-hand 2
Domain427 – 561135DAGKc
Calcium binding185 – 196121 Potential
Calcium binding230 – 241122 Potential
Zinc finger268 – 31851Phorbol-ester/DAG-type 1
Zinc finger333 – 38048Phorbol-ester/DAG-type 2

Sequences

Sequence LengthMass (Da)Tools
Q91WG7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 969298DFD144F5DF

FASTA78888,523
        10         20         30         40         50         60 
MSEEQWVSLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LRQYDPHKPI SYDVFKLFMR 

        70         80         90        100        110        120 
AYLEVDLPQP LSTHLFLAFS QKPRQETPDH PKEGASSSEP NVSDYNSDNA AKADEACAPD 

       130        140        150        160        170        180 
TESKTTKTQA PSKELEAAAP WEDPGALASS SDAPVVYLKD VVCYLSLMET GRPQDKLEFM 

       190        200        210        220        230        240 
FRLYDSDENG LLDQAEMDQI VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YDKDGFVSLQ 

       250        260        270        280        290        300 
EWINGGMTTI PLLVLLGMDD SGSKGDGRHA WTLKHFKKPT YCNFCRAMLM GVGKQGLCCI 

       310        320        330        340        350        360 
YCKYTVHQRC VSKTIHGCVK TNSKAKRSGE VMQHAWVEGN SSVKCDRCHK SIKCYQSVTA 

       370        380        390        400        410        420 
RHCVWCRMTF HRKCELSTVC DGGELKDHIL LPTSICPVSG DRQGGKSDGS VAAKGELVTQ 

       430        440        450        460        470        480 
YKIIPSPGTH PLLVLVNPKS GGRQGERILR KFHYLLNPEQ VFNLDNGGPT PGLNFFHDTP 

       490        500        510        520        530        540 
DFRVLACGGD GTVGWILDCI DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI 

       550        560        570        580        590        600 
LKEIEQSPLV MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHMMREKHP 

       610        620        630        640        650        660 
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE GIAILNIPSM 

       670        680        690        700        710        720 
YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ LLEVVGLEGA MEMGQIYTGL 

       730        740        750        760        770        780 
KSAGRRLAQC SSVTIRTNKL LPMQVDGEPW MQPQCTIKIT HKNQAPMMMG PPQKSSFFSL 


RRKSRSKD 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC015278 mRNA. Translation: AAH15278.1.
RefSeqNP_619591.1. NM_138650.2.
UniGeneMm.194986.
Mm.448158.

3D structure databases

ProteinModelPortalQ91WG7.
SMRQ91WG7. Positions 1-320, 330-382.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91WG7.

Proteomic databases

PaxDbQ91WG7.
PRIDEQ91WG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089925; ENSMUSP00000087371; ENSMUSG00000022861.
GeneID110197.
KEGGmmu:110197.
UCSCuc007ysg.2. mouse.

Organism-specific databases

CTD1608.
MGIMGI:105060. Dgkg.

Phylogenomic databases

eggNOGNOG47311.
GeneTreeENSGT00750000117569.
HOVERGENHBG051345.
InParanoidQ91WG7.
KOK00901.
OMACYQSVTA.
OrthoDBEOG75XGK8.
TreeFamTF313104.

Gene expression databases

ArrayExpressQ91WG7.
BgeeQ91WG7.
CleanExMM_DGKG.
GenevestigatorQ91WG7.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamPF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
PROSITEPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio363515.
PROQ91WG7.
SOURCESearch...

Entry information

Entry nameDGKG_MOUSE
AccessionPrimary (citable) accession number: Q91WG7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot