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Q91WG7

- DGKG_MOUSE

UniProt

Q91WG7 - DGKG_MOUSE

Protein

Diacylglycerol kinase gamma

Gene

Dgkg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi185 – 196121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi230 – 241122PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. diacylglycerol kinase activity Source: UniProtKB-EC
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. neuron development Source: Ensembl
    3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_219232. Effects of PIP2 hydrolysis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase gamma (EC:2.7.1.107)
    Short name:
    DAG kinase gamma
    Alternative name(s):
    88 kDa diacylglycerol kinase
    Diglyceride kinase gamma
    Short name:
    DGK-gamma
    Gene namesi
    Name:Dgkg
    Synonyms:Dagk3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:105060. Dgkg.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. plasma membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 788788Diacylglycerol kinase gammaPRO_0000218460Add
    BLAST

    Proteomic databases

    MaxQBiQ91WG7.
    PaxDbiQ91WG7.
    PRIDEiQ91WG7.

    PTM databases

    PhosphoSiteiQ91WG7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91WG7.
    BgeeiQ91WG7.
    CleanExiMM_DGKG.
    GenevestigatoriQ91WG7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WG7.
    SMRiQ91WG7. Positions 1-245, 262-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini172 – 20736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini217 – 25236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini427 – 561135DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG47311.
    GeneTreeiENSGT00750000117569.
    HOVERGENiHBG051345.
    InParanoidiQ91WG7.
    KOiK00901.
    OMAiCYQSVTA.
    OrthoDBiEOG75XGK8.
    TreeFamiTF313104.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.238.110. 2 hits.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF14513. DAG_kinase_N. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91WG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEEQWVSLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LRQYDPHKPI    50
    SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRQETPDH PKEGASSSEP 100
    NVSDYNSDNA AKADEACAPD TESKTTKTQA PSKELEAAAP WEDPGALASS 150
    SDAPVVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENG LLDQAEMDQI 200
    VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YDKDGFVSLQ EWINGGMTTI 250
    PLLVLLGMDD SGSKGDGRHA WTLKHFKKPT YCNFCRAMLM GVGKQGLCCI 300
    YCKYTVHQRC VSKTIHGCVK TNSKAKRSGE VMQHAWVEGN SSVKCDRCHK 350
    SIKCYQSVTA RHCVWCRMTF HRKCELSTVC DGGELKDHIL LPTSICPVSG 400
    DRQGGKSDGS VAAKGELVTQ YKIIPSPGTH PLLVLVNPKS GGRQGERILR 450
    KFHYLLNPEQ VFNLDNGGPT PGLNFFHDTP DFRVLACGGD GTVGWILDCI 500
    DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV 550
    MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHMMREKHP 600
    EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE 650
    GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ 700
    LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTNKL LPMQVDGEPW 750
    MQPQCTIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD 788
    Length:788
    Mass (Da):88,523
    Last modified:December 1, 2001 - v1
    Checksum:i969298DFD144F5DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC015278 mRNA. Translation: AAH15278.1.
    CCDSiCCDS28068.1.
    RefSeqiNP_619591.1. NM_138650.2.
    UniGeneiMm.194986.
    Mm.448158.

    Genome annotation databases

    EnsembliENSMUST00000089925; ENSMUSP00000087371; ENSMUSG00000022861.
    GeneIDi110197.
    KEGGimmu:110197.
    UCSCiuc007ysg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC015278 mRNA. Translation: AAH15278.1 .
    CCDSi CCDS28068.1.
    RefSeqi NP_619591.1. NM_138650.2.
    UniGenei Mm.194986.
    Mm.448158.

    3D structure databases

    ProteinModelPortali Q91WG7.
    SMRi Q91WG7. Positions 1-245, 262-310.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91WG7.

    Proteomic databases

    MaxQBi Q91WG7.
    PaxDbi Q91WG7.
    PRIDEi Q91WG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089925 ; ENSMUSP00000087371 ; ENSMUSG00000022861 .
    GeneIDi 110197.
    KEGGi mmu:110197.
    UCSCi uc007ysg.2. mouse.

    Organism-specific databases

    CTDi 1608.
    MGIi MGI:105060. Dgkg.

    Phylogenomic databases

    eggNOGi NOG47311.
    GeneTreei ENSGT00750000117569.
    HOVERGENi HBG051345.
    InParanoidi Q91WG7.
    KOi K00901.
    OMAi CYQSVTA.
    OrthoDBi EOG75XGK8.
    TreeFami TF313104.

    Enzyme and pathway databases

    Reactomei REACT_219232. Effects of PIP2 hydrolysis.

    Miscellaneous databases

    NextBioi 363515.
    PROi Q91WG7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91WG7.
    Bgeei Q91WG7.
    CleanExi MM_DGKG.
    Genevestigatori Q91WG7.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.238.110. 2 hits.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF14513. DAG_kinase_N. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiDGKG_MOUSE
    AccessioniPrimary (citable) accession number: Q91WG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3