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Q91WG7

- DGKG_MOUSE

UniProt

Q91WG7 - DGKG_MOUSE

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Protein

Diacylglycerol kinase gamma

Gene

Dgkg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi185 – 196121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi230 – 241122PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. diacylglycerol kinase activity Source: UniProtKB-EC
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. neuron development Source: Ensembl
  3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_219232. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.107)
Short name:
DAG kinase gamma
Alternative name(s):
88 kDa diacylglycerol kinase
Diglyceride kinase gamma
Short name:
DGK-gamma
Gene namesi
Name:Dgkg
Synonyms:Dagk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:105060. Dgkg.

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: Ensembl
  2. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 788788Diacylglycerol kinase gammaPRO_0000218460Add
BLAST

Proteomic databases

MaxQBiQ91WG7.
PaxDbiQ91WG7.
PRIDEiQ91WG7.

PTM databases

PhosphoSiteiQ91WG7.

Expressioni

Gene expression databases

BgeeiQ91WG7.
CleanExiMM_DGKG.
ExpressionAtlasiQ91WG7. baseline and differential.
GenevestigatoriQ91WG7.

Structurei

3D structure databases

ProteinModelPortaliQ91WG7.
SMRiQ91WG7. Positions 1-245, 262-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 20736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini217 – 25236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini427 – 561135DAGKcPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00760000119050.
HOVERGENiHBG051345.
InParanoidiQ91WG7.
KOiK00901.
OMAiCYQSVTA.
OrthoDBiEOG75XGK8.
TreeFamiTF313104.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WG7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEEQWVSLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LRQYDPHKPI
60 70 80 90 100
SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRQETPDH PKEGASSSEP
110 120 130 140 150
NVSDYNSDNA AKADEACAPD TESKTTKTQA PSKELEAAAP WEDPGALASS
160 170 180 190 200
SDAPVVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENG LLDQAEMDQI
210 220 230 240 250
VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YDKDGFVSLQ EWINGGMTTI
260 270 280 290 300
PLLVLLGMDD SGSKGDGRHA WTLKHFKKPT YCNFCRAMLM GVGKQGLCCI
310 320 330 340 350
YCKYTVHQRC VSKTIHGCVK TNSKAKRSGE VMQHAWVEGN SSVKCDRCHK
360 370 380 390 400
SIKCYQSVTA RHCVWCRMTF HRKCELSTVC DGGELKDHIL LPTSICPVSG
410 420 430 440 450
DRQGGKSDGS VAAKGELVTQ YKIIPSPGTH PLLVLVNPKS GGRQGERILR
460 470 480 490 500
KFHYLLNPEQ VFNLDNGGPT PGLNFFHDTP DFRVLACGGD GTVGWILDCI
510 520 530 540 550
DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV
560 570 580 590 600
MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHMMREKHP
610 620 630 640 650
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE
660 670 680 690 700
GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ
710 720 730 740 750
LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTNKL LPMQVDGEPW
760 770 780
MQPQCTIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD
Length:788
Mass (Da):88,523
Last modified:December 1, 2001 - v1
Checksum:i969298DFD144F5DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC015278 mRNA. Translation: AAH15278.1.
CCDSiCCDS28068.1.
RefSeqiNP_619591.1. NM_138650.2.
UniGeneiMm.194986.
Mm.448158.

Genome annotation databases

EnsembliENSMUST00000089925; ENSMUSP00000087371; ENSMUSG00000022861.
GeneIDi110197.
KEGGimmu:110197.
UCSCiuc007ysg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC015278 mRNA. Translation: AAH15278.1 .
CCDSi CCDS28068.1.
RefSeqi NP_619591.1. NM_138650.2.
UniGenei Mm.194986.
Mm.448158.

3D structure databases

ProteinModelPortali Q91WG7.
SMRi Q91WG7. Positions 1-245, 262-310.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91WG7.

Proteomic databases

MaxQBi Q91WG7.
PaxDbi Q91WG7.
PRIDEi Q91WG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089925 ; ENSMUSP00000087371 ; ENSMUSG00000022861 .
GeneIDi 110197.
KEGGi mmu:110197.
UCSCi uc007ysg.2. mouse.

Organism-specific databases

CTDi 1608.
MGIi MGI:105060. Dgkg.

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00760000119050.
HOVERGENi HBG051345.
InParanoidi Q91WG7.
KOi K00901.
OMAi CYQSVTA.
OrthoDBi EOG75XGK8.
TreeFami TF313104.

Enzyme and pathway databases

Reactomei REACT_219232. Effects of PIP2 hydrolysis.

Miscellaneous databases

NextBioi 363515.
PROi Q91WG7.
SOURCEi Search...

Gene expression databases

Bgeei Q91WG7.
CleanExi MM_DGKG.
ExpressionAtlasi Q91WG7. baseline and differential.
Genevestigatori Q91WG7.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDGKG_MOUSE
AccessioniPrimary (citable) accession number: Q91WG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3