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Protein

Probable tRNA pseudouridine synthase 2

Gene

Trub2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.By similarity

Catalytic activityi

tRNA uridine = tRNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase 2 (EC:5.4.99.-)
Gene namesi
Name:Trub2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442186. Trub2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Probable tRNA pseudouridine synthase 2PRO_0000252091Add
BLAST

Proteomic databases

EPDiQ91WG3.
MaxQBiQ91WG3.
PaxDbiQ91WG3.
PeptideAtlasiQ91WG3.
PRIDEiQ91WG3.

PTM databases

PhosphoSiteiQ91WG3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039826.
ExpressionAtlasiQ91WG3. baseline and differential.
GenevisibleiQ91WG3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041848.

Structurei

3D structure databases

ProteinModelPortaliQ91WG3.
SMRiQ91WG3. Positions 97-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Phylogenomic databases

eggNOGiKOG2559. Eukaryota.
ENOG4110V1W. LUCA.
GeneTreeiENSGT00530000063611.
HOGENOMiHOG000231821.
HOVERGENiHBG053337.
InParanoidiQ91WG3.
OMAiHGCRLLT.
OrthoDBiEOG091G0FSQ.
PhylomeDBiQ91WG3.
TreeFamiTF320759.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
[Graphical view]
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.

Sequencei

Sequence statusi: Complete.

Q91WG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSGLARLQ GLFAVYKPPG LKWLHLRETV ELQLLKGLNA QQPPAPDQRV
60 70 80 90 100
RFLLGPVEGS EEKKLTLRAT NVPSLTTHRL VRGPAFTNLK IGVGHRLDVQ
110 120 130 140 150
ASGVLVLAVG HGRSLLTDMY DAHLTKDYTV RGLLGKATDN FCEDGRLIEK
160 170 180 190 200
TTYDHVTRER LDRILAVIQG SHQKALVMYS NLDLKSQEAY EMAVQGVIRP
210 220 230 240 250
MNKSPMLISG IRCLHFAPPE FLLEVQCMHE TQQQLRKLVH EIGLELKTSA
260 270 280 290 300
VCTQVRRTRD GFFGLDDALL RTQWDLHNIQ DAIQAAAPRV AAELQKNLSL
310 320 330
KLGHHQLPST GQPWGLKDPS STLELESCSG Q
Length:331
Mass (Da):36,807
Last modified:December 1, 2001 - v1
Checksum:i918D5634828FA63A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti266 – 2661D → H in BAC41040 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090004 mRNA. Translation: BAC41040.1.
AK167294 mRNA. Translation: BAE39399.1.
BC015285 mRNA. Translation: AAH15285.1.
BC024075 mRNA. Translation: AAH24075.1.
CCDSiCCDS15856.1.
RefSeqiNP_001277425.1. NM_001290496.1.
NP_663495.3. NM_145520.5.
UniGeneiMm.245739.

Genome annotation databases

EnsembliENSMUST00000048044; ENSMUSP00000041848; ENSMUSG00000039826.
GeneIDi227682.
KEGGimmu:227682.
UCSCiuc008jaa.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090004 mRNA. Translation: BAC41040.1.
AK167294 mRNA. Translation: BAE39399.1.
BC015285 mRNA. Translation: AAH15285.1.
BC024075 mRNA. Translation: AAH24075.1.
CCDSiCCDS15856.1.
RefSeqiNP_001277425.1. NM_001290496.1.
NP_663495.3. NM_145520.5.
UniGeneiMm.245739.

3D structure databases

ProteinModelPortaliQ91WG3.
SMRiQ91WG3. Positions 97-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041848.

PTM databases

PhosphoSiteiQ91WG3.

Proteomic databases

EPDiQ91WG3.
MaxQBiQ91WG3.
PaxDbiQ91WG3.
PeptideAtlasiQ91WG3.
PRIDEiQ91WG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048044; ENSMUSP00000041848; ENSMUSG00000039826.
GeneIDi227682.
KEGGimmu:227682.
UCSCiuc008jaa.3. mouse.

Organism-specific databases

CTDi26995.
MGIiMGI:2442186. Trub2.

Phylogenomic databases

eggNOGiKOG2559. Eukaryota.
ENOG4110V1W. LUCA.
GeneTreeiENSGT00530000063611.
HOGENOMiHOG000231821.
HOVERGENiHBG053337.
InParanoidiQ91WG3.
OMAiHGCRLLT.
OrthoDBiEOG091G0FSQ.
PhylomeDBiQ91WG3.
TreeFamiTF320759.

Miscellaneous databases

PROiQ91WG3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039826.
ExpressionAtlasiQ91WG3. baseline and differential.
GenevisibleiQ91WG3. MM.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
[Graphical view]
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUB2_MOUSE
AccessioniPrimary (citable) accession number: Q91WG3
Secondary accession number(s): Q8BTK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.