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Protein

Rab GTPase-binding effector protein 2

Gene

Rabep2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in membrane trafficking and in homotypic early endosome fusion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GTPase-binding effector protein 2
Alternative name(s):
Rabaptin-5beta
Gene namesi
Name:Rabep2
Synonyms:Rabpt5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917564 Rabep2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001875601 – 554Rab GTPase-binding effector protein 2Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176PhosphoserineBy similarity1
Modified residuei180PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91WG2
MaxQBiQ91WG2
PaxDbiQ91WG2
PeptideAtlasiQ91WG2
PRIDEiQ91WG2

PTM databases

iPTMnetiQ91WG2
PhosphoSitePlusiQ91WG2

Expressioni

Gene expression databases

BgeeiENSMUSG00000030727
CleanExiMM_RABEP2
ExpressionAtlasiQ91WG2 baseline and differential
GenevisibleiQ91WG2 MM

Interactioni

Subunit structurei

Heterodimer with RABGEF1. The dimer binds RAB5A that has been activated by GTP-binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213981, 5 interactors
IntActiQ91WG2, 5 interactors
STRINGi10090.ENSMUSP00000102015

Structurei

3D structure databases

ProteinModelPortaliQ91WG2
SMRiQ91WG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 173Sequence analysisAdd BLAST159
Coiled coili274 – 509Sequence analysisAdd BLAST236

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 100Poly-Gln5
Compositional biasi313 – 463Gln-richAdd BLAST151

Sequence similaritiesi

Belongs to the rabaptin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0993 Eukaryota
ENOG410XSZ1 LUCA
GeneTreeiENSGT00530000063743
HOGENOMiHOG000154063
HOVERGENiHBG108391
InParanoidiQ91WG2
KOiK20130
OMAiEGRQLQK
OrthoDBiEOG091G0H2C
PhylomeDBiQ91WG2
TreeFamiTF329365

Family and domain databases

InterProiView protein in InterPro
IPR003914 Rabaptin
IPR029882 Rabaptin-5beta
IPR018514 Rabaptin_coiled-coil
IPR015390 Rabaptin_Rab5-bd_dom
PANTHERiPTHR31179:SF6 PTHR31179:SF6, 1 hit
PfamiView protein in Pfam
PF09311 Rab5-bind, 1 hit
PF03528 Rabaptin, 1 hit
PRINTSiPR01432 RABAPTIN

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91WG2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPATLAL DPQPQEKQKD ASESSELSRL RAELAGALAE METMKAVAEV
60 70 80 90 100
SESTKAEAVA AVQRQCQEEV ASLQAILKDS ISSYETQIAA LKQERQQQQQ
110 120 130 140 150
DFEEKDRELG HLKQLLARAH PLDSLEKQME KAHEDSEKLR EIVLPMEQEI
160 170 180 190 200
TELKGKLQRA EELIQEIQRR PRQPASLHGS TELLPLSRNP SPPLEPLEEP
210 220 230 240 250
SGDAGPAAEA FAHNCDDSAS ISSFSLGGAA GSASLRGPQG LSPEQEETAS
260 270 280 290 300
LVSTGTLVPE GIFLPPPGYQ LVPDSQWEQL QVEGRQLQKE LESVSRERDE
310 320 330 340 350
LQEGLRRSNE DCAKQMQVLL AQVQNSEQLL RTLQGTVSQA QERVQLQMAE
360 370 380 390 400
LATSHKCLSQ EVKRLNEENQ GLRAEQLPSS ALQGSEQRED QDEALPSSIQ
410 420 430 440 450
ELHLLVQNTR QQARARQQAQ EHEAERLRIE IVKLREALDE ETAAKASLER
460 470 480 490 500
QLRVQREETD VLEASLCSLR IETERVQQEQ RKAQLTDLLS EQRAKTLRLQ
510 520 530 540 550
AELETSEQVQ RDFVRLSQAL QVRLERIRQA ETLQQVRSIL DEAPLRDIRD

IKDS
Length:554
Mass (Da):62,132
Last modified:September 2, 2008 - v3
Checksum:iE94C2FB6A8A89130
GO
Isoform 2 (identifier: Q91WG2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:511
Mass (Da):57,623
Checksum:iB54FD77D69743509
GO
Isoform 3 (identifier: Q91WG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-554: AQLTDLLSEQ...LRDIRDIKDS → VSGAGGLA

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):54,334
Checksum:iE01A981533CA69E9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0104601 – 43Missing in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_010461483 – 554AQLTD…DIKDS → VSGAGGLA in isoform 3. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144836 mRNA Translation: BAE26090.1
BC004088 mRNA Translation: AAH04088.1
BC015287 mRNA Translation: AAH15287.1
CCDSiCCDS21829.2 [Q91WG2-3]
RefSeqiNP_085043.2, NM_030566.2 [Q91WG2-3]
UniGeneiMm.35467

Genome annotation databases

EnsembliENSMUST00000106405; ENSMUSP00000102013; ENSMUSG00000030727 [Q91WG2-1]
ENSMUST00000106407; ENSMUSP00000102015; ENSMUSG00000030727 [Q91WG2-3]
GeneIDi70314
KEGGimmu:70314
UCSCiuc009jrd.1 mouse [Q91WG2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRABE2_MOUSE
AccessioniPrimary (citable) accession number: Q91WG2
Secondary accession number(s): Q3UMK8, Q99KN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health