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Reviewed, UniProtKB/Swiss-Prot Q91WF3 (ADCY4_MOUSE)

Last modified January 19, 2010. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 4
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type IV
    ATP pyrophosphate-lyase 4
    Adenylyl cyclase 4
Gene names
Name: Adcy4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1077 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10771077Adenylate cyclase type 4
PRO_0000195691

Regions

Topological domain1 – 2828Cytoplasmic Potential
Transmembrane29 – 5022 Potential
Transmembrane61 – 8020 Potential
Transmembrane94 – 11724 Potential
Transmembrane120 – 13819 Potential
Transmembrane141 – 16222 Potential
Transmembrane170 – 19021 Potential
Topological domain191 – 582392Cytoplasmic Potential
Transmembrane583 – 60422 Potential
Transmembrane608 – 63023 Potential
Transmembrane661 – 68424 Potential
Topological domain685 – 71733Extracellular Potential
Transmembrane718 – 73821 Potential
Transmembrane746 – 76621 Potential
Transmembrane793 – 80917 Potential
Topological domain810 – 1077268Cytoplasmic Potential

Sites

Metal binding2781Magnesium 1 By similarity
Metal binding2781Magnesium 2 By similarity
Metal binding2791Magnesium 2; via carbonyl oxygen By similarity
Metal binding3221Magnesium 1 By similarity
Metal binding3221Magnesium 2 By similarity

Amino acid modifications

Glycosylation6941N-linked (GlcNAc...) Potential
Glycosylation7011N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q91WF3-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 03EA262D05F4B36D

FASTA1,077120,380
        10         20         30         40         50         60 
MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA LVALPAVAWA SGRELTSDPS 

        70         80         90        100        110        120 
FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWVAL LALGYGFLFT GGVVSAWDQV 

       130        140        150        160        170        180 
SFFLFIIFTV YAMLPLGMRD AAAAGVISSL SHLLVLGLYL GWQPESQRAL LPQLAANAVL 

       190        200        210        220        230        240 
FLCGNVVGAY HKALMERALR ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK 

       250        260        270        280        290        300 
AEIMARLQAG QRSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 

       310        320        330        340        350        360 
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR AIRKLRVATG 

       370        380        390        400        410        420 
VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME AGGVPGRVHI TGATLALLAG 

       430        440        450        460        470        480 
AYAVERADTE HRDPYLRELG EPTYLVIDPR AEEEDEKGTA KGLLSSLEGH TMRPSLLMTR 

       490        500        510        520        530        540 
YLESWGAAKP FAHLSHLDSP VSTSTPLPEK AFSPQWSLDR SRTPRGLDDE LDTGDAKFFQ 

       550        560        570        580        590        600 
VIEQLNSQKQ WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 

       610        620        630        640        650        660 
LVTTRPPALI ITYSITFLLF FLLLFVCFSE HLTKCVQKGP KMLHWLPALS VLVATRPGFR 

       670        680        690        700        710        720 
VALGTATILL VFTMAIASLL FLPVSSDCLF LASNVSSVTF NASWEMPGSL PLISIPLISI 

       730        740        750        760        770        780 
PYSMHCCVLG FLSCSLFLHM SFELKLLLLL LWLVASCSLF LHSHAWLSDC LIARLYQSPS 

       790        800        810        820        830        840 
DSRPGVLKEP KLMGAIYFFI FFFTLLVLAR QNEYYCRLDF LWKKKLRQER EETETMENLT 

       850        860        870        880        890        900 
RLLLENVLPA HVAPQFIGQN RRNEDLYHQS YECVCVLFAS VPDFKEFYSE SNINHEGLEC 

       910        920        930        940        950        960 
LRLLNEIIAD FDELLSKPKF SGVEKIKTIG STYMAATGLN ATSGQDTQQD SERSCSHLGT 

       970        980        990       1000       1010       1020 
MVEFAVALGS KLGVINKHSF NNFRLRVGLN HGPVVAGVIG AQKPQYDIWG NTVNVASRME 

      1030       1040       1050       1060       1070 
STGVLGKIQV TEETARALQS LGYTCYSRGS IKVKGKGELC TYFLNTDLTR TGSPSAS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of mouse adenylyl cyclase type IV."
Rui X., Schimmer B.P.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB/N.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 355-366, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF442771 mRNA. Translation: AAL38004.1.
BC015299 mRNA. Translation: AAH15299.1.
IPIIPI00128097.
RefSeqNP_536683.1.
UniGeneMm.287010

3D structure databases

SMRQ91WF3. Positions 261-447, 867-1066.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ91WF3.

PTM databases

PhosphoSiteQ91WF3.

Proteomic databases

PRIDEQ91WF3.

Genome annotation databases

EnsemblENSMUST00000002398; ENSMUSP00000002398; ENSMUSG00000022220; Mus musculus. [Genome view]
GeneID104110.
KEGGmmu:104110.
UCSCuc007uat.1. mouse.

Organism-specific databases

CTD104110.
MGIMGI:99674. Adcy4.

Phylogenomic databases

HOGENOMHBG445220.
HOVERGENQ91WF3.
InParanoidQ91WF3.
OMASCSLFLH.
OrthoDBEOG9S4S1S.
PhylomeDBQ91WF3.

Enzyme and pathway databases

BRENDA4.6.1.1. 244.

Gene expression databases

ArrayExpressQ91WF3.
BgeeQ91WF3.
CleanExMM_ADCY4.
GenevestigatorQ91WF3.
GermOnlineENSMUSG00000022220. Mus musculus.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Aden_cycl-like.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio356540.
SOURCESearch...

Entry information

Entry nameADCY4_MOUSE
AccessionPrimary (citable) accession number: Q91WF3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: January 19, 2010
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents