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Q91WF3

- ADCY4_MOUSE

UniProt

Q91WF3 - ADCY4_MOUSE

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Protein
Adenylate cyclase type 4
Gene
Adcy4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase By similarity.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulationi

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi278 – 2781Magnesium 1 By similarity
Metal bindingi278 – 2781Magnesium 2 By similarity
Metal bindingi279 – 2791Magnesium 2; via carbonyl oxygen By similarity
Metal bindingi322 – 3221Magnesium 1 By similarity
Metal bindingi322 – 3221Magnesium 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: MGI
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  3. cAMP biosynthetic process Source: MGI
  4. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 4 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 4
Adenylate cyclase type IV
Adenylyl cyclase 4
Gene namesi
Name:Adcy4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:99674. Adcy4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei29 – 5022Helical; Reviewed prediction
Add
BLAST
Transmembranei61 – 8020Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11724Helical; Reviewed prediction
Add
BLAST
Transmembranei120 – 13819Helical; Reviewed prediction
Add
BLAST
Transmembranei141 – 16222Helical; Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 582392Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei583 – 60422Helical; Reviewed prediction
Add
BLAST
Transmembranei608 – 63023Helical; Reviewed prediction
Add
BLAST
Transmembranei661 – 68424Helical; Reviewed prediction
Add
BLAST
Topological domaini685 – 71733Extracellular Reviewed prediction
Add
BLAST
Transmembranei718 – 73821Helical; Reviewed prediction
Add
BLAST
Transmembranei746 – 76621Helical; Reviewed prediction
Add
BLAST
Transmembranei793 – 80917Helical; Reviewed prediction
Add
BLAST
Topological domaini810 – 1077268Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. dendrite Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10771077Adenylate cyclase type 4
PRO_0000195691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi694 – 6941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi701 – 7011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91WF3.
PRIDEiQ91WF3.

PTM databases

PhosphoSiteiQ91WF3.

Expressioni

Gene expression databases

BgeeiQ91WF3.
CleanExiMM_ADCY4.
GenevestigatoriQ91WF3.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ91WF3.
SMRiQ91WF3. Positions 261-447, 866-1045.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00750000117304.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ91WF3.
KOiK08044.
OMAiFLHSHAW.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ91WF3.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WF3-1 [UniParc]FASTAAdd to Basket

« Hide

MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA LVALPAVAWA     50
SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWVAL 100
LALGYGFLFT GGVVSAWDQV SFFLFIIFTV YAMLPLGMRD AAAAGVISSL 150
SHLLVLGLYL GWQPESQRAL LPQLAANAVL FLCGNVVGAY HKALMERALR 200
ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG 250
QRSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 300
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR 350
AIRKLRVATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME 400
AGGVPGRVHI TGATLALLAG AYAVERADTE HRDPYLRELG EPTYLVIDPR 450
AEEEDEKGTA KGLLSSLEGH TMRPSLLMTR YLESWGAAKP FAHLSHLDSP 500
VSTSTPLPEK AFSPQWSLDR SRTPRGLDDE LDTGDAKFFQ VIEQLNSQKQ 550
WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 600
LVTTRPPALI ITYSITFLLF FLLLFVCFSE HLTKCVQKGP KMLHWLPALS 650
VLVATRPGFR VALGTATILL VFTMAIASLL FLPVSSDCLF LASNVSSVTF 700
NASWEMPGSL PLISIPLISI PYSMHCCVLG FLSCSLFLHM SFELKLLLLL 750
LWLVASCSLF LHSHAWLSDC LIARLYQSPS DSRPGVLKEP KLMGAIYFFI 800
FFFTLLVLAR QNEYYCRLDF LWKKKLRQER EETETMENLT RLLLENVLPA 850
HVAPQFIGQN RRNEDLYHQS YECVCVLFAS VPDFKEFYSE SNINHEGLEC 900
LRLLNEIIAD FDELLSKPKF SGVEKIKTIG STYMAATGLN ATSGQDTQQD 950
SERSCSHLGT MVEFAVALGS KLGVINKHSF NNFRLRVGLN HGPVVAGVIG 1000
AQKPQYDIWG NTVNVASRME STGVLGKIQV TEETARALQS LGYTCYSRGS 1050
IKVKGKGELC TYFLNTDLTR TGSPSAS 1077
Length:1,077
Mass (Da):120,380
Last modified:December 1, 2001 - v1
Checksum:i03EA262D05F4B36D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF442771 mRNA. Translation: AAL38004.1.
BC015299 mRNA. Translation: AAH15299.1.
CCDSiCCDS27130.1.
RefSeqiNP_536683.1. NM_080435.1.
XP_006518386.1. XM_006518323.1.
XP_006518387.1. XM_006518324.1.
UniGeneiMm.287010.

Genome annotation databases

EnsembliENSMUST00000002398; ENSMUSP00000002398; ENSMUSG00000022220.
ENSMUST00000170223; ENSMUSP00000130530; ENSMUSG00000022220.
GeneIDi104110.
KEGGimmu:104110.
UCSCiuc007uat.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF442771 mRNA. Translation: AAL38004.1 .
BC015299 mRNA. Translation: AAH15299.1 .
CCDSi CCDS27130.1.
RefSeqi NP_536683.1. NM_080435.1.
XP_006518386.1. XM_006518323.1.
XP_006518387.1. XM_006518324.1.
UniGenei Mm.287010.

3D structure databases

ProteinModelPortali Q91WF3.
SMRi Q91WF3. Positions 261-447, 866-1045.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q91WF3.

PTM databases

PhosphoSitei Q91WF3.

Proteomic databases

PaxDbi Q91WF3.
PRIDEi Q91WF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002398 ; ENSMUSP00000002398 ; ENSMUSG00000022220 .
ENSMUST00000170223 ; ENSMUSP00000130530 ; ENSMUSG00000022220 .
GeneIDi 104110.
KEGGi mmu:104110.
UCSCi uc007uat.1. mouse.

Organism-specific databases

CTDi 196883.
MGIi MGI:99674. Adcy4.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00750000117304.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi Q91WF3.
KOi K08044.
OMAi FLHSHAW.
OrthoDBi EOG76X5ZC.
PhylomeDBi Q91WF3.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

NextBioi 356540.
PROi Q91WF3.
SOURCEi Search...

Gene expression databases

Bgeei Q91WF3.
CleanExi MM_ADCY4.
Genevestigatori Q91WF3.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of mouse adenylyl cyclase type IV."
    Rui X., Schimmer B.P.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 355-366, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiADCY4_MOUSE
AccessioniPrimary (citable) accession number: Q91WF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi