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Q91WF3

- ADCY4_MOUSE

UniProt

Q91WF3 - ADCY4_MOUSE

Protein

Adenylate cyclase type 4

Gene

Adcy4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.By similarity

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi278 – 2781Magnesium 1PROSITE-ProRule annotation
    Metal bindingi278 – 2781Magnesium 2PROSITE-ProRule annotation
    Metal bindingi279 – 2791Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi322 – 3221Magnesium 1PROSITE-ProRule annotation
    Metal bindingi322 – 3221Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
    3. cAMP biosynthetic process Source: MGI
    4. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 4 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 4
    Adenylate cyclase type IV
    Adenylyl cyclase 4
    Gene namesi
    Name:Adcy4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:99674. Adcy4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. dendrite Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10771077Adenylate cyclase type 4PRO_0000195691Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ91WF3.
    PRIDEiQ91WF3.

    PTM databases

    PhosphoSiteiQ91WF3.

    Expressioni

    Gene expression databases

    BgeeiQ91WF3.
    CleanExiMM_ADCY4.
    GenevestigatoriQ91WF3.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WF3.
    SMRiQ91WF3. Positions 261-447, 866-1045.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 582392CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini685 – 71733ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini810 – 1077268CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11724HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 13819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei583 – 60422HelicalSequence AnalysisAdd
    BLAST
    Transmembranei608 – 63023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei661 – 68424HelicalSequence AnalysisAdd
    BLAST
    Transmembranei718 – 73821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei746 – 76621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei793 – 80917HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00750000117304.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiQ91WF3.
    KOiK08044.
    OMAiFLHSHAW.
    OrthoDBiEOG76X5ZC.
    PhylomeDBiQ91WF3.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91WF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA LVALPAVAWA     50
    SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWVAL 100
    LALGYGFLFT GGVVSAWDQV SFFLFIIFTV YAMLPLGMRD AAAAGVISSL 150
    SHLLVLGLYL GWQPESQRAL LPQLAANAVL FLCGNVVGAY HKALMERALR 200
    ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG 250
    QRSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 300
    LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR 350
    AIRKLRVATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME 400
    AGGVPGRVHI TGATLALLAG AYAVERADTE HRDPYLRELG EPTYLVIDPR 450
    AEEEDEKGTA KGLLSSLEGH TMRPSLLMTR YLESWGAAKP FAHLSHLDSP 500
    VSTSTPLPEK AFSPQWSLDR SRTPRGLDDE LDTGDAKFFQ VIEQLNSQKQ 550
    WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 600
    LVTTRPPALI ITYSITFLLF FLLLFVCFSE HLTKCVQKGP KMLHWLPALS 650
    VLVATRPGFR VALGTATILL VFTMAIASLL FLPVSSDCLF LASNVSSVTF 700
    NASWEMPGSL PLISIPLISI PYSMHCCVLG FLSCSLFLHM SFELKLLLLL 750
    LWLVASCSLF LHSHAWLSDC LIARLYQSPS DSRPGVLKEP KLMGAIYFFI 800
    FFFTLLVLAR QNEYYCRLDF LWKKKLRQER EETETMENLT RLLLENVLPA 850
    HVAPQFIGQN RRNEDLYHQS YECVCVLFAS VPDFKEFYSE SNINHEGLEC 900
    LRLLNEIIAD FDELLSKPKF SGVEKIKTIG STYMAATGLN ATSGQDTQQD 950
    SERSCSHLGT MVEFAVALGS KLGVINKHSF NNFRLRVGLN HGPVVAGVIG 1000
    AQKPQYDIWG NTVNVASRME STGVLGKIQV TEETARALQS LGYTCYSRGS 1050
    IKVKGKGELC TYFLNTDLTR TGSPSAS 1077
    Length:1,077
    Mass (Da):120,380
    Last modified:December 1, 2001 - v1
    Checksum:i03EA262D05F4B36D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF442771 mRNA. Translation: AAL38004.1.
    BC015299 mRNA. Translation: AAH15299.1.
    CCDSiCCDS27130.1.
    RefSeqiNP_536683.1. NM_080435.1.
    XP_006518386.1. XM_006518323.1.
    XP_006518387.1. XM_006518324.1.
    UniGeneiMm.287010.

    Genome annotation databases

    EnsembliENSMUST00000002398; ENSMUSP00000002398; ENSMUSG00000022220.
    ENSMUST00000170223; ENSMUSP00000130530; ENSMUSG00000022220.
    GeneIDi104110.
    KEGGimmu:104110.
    UCSCiuc007uat.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF442771 mRNA. Translation: AAL38004.1 .
    BC015299 mRNA. Translation: AAH15299.1 .
    CCDSi CCDS27130.1.
    RefSeqi NP_536683.1. NM_080435.1.
    XP_006518386.1. XM_006518323.1.
    XP_006518387.1. XM_006518324.1.
    UniGenei Mm.287010.

    3D structure databases

    ProteinModelPortali Q91WF3.
    SMRi Q91WF3. Positions 261-447, 866-1045.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q91WF3.

    PTM databases

    PhosphoSitei Q91WF3.

    Proteomic databases

    PaxDbi Q91WF3.
    PRIDEi Q91WF3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002398 ; ENSMUSP00000002398 ; ENSMUSG00000022220 .
    ENSMUST00000170223 ; ENSMUSP00000130530 ; ENSMUSG00000022220 .
    GeneIDi 104110.
    KEGGi mmu:104110.
    UCSCi uc007uat.1. mouse.

    Organism-specific databases

    CTDi 196883.
    MGIi MGI:99674. Adcy4.

    Phylogenomic databases

    eggNOGi COG2114.
    GeneTreei ENSGT00750000117304.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi Q91WF3.
    KOi K08044.
    OMAi FLHSHAW.
    OrthoDBi EOG76X5ZC.
    PhylomeDBi Q91WF3.
    TreeFami TF313845.

    Enzyme and pathway databases

    Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Miscellaneous databases

    NextBioi 356540.
    PROi Q91WF3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91WF3.
    CleanExi MM_ADCY4.
    Genevestigatori Q91WF3.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of mouse adenylyl cyclase type IV."
      Rui X., Schimmer B.P.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 355-366, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiADCY4_MOUSE
    AccessioniPrimary (citable) accession number: Q91WF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3