Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenylate cyclase type 4

Gene

Adcy4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.By similarity

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi278 – 2781Magnesium 1PROSITE-ProRule annotation
Metal bindingi278 – 2781Magnesium 2PROSITE-ProRule annotation
Metal bindingi279 – 2791Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi322 – 3221Magnesium 1PROSITE-ProRule annotation
Metal bindingi322 – 3221Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  3. cAMP biosynthetic process Source: MGI
  4. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_278699. Hedgehog 'off' state.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_295338. PKA activation in glucagon signalling.
REACT_296380. G alpha (z) signalling events.
REACT_297425. Adenylate cyclase activating pathway.
REACT_309686. Adenylate cyclase inhibitory pathway.
REACT_310977. PKA activation.
REACT_313192. G alpha (s) signalling events.
REACT_331048. G alpha (i) signalling events.
REACT_345203. Glucagon signaling in metabolic regulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 4 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 4
Adenylate cyclase type IV
Adenylyl cyclase 4
Gene namesi
Name:Adcy4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:99674. Adcy4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei29 – 5022HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8020HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11724HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 13819HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 16222HelicalSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Topological domaini191 – 582392CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei583 – 60422HelicalSequence AnalysisAdd
BLAST
Transmembranei608 – 63023HelicalSequence AnalysisAdd
BLAST
Transmembranei661 – 68424HelicalSequence AnalysisAdd
BLAST
Topological domaini685 – 71733ExtracellularSequence AnalysisAdd
BLAST
Transmembranei718 – 73821HelicalSequence AnalysisAdd
BLAST
Transmembranei746 – 76621HelicalSequence AnalysisAdd
BLAST
Transmembranei793 – 80917HelicalSequence AnalysisAdd
BLAST
Topological domaini810 – 1077268CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. dendrite Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10771077Adenylate cyclase type 4PRO_0000195691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91WF3.
PRIDEiQ91WF3.

PTM databases

PhosphoSiteiQ91WF3.

Expressioni

Gene expression databases

BgeeiQ91WF3.
CleanExiMM_ADCY4.
GenevestigatoriQ91WF3.

Structurei

3D structure databases

ProteinModelPortaliQ91WF3.
SMRiQ91WF3. Positions 261-447, 866-1045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ91WF3.
KOiK08044.
OMAiFLHSHAW.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ91WF3.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA LVALPAVAWA
60 70 80 90 100
SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWVAL
110 120 130 140 150
LALGYGFLFT GGVVSAWDQV SFFLFIIFTV YAMLPLGMRD AAAAGVISSL
160 170 180 190 200
SHLLVLGLYL GWQPESQRAL LPQLAANAVL FLCGNVVGAY HKALMERALR
210 220 230 240 250
ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG
260 270 280 290 300
QRSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE
310 320 330 340 350
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR
360 370 380 390 400
AIRKLRVATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME
410 420 430 440 450
AGGVPGRVHI TGATLALLAG AYAVERADTE HRDPYLRELG EPTYLVIDPR
460 470 480 490 500
AEEEDEKGTA KGLLSSLEGH TMRPSLLMTR YLESWGAAKP FAHLSHLDSP
510 520 530 540 550
VSTSTPLPEK AFSPQWSLDR SRTPRGLDDE LDTGDAKFFQ VIEQLNSQKQ
560 570 580 590 600
WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM
610 620 630 640 650
LVTTRPPALI ITYSITFLLF FLLLFVCFSE HLTKCVQKGP KMLHWLPALS
660 670 680 690 700
VLVATRPGFR VALGTATILL VFTMAIASLL FLPVSSDCLF LASNVSSVTF
710 720 730 740 750
NASWEMPGSL PLISIPLISI PYSMHCCVLG FLSCSLFLHM SFELKLLLLL
760 770 780 790 800
LWLVASCSLF LHSHAWLSDC LIARLYQSPS DSRPGVLKEP KLMGAIYFFI
810 820 830 840 850
FFFTLLVLAR QNEYYCRLDF LWKKKLRQER EETETMENLT RLLLENVLPA
860 870 880 890 900
HVAPQFIGQN RRNEDLYHQS YECVCVLFAS VPDFKEFYSE SNINHEGLEC
910 920 930 940 950
LRLLNEIIAD FDELLSKPKF SGVEKIKTIG STYMAATGLN ATSGQDTQQD
960 970 980 990 1000
SERSCSHLGT MVEFAVALGS KLGVINKHSF NNFRLRVGLN HGPVVAGVIG
1010 1020 1030 1040 1050
AQKPQYDIWG NTVNVASRME STGVLGKIQV TEETARALQS LGYTCYSRGS
1060 1070
IKVKGKGELC TYFLNTDLTR TGSPSAS
Length:1,077
Mass (Da):120,380
Last modified:December 1, 2001 - v1
Checksum:i03EA262D05F4B36D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442771 mRNA. Translation: AAL38004.1.
BC015299 mRNA. Translation: AAH15299.1.
CCDSiCCDS27130.1.
RefSeqiNP_536683.1. NM_080435.1.
XP_006518386.1. XM_006518323.1.
XP_006518387.1. XM_006518324.1.
UniGeneiMm.287010.

Genome annotation databases

EnsembliENSMUST00000002398; ENSMUSP00000002398; ENSMUSG00000022220.
ENSMUST00000170223; ENSMUSP00000130530; ENSMUSG00000022220.
GeneIDi104110.
KEGGimmu:104110.
UCSCiuc007uat.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442771 mRNA. Translation: AAL38004.1.
BC015299 mRNA. Translation: AAH15299.1.
CCDSiCCDS27130.1.
RefSeqiNP_536683.1. NM_080435.1.
XP_006518386.1. XM_006518323.1.
XP_006518387.1. XM_006518324.1.
UniGeneiMm.287010.

3D structure databases

ProteinModelPortaliQ91WF3.
SMRiQ91WF3. Positions 261-447, 866-1045.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ91WF3.

Proteomic databases

PaxDbiQ91WF3.
PRIDEiQ91WF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002398; ENSMUSP00000002398; ENSMUSG00000022220.
ENSMUST00000170223; ENSMUSP00000130530; ENSMUSG00000022220.
GeneIDi104110.
KEGGimmu:104110.
UCSCiuc007uat.1. mouse.

Organism-specific databases

CTDi196883.
MGIiMGI:99674. Adcy4.

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ91WF3.
KOiK08044.
OMAiFLHSHAW.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ91WF3.
TreeFamiTF313845.

Enzyme and pathway databases

ReactomeiREACT_278699. Hedgehog 'off' state.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_295338. PKA activation in glucagon signalling.
REACT_296380. G alpha (z) signalling events.
REACT_297425. Adenylate cyclase activating pathway.
REACT_309686. Adenylate cyclase inhibitory pathway.
REACT_310977. PKA activation.
REACT_313192. G alpha (s) signalling events.
REACT_331048. G alpha (i) signalling events.
REACT_345203. Glucagon signaling in metabolic regulation.

Miscellaneous databases

NextBioi356540.
PROiQ91WF3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WF3.
CleanExiMM_ADCY4.
GenevestigatoriQ91WF3.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of mouse adenylyl cyclase type IV."
    Rui X., Schimmer B.P.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 355-366, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiADCY4_MOUSE
AccessioniPrimary (citable) accession number: Q91WF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.