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Q91WE3

- RPP25_MOUSE

UniProt

Q91WE3 - RPP25_MOUSE

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Protein
Ribonuclease P protein subunit p25
Gene
Rpp25
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA By similarity.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p25 (EC:3.1.26.5)
Short name:
RNase P protein subunit p25
Gene namesi
Name:Rpp25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2143151. Rpp25.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Ribonuclease P protein subunit p25
PRO_0000237583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ91WE3.

PTM databases

PhosphoSiteiQ91WE3.

Expressioni

Gene expression databases

BgeeiQ91WE3.
CleanExiMM_RPP25.
GenevestigatoriQ91WE3.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079358.

Structurei

3D structure databases

ProteinModelPortaliQ91WE3.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.

Phylogenomic databases

eggNOGiNOG247262.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ91WE3.
KOiK14525.
OMAiMENFRKV.
OrthoDBiEOG7XM309.
PhylomeDBiQ91WE3.
TreeFamiTF325688.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WE3-1 [UniParc]FASTAAdd to Basket

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MENFRKVRSE EAPAGDGDEG GSPNSGPFAD LAPGAVHMRV KEGSKIRNLL    50
AFATASMAQP ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR 100
SVREVWQSLP PGPTPGQTPS DPAASLSVLK NVPSLAILLS KDALDPRQLG 150
YQPPNLSPGP SSPPTVSTSK RSLGESAAEE GTAKRSQPEP EAENEDRTA 199
Length:199
Mass (Da):21,038
Last modified:December 1, 2001 - v1
Checksum:iB9DE105BE3293D64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK082822 mRNA. Translation: BAC38636.1.
BC016085 mRNA. Translation: AAH16085.1.
BC083064 mRNA. Translation: AAH83064.1.
CCDSiCCDS23222.1.
RefSeqiNP_598743.1. NM_133982.1.
UniGeneiMm.274421.

Genome annotation databases

EnsembliENSMUST00000080514; ENSMUSP00000079358; ENSMUSG00000062309.
GeneIDi102614.
KEGGimmu:102614.
UCSCiuc009puy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK082822 mRNA. Translation: BAC38636.1 .
BC016085 mRNA. Translation: AAH16085.1 .
BC083064 mRNA. Translation: AAH83064.1 .
CCDSi CCDS23222.1.
RefSeqi NP_598743.1. NM_133982.1.
UniGenei Mm.274421.

3D structure databases

ProteinModelPortali Q91WE3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000079358.

PTM databases

PhosphoSitei Q91WE3.

Proteomic databases

PRIDEi Q91WE3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080514 ; ENSMUSP00000079358 ; ENSMUSG00000062309 .
GeneIDi 102614.
KEGGi mmu:102614.
UCSCi uc009puy.1. mouse.

Organism-specific databases

CTDi 54913.
MGIi MGI:2143151. Rpp25.

Phylogenomic databases

eggNOGi NOG247262.
GeneTreei ENSGT00390000002564.
HOGENOMi HOG000231665.
HOVERGENi HBG056729.
InParanoidi Q91WE3.
KOi K14525.
OMAi MENFRKV.
OrthoDBi EOG7XM309.
PhylomeDBi Q91WE3.
TreeFami TF325688.

Miscellaneous databases

NextBioi 355562.
PROi Q91WE3.
SOURCEi Search...

Gene expression databases

Bgeei Q91WE3.
CleanExi MM_RPP25.
Genevestigatori Q91WE3.

Family and domain databases

Gene3Di 3.30.110.20. 1 hit.
InterProi IPR002775. DNA/RNA-bd_Alba-like.
[Graphical view ]
Pfami PF01918. Alba. 1 hit.
[Graphical view ]
SUPFAMi SSF82704. SSF82704. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiRPP25_MOUSE
AccessioniPrimary (citable) accession number: Q91WE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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