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Q91WE3

- RPP25_MOUSE

UniProt

Q91WE3 - RPP25_MOUSE

Protein

Ribonuclease P protein subunit p25

Gene

Rpp25

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p25 (EC:3.1.26.5)
    Short name:
    RNase P protein subunit p25
    Gene namesi
    Name:Rpp25
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2143151. Rpp25.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Ribonuclease P protein subunit p25PRO_0000237583Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei172 – 1721PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ91WE3.

    PTM databases

    PhosphoSiteiQ91WE3.

    Expressioni

    Gene expression databases

    BgeeiQ91WE3.
    CleanExiMM_RPP25.
    GenevestigatoriQ91WE3.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000079358.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WE3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone-like Alba family.Curated

    Phylogenomic databases

    eggNOGiNOG247262.
    GeneTreeiENSGT00390000002564.
    HOGENOMiHOG000231665.
    HOVERGENiHBG056729.
    InParanoidiQ91WE3.
    KOiK14525.
    OMAiMENFRKV.
    OrthoDBiEOG7XM309.
    PhylomeDBiQ91WE3.
    TreeFamiTF325688.

    Family and domain databases

    Gene3Di3.30.110.20. 1 hit.
    InterProiIPR002775. DNA/RNA-bd_Alba-like.
    [Graphical view]
    PfamiPF01918. Alba. 1 hit.
    [Graphical view]
    SUPFAMiSSF82704. SSF82704. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91WE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENFRKVRSE EAPAGDGDEG GSPNSGPFAD LAPGAVHMRV KEGSKIRNLL    50
    AFATASMAQP ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR 100
    SVREVWQSLP PGPTPGQTPS DPAASLSVLK NVPSLAILLS KDALDPRQLG 150
    YQPPNLSPGP SSPPTVSTSK RSLGESAAEE GTAKRSQPEP EAENEDRTA 199
    Length:199
    Mass (Da):21,038
    Last modified:December 1, 2001 - v1
    Checksum:iB9DE105BE3293D64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK082822 mRNA. Translation: BAC38636.1.
    BC016085 mRNA. Translation: AAH16085.1.
    BC083064 mRNA. Translation: AAH83064.1.
    CCDSiCCDS23222.1.
    RefSeqiNP_598743.1. NM_133982.1.
    UniGeneiMm.274421.

    Genome annotation databases

    EnsembliENSMUST00000080514; ENSMUSP00000079358; ENSMUSG00000062309.
    GeneIDi102614.
    KEGGimmu:102614.
    UCSCiuc009puy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK082822 mRNA. Translation: BAC38636.1 .
    BC016085 mRNA. Translation: AAH16085.1 .
    BC083064 mRNA. Translation: AAH83064.1 .
    CCDSi CCDS23222.1.
    RefSeqi NP_598743.1. NM_133982.1.
    UniGenei Mm.274421.

    3D structure databases

    ProteinModelPortali Q91WE3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000079358.

    PTM databases

    PhosphoSitei Q91WE3.

    Proteomic databases

    PRIDEi Q91WE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080514 ; ENSMUSP00000079358 ; ENSMUSG00000062309 .
    GeneIDi 102614.
    KEGGi mmu:102614.
    UCSCi uc009puy.1. mouse.

    Organism-specific databases

    CTDi 54913.
    MGIi MGI:2143151. Rpp25.

    Phylogenomic databases

    eggNOGi NOG247262.
    GeneTreei ENSGT00390000002564.
    HOGENOMi HOG000231665.
    HOVERGENi HBG056729.
    InParanoidi Q91WE3.
    KOi K14525.
    OMAi MENFRKV.
    OrthoDBi EOG7XM309.
    PhylomeDBi Q91WE3.
    TreeFami TF325688.

    Miscellaneous databases

    NextBioi 355562.
    PROi Q91WE3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91WE3.
    CleanExi MM_RPP25.
    Genevestigatori Q91WE3.

    Family and domain databases

    Gene3Di 3.30.110.20. 1 hit.
    InterProi IPR002775. DNA/RNA-bd_Alba-like.
    [Graphical view ]
    Pfami PF01918. Alba. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82704. SSF82704. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiRPP25_MOUSE
    AccessioniPrimary (citable) accession number: Q91WE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3