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Protein

Ribonuclease P protein subunit p25

Gene

Rpp25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. poly(A) RNA binding Source: MGI
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p25 (EC:3.1.26.5)
Short name:
RNase P protein subunit p25
Gene namesi
Name:Rpp25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143151. Rpp25.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. microtubule organizing center Source: MGI
  2. nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Ribonuclease P protein subunit p25PRO_0000237583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91WE3.
PRIDEiQ91WE3.

PTM databases

PhosphoSiteiQ91WE3.

Expressioni

Gene expression databases

BgeeiQ91WE3.
CleanExiMM_RPP25.
GenevestigatoriQ91WE3.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079358.

Structurei

3D structure databases

ProteinModelPortaliQ91WE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiNOG247262.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ91WE3.
KOiK14525.
OMAiMENFRKV.
OrthoDBiEOG7XM309.
PhylomeDBiQ91WE3.
TreeFamiTF325688.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFRKVRSE EAPAGDGDEG GSPNSGPFAD LAPGAVHMRV KEGSKIRNLL
60 70 80 90 100
AFATASMAQP ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR
110 120 130 140 150
SVREVWQSLP PGPTPGQTPS DPAASLSVLK NVPSLAILLS KDALDPRQLG
160 170 180 190
YQPPNLSPGP SSPPTVSTSK RSLGESAAEE GTAKRSQPEP EAENEDRTA
Length:199
Mass (Da):21,038
Last modified:November 30, 2001 - v1
Checksum:iB9DE105BE3293D64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082822 mRNA. Translation: BAC38636.1.
BC016085 mRNA. Translation: AAH16085.1.
BC083064 mRNA. Translation: AAH83064.1.
CCDSiCCDS23222.1.
RefSeqiNP_598743.1. NM_133982.1.
UniGeneiMm.274421.

Genome annotation databases

EnsembliENSMUST00000080514; ENSMUSP00000079358; ENSMUSG00000062309.
GeneIDi102614.
KEGGimmu:102614.
UCSCiuc009puy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082822 mRNA. Translation: BAC38636.1.
BC016085 mRNA. Translation: AAH16085.1.
BC083064 mRNA. Translation: AAH83064.1.
CCDSiCCDS23222.1.
RefSeqiNP_598743.1. NM_133982.1.
UniGeneiMm.274421.

3D structure databases

ProteinModelPortaliQ91WE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079358.

PTM databases

PhosphoSiteiQ91WE3.

Proteomic databases

MaxQBiQ91WE3.
PRIDEiQ91WE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080514; ENSMUSP00000079358; ENSMUSG00000062309.
GeneIDi102614.
KEGGimmu:102614.
UCSCiuc009puy.1. mouse.

Organism-specific databases

CTDi54913.
MGIiMGI:2143151. Rpp25.

Phylogenomic databases

eggNOGiNOG247262.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ91WE3.
KOiK14525.
OMAiMENFRKV.
OrthoDBiEOG7XM309.
PhylomeDBiQ91WE3.
TreeFamiTF325688.

Miscellaneous databases

NextBioi355562.
PROiQ91WE3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WE3.
CleanExiMM_RPP25.
GenevestigatoriQ91WE3.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiRPP25_MOUSE
AccessioniPrimary (citable) accession number: Q91WE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2006
Last sequence update: November 30, 2001
Last modified: March 3, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.