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Q91WE1

- SNX15_MOUSE

UniProt

Q91WE1 - SNX15_MOUSE

Protein

Sorting nexin-15

Gene

Snx15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei53 – 531Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei87 – 871Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei96 – 961Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: InterPro

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-15
    Gene namesi
    Name:Snx15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1916274. Snx15.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Sorting nexin-15PRO_0000236202Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei227 – 2271PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ91WE1.
    PaxDbiQ91WE1.
    PRIDEiQ91WE1.

    PTM databases

    PhosphoSiteiQ91WE1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91WE1.
    BgeeiQ91WE1.
    CleanExiMM_SNX15.
    GenevestigatoriQ91WE1.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SNX1, SNX2 and SNX4 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000025702.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WE1.
    SMRiQ91WE1. Positions 4-131, 269-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 130130PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini265 – 33773MITAdd
    BLAST

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 MIT domain.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245612.
    GeneTreeiENSGT00530000063268.
    HOGENOMiHOG000154362.
    HOVERGENiHBG066336.
    InParanoidiQ91WE1.
    KOiK17927.
    OMAiVSRDLHI.
    OrthoDBiEOG7B31NH.
    PhylomeDBiQ91WE1.
    TreeFamiTF323964.

    Family and domain databases

    Gene3Di1.20.58.280. 1 hit.
    3.30.1520.10. 1 hit.
    InterProiIPR007330. MIT.
    IPR001683. Phox.
    [Graphical view]
    PfamiPF04212. MIT. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00745. MIT. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF116846. SSF116846. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91WE1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDIKEVVVWK    50
    RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA 100
    EDLLRFTVPI PALNNSPQLK EFFRGGEVTR PSEVSRDLRI LPPPLIPTPP 150
    PDEARLLQPL PAERRGQEEL EVPVDPLPSS PAQEALDLLF SCDSTEEASS 200
    SLARGPLSEA ELALFDPYSK EESTGPSPTH TGELAAIEVE SKRLDQEPWE 250
    PGGQEEEEAE DGEPAPAYLG QATELITQAL RNEKAGAYAA ALQGYQDGVH 300
    ILLQGVSGDP SPARREGVKK KAAEYLKRAE MLHTHLP 337
    Length:337
    Mass (Da):37,742
    Last modified:December 1, 2001 - v1
    Checksum:i743923E18ED9EF4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016091 mRNA. Translation: AAH16091.1.
    CCDSiCCDS29495.1.
    RefSeqiNP_081188.1. NM_026912.1.
    XP_006531894.1. XM_006531831.1.
    XP_006531895.1. XM_006531832.1.
    UniGeneiMm.329629.

    Genome annotation databases

    EnsembliENSMUST00000025702; ENSMUSP00000025702; ENSMUSG00000024787.
    GeneIDi69024.
    KEGGimmu:69024.
    UCSCiuc008ghm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016091 mRNA. Translation: AAH16091.1 .
    CCDSi CCDS29495.1.
    RefSeqi NP_081188.1. NM_026912.1.
    XP_006531894.1. XM_006531831.1.
    XP_006531895.1. XM_006531832.1.
    UniGenei Mm.329629.

    3D structure databases

    ProteinModelPortali Q91WE1.
    SMRi Q91WE1. Positions 4-131, 269-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000025702.

    PTM databases

    PhosphoSitei Q91WE1.

    Proteomic databases

    MaxQBi Q91WE1.
    PaxDbi Q91WE1.
    PRIDEi Q91WE1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025702 ; ENSMUSP00000025702 ; ENSMUSG00000024787 .
    GeneIDi 69024.
    KEGGi mmu:69024.
    UCSCi uc008ghm.1. mouse.

    Organism-specific databases

    CTDi 29907.
    MGIi MGI:1916274. Snx15.

    Phylogenomic databases

    eggNOGi NOG245612.
    GeneTreei ENSGT00530000063268.
    HOGENOMi HOG000154362.
    HOVERGENi HBG066336.
    InParanoidi Q91WE1.
    KOi K17927.
    OMAi VSRDLHI.
    OrthoDBi EOG7B31NH.
    PhylomeDBi Q91WE1.
    TreeFami TF323964.

    Miscellaneous databases

    ChiTaRSi SNX15. mouse.
    NextBioi 328411.
    PROi Q91WE1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91WE1.
    Bgeei Q91WE1.
    CleanExi MM_SNX15.
    Genevestigatori Q91WE1.

    Family and domain databases

    Gene3Di 1.20.58.280. 1 hit.
    3.30.1520.10. 1 hit.
    InterProi IPR007330. MIT.
    IPR001683. Phox.
    [Graphical view ]
    Pfami PF04212. MIT. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00745. MIT. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF116846. SSF116846. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiSNX15_MOUSE
    AccessioniPrimary (citable) accession number: Q91WE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3