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Protein

Sorting nexin-15

Gene

Snx15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei53Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei87Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei96Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-15
Gene namesi
Name:Snx15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1916274. Snx15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002362021 – 337Sorting nexin-15Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105Omega-N-methylarginineCombined sources1
Modified residuei201PhosphoserineBy similarity1
Modified residuei227PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ91WE1.
MaxQBiQ91WE1.
PaxDbiQ91WE1.
PeptideAtlasiQ91WE1.
PRIDEiQ91WE1.

PTM databases

iPTMnetiQ91WE1.
PhosphoSitePlusiQ91WE1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024787.
CleanExiMM_SNX15.
ExpressionAtlasiQ91WE1. baseline and differential.
GenevisibleiQ91WE1. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with SNX1, SNX2 and SNX4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025702.

Structurei

3D structure databases

ProteinModelPortaliQ91WE1.
SMRiQ91WE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 130PXPROSITE-ProRule annotationAdd BLAST130
Domaini265 – 337MITAdd BLAST73

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG4111HIS. LUCA.
GeneTreeiENSGT00890000139413.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ91WE1.
KOiK17927.
OMAiVSRDLHI.
OrthoDBiEOG091G0CNL.
PhylomeDBiQ91WE1.
TreeFamiTF323964.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR007330. MIT.
IPR036181. MIT_dom_sf.
IPR001683. Phox.
IPR036871. PX_dom_sf.
IPR035048. SNX15.
PANTHERiPTHR15508:SF7. PTHR15508:SF7. 1 hit.
PfamiView protein in Pfam
PF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
SMARTiView protein in SMART
SM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50195. PX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDIKEVVVWK
60 70 80 90 100
RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA
110 120 130 140 150
EDLLRFTVPI PALNNSPQLK EFFRGGEVTR PSEVSRDLRI LPPPLIPTPP
160 170 180 190 200
PDEARLLQPL PAERRGQEEL EVPVDPLPSS PAQEALDLLF SCDSTEEASS
210 220 230 240 250
SLARGPLSEA ELALFDPYSK EESTGPSPTH TGELAAIEVE SKRLDQEPWE
260 270 280 290 300
PGGQEEEEAE DGEPAPAYLG QATELITQAL RNEKAGAYAA ALQGYQDGVH
310 320 330
ILLQGVSGDP SPARREGVKK KAAEYLKRAE MLHTHLP
Length:337
Mass (Da):37,742
Last modified:December 1, 2001 - v1
Checksum:i743923E18ED9EF4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016091 mRNA. Translation: AAH16091.1.
CCDSiCCDS29495.1.
RefSeqiNP_081188.1. NM_026912.1.
XP_006531894.1. XM_006531831.3.
UniGeneiMm.329629.

Genome annotation databases

EnsembliENSMUST00000025702; ENSMUSP00000025702; ENSMUSG00000024787.
GeneIDi69024.
KEGGimmu:69024.
UCSCiuc008ghm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSNX15_MOUSE
AccessioniPrimary (citable) accession number: Q91WE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families