Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91WE1 (SNX15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-15
Gene names
Name:Snx15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN By similarity.

Subunit structure

Homodimer. Interacts with SNX1, SNX2 and SNX4 By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate By similarity.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 MIT domain.

Contains 1 PX (phox homology) domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCytoplasm
Cytoplasmic vesicle
Membrane
   LigandLipid-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasmic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionphosphatidylinositol binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Sorting nexin-15
PRO_0000236202

Regions

Domain1 – 130130PX
Domain265 – 33773MIT

Sites

Binding site511Phosphatidylinositol 3-phosphate By similarity
Binding site531Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site871Phosphatidylinositol 3-phosphate By similarity
Binding site961Phosphatidylinositol 3-phosphate By similarity

Amino acid modifications

Modified residue2271Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91WE1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 743923E18ED9EF4B

FASTA33737,742
        10         20         30         40         50         60 
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDIKEVVVWK RYSDFRKLHG 

        70         80         90        100        110        120 
DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVPI PALNNSPQLK 

       130        140        150        160        170        180 
EFFRGGEVTR PSEVSRDLRI LPPPLIPTPP PDEARLLQPL PAERRGQEEL EVPVDPLPSS 

       190        200        210        220        230        240 
PAQEALDLLF SCDSTEEASS SLARGPLSEA ELALFDPYSK EESTGPSPTH TGELAAIEVE 

       250        260        270        280        290        300 
SKRLDQEPWE PGGQEEEEAE DGEPAPAYLG QATELITQAL RNEKAGAYAA ALQGYQDGVH 

       310        320        330 
ILLQGVSGDP SPARREGVKK KAAEYLKRAE MLHTHLP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016091 mRNA. Translation: AAH16091.1.
CCDSCCDS29495.1.
RefSeqNP_081188.1. NM_026912.1.
XP_006531894.1. XM_006531831.1.
XP_006531895.1. XM_006531832.1.
UniGeneMm.329629.

3D structure databases

ProteinModelPortalQ91WE1.
SMRQ91WE1. Positions 4-131, 269-336.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025702.

PTM databases

PhosphoSiteQ91WE1.

Proteomic databases

MaxQBQ91WE1.
PaxDbQ91WE1.
PRIDEQ91WE1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025702; ENSMUSP00000025702; ENSMUSG00000024787.
GeneID69024.
KEGGmmu:69024.
UCSCuc008ghm.1. mouse.

Organism-specific databases

CTD29907.
MGIMGI:1916274. Snx15.

Phylogenomic databases

eggNOGNOG245612.
GeneTreeENSGT00530000063268.
HOGENOMHOG000154362.
HOVERGENHBG066336.
InParanoidQ91WE1.
KOK17927.
OMAVSRDLHI.
OrthoDBEOG7B31NH.
PhylomeDBQ91WE1.
TreeFamTF323964.

Gene expression databases

ArrayExpressQ91WE1.
BgeeQ91WE1.
CleanExMM_SNX15.
GenevestigatorQ91WE1.

Family and domain databases

Gene3D1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSNX15. mouse.
NextBio328411.
PROQ91WE1.
SOURCESearch...

Entry information

Entry nameSNX15_MOUSE
AccessionPrimary (citable) accession number: Q91WE1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot