Q91WD9 (SEGN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secretagogin

Gene names

Name:

Scgn

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm. Secreted By similarity. Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions By similarity.
Sequence similarities	Contains 6 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoplasmic vesicle Membrane Secreted
Domain	Repeat
Ligand	Calcium Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell transport vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Secretagogin		PRO_0000073637
Regions
	Domain	12 – 47	36	EF-hand 1
	Domain	58 – 93	36	EF-hand 2
	Domain	105 – 140	36	EF-hand 3
	Domain	149 – 184	36	EF-hand 4
	Domain	197 – 232	36	EF-hand 5
	Domain	240 – 276	37	EF-hand 6
	Calcium binding	25 – 36	12	1 Potential
	Calcium binding	71 – 82	12	2 Potential
	Calcium binding	118 – 129	12	3 Potential
	Calcium binding	162 – 173	12	4 Potential
	Calcium binding	210 – 221	12	5 Potential
	Calcium binding	254 – 265	12	6 Potential

Sequences

	Sequence		Length	Mass (Da)
	Q91WD9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: DBC86BF7F1CF9987	FASTA	276	32,146
	10 20 30 40 50 60 MDNARRKTPA RLDAACFWQI WQRFDKEEKG YIRETELDAF FDHLLAKSGT EDTLMEENVQ 70 80 90 100 110 120 KVKEQLMTSH NVSKEGRILM KELASMFLSE DENFLLFFRL ETPLDNSVEF MQIWRKYDAD 130 140 150 160 170 180 SSGFISAAEL CNFLRDLFLH HKKNISEAEL EEYTSTMMKI FDKNKDGRLD LNDLARILAL 190 200 210 220 230 240 QENFLLQFKM DASSTEERKR DFEKIFAHYD VSKTGALEGP EVDGFVKDMM ELVQPSISGV 250 260 270 DLDKFREILL RHCDVNKDGK IQKSELALCL GLKINP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC016093 mRNA. Translation: AAH16093.1.
IPI	IPI00128028.
RefSeq	NP_663374.1. NM_145399.1.
UniGene	Mm.255667.
3D structure databases
ProteinModelPortal	Q91WD9.
SMR	Q91WD9. Positions 10-276.
ModBase	Search...
PTM databases
PhosphoSite	Q91WD9.
Proteomic databases
PRIDE	Q91WD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021770; ENSMUSP00000021770; ENSMUSG00000021337.
GeneID	214189.
KEGG	mmu:214189.
Organism-specific databases
CTD	10590.
MGI	MGI:2384873. Scgn.
Phylogenomic databases
eggNOG	NOG299305.
GeneTree	ENSGT00390000013118.
HOGENOM	HOG000231866.
HOVERGEN	HBG000855.
InParanoid	Q91WD9.
OMA	HHKKAIS.
OrthoDB	EOG4933JN.
Gene expression databases
ArrayExpress	Q91WD9.
Bgee	Q91WD9.
CleanEx	MM_SCGN.
Genevestigator	Q91WD9.
GermOnline	ENSMUSG00000021337. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
Pfam	PF13202. EF_hand_3. 1 hit. PF13499. EF_hand_5. 1 hit. [Graphical view]
SMART	SM00054. EFh. 5 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	374218.
SOURCE	Search...

Entry information

Entry name

SEGN_MOUSE

Accession

Primary (citable) accession number: Q91WD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 22, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program