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Q91WD7

- KI18A_MOUSE

UniProt

Q91WD7 - KI18A_MOUSE

Protein

Kinesin-like protein KIF18A

Gene

Kif18a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi113 – 1208ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. microtubule binding Source: UniProtKB
    4. microtubule plus-end binding Source: UniProtKB
    5. plus-end-directed microtubule motor activity Source: UniProtKB
    6. tubulin-dependent ATPase activity Source: UniProtKB
    7. ubiquitin binding Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. metabolic process Source: GOC
    3. microtubule-based movement Source: InterPro
    4. microtubule depolymerization Source: UniProtKB
    5. mitotic metaphase plate congression Source: UniProtKB
    6. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_199117. Kinesins.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF18A
    Gene namesi
    Name:Kif18a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2446977. Kif18a.

    Subcellular locationi

    Cell projectionruffle By similarity. Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

    GO - Cellular componenti

    1. caveola Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. kinesin complex Source: InterPro
    4. kinetochore microtubule Source: UniProtKB
    5. microtubule organizing center Source: UniProtKB-SubCell
    6. nucleus Source: UniProtKB
    7. ruffle Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 886886Kinesin-like protein KIF18APRO_0000125459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei674 – 6741PhosphoserineBy similarity

    Post-translational modificationi

    Glycosylated.By similarity
    Ubiquitinated.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ91WD7.

    PTM databases

    PhosphoSiteiQ91WD7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91WD7.
    BgeeiQ91WD7.
    CleanExiMM_KIF18A.
    GenevestigatoriQ91WD7.

    Interactioni

    Subunit structurei

    Interacts with CENPE and ESR1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WD7.
    SMRiQ91WD7. Positions 4-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 355345Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili370 – 40435Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00750000117497.
    HOGENOMiHOG000231436.
    HOVERGENiHBG052245.
    InParanoidiQ91WD7.
    KOiK10401.
    OMAiWLHRVEN.
    OrthoDBiEOG7Z95KM.
    PhylomeDBiQ91WD7.
    TreeFamiTF105231.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91WD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTEEDLCH RMKVVVRVRP ENTKEKAVQF CKVVHVVDKH ILSFDPKQEE    50
    ISFFHRKKTT NFDITKRQNK DLKFVFDAVF DETSTQMEVF EHTTKPILHS 100
    FLNGYNCTVF AYGATGSGKT HTMLGSAAEP GVMYLTMLDL FKCIDEIKEE 150
    KECSTAVSYL EVYNEQIRDL LTNSGPLAVR EDSQKGVVVQ GLTLHQPKSS 200
    EEILQLLDNG NKNRTQHPTD VNAVSSRSHA VFQIYLRQQD KTASINQNVR 250
    IAKMSLIDLA GSERASVSGA KGSRFVEGTN INKSLLALGN VINALANTKR 300
    RNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSLFYD DTYNTLKYAN 350
    RAKEIKSSLK SNVLNLNSHI SQYVKICNMQ KAEILMLKEK LKAYEEQKAL 400
    SDRNDCAKLV HSNPEDRETE RFQEILNCLF QNREGIRQEY LKLEMLLKAN 450
    ALKSSYHQQC HKQIEMMCSE DKVEKATCKR DHRLEKLKTN SCFLEKKKEE 500
    VSKQFDENTN WLHRVENEMR LLGQNGDIPE ALNKELHCHH LHLQNKELKT 550
    QMAHMTALAC LQEQQHKQTE AVLNALLPVL RKQYWKLKET GLSNAAFDSD 600
    FKDIEHLVER KKVVAWADQT NEHSNRNDLP GISLLMTFPQ LEPIQSISCC 650
    TSVSDPNVLK LTPQRRTRRK IIPSPLKVQH TQKSALSEST QLNDSFSKEL 700
    QPIVYTPEDC KKAQDLFPSL TRTSSQSANV MNDNSQKALC RIESPLSRTE 750
    CKQGLYSTST LCDSIRGLKN KWPEQEPLAS SKSSVHRIES SSFSTKDSMP 800
    ESAGVPSYMA MTTAAKRKWK QMSSTSNASI KSDESCGFAK RIRRDNSSVK 850
    PMQENRLKVG YKRNTNKTNS NMLRKFRRNT SKENVQ 886
    Length:886
    Mass (Da):100,935
    Last modified:December 1, 2001 - v1
    Checksum:iF611802A899AF0E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044795 mRNA. Translation: BAC32095.2.
    AK164649 mRNA. Translation: BAE37860.1.
    BC016095 mRNA. Translation: AAH16095.1.
    CCDSiCCDS16507.1.
    RefSeqiNP_647464.1. NM_139303.1.
    UniGeneiMm.274086.

    Genome annotation databases

    EnsembliENSMUST00000028527; ENSMUSP00000028527; ENSMUSG00000027115.
    GeneIDi228421.
    KEGGimmu:228421.
    UCSCiuc008lmb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044795 mRNA. Translation: BAC32095.2 .
    AK164649 mRNA. Translation: BAE37860.1 .
    BC016095 mRNA. Translation: AAH16095.1 .
    CCDSi CCDS16507.1.
    RefSeqi NP_647464.1. NM_139303.1.
    UniGenei Mm.274086.

    3D structure databases

    ProteinModelPortali Q91WD7.
    SMRi Q91WD7. Positions 4-405.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91WD7.

    Proteomic databases

    PRIDEi Q91WD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028527 ; ENSMUSP00000028527 ; ENSMUSG00000027115 .
    GeneIDi 228421.
    KEGGi mmu:228421.
    UCSCi uc008lmb.1. mouse.

    Organism-specific databases

    CTDi 81930.
    MGIi MGI:2446977. Kif18a.

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00750000117497.
    HOGENOMi HOG000231436.
    HOVERGENi HBG052245.
    InParanoidi Q91WD7.
    KOi K10401.
    OMAi WLHRVEN.
    OrthoDBi EOG7Z95KM.
    PhylomeDBi Q91WD7.
    TreeFami TF105231.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_199117. Kinesins.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 379000.
    PROi Q91WD7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91WD7.
    Bgeei Q91WD7.
    CleanExi MM_KIF18A.
    Genevestigatori Q91WD7.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiKI18A_MOUSE
    AccessioniPrimary (citable) accession number: Q91WD7
    Secondary accession number(s): Q3TP77, Q8BLL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3