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Q91WD7 (KI18A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF18A
Gene names
Name:Kif18a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length886 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression By similarity.

Subunit structure

Interacts with CENPE and ESR1 By similarity.

Subcellular location

Cell projection › ruffle By similarity. Cytoplasm By similarity. Nucleus By similarity. Cytoplasm › cytoskeleton › centrosome By similarity.

Post-translational modification

Glycosylated By similarity.

Ubiquitinated By similarity.

Sequence similarities

Belongs to the kinesin-like protein family.

Contains 1 kinesin-motor domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCell projection
Cytoplasm
Cytoskeleton
Microtubule
Nucleus
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionMotor protein
   PTMGlycoprotein
Phosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmicrotubule depolymerization

Inferred from sequence or structural similarity. Source: UniProtKB

microtubule-based movement

Inferred from electronic annotation. Source: InterPro

mitotic metaphase plate congression

Inferred from sequence or structural similarity. Source: UniProtKB

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcaveola

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

kinetochore microtubule

Inferred from sequence or structural similarity. Source: UniProtKB

microtubule associated complex

Inferred from electronic annotation. Source: InterPro

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

ruffle

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

actin binding

Inferred from sequence or structural similarity. Source: UniProtKB

microtubule plus-end binding

Inferred from sequence or structural similarity. Source: UniProtKB

plus-end-directed microtubule motor activity

Inferred from sequence or structural similarity. Source: UniProtKB

tubulin-dependent ATPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

ubiquitin binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 886886Kinesin-like protein KIF18A
PRO_0000125459

Regions

Domain1 – 283283Kinesin-motor
Nucleotide binding113 – 1208ATP By similarity
Coiled coil370 – 40435 Potential

Amino acid modifications

Modified residue6741Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91WD7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F611802A899AF0E1

FASTA886100,935
        10         20         30         40         50         60 
MSGTEEDLCH RMKVVVRVRP ENTKEKAVQF CKVVHVVDKH ILSFDPKQEE ISFFHRKKTT 

        70         80         90        100        110        120 
NFDITKRQNK DLKFVFDAVF DETSTQMEVF EHTTKPILHS FLNGYNCTVF AYGATGSGKT 

       130        140        150        160        170        180 
HTMLGSAAEP GVMYLTMLDL FKCIDEIKEE KECSTAVSYL EVYNEQIRDL LTNSGPLAVR 

       190        200        210        220        230        240 
EDSQKGVVVQ GLTLHQPKSS EEILQLLDNG NKNRTQHPTD VNAVSSRSHA VFQIYLRQQD 

       250        260        270        280        290        300 
KTASINQNVR IAKMSLIDLA GSERASVSGA KGSRFVEGTN INKSLLALGN VINALANTKR 

       310        320        330        340        350        360 
RNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSLFYD DTYNTLKYAN RAKEIKSSLK 

       370        380        390        400        410        420 
SNVLNLNSHI SQYVKICNMQ KAEILMLKEK LKAYEEQKAL SDRNDCAKLV HSNPEDRETE 

       430        440        450        460        470        480 
RFQEILNCLF QNREGIRQEY LKLEMLLKAN ALKSSYHQQC HKQIEMMCSE DKVEKATCKR 

       490        500        510        520        530        540 
DHRLEKLKTN SCFLEKKKEE VSKQFDENTN WLHRVENEMR LLGQNGDIPE ALNKELHCHH 

       550        560        570        580        590        600 
LHLQNKELKT QMAHMTALAC LQEQQHKQTE AVLNALLPVL RKQYWKLKET GLSNAAFDSD 

       610        620        630        640        650        660 
FKDIEHLVER KKVVAWADQT NEHSNRNDLP GISLLMTFPQ LEPIQSISCC TSVSDPNVLK 

       670        680        690        700        710        720 
LTPQRRTRRK IIPSPLKVQH TQKSALSEST QLNDSFSKEL QPIVYTPEDC KKAQDLFPSL 

       730        740        750        760        770        780 
TRTSSQSANV MNDNSQKALC RIESPLSRTE CKQGLYSTST LCDSIRGLKN KWPEQEPLAS 

       790        800        810        820        830        840 
SKSSVHRIES SSFSTKDSMP ESAGVPSYMA MTTAAKRKWK QMSSTSNASI KSDESCGFAK 

       850        860        870        880 
RIRRDNSSVK PMQENRLKVG YKRNTNKTNS NMLRKFRRNT SKENVQ

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Stomach.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK044795 mRNA. Translation: BAC32095.2.
AK164649 mRNA. Translation: BAE37860.1.
BC016095 mRNA. Translation: AAH16095.1.
IPIIPI00128025.
RefSeqNP_647464.1. NM_139303.1.
UniGeneMm.274086.

3D structure databases

ProteinModelPortalQ91WD7.
SMRQ91WD7. Positions 10-405.
ModBaseSearch...

PTM databases

PhosphoSiteQ91WD7.

Proteomic databases

PRIDEQ91WD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028527; ENSMUSP00000028527; ENSMUSG00000027115.
GeneID228421.
KEGGmmu:228421.

Organism-specific databases

CTD81930.
MGIMGI:2446977. Kif18a.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00690000101722.
HOGENOMHOG000231436.
HOVERGENHBG052245.
InParanoidQ91WD7.
KOK10401.
OMAKRKNQHI.
OrthoDBEOG4QZ7K8.

Gene expression databases

ArrayExpressQ91WD7.
BgeeQ91WD7.
CleanExMM_KIF18A.
GenevestigatorQ91WD7.
GermOnlineENSMUSG00000027115. Mus musculus.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
[Graphical view]
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio379000.
SOURCESearch...

Entry information

Entry nameKI18A_MOUSE
AccessionPrimary (citable) accession number: Q91WD7
Secondary accession number(s): Q3TP77, Q8BLL1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents