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Q91WD7

- KI18A_MOUSE

UniProt

Q91WD7 - KI18A_MOUSE

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Protein
Kinesin-like protein KIF18A
Gene
Kif18a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi113 – 1208ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. actin binding Source: UniProtKB
  3. microtubule binding Source: UniProtKB
  4. microtubule plus-end binding Source: UniProtKB
  5. plus-end-directed microtubule motor activity Source: UniProtKB
  6. tubulin-dependent ATPase activity Source: UniProtKB
  7. ubiquitin binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. metabolic process Source: GOC
  3. microtubule depolymerization Source: UniProtKB
  4. microtubule-based movement Source: InterPro
  5. mitotic metaphase plate congression Source: UniProtKB
  6. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_199117. Kinesins.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF18A
Gene namesi
Name:Kif18a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2446977. Kif18a.

Subcellular locationi

Cell projectionruffle By similarity. Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

GO - Cellular componenti

  1. caveola Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. kinesin complex Source: InterPro
  4. kinetochore microtubule Source: UniProtKB
  5. microtubule organizing center Source: UniProtKB-SubCell
  6. nucleus Source: UniProtKB
  7. ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Kinesin-like protein KIF18A
PRO_0000125459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei674 – 6741Phosphoserine By similarity

Post-translational modificationi

Glycosylated By similarity.
Ubiquitinated By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ91WD7.

PTM databases

PhosphoSiteiQ91WD7.

Expressioni

Gene expression databases

ArrayExpressiQ91WD7.
BgeeiQ91WD7.
CleanExiMM_KIF18A.
GenevestigatoriQ91WD7.

Interactioni

Subunit structurei

Interacts with CENPE and ESR1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ91WD7.
SMRiQ91WD7. Positions 4-405.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 355345Kinesin motor
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili370 – 40435 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00750000117497.
HOGENOMiHOG000231436.
HOVERGENiHBG052245.
InParanoidiQ91WD7.
KOiK10401.
OMAiWLHRVEN.
OrthoDBiEOG7Z95KM.
PhylomeDBiQ91WD7.
TreeFamiTF105231.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WD7-1 [UniParc]FASTAAdd to Basket

« Hide

MSGTEEDLCH RMKVVVRVRP ENTKEKAVQF CKVVHVVDKH ILSFDPKQEE    50
ISFFHRKKTT NFDITKRQNK DLKFVFDAVF DETSTQMEVF EHTTKPILHS 100
FLNGYNCTVF AYGATGSGKT HTMLGSAAEP GVMYLTMLDL FKCIDEIKEE 150
KECSTAVSYL EVYNEQIRDL LTNSGPLAVR EDSQKGVVVQ GLTLHQPKSS 200
EEILQLLDNG NKNRTQHPTD VNAVSSRSHA VFQIYLRQQD KTASINQNVR 250
IAKMSLIDLA GSERASVSGA KGSRFVEGTN INKSLLALGN VINALANTKR 300
RNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSLFYD DTYNTLKYAN 350
RAKEIKSSLK SNVLNLNSHI SQYVKICNMQ KAEILMLKEK LKAYEEQKAL 400
SDRNDCAKLV HSNPEDRETE RFQEILNCLF QNREGIRQEY LKLEMLLKAN 450
ALKSSYHQQC HKQIEMMCSE DKVEKATCKR DHRLEKLKTN SCFLEKKKEE 500
VSKQFDENTN WLHRVENEMR LLGQNGDIPE ALNKELHCHH LHLQNKELKT 550
QMAHMTALAC LQEQQHKQTE AVLNALLPVL RKQYWKLKET GLSNAAFDSD 600
FKDIEHLVER KKVVAWADQT NEHSNRNDLP GISLLMTFPQ LEPIQSISCC 650
TSVSDPNVLK LTPQRRTRRK IIPSPLKVQH TQKSALSEST QLNDSFSKEL 700
QPIVYTPEDC KKAQDLFPSL TRTSSQSANV MNDNSQKALC RIESPLSRTE 750
CKQGLYSTST LCDSIRGLKN KWPEQEPLAS SKSSVHRIES SSFSTKDSMP 800
ESAGVPSYMA MTTAAKRKWK QMSSTSNASI KSDESCGFAK RIRRDNSSVK 850
PMQENRLKVG YKRNTNKTNS NMLRKFRRNT SKENVQ 886
Length:886
Mass (Da):100,935
Last modified:December 1, 2001 - v1
Checksum:iF611802A899AF0E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044795 mRNA. Translation: BAC32095.2.
AK164649 mRNA. Translation: BAE37860.1.
BC016095 mRNA. Translation: AAH16095.1.
CCDSiCCDS16507.1.
RefSeqiNP_647464.1. NM_139303.1.
UniGeneiMm.274086.

Genome annotation databases

EnsembliENSMUST00000028527; ENSMUSP00000028527; ENSMUSG00000027115.
GeneIDi228421.
KEGGimmu:228421.
UCSCiuc008lmb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044795 mRNA. Translation: BAC32095.2 .
AK164649 mRNA. Translation: BAE37860.1 .
BC016095 mRNA. Translation: AAH16095.1 .
CCDSi CCDS16507.1.
RefSeqi NP_647464.1. NM_139303.1.
UniGenei Mm.274086.

3D structure databases

ProteinModelPortali Q91WD7.
SMRi Q91WD7. Positions 4-405.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91WD7.

Proteomic databases

PRIDEi Q91WD7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028527 ; ENSMUSP00000028527 ; ENSMUSG00000027115 .
GeneIDi 228421.
KEGGi mmu:228421.
UCSCi uc008lmb.1. mouse.

Organism-specific databases

CTDi 81930.
MGIi MGI:2446977. Kif18a.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00750000117497.
HOGENOMi HOG000231436.
HOVERGENi HBG052245.
InParanoidi Q91WD7.
KOi K10401.
OMAi WLHRVEN.
OrthoDBi EOG7Z95KM.
PhylomeDBi Q91WD7.
TreeFami TF105231.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_199117. Kinesins.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 379000.
PROi Q91WD7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91WD7.
Bgeei Q91WD7.
CleanExi MM_KIF18A.
Genevestigatori Q91WD7.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKI18A_MOUSE
AccessioniPrimary (citable) accession number: Q91WD7
Secondary accession number(s): Q3TP77, Q8BLL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi