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Q91WD7

- KI18A_MOUSE

UniProt

Q91WD7 - KI18A_MOUSE

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Protein

Kinesin-like protein KIF18A

Gene

Kif18a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi113 – 1208ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. ATPase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. microtubule binding Source: UniProtKB
  5. microtubule plus-end binding Source: UniProtKB
  6. plus-end-directed microtubule motor activity Source: UniProtKB
  7. tubulin-dependent ATPase activity Source: UniProtKB
  8. ubiquitin binding Source: UniProtKB

GO - Biological processi

  1. microtubule-based movement Source: RefGenome
  2. microtubule depolymerization Source: UniProtKB
  3. mitotic metaphase plate congression Source: UniProtKB
  4. mitotic sister chromatid segregation Source: RefGenome
  5. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_199117. Kinesins.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF18A
Gene namesi
Name:Kif18a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2446977. Kif18a.

Subcellular locationi

Cell projectionruffle By similarity. Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

GO - Cellular componenti

  1. caveola Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. kinesin complex Source: RefGenome
  4. kinetochore microtubule Source: UniProtKB
  5. nucleus Source: UniProtKB
  6. ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Kinesin-like protein KIF18APRO_0000125459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei674 – 6741PhosphoserineBy similarity

Post-translational modificationi

Glycosylated.By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ91WD7.
PRIDEiQ91WD7.

PTM databases

PhosphoSiteiQ91WD7.

Expressioni

Gene expression databases

BgeeiQ91WD7.
CleanExiMM_KIF18A.
ExpressionAtlasiQ91WD7. baseline and differential.
GenevestigatoriQ91WD7.

Interactioni

Subunit structurei

Interacts with CENPE and ESR1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91WD7.
SMRiQ91WD7. Positions 4-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 355345Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili370 – 40435Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120451.
HOGENOMiHOG000231436.
HOVERGENiHBG052245.
InParanoidiQ91WD7.
KOiK10401.
OMAiWLHRVEN.
OrthoDBiEOG7Z95KM.
PhylomeDBiQ91WD7.
TreeFamiTF105231.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WD7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTEEDLCH RMKVVVRVRP ENTKEKAVQF CKVVHVVDKH ILSFDPKQEE
60 70 80 90 100
ISFFHRKKTT NFDITKRQNK DLKFVFDAVF DETSTQMEVF EHTTKPILHS
110 120 130 140 150
FLNGYNCTVF AYGATGSGKT HTMLGSAAEP GVMYLTMLDL FKCIDEIKEE
160 170 180 190 200
KECSTAVSYL EVYNEQIRDL LTNSGPLAVR EDSQKGVVVQ GLTLHQPKSS
210 220 230 240 250
EEILQLLDNG NKNRTQHPTD VNAVSSRSHA VFQIYLRQQD KTASINQNVR
260 270 280 290 300
IAKMSLIDLA GSERASVSGA KGSRFVEGTN INKSLLALGN VINALANTKR
310 320 330 340 350
RNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSLFYD DTYNTLKYAN
360 370 380 390 400
RAKEIKSSLK SNVLNLNSHI SQYVKICNMQ KAEILMLKEK LKAYEEQKAL
410 420 430 440 450
SDRNDCAKLV HSNPEDRETE RFQEILNCLF QNREGIRQEY LKLEMLLKAN
460 470 480 490 500
ALKSSYHQQC HKQIEMMCSE DKVEKATCKR DHRLEKLKTN SCFLEKKKEE
510 520 530 540 550
VSKQFDENTN WLHRVENEMR LLGQNGDIPE ALNKELHCHH LHLQNKELKT
560 570 580 590 600
QMAHMTALAC LQEQQHKQTE AVLNALLPVL RKQYWKLKET GLSNAAFDSD
610 620 630 640 650
FKDIEHLVER KKVVAWADQT NEHSNRNDLP GISLLMTFPQ LEPIQSISCC
660 670 680 690 700
TSVSDPNVLK LTPQRRTRRK IIPSPLKVQH TQKSALSEST QLNDSFSKEL
710 720 730 740 750
QPIVYTPEDC KKAQDLFPSL TRTSSQSANV MNDNSQKALC RIESPLSRTE
760 770 780 790 800
CKQGLYSTST LCDSIRGLKN KWPEQEPLAS SKSSVHRIES SSFSTKDSMP
810 820 830 840 850
ESAGVPSYMA MTTAAKRKWK QMSSTSNASI KSDESCGFAK RIRRDNSSVK
860 870 880
PMQENRLKVG YKRNTNKTNS NMLRKFRRNT SKENVQ
Length:886
Mass (Da):100,935
Last modified:December 1, 2001 - v1
Checksum:iF611802A899AF0E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044795 mRNA. Translation: BAC32095.2.
AK164649 mRNA. Translation: BAE37860.1.
BC016095 mRNA. Translation: AAH16095.1.
CCDSiCCDS16507.1.
RefSeqiNP_647464.1. NM_139303.1.
UniGeneiMm.274086.

Genome annotation databases

EnsembliENSMUST00000028527; ENSMUSP00000028527; ENSMUSG00000027115.
GeneIDi228421.
KEGGimmu:228421.
UCSCiuc008lmb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044795 mRNA. Translation: BAC32095.2 .
AK164649 mRNA. Translation: BAE37860.1 .
BC016095 mRNA. Translation: AAH16095.1 .
CCDSi CCDS16507.1.
RefSeqi NP_647464.1. NM_139303.1.
UniGenei Mm.274086.

3D structure databases

ProteinModelPortali Q91WD7.
SMRi Q91WD7. Positions 4-405.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91WD7.

Proteomic databases

MaxQBi Q91WD7.
PRIDEi Q91WD7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028527 ; ENSMUSP00000028527 ; ENSMUSG00000027115 .
GeneIDi 228421.
KEGGi mmu:228421.
UCSCi uc008lmb.1. mouse.

Organism-specific databases

CTDi 81930.
MGIi MGI:2446977. Kif18a.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00770000120451.
HOGENOMi HOG000231436.
HOVERGENi HBG052245.
InParanoidi Q91WD7.
KOi K10401.
OMAi WLHRVEN.
OrthoDBi EOG7Z95KM.
PhylomeDBi Q91WD7.
TreeFami TF105231.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_199117. Kinesins.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Miscellaneous databases

NextBioi 379000.
PROi Q91WD7.
SOURCEi Search...

Gene expression databases

Bgeei Q91WD7.
CleanExi MM_KIF18A.
ExpressionAtlasi Q91WD7. baseline and differential.
Genevestigatori Q91WD7.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKI18A_MOUSE
AccessioniPrimary (citable) accession number: Q91WD7
Secondary accession number(s): Q3TP77, Q8BLL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3