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Q91WD1

- RPC4_MOUSE

UniProt

Q91WD1 - RPC4_MOUSE

Protein

DNA-directed RNA polymerase III subunit RPC4

Gene

Polr3d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: InterPro
    3. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. defense response to virus Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW
    3. positive regulation of innate immune response Source: UniProtKB
    4. positive regulation of interferon-beta production Source: UniProtKB
    5. transcription from RNA polymerase III promoter Source: InterPro

    Keywords - Biological processi

    Antiviral defense, Immunity, Innate immunity, Transcription

    Enzyme and pathway databases

    ReactomeiREACT_205207. RNA Polymerase III Chain Elongation.
    REACT_221403. RNA Polymerase III Transcription Termination.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC4
    Short name:
    RNA polymerase III subunit C4
    Alternative name(s):
    DNA-directed RNA polymerase III subunit D
    Gene namesi
    Name:Polr3d
    Synonyms:Bn51t
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1914315. Polr3d.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. DNA-directed RNA polymerase III complex Source: RefGenome
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 398397DNA-directed RNA polymerase III subunit RPC4PRO_0000073968Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ91WD1.

    PTM databases

    PhosphoSiteiQ91WD1.

    Expressioni

    Gene expression databases

    BgeeiQ91WD1.
    CleanExiMM_POLR3D.
    GenevestigatoriQ91WD1.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with POLR3E/RPC5 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WD1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG239914.
    GeneTreeiENSGT00390000013948.
    HOGENOMiHOG000008080.
    HOVERGENiHBG039777.
    InParanoidiQ3U0T3.
    KOiK03026.
    OMAiWDKTVDM.
    OrthoDBiEOG7J180B.

    Family and domain databases

    InterProiIPR007811. RPC4.
    [Graphical view]
    PANTHERiPTHR13408. PTHR13408. 1 hit.
    PfamiPF05132. RNA_pol_Rpc4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91WD1-1 [UniParc]FASTAAdd to Basket

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    MSEGNAAGEP SNPGGPRPLL SGGRGLIGRR PAPPLTPGRL PSIRSRDLTL    50
    GGVKKKTFTP NIISRKIKEE PKEEVTMKKE KRERDRDRQR EGHGRGRGRP 100
    EVIQSHSIFE QGPAEMMKKK GNWDKTVDMS DMGPSHIINI KKEKRETDEE 150
    TKQILRMLEK DDFIDDPGLK NDTRNMPVQL PLAHSGWLFK EESEEPEAKP 200
    FSAGPKEEDM EVDVPAVKVK EEPRDEEEEA KVKAPPRAAR KTPGLPKDVS 250
    VAELLRELSL MKDEELLFLQ LPDTLPGQPP TQDIKPVKTE VQGEDGQMVV 300
    IKQEKDREAR LAENACTLAD LTEGQVGKLL IRKSGKVQLL LGKVTLDVTM 350
    GTTCSFLQEL VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR 398
    Length:398
    Mass (Da):44,357
    Last modified:July 27, 2011 - v2
    Checksum:iB70179A124C1231B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti201 – 2011F → L in AAH16102. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013165 mRNA. Translation: BAB28687.1.
    AK156587 mRNA. Translation: BAE33768.1.
    CH466535 Genomic DNA. Translation: EDL35903.1.
    BC016102 mRNA. Translation: AAH16102.1.
    CCDSiCCDS27253.1.
    RefSeqiNP_001157554.1. NM_001164082.1.
    NP_080221.3. NM_025945.3.
    UniGeneiMm.20420.

    Genome annotation databases

    EnsembliENSMUST00000000793; ENSMUSP00000000793; ENSMUSG00000000776.
    ENSMUST00000180358; ENSMUSP00000137614; ENSMUSG00000000776.
    GeneIDi67065.
    KEGGimmu:67065.
    UCSCiuc007uny.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013165 mRNA. Translation: BAB28687.1 .
    AK156587 mRNA. Translation: BAE33768.1 .
    CH466535 Genomic DNA. Translation: EDL35903.1 .
    BC016102 mRNA. Translation: AAH16102.1 .
    CCDSi CCDS27253.1.
    RefSeqi NP_001157554.1. NM_001164082.1.
    NP_080221.3. NM_025945.3.
    UniGenei Mm.20420.

    3D structure databases

    ProteinModelPortali Q91WD1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91WD1.

    Proteomic databases

    PRIDEi Q91WD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000793 ; ENSMUSP00000000793 ; ENSMUSG00000000776 .
    ENSMUST00000180358 ; ENSMUSP00000137614 ; ENSMUSG00000000776 .
    GeneIDi 67065.
    KEGGi mmu:67065.
    UCSCi uc007uny.2. mouse.

    Organism-specific databases

    CTDi 661.
    MGIi MGI:1914315. Polr3d.

    Phylogenomic databases

    eggNOGi NOG239914.
    GeneTreei ENSGT00390000013948.
    HOGENOMi HOG000008080.
    HOVERGENi HBG039777.
    InParanoidi Q3U0T3.
    KOi K03026.
    OMAi WDKTVDM.
    OrthoDBi EOG7J180B.

    Enzyme and pathway databases

    Reactomei REACT_205207. RNA Polymerase III Chain Elongation.
    REACT_221403. RNA Polymerase III Transcription Termination.

    Miscellaneous databases

    NextBioi 323468.
    PROi Q91WD1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91WD1.
    CleanExi MM_POLR3D.
    Genevestigatori Q91WD1.

    Family and domain databases

    InterProi IPR007811. RPC4.
    [Graphical view ]
    PANTHERi PTHR13408. PTHR13408. 1 hit.
    Pfami PF05132. RNA_pol_Rpc4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo and Spleen.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiRPC4_MOUSE
    AccessioniPrimary (citable) accession number: Q91WD1
    Secondary accession number(s): Q3U0T3, Q9CZ02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3