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Q91WD1

- RPC4_MOUSE

UniProt

Q91WD1 - RPC4_MOUSE

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Protein

DNA-directed RNA polymerase III subunit RPC4

Gene

Polr3d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: InterPro
  3. DNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
  3. positive regulation of innate immune response Source: UniProtKB
  4. positive regulation of interferon-beta production Source: UniProtKB
  5. transcription from RNA polymerase III promoter Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiREACT_205207. RNA Polymerase III Chain Elongation.
REACT_221403. RNA Polymerase III Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC4
Short name:
RNA polymerase III subunit C4
Alternative name(s):
DNA-directed RNA polymerase III subunit D
Gene namesi
Name:Polr3d
Synonyms:Bn51t
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1914315. Polr3d.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. DNA-directed RNA polymerase III complex Source: RefGenome
  2. nuclear chromatin Source: Ensembl
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 398397DNA-directed RNA polymerase III subunit RPC4PRO_0000073968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ91WD1.
PRIDEiQ91WD1.

PTM databases

PhosphoSiteiQ91WD1.

Expressioni

Gene expression databases

BgeeiQ91WD1.
CleanExiMM_POLR3D.
GenevestigatoriQ91WD1.

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with POLR3E/RPC5 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91WD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG239914.
GeneTreeiENSGT00390000013948.
HOGENOMiHOG000008080.
HOVERGENiHBG039777.
InParanoidiQ91WD1.
KOiK03026.
OMAiWDKTVDM.
OrthoDBiEOG7J180B.

Family and domain databases

InterProiIPR007811. RPC4.
[Graphical view]
PANTHERiPTHR13408. PTHR13408. 1 hit.
PfamiPF05132. RNA_pol_Rpc4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEGNAAGEP SNPGGPRPLL SGGRGLIGRR PAPPLTPGRL PSIRSRDLTL
60 70 80 90 100
GGVKKKTFTP NIISRKIKEE PKEEVTMKKE KRERDRDRQR EGHGRGRGRP
110 120 130 140 150
EVIQSHSIFE QGPAEMMKKK GNWDKTVDMS DMGPSHIINI KKEKRETDEE
160 170 180 190 200
TKQILRMLEK DDFIDDPGLK NDTRNMPVQL PLAHSGWLFK EESEEPEAKP
210 220 230 240 250
FSAGPKEEDM EVDVPAVKVK EEPRDEEEEA KVKAPPRAAR KTPGLPKDVS
260 270 280 290 300
VAELLRELSL MKDEELLFLQ LPDTLPGQPP TQDIKPVKTE VQGEDGQMVV
310 320 330 340 350
IKQEKDREAR LAENACTLAD LTEGQVGKLL IRKSGKVQLL LGKVTLDVTM
360 370 380 390
GTTCSFLQEL VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR
Length:398
Mass (Da):44,357
Last modified:July 27, 2011 - v2
Checksum:iB70179A124C1231B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011F → L in AAH16102. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013165 mRNA. Translation: BAB28687.1.
AK156587 mRNA. Translation: BAE33768.1.
CH466535 Genomic DNA. Translation: EDL35903.1.
BC016102 mRNA. Translation: AAH16102.1.
CCDSiCCDS27253.1.
RefSeqiNP_001157554.1. NM_001164082.1.
NP_080221.3. NM_025945.3.
UniGeneiMm.20420.

Genome annotation databases

EnsembliENSMUST00000000793; ENSMUSP00000000793; ENSMUSG00000000776.
ENSMUST00000180358; ENSMUSP00000137614; ENSMUSG00000000776.
GeneIDi67065.
KEGGimmu:67065.
UCSCiuc007uny.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013165 mRNA. Translation: BAB28687.1 .
AK156587 mRNA. Translation: BAE33768.1 .
CH466535 Genomic DNA. Translation: EDL35903.1 .
BC016102 mRNA. Translation: AAH16102.1 .
CCDSi CCDS27253.1.
RefSeqi NP_001157554.1. NM_001164082.1.
NP_080221.3. NM_025945.3.
UniGenei Mm.20420.

3D structure databases

ProteinModelPortali Q91WD1.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91WD1.

Proteomic databases

MaxQBi Q91WD1.
PRIDEi Q91WD1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000793 ; ENSMUSP00000000793 ; ENSMUSG00000000776 .
ENSMUST00000180358 ; ENSMUSP00000137614 ; ENSMUSG00000000776 .
GeneIDi 67065.
KEGGi mmu:67065.
UCSCi uc007uny.2. mouse.

Organism-specific databases

CTDi 661.
MGIi MGI:1914315. Polr3d.

Phylogenomic databases

eggNOGi NOG239914.
GeneTreei ENSGT00390000013948.
HOGENOMi HOG000008080.
HOVERGENi HBG039777.
InParanoidi Q91WD1.
KOi K03026.
OMAi WDKTVDM.
OrthoDBi EOG7J180B.

Enzyme and pathway databases

Reactomei REACT_205207. RNA Polymerase III Chain Elongation.
REACT_221403. RNA Polymerase III Transcription Termination.

Miscellaneous databases

NextBioi 323468.
PROi Q91WD1.
SOURCEi Search...

Gene expression databases

Bgeei Q91WD1.
CleanExi MM_POLR3D.
Genevestigatori Q91WD1.

Family and domain databases

InterProi IPR007811. RPC4.
[Graphical view ]
PANTHERi PTHR13408. PTHR13408. 1 hit.
Pfami PF05132. RNA_pol_Rpc4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo and Spleen.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiRPC4_MOUSE
AccessioniPrimary (citable) accession number: Q91WD1
Secondary accession number(s): Q3U0T3, Q9CZ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3