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Protein

DNA-directed RNA polymerase III subunit RPC4

Gene

Polr3d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: InterPro
  • DNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC4
Short name:
RNA polymerase III subunit C4
Alternative name(s):
DNA-directed RNA polymerase III subunit D
Gene namesi
Name:Polr3d
Synonyms:Bn51t
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914315. Polr3d.

Subcellular locationi

GO - Cellular componenti

  • DNA-directed RNA polymerase III complex Source: MGI
  • nuclear chromatin Source: Ensembl
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000739682 – 398DNA-directed RNA polymerase III subunit RPC4Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei42PhosphoserineBy similarity1
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei95Omega-N-methylarginineBy similarity1
Modified residuei97Omega-N-methylarginineBy similarity1
Modified residuei99Omega-N-methylarginineBy similarity1
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki302Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91WD1.
MaxQBiQ91WD1.
PaxDbiQ91WD1.
PeptideAtlasiQ91WD1.
PRIDEiQ91WD1.

PTM databases

PhosphoSitePlusiQ91WD1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000776.
CleanExiMM_POLR3D.
GenevisibleiQ91WD1. MM.

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with POLR3E/RPC5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000793.

Structurei

3D structure databases

ProteinModelPortaliQ91WD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3122. Eukaryota.
ENOG410XPDH. LUCA.
GeneTreeiENSGT00390000013948.
HOGENOMiHOG000008080.
HOVERGENiHBG039777.
InParanoidiQ91WD1.
KOiK03026.
OMAiWDKTVDM.
OrthoDBiEOG091G13BB.

Family and domain databases

InterProiIPR007811. RPC4.
[Graphical view]
PANTHERiPTHR13408. PTHR13408. 1 hit.
PfamiPF05132. RNA_pol_Rpc4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGNAAGEP SNPGGPRPLL SGGRGLIGRR PAPPLTPGRL PSIRSRDLTL
60 70 80 90 100
GGVKKKTFTP NIISRKIKEE PKEEVTMKKE KRERDRDRQR EGHGRGRGRP
110 120 130 140 150
EVIQSHSIFE QGPAEMMKKK GNWDKTVDMS DMGPSHIINI KKEKRETDEE
160 170 180 190 200
TKQILRMLEK DDFIDDPGLK NDTRNMPVQL PLAHSGWLFK EESEEPEAKP
210 220 230 240 250
FSAGPKEEDM EVDVPAVKVK EEPRDEEEEA KVKAPPRAAR KTPGLPKDVS
260 270 280 290 300
VAELLRELSL MKDEELLFLQ LPDTLPGQPP TQDIKPVKTE VQGEDGQMVV
310 320 330 340 350
IKQEKDREAR LAENACTLAD LTEGQVGKLL IRKSGKVQLL LGKVTLDVTM
360 370 380 390
GTTCSFLQEL VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR
Length:398
Mass (Da):44,357
Last modified:July 27, 2011 - v2
Checksum:iB70179A124C1231B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201F → L in AAH16102 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013165 mRNA. Translation: BAB28687.1.
AK156587 mRNA. Translation: BAE33768.1.
CH466535 Genomic DNA. Translation: EDL35903.1.
BC016102 mRNA. Translation: AAH16102.1.
CCDSiCCDS27253.1.
RefSeqiNP_001157554.1. NM_001164082.1.
NP_080221.3. NM_025945.3.
UniGeneiMm.20420.

Genome annotation databases

EnsembliENSMUST00000000793; ENSMUSP00000000793; ENSMUSG00000000776.
ENSMUST00000180358; ENSMUSP00000137614; ENSMUSG00000000776.
GeneIDi67065.
KEGGimmu:67065.
UCSCiuc007uny.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013165 mRNA. Translation: BAB28687.1.
AK156587 mRNA. Translation: BAE33768.1.
CH466535 Genomic DNA. Translation: EDL35903.1.
BC016102 mRNA. Translation: AAH16102.1.
CCDSiCCDS27253.1.
RefSeqiNP_001157554.1. NM_001164082.1.
NP_080221.3. NM_025945.3.
UniGeneiMm.20420.

3D structure databases

ProteinModelPortaliQ91WD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000793.

PTM databases

PhosphoSitePlusiQ91WD1.

Proteomic databases

EPDiQ91WD1.
MaxQBiQ91WD1.
PaxDbiQ91WD1.
PeptideAtlasiQ91WD1.
PRIDEiQ91WD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000793; ENSMUSP00000000793; ENSMUSG00000000776.
ENSMUST00000180358; ENSMUSP00000137614; ENSMUSG00000000776.
GeneIDi67065.
KEGGimmu:67065.
UCSCiuc007uny.2. mouse.

Organism-specific databases

CTDi661.
MGIiMGI:1914315. Polr3d.

Phylogenomic databases

eggNOGiKOG3122. Eukaryota.
ENOG410XPDH. LUCA.
GeneTreeiENSGT00390000013948.
HOGENOMiHOG000008080.
HOVERGENiHBG039777.
InParanoidiQ91WD1.
KOiK03026.
OMAiWDKTVDM.
OrthoDBiEOG091G13BB.

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

PROiQ91WD1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000776.
CleanExiMM_POLR3D.
GenevisibleiQ91WD1. MM.

Family and domain databases

InterProiIPR007811. RPC4.
[Graphical view]
PANTHERiPTHR13408. PTHR13408. 1 hit.
PfamiPF05132. RNA_pol_Rpc4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPC4_MOUSE
AccessioniPrimary (citable) accession number: Q91WD1
Secondary accession number(s): Q3U0T3, Q9CZ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.