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Q91WD1 (RPC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase III subunit RPC4
Short name=RNA polymerase III subunit C4
Alternative name(s):
DNA-directed RNA polymerase III subunit D
Gene names
Name:Polr3d
Synonyms:Bn51t
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity.

Subunit structure

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with POLR3E/RPC5 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398DNA-directed RNA polymerase III subunit RPC4
PRO_0000073968

Experimental info

Sequence conflict2011F → L in AAH16102. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q91WD1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: B70179A124C1231B

FASTA39844,357
        10         20         30         40         50         60 
MSEGNAAGEP SNPGGPRPLL SGGRGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP 

        70         80         90        100        110        120 
NIISRKIKEE PKEEVTMKKE KRERDRDRQR EGHGRGRGRP EVIQSHSIFE QGPAEMMKKK 

       130        140        150        160        170        180 
GNWDKTVDMS DMGPSHIINI KKEKRETDEE TKQILRMLEK DDFIDDPGLK NDTRNMPVQL 

       190        200        210        220        230        240 
PLAHSGWLFK EESEEPEAKP FSAGPKEEDM EVDVPAVKVK EEPRDEEEEA KVKAPPRAAR 

       250        260        270        280        290        300 
KTPGLPKDVS VAELLRELSL MKDEELLFLQ LPDTLPGQPP TQDIKPVKTE VQGEDGQMVV 

       310        320        330        340        350        360 
IKQEKDREAR LAENACTLAD LTEGQVGKLL IRKSGKVQLL LGKVTLDVTM GTTCSFLQEL 

       370        380        390 
VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Embryo and Spleen.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK013165 mRNA. Translation: BAB28687.1.
AK156587 mRNA. Translation: BAE33768.1.
CH466535 Genomic DNA. Translation: EDL35903.1.
BC016102 mRNA. Translation: AAH16102.1.
IPIIPI00313986.
RefSeqNP_001157554.1. NM_001164082.1.
NP_080221.3. NM_025945.3.
UniGeneMm.20420.

3D structure databases

ProteinModelPortalQ91WD1.
ModBaseSearch...

PTM databases

PhosphoSiteQ91WD1.

Proteomic databases

PRIDEQ91WD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000793; ENSMUSP00000000793; ENSMUSG00000000776.
ENSMUST00000180358; ENSMUSP00000137614; ENSMUSG00000000776.
GeneID67065.
KEGGmmu:67065.
UCSCuc007uny.2. mouse.

Organism-specific databases

CTD661.
MGIMGI:1914315. Polr3d.

Phylogenomic databases

eggNOGNOG239914.
GeneTreeENSGT00390000013948.
HOGENOMHOG000008080.
HOVERGENHBG039777.
InParanoidQ3U0T3.
KOK03026.
OMAGTTCSFL.
OrthoDBEOG4KSPKB.

Gene expression databases

BgeeQ91WD1.
CleanExMM_POLR3D.
GenevestigatorQ91WD1.
GermOnlineENSMUSG00000000776. Mus musculus.

Family and domain databases

InterProIPR007811. RNA_pol_III_Rpc4.
[Graphical view]
PANTHERPTHR13408. PTHR13408. 1 hit.
PfamPF05132. RNA_pol_Rpc4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio323468.
SOURCESearch...

Entry information

Entry nameRPC4_MOUSE
AccessionPrimary (citable) accession number: Q91WD1
Secondary accession number(s): Q3U0T3, Q9CZ02
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: July 27, 2011
Last modified: May 29, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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