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Q91WC3

- ACSL6_MOUSE

UniProt

Q91WC3 - ACSL6_MOUSE

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Protein

Long-chain-fatty-acid--CoA ligase 6

Gene

Acsl6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid (By similarity).By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: MGI

GO - Biological processi

  1. cellular response to insulin stimulus Source: Ensembl
  2. fatty acid transport Source: Ensembl
  3. neuroblast proliferation Source: MGI
  4. neuron development Source: Ensembl
  5. phospholipid biosynthetic process Source: Ensembl
  6. positive regulation of neuron projection development Source: Ensembl
  7. positive regulation of plasma membrane long-chain fatty acid transport Source: Ensembl
  8. positive regulation of triglyceride biosynthetic process Source: Ensembl
  9. response to gravity Source: Ensembl
  10. response to hypoxia Source: Ensembl
  11. response to nutrient Source: Ensembl
  12. response to steroid hormone Source: Ensembl
  13. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 6 (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase 6
Short name:
LACS 6
Gene namesi
Name:Acsl6
Synonyms:Facl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:894291. Acsl6.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial outer membrane Source: UniProtKB-KW
  4. mitochondrion Source: MGI
  5. nucleus Source: Ensembl
  6. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Long-chain-fatty-acid--CoA ligase 6PRO_0000193116Add
BLAST

Proteomic databases

MaxQBiQ91WC3.
PaxDbiQ91WC3.
PRIDEiQ91WC3.

PTM databases

PhosphoSiteiQ91WC3.

Expressioni

Gene expression databases

BgeeiQ91WC3.
CleanExiMM_ACSL6.
ExpressionAtlasiQ91WC3. baseline and differential.
GenevestigatoriQ91WC3.

Interactioni

Protein-protein interaction databases

BioGridi229776. 1 interaction.
IntActiQ91WC3. 3 interactions.
MINTiMINT-1861033.
STRINGi10090.ENSMUSP00000104533.

Structurei

3D structure databases

ProteinModelPortaliQ91WC3.
SMRiQ91WC3. Positions 114-634.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini46 – 697652CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000159459.
HOVERGENiHBG050452.
InParanoidiQ91WC3.
KOiK01897.
OrthoDBiEOG71CFKN.
PhylomeDBiQ91WC3.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91WC3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTQEILRIL RLPELSDLGQ FFRSLSATTL VSVGALAAVL AYWLTHRPKA
60 70 80 90 100
LQPPCNLLKQ SEEVEDGGGA RRSVIGGCTQ LLTHYYDDAR TMYQVFRRGL
110 120 130 140 150
SISGNGPCLG FRKPEQPYQW LSYQEVAKRA EFLGSGLLQH DCKVGTEQFV
160 170 180 190 200
GVFAQNRPEW IIAELACYTY SMVVVPLYDT LGPGSISYII NTADICTVIV
210 220 230 240 250
DKPHKATLLL EHVERKETPG LKLVILMEPF EDALRERGKK CGVDIKSMQA
260 270 280 290 300
IEDCGRENHH APVPPRPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
310 320 330 340 350
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL
360 370 380 390 400
LSDDMKALRP TIFPVVPRLL NRMYDKIFHQ ADTSLKRWLL EFAAKRKQAE
410 420 430 440 450
VRSGIIRNNS IWDELFFNKI QASLGGHVRM IVTGAAPASP TVLGFLRAAL
460 470 480 490 500
GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV GAPLPCNHIK LVDAEELNYW
510 520 530 540 550
TCKGEGEICV KGPNVFKGYL KDEDRTKEAL DSDGWLHTGD IGKWLPEGTL
560 570 580 590 600
KIIDRKKHIF KLAQGEYVAP EKIENIYIRS EPVAQIYVHG DSLKAFLVGI
610 620 630 640 650
VVPDPEVMPS WAQKKGIEGT YQELCMKKEL KKAILDDMVM LGKESGLHSF
660 670 680 690
EQVKAIYIHC DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYLVSV
Length:697
Mass (Da):78,017
Last modified:December 1, 2001 - v1
Checksum:iADAFC99E5D97DC22
GO
Isoform 2 (identifier: Q91WC3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTFFLVSGGSLWLFAEIALSLLEKM

Show »
Length:722
Mass (Da):80,786
Checksum:i989C3ADB76346764
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti364 – 3641P → S in AAO38689. (PubMed:12767919)Curated
Sequence conflicti680 – 6801E → G in AAO38689. (PubMed:12767919)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MLTFFLVSGGSLWLFAEIAL SLLEKM in isoform 2. 1 PublicationVSP_037824

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167035 mRNA. Translation: AAO38689.1.
BC016114 mRNA. Translation: AAH16114.1.
CCDSiCCDS24695.1. [Q91WC3-2]
CCDS24696.1. [Q91WC3-1]
RefSeqiNP_001028770.1. NM_001033598.1. [Q91WC3-1]
XP_006532906.1. XM_006532843.1. [Q91WC3-1]
XP_006532907.1. XM_006532844.1. [Q91WC3-1]
UniGeneiMm.267478.

Genome annotation databases

EnsembliENSMUST00000072178; ENSMUSP00000072040; ENSMUSG00000020333. [Q91WC3-1]
ENSMUST00000093106; ENSMUSP00000090795; ENSMUSG00000020333. [Q91WC3-1]
ENSMUST00000094194; ENSMUSP00000091746; ENSMUSG00000020333. [Q91WC3-1]
ENSMUST00000108905; ENSMUSP00000104533; ENSMUSG00000020333. [Q91WC3-2]
GeneIDi216739.
KEGGimmu:216739.
UCSCiuc007ixo.1. mouse. [Q91WC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167035 mRNA. Translation: AAO38689.1 .
BC016114 mRNA. Translation: AAH16114.1 .
CCDSi CCDS24695.1. [Q91WC3-2 ]
CCDS24696.1. [Q91WC3-1 ]
RefSeqi NP_001028770.1. NM_001033598.1. [Q91WC3-1 ]
XP_006532906.1. XM_006532843.1. [Q91WC3-1 ]
XP_006532907.1. XM_006532844.1. [Q91WC3-1 ]
UniGenei Mm.267478.

3D structure databases

ProteinModelPortali Q91WC3.
SMRi Q91WC3. Positions 114-634.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229776. 1 interaction.
IntActi Q91WC3. 3 interactions.
MINTi MINT-1861033.
STRINGi 10090.ENSMUSP00000104533.

PTM databases

PhosphoSitei Q91WC3.

Proteomic databases

MaxQBi Q91WC3.
PaxDbi Q91WC3.
PRIDEi Q91WC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072178 ; ENSMUSP00000072040 ; ENSMUSG00000020333 . [Q91WC3-1 ]
ENSMUST00000093106 ; ENSMUSP00000090795 ; ENSMUSG00000020333 . [Q91WC3-1 ]
ENSMUST00000094194 ; ENSMUSP00000091746 ; ENSMUSG00000020333 . [Q91WC3-1 ]
ENSMUST00000108905 ; ENSMUSP00000104533 ; ENSMUSG00000020333 . [Q91WC3-2 ]
GeneIDi 216739.
KEGGi mmu:216739.
UCSCi uc007ixo.1. mouse. [Q91WC3-1 ]

Organism-specific databases

CTDi 23305.
MGIi MGI:894291. Acsl6.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000101725.
HOGENOMi HOG000159459.
HOVERGENi HBG050452.
InParanoidi Q91WC3.
KOi K01897.
OrthoDBi EOG71CFKN.
PhylomeDBi Q91WC3.

Enzyme and pathway databases

BRENDAi 6.2.1.3. 3474.

Miscellaneous databases

NextBioi 375272.
PROi Q91WC3.
SOURCEi Search...

Gene expression databases

Bgeei Q91WC3.
CleanExi MM_ACSL6.
ExpressionAtlasi Q91WC3. baseline and differential.
Genevestigatori Q91WC3.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel murine long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation."
    Kee H.J., Koh J.T., Yang S.Y., Lee Z.H., Baik Y.H., Kim K.K.
    Biochem. Biophys. Res. Commun. 305:925-933(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.

Entry informationi

Entry nameiACSL6_MOUSE
AccessioniPrimary (citable) accession number: Q91WC3
Secondary accession number(s): Q80ZF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3