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Q91WC3

- ACSL6_MOUSE

UniProt

Q91WC3 - ACSL6_MOUSE

Protein

Long-chain-fatty-acid--CoA ligase 6

Gene

Acsl6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid By similarity.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. cellular response to insulin stimulus Source: Ensembl
    2. fatty acid transport Source: Ensembl
    3. neuroblast proliferation Source: MGI
    4. neuron development Source: Ensembl
    5. phospholipid biosynthetic process Source: Ensembl
    6. positive regulation of neuron projection development Source: Ensembl
    7. positive regulation of plasma membrane long-chain fatty acid transport Source: Ensembl
    8. positive regulation of triglyceride biosynthetic process Source: Ensembl
    9. response to gravity Source: Ensembl
    10. response to hypoxia Source: Ensembl
    11. response to nutrient Source: Ensembl
    12. response to steroid hormone Source: Ensembl
    13. triglyceride metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.2.1.3. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 6 (EC:6.2.1.3)
    Alternative name(s):
    Long-chain acyl-CoA synthetase 6
    Short name:
    LACS 6
    Gene namesi
    Name:Acsl6
    Synonyms:Facl6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:894291. Acsl6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial outer membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: MGI
    5. nucleus Source: Ensembl
    6. peroxisomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Long-chain-fatty-acid--CoA ligase 6PRO_0000193116Add
    BLAST

    Proteomic databases

    MaxQBiQ91WC3.
    PaxDbiQ91WC3.
    PRIDEiQ91WC3.

    PTM databases

    PhosphoSiteiQ91WC3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91WC3.
    BgeeiQ91WC3.
    CleanExiMM_ACSL6.
    GenevestigatoriQ91WC3.

    Interactioni

    Protein-protein interaction databases

    BioGridi229776. 1 interaction.
    IntActiQ91WC3. 3 interactions.
    MINTiMINT-1861033.
    STRINGi10090.ENSMUSP00000104533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WC3.
    SMRiQ91WC3. Positions 114-634.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini46 – 697652CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000101725.
    HOGENOMiHOG000159459.
    HOVERGENiHBG050452.
    KOiK01897.
    OrthoDBiEOG71CFKN.
    PhylomeDBiQ91WC3.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91WC3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQTQEILRIL RLPELSDLGQ FFRSLSATTL VSVGALAAVL AYWLTHRPKA    50
    LQPPCNLLKQ SEEVEDGGGA RRSVIGGCTQ LLTHYYDDAR TMYQVFRRGL 100
    SISGNGPCLG FRKPEQPYQW LSYQEVAKRA EFLGSGLLQH DCKVGTEQFV 150
    GVFAQNRPEW IIAELACYTY SMVVVPLYDT LGPGSISYII NTADICTVIV 200
    DKPHKATLLL EHVERKETPG LKLVILMEPF EDALRERGKK CGVDIKSMQA 250
    IEDCGRENHH APVPPRPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 300
    LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL 350
    LSDDMKALRP TIFPVVPRLL NRMYDKIFHQ ADTSLKRWLL EFAAKRKQAE 400
    VRSGIIRNNS IWDELFFNKI QASLGGHVRM IVTGAAPASP TVLGFLRAAL 450
    GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV GAPLPCNHIK LVDAEELNYW 500
    TCKGEGEICV KGPNVFKGYL KDEDRTKEAL DSDGWLHTGD IGKWLPEGTL 550
    KIIDRKKHIF KLAQGEYVAP EKIENIYIRS EPVAQIYVHG DSLKAFLVGI 600
    VVPDPEVMPS WAQKKGIEGT YQELCMKKEL KKAILDDMVM LGKESGLHSF 650
    EQVKAIYIHC DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYLVSV 697
    Length:697
    Mass (Da):78,017
    Last modified:December 1, 2001 - v1
    Checksum:iADAFC99E5D97DC22
    GO
    Isoform 2 (identifier: Q91WC3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLTFFLVSGGSLWLFAEIALSLLEKM

    Show »
    Length:722
    Mass (Da):80,786
    Checksum:i989C3ADB76346764
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti364 – 3641P → S in AAO38689. (PubMed:12767919)Curated
    Sequence conflicti680 – 6801E → G in AAO38689. (PubMed:12767919)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MLTFFLVSGGSLWLFAEIAL SLLEKM in isoform 2. 1 PublicationVSP_037824

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167035 mRNA. Translation: AAO38689.1.
    BC016114 mRNA. Translation: AAH16114.1.
    CCDSiCCDS24695.1. [Q91WC3-2]
    CCDS24696.1. [Q91WC3-1]
    RefSeqiNP_001028770.1. NM_001033598.1. [Q91WC3-1]
    XP_006532906.1. XM_006532843.1. [Q91WC3-1]
    XP_006532907.1. XM_006532844.1. [Q91WC3-1]
    UniGeneiMm.267478.

    Genome annotation databases

    EnsembliENSMUST00000072178; ENSMUSP00000072040; ENSMUSG00000020333. [Q91WC3-1]
    ENSMUST00000093106; ENSMUSP00000090795; ENSMUSG00000020333. [Q91WC3-1]
    ENSMUST00000094194; ENSMUSP00000091746; ENSMUSG00000020333. [Q91WC3-1]
    ENSMUST00000108905; ENSMUSP00000104533; ENSMUSG00000020333. [Q91WC3-2]
    GeneIDi216739.
    KEGGimmu:216739.
    UCSCiuc007ixo.1. mouse. [Q91WC3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167035 mRNA. Translation: AAO38689.1 .
    BC016114 mRNA. Translation: AAH16114.1 .
    CCDSi CCDS24695.1. [Q91WC3-2 ]
    CCDS24696.1. [Q91WC3-1 ]
    RefSeqi NP_001028770.1. NM_001033598.1. [Q91WC3-1 ]
    XP_006532906.1. XM_006532843.1. [Q91WC3-1 ]
    XP_006532907.1. XM_006532844.1. [Q91WC3-1 ]
    UniGenei Mm.267478.

    3D structure databases

    ProteinModelPortali Q91WC3.
    SMRi Q91WC3. Positions 114-634.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229776. 1 interaction.
    IntActi Q91WC3. 3 interactions.
    MINTi MINT-1861033.
    STRINGi 10090.ENSMUSP00000104533.

    PTM databases

    PhosphoSitei Q91WC3.

    Proteomic databases

    MaxQBi Q91WC3.
    PaxDbi Q91WC3.
    PRIDEi Q91WC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072178 ; ENSMUSP00000072040 ; ENSMUSG00000020333 . [Q91WC3-1 ]
    ENSMUST00000093106 ; ENSMUSP00000090795 ; ENSMUSG00000020333 . [Q91WC3-1 ]
    ENSMUST00000094194 ; ENSMUSP00000091746 ; ENSMUSG00000020333 . [Q91WC3-1 ]
    ENSMUST00000108905 ; ENSMUSP00000104533 ; ENSMUSG00000020333 . [Q91WC3-2 ]
    GeneIDi 216739.
    KEGGi mmu:216739.
    UCSCi uc007ixo.1. mouse. [Q91WC3-1 ]

    Organism-specific databases

    CTDi 23305.
    MGIi MGI:894291. Acsl6.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000101725.
    HOGENOMi HOG000159459.
    HOVERGENi HBG050452.
    KOi K01897.
    OrthoDBi EOG71CFKN.
    PhylomeDBi Q91WC3.

    Enzyme and pathway databases

    BRENDAi 6.2.1.3. 3474.

    Miscellaneous databases

    NextBioi 375272.
    PROi Q91WC3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91WC3.
    Bgeei Q91WC3.
    CleanExi MM_ACSL6.
    Genevestigatori Q91WC3.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel murine long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation."
      Kee H.J., Koh J.T., Yang S.Y., Lee Z.H., Baik Y.H., Kim K.K.
      Biochem. Biophys. Res. Commun. 305:925-933(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: ICR.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.

    Entry informationi

    Entry nameiACSL6_MOUSE
    AccessioniPrimary (citable) accession number: Q91WC3
    Secondary accession number(s): Q80ZF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3