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Q91WC3

- ACSL6_MOUSE

UniProt

Q91WC3 - ACSL6_MOUSE

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Protein
Long-chain-fatty-acid--CoA ligase 6
Gene
Acsl6, Facl6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: MGI
  3. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cellular response to insulin stimulus Source: Ensembl
  2. fatty acid transport Source: Ensembl
  3. neuroblast proliferation Source: MGI
  4. neuron development Source: Ensembl
  5. phospholipid biosynthetic process Source: Ensembl
  6. positive regulation of neuron projection development Source: Ensembl
  7. positive regulation of plasma membrane long-chain fatty acid transport Source: Ensembl
  8. positive regulation of triglyceride biosynthetic process Source: Ensembl
  9. response to gravity Source: Ensembl
  10. response to hypoxia Source: Ensembl
  11. response to nutrient Source: Ensembl
  12. response to steroid hormone Source: Ensembl
  13. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 6 (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase 6
Short name:
LACS 6
Gene namesi
Name:Acsl6
Synonyms:Facl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:894291. Acsl6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Signal-anchor for type III membrane protein; Reviewed prediction
Add
BLAST
Topological domaini46 – 697652Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial outer membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: MGI
  5. nucleus Source: Ensembl
  6. peroxisomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Long-chain-fatty-acid--CoA ligase 6
PRO_0000193116Add
BLAST

Proteomic databases

MaxQBiQ91WC3.
PaxDbiQ91WC3.
PRIDEiQ91WC3.

PTM databases

PhosphoSiteiQ91WC3.

Expressioni

Gene expression databases

ArrayExpressiQ91WC3.
BgeeiQ91WC3.
CleanExiMM_ACSL6.
GenevestigatoriQ91WC3.

Interactioni

Protein-protein interaction databases

BioGridi229776. 1 interaction.
IntActiQ91WC3. 3 interactions.
MINTiMINT-1861033.
STRINGi10090.ENSMUSP00000104533.

Structurei

3D structure databases

ProteinModelPortaliQ91WC3.
SMRiQ91WC3. Positions 114-634.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000159459.
HOVERGENiHBG050452.
KOiK01897.
OrthoDBiEOG71CFKN.
PhylomeDBiQ91WC3.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91WC3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQTQEILRIL RLPELSDLGQ FFRSLSATTL VSVGALAAVL AYWLTHRPKA    50
LQPPCNLLKQ SEEVEDGGGA RRSVIGGCTQ LLTHYYDDAR TMYQVFRRGL 100
SISGNGPCLG FRKPEQPYQW LSYQEVAKRA EFLGSGLLQH DCKVGTEQFV 150
GVFAQNRPEW IIAELACYTY SMVVVPLYDT LGPGSISYII NTADICTVIV 200
DKPHKATLLL EHVERKETPG LKLVILMEPF EDALRERGKK CGVDIKSMQA 250
IEDCGRENHH APVPPRPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 300
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL 350
LSDDMKALRP TIFPVVPRLL NRMYDKIFHQ ADTSLKRWLL EFAAKRKQAE 400
VRSGIIRNNS IWDELFFNKI QASLGGHVRM IVTGAAPASP TVLGFLRAAL 450
GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV GAPLPCNHIK LVDAEELNYW 500
TCKGEGEICV KGPNVFKGYL KDEDRTKEAL DSDGWLHTGD IGKWLPEGTL 550
KIIDRKKHIF KLAQGEYVAP EKIENIYIRS EPVAQIYVHG DSLKAFLVGI 600
VVPDPEVMPS WAQKKGIEGT YQELCMKKEL KKAILDDMVM LGKESGLHSF 650
EQVKAIYIHC DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYLVSV 697
Length:697
Mass (Da):78,017
Last modified:December 1, 2001 - v1
Checksum:iADAFC99E5D97DC22
GO
Isoform 2 (identifier: Q91WC3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTFFLVSGGSLWLFAEIALSLLEKM

Show »
Length:722
Mass (Da):80,786
Checksum:i989C3ADB76346764
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MLTFFLVSGGSLWLFAEIAL SLLEKM in isoform 2.
VSP_037824

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti364 – 3641P → S in AAO38689. 1 Publication
Sequence conflicti680 – 6801E → G in AAO38689. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167035 mRNA. Translation: AAO38689.1.
BC016114 mRNA. Translation: AAH16114.1.
CCDSiCCDS24695.1. [Q91WC3-2]
CCDS24696.1. [Q91WC3-1]
RefSeqiNP_001028770.1. NM_001033598.1. [Q91WC3-1]
XP_006532906.1. XM_006532843.1. [Q91WC3-1]
XP_006532907.1. XM_006532844.1. [Q91WC3-1]
UniGeneiMm.267478.

Genome annotation databases

EnsembliENSMUST00000072178; ENSMUSP00000072040; ENSMUSG00000020333. [Q91WC3-1]
ENSMUST00000093106; ENSMUSP00000090795; ENSMUSG00000020333. [Q91WC3-1]
ENSMUST00000094194; ENSMUSP00000091746; ENSMUSG00000020333. [Q91WC3-1]
ENSMUST00000108905; ENSMUSP00000104533; ENSMUSG00000020333. [Q91WC3-2]
GeneIDi216739.
KEGGimmu:216739.
UCSCiuc007ixo.1. mouse. [Q91WC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167035 mRNA. Translation: AAO38689.1 .
BC016114 mRNA. Translation: AAH16114.1 .
CCDSi CCDS24695.1. [Q91WC3-2 ]
CCDS24696.1. [Q91WC3-1 ]
RefSeqi NP_001028770.1. NM_001033598.1. [Q91WC3-1 ]
XP_006532906.1. XM_006532843.1. [Q91WC3-1 ]
XP_006532907.1. XM_006532844.1. [Q91WC3-1 ]
UniGenei Mm.267478.

3D structure databases

ProteinModelPortali Q91WC3.
SMRi Q91WC3. Positions 114-634.
ModBasei Search...

Protein-protein interaction databases

BioGridi 229776. 1 interaction.
IntActi Q91WC3. 3 interactions.
MINTi MINT-1861033.
STRINGi 10090.ENSMUSP00000104533.

PTM databases

PhosphoSitei Q91WC3.

Proteomic databases

MaxQBi Q91WC3.
PaxDbi Q91WC3.
PRIDEi Q91WC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072178 ; ENSMUSP00000072040 ; ENSMUSG00000020333 . [Q91WC3-1 ]
ENSMUST00000093106 ; ENSMUSP00000090795 ; ENSMUSG00000020333 . [Q91WC3-1 ]
ENSMUST00000094194 ; ENSMUSP00000091746 ; ENSMUSG00000020333 . [Q91WC3-1 ]
ENSMUST00000108905 ; ENSMUSP00000104533 ; ENSMUSG00000020333 . [Q91WC3-2 ]
GeneIDi 216739.
KEGGi mmu:216739.
UCSCi uc007ixo.1. mouse. [Q91WC3-1 ]

Organism-specific databases

CTDi 23305.
MGIi MGI:894291. Acsl6.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000101725.
HOGENOMi HOG000159459.
HOVERGENi HBG050452.
KOi K01897.
OrthoDBi EOG71CFKN.
PhylomeDBi Q91WC3.

Enzyme and pathway databases

BRENDAi 6.2.1.3. 3474.

Miscellaneous databases

NextBioi 375272.
PROi Q91WC3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91WC3.
Bgeei Q91WC3.
CleanExi MM_ACSL6.
Genevestigatori Q91WC3.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel murine long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation."
    Kee H.J., Koh J.T., Yang S.Y., Lee Z.H., Baik Y.H., Kim K.K.
    Biochem. Biophys. Res. Commun. 305:925-933(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.

Entry informationi

Entry nameiACSL6_MOUSE
AccessioniPrimary (citable) accession number: Q91WC3
Secondary accession number(s): Q80ZF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi