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Protein

Protection of telomeres protein 1

Gene

Pot1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
Protection of telomeres protein 1
Short name:
mPot1
Alternative name(s):
POT1-like telomere end-binding protein
Gene namesi
Name:Pot1
Synonyms:Pot1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2141503 Pot1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217301 – 640Protection of telomeres protein 1Add BLAST640

Proteomic databases

EPDiQ91WC1
PaxDbiQ91WC1
PeptideAtlasiQ91WC1
PRIDEiQ91WC1

PTM databases

PhosphoSitePlusiQ91WC1

Expressioni

Gene expression databases

BgeeiENSMUSG00000029676
CleanExiMM_POT1A
ExpressionAtlasiQ91WC1 baseline and differential
GenevisibleiQ91WC1 MM

Interactioni

Subunit structurei

Homodimer or homooligomer. Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1. Binds single-stranded telomeric DNA as a monomer. Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1. Forms heterodimers with ACD (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221602, 1 interactor
DIPiDIP-29608N
IntActiQ91WC1, 4 interactors
MINTiQ91WC1
STRINGi10090.ENSMUSP00000110986

Structurei

3D structure databases

ProteinModelPortaliQ91WC1
SMRiQ91WC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the telombin family.Curated

Phylogenomic databases

eggNOGiKOG4757 Eukaryota
ENOG410Z1J0 LUCA
GeneTreeiENSGT00390000018285
HOGENOMiHOG000015271
HOVERGENiHBG053641
InParanoidiQ91WC1
KOiK11109
OMAiDKTSWIP
OrthoDBiEOG091G01T8
PhylomeDBiQ91WC1
TreeFamiTF328398

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR028389 POT1
IPR032042 POT1PC
IPR011564 Telomer_end-bd_POT1/Cdc13
PANTHERiPTHR14513 PTHR14513, 1 hit
PfamiView protein in Pfam
PF02765 POT1, 1 hit
PF16686 POT1PC, 1 hit
SMARTiView protein in SMART
SM00976 Telo_bind, 1 hit
SUPFAMiSSF50249 SSF50249, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91WC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVSTAPYT YTPLNLLKEG TIANVYGVVK FFKPPYVSKG TDYCSVVTIV
60 70 80 90 100
DQTNVKLTCM LFSGNYEALP IIYKVGDIVR FHRLKIQVYK NELQGINCSG
110 120 130 140 150
FASLTFEGTV GMPVTARTSS KVFSFTPQDQ KMVEALRVWA SKHISASSTL
160 170 180 190 200
VQLCDAQPMQ YYDLTCQLLG KAQVDSTAFL LKVWDGTQTV LPSWRVSTQD
210 220 230 240 250
LTFEGDLSHI ERLQSLVVDI LVYDNHVQVA RSIEVGCFLR LYSLHTKLQP
260 270 280 290 300
GNSETSSSES LRLEFHLHGG TSYGRGIRVL PDTSPCVDQL KKALEGANLP
310 320 330 340 350
VTETSTGICQ SENGDSSALS NSGSGAVSPY EEERCQQVSA TILTNHQHLE
360 370 380 390 400
KTPLCAILTQ KAPQQYRVRA KLRSYLPRRL SQSVKLLCPK CHSVQEVPHG
410 420 430 440 450
DSLDKILQDA ATEAPDIKLK ATSLYYSKVW TTEDQGGRQV AVHFVKNNGI
460 470 480 490 500
LPASSECLIL IEGGRLCEVS KLSSKFHSVM PVRSGPESLE LLTLSAPFLI
510 520 530 540 550
QGKVHHYGCK QCSSLKPIQN LNSRFHKGPW TPSSVAEALG VVPLQYVFVM
560 570 580 590 600
VFTLDDGTGV LEAYLKDSEH FFKIPASEVL TDDDLQRSLE TIMDMICPPG
610 620 630 640
IKVDAYPWLE CLLKSYNVTI GTERRICYQI FDTTVAENVV
Length:640
Mass (Da):70,863
Last modified:December 1, 2001 - v1
Checksum:i64393BA48F14965E
GO
Isoform 2 (identifier: Q91WC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-538: A → G
     539-640: Missing.

Note: No experimental confirmation available.
Show »
Length:538
Mass (Da):59,299
Checksum:i408F0D9F7CF4AD83
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010848538A → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_010849539 – 640Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036052 mRNA Translation: BAC29288.1
AK040864 mRNA Translation: BAC30723.1
AK085041 mRNA Translation: BAC39349.1
BC016121 mRNA Translation: AAH16121.1
CCDSiCCDS39442.1 [Q91WC1-1]
RefSeqiNP_598692.1, NM_133931.4 [Q91WC1-1]
UniGeneiMm.274589
Mm.397208

Genome annotation databases

EnsembliENSMUST00000115330; ENSMUSP00000110986; ENSMUSG00000029676 [Q91WC1-1]
ENSMUST00000166445; ENSMUSP00000131928; ENSMUSG00000029676 [Q91WC1-1]
GeneIDi101185
KEGGimmu:101185
UCSCiuc009bce.1 mouse [Q91WC1-1]
uc009bcf.1 mouse [Q91WC1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPOTE1_MOUSE
AccessioniPrimary (citable) accession number: Q91WC1
Secondary accession number(s): Q8BUH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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