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Protein

Ubiquitin domain-containing protein 1

Gene

Ubtd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 1
Gene namesi
Name:Ubtd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2385092 Ubtd1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426751 – 227Ubiquitin domain-containing protein 1Add BLAST227

Proteomic databases

MaxQBiQ91WB7
PaxDbiQ91WB7
PeptideAtlasiQ91WB7
PRIDEiQ91WB7

PTM databases

iPTMnetiQ91WB7
PhosphoSitePlusiQ91WB7
SwissPalmiQ91WB7

Expressioni

Gene expression databases

BgeeiENSMUSG00000025171
CleanExiMM_UBTD1
GenevisibleiQ91WB7 MM

Interactioni

Subunit structurei

Interacts with UBTD1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ91WB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 224Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0013 Eukaryota
ENOG410XRPV LUCA
GeneTreeiENSGT00390000006816
HOGENOMiHOG000231205
HOVERGENiHBG080179
InParanoidiQ91WB7
OMAiLGDKMHI
OrthoDBiEOG091G0FKF
PhylomeDBiQ91WB7
TreeFamiTF323925

Family and domain databases

Gene3Di1.20.225.20, 1 hit
InterProiView protein in InterPro
IPR032752 DC-UbP/UBTD2_N
IPR038169 DC-UbP/UBTD2_N_sf
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF16455 UBD, 1 hit
PF00240 ubiquitin, 1 hit
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK
60 70 80 90 100
RDEFWDTAPA FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG
110 120 130 140 150
TLCECYDELG NRYQLPIYCL SPPVNLLLEH TEEESLEPPE PTPSVRREFP
160 170 180 190 200
LKVRLSTGKD VRLNASLPDT VGQLKRQLHS QEGIEPSWQR WFFSGKLLTD
210 220
RTRLQETKIQ KDFVIQVIIN QPPPPQD
Length:227
Mass (Da):25,985
Last modified:December 1, 2001 - v1
Checksum:i2C80D125D77E18F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078479 mRNA Translation: BAC37298.1
BC016129 mRNA Translation: AAH16129.1
CCDSiCCDS29819.1
RefSeqiNP_663475.1, NM_145500.3
UniGeneiMm.22948

Genome annotation databases

EnsembliENSMUST00000026170; ENSMUSP00000026170; ENSMUSG00000025171
GeneIDi226122
KEGGimmu:226122
UCSCiuc008hmz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiUBTD1_MOUSE
AccessioniPrimary (citable) accession number: Q91WB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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