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Protein

Ubiquitin domain-containing protein 1

Gene

Ubtd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 1
Gene namesi
Name:Ubtd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2385092. Ubtd1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426751 – 227Ubiquitin domain-containing protein 1Add BLAST227

Proteomic databases

MaxQBiQ91WB7.
PaxDbiQ91WB7.
PeptideAtlasiQ91WB7.
PRIDEiQ91WB7.

PTM databases

iPTMnetiQ91WB7.
PhosphoSitePlusiQ91WB7.
SwissPalmiQ91WB7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025171.
CleanExiMM_UBTD1.
GenevisibleiQ91WB7. MM.

Interactioni

Subunit structurei

Interacts with UBTD1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ91WB7.
SMRiQ91WB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 224Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0013. Eukaryota.
ENOG410XRPV. LUCA.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ91WB7.
OMAiLGDKMHI.
OrthoDBiEOG091G0FKF.
PhylomeDBiQ91WB7.
TreeFamiTF323925.

Family and domain databases

InterProiView protein in InterPro
IPR032752. UBD.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF16455. UBD. 1 hit.
PF00240. ubiquitin. 1 hit.
PRINTSiPR00348. UBIQUITIN.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK
60 70 80 90 100
RDEFWDTAPA FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG
110 120 130 140 150
TLCECYDELG NRYQLPIYCL SPPVNLLLEH TEEESLEPPE PTPSVRREFP
160 170 180 190 200
LKVRLSTGKD VRLNASLPDT VGQLKRQLHS QEGIEPSWQR WFFSGKLLTD
210 220
RTRLQETKIQ KDFVIQVIIN QPPPPQD
Length:227
Mass (Da):25,985
Last modified:December 1, 2001 - v1
Checksum:i2C80D125D77E18F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078479 mRNA. Translation: BAC37298.1.
BC016129 mRNA. Translation: AAH16129.1.
CCDSiCCDS29819.1.
RefSeqiNP_663475.1. NM_145500.3.
UniGeneiMm.22948.

Genome annotation databases

EnsembliENSMUST00000026170; ENSMUSP00000026170; ENSMUSG00000025171.
GeneIDi226122.
KEGGimmu:226122.
UCSCiuc008hmz.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBTD1_MOUSE
AccessioniPrimary (citable) accession number: Q91WB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot