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Protein

Inactive phospholipid phosphatase 7

Gene

Plpp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis.1 Publication

GO - Biological processi

  • negative regulation of myotube differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipid phosphatase 7By similarity
Alternative name(s):
Nuclear envelope transmembrane protein 39
Phosphatidic acid phosphatase type 2 domain-containing protein 3
Gene namesi
Name:Plpp7By similarity
Synonyms:Net39, Ppapdc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445183. Plpp7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 112112CytoplasmicSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 1418ExtracellularSequence analysis
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Topological domaini163 – 20240CytoplasmicSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 23916ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Topological domaini261 – 27111CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • nuclear envelope Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Inactive phospholipid phosphatase 7PRO_0000239402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineCombined sources
Modified residuei62 – 621PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91WB2.
PaxDbiQ91WB2.
PRIDEiQ91WB2.

PTM databases

iPTMnetiQ91WB2.
PhosphoSiteiQ91WB2.

Expressioni

Tissue specificityi

Highly expressed in heart and muscle.2 Publications

Inductioni

Up-regulated during myoblast differentiation.2 Publications

Gene expression databases

BgeeiQ91WB2.
ExpressionAtlasiQ91WB2. baseline and differential.
GenevisibleiQ91WB2. MM.

Interactioni

Subunit structurei

Homo- and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054337.

Structurei

3D structure databases

ProteinModelPortaliQ91WB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 9122Interaction with MTORAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4268. Eukaryota.
ENOG410ZVFK. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ91WB2.
OMAiLWAFCVG.
OrthoDBiEOG7BW0MW.
PhylomeDBiQ91WB2.
TreeFamiTF323272.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASQSRARA RDRNNVLNRA EFLSLNQPPK GTQEPRSSGR KASGPSTQPP
60 70 80 90 100
PSSDGARERR QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA
110 120 130 140 150
GRAASWASAR SMVKLIGITG HGIPWIGGTI LCLVRSSTLA GQEVLMNLLL
160 170 180 190 200
ALLLDIMTVA GVQKLIKRRG PYETSPGLLD YLTMDIYAFP AGHASRAAMV
210 220 230 240 250
SKFFLSHLVL AVPLRVLLVL WAFCVGLSRV MIGRHHITDV ISGFIIGYFQ
260 270
FRLVELVWMS SNTCQMLISA W
Length:271
Mass (Da):29,710
Last modified:December 1, 2001 - v1
Checksum:i91595666F0BF0508
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052883 mRNA. Translation: BAC35188.1.
AK134638 mRNA. Translation: BAE22220.1.
BC016136 mRNA. Translation: AAH16136.1.
CCDSiCCDS15906.1.
RefSeqiNP_663496.1. NM_145521.3.
UniGeneiMm.257236.

Genome annotation databases

EnsembliENSMUST00000057423; ENSMUSP00000054337; ENSMUSG00000051373.
GeneIDi227721.
KEGGimmu:227721.
UCSCiuc008jel.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052883 mRNA. Translation: BAC35188.1.
AK134638 mRNA. Translation: BAE22220.1.
BC016136 mRNA. Translation: AAH16136.1.
CCDSiCCDS15906.1.
RefSeqiNP_663496.1. NM_145521.3.
UniGeneiMm.257236.

3D structure databases

ProteinModelPortaliQ91WB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054337.

PTM databases

iPTMnetiQ91WB2.
PhosphoSiteiQ91WB2.

Proteomic databases

MaxQBiQ91WB2.
PaxDbiQ91WB2.
PRIDEiQ91WB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057423; ENSMUSP00000054337; ENSMUSG00000051373.
GeneIDi227721.
KEGGimmu:227721.
UCSCiuc008jel.1. mouse.

Organism-specific databases

CTDi84814.
MGIiMGI:2445183. Plpp7.

Phylogenomic databases

eggNOGiKOG4268. Eukaryota.
ENOG410ZVFK. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ91WB2.
OMAiLWAFCVG.
OrthoDBiEOG7BW0MW.
PhylomeDBiQ91WB2.
TreeFamiTF323272.

Miscellaneous databases

PROiQ91WB2.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WB2.
ExpressionAtlasiQ91WB2. baseline and differential.
GenevisibleiQ91WB2. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart and Medulla oblongata.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  3. "Nuclear envelope transmembrane proteins (NETs) that are up-regulated during myogenesis."
    Chen I.-H., Huber M., Guan T., Bubeck A., Gerace L.
    BMC Cell Biol. 7:38-38(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  4. "Regulation of myoblast differentiation by the nuclear envelope protein NET39."
    Liu G.H., Guan T., Datta K., Coppinger J., Yates J. III, Gerace L.
    Mol. Cell. Biol. 29:5800-5812(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, LACK OF ENZYMATIC ACTIVITY, SUBUNIT, INTERACTION WITH MTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY, INDUCTION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas and Testis.

Entry informationi

Entry nameiPLPP7_MOUSE
AccessioniPrimary (citable) accession number: Q91WB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.