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Protein
Submitted name:

ATP-binding cassette transporter ABCG4

Gene

Abcg4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotationImported, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette transporter ABCG4Imported
Submitted name:
ATP-binding cassette transporter White2Imported
Submitted name:
ATP-binding cassette transporter sub-family G member 4Imported
Submitted name:
ATP-binding cassette, sub-family G (WHITE), member 4Imported
Submitted name:
Protein Abcg4Imported
Submitted name:
Putative white family ABC-transporterImported
Gene namesi
Name:Abcg4Imported
Synonyms:ABCG4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1890594. Abcg4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei396 – 413HelicalSequence analysisAdd BLAST18
Transmembranei425 – 446HelicalSequence analysisAdd BLAST22
Transmembranei466 – 491HelicalSequence analysisAdd BLAST26
Transmembranei503 – 527HelicalSequence analysisAdd BLAST25
Transmembranei533 – 555HelicalSequence analysisAdd BLAST23
Transmembranei567 – 585HelicalSequence analysisAdd BLAST19
Transmembranei616 – 638HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000032131.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034648.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 301ABC transporterInterPro annotationAdd BLAST241

Sequence similaritiesi

Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG103052.
KOiK05680.
OMAiAPCPTCP.
OrthoDBiEOG091G050S.
TreeFamiTF105210.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKALEAVG CGLGPGAVAM AVTLEDGAEP PVLTTHLKKV ENHITEAQRF
60 70 80 90 100
SHLPKRSAVD IEFVELSYSV REGPCWRKRG YKTLLKCLSG KFCRRELIGI
110 120 130 140 150
MGPSGAGKST FMNILAGYRE SGMKGQILVN GRPRELRTFR KMSCYIMQDD
160 170 180 190 200
MLLPHLTVLE AMMVSANLKL SEKQEVKKEL VTEILTALGL MSCSHTRTAL
210 220 230 240 250
LSGGQRKRLA IALELVNNPP VMFFDEPTSG LDSASCFQVV SLMKSLAHGG
260 270 280 290 300
RTVICTIHQP SAKLFEMFDK LYILSQGQCI FKGVVTNLIP YLKGLGLHCP
310 320 330 340 350
TYHNPADFII EVASGEYGDL NPMLFRAVQN GLCTMAEKKS SPGKNELPAH
360 370 380 390 400
CPTCPPELDP IESHTFATST LTQFCILFRR TFLSILRDTV LTHLRFMSHV
410 420 430 440 450
LIGVLIGLLY LHIGDDASKV FNNTGFLFFS MLFLMFAALM PTVLTFPLEM
460 470 480 490 500
AVFMREHLNY WYTLKAYYLA KTMADVPFQV VCPVVYCSIV YWMTGQPAET
510 520 530 540 550
SRFLLFSALA IATALVAQSL GLLIGAASTS LQVATFVGPV TAIPVLLFSG
560 570 580 590 600
FFVSFKTIPT YLQWSSYLSY VRYGFEGLIL TIYGMERGHL TCLDEQCPFR
610 620 630 640
DPQIILRELD VEEAKLYMDF LVLGIFFLAL RLLAYLVLRY RVKSER
Length:646
Mass (Da):72,098
Last modified:March 1, 2004 - v2
Checksum:iED83A4C4301ED6FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124577 Genomic DNA. No translation available.
BC016200 mRNA. Translation: AAH16200.2.
AY040865 mRNA. Translation: AAK91781.1.
AF411084 mRNA. Translation: AAL57369.1.
AF378330 mRNA. Translation: AAO13805.1.
AJ426047 mRNA. Translation: CAD19779.2.
RefSeqiNP_620405.3. NM_138955.3.
XP_011240723.1. XM_011242421.2.
UniGeneiMm.101876.

Genome annotation databases

EnsembliENSMUST00000034648; ENSMUSP00000034648; ENSMUSG00000032131.
ENSMUST00000161354; ENSMUSP00000124647; ENSMUSG00000032131.
GeneIDi192663.
KEGGimmu:192663.
UCSCiuc009pcp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124577 Genomic DNA. No translation available.
BC016200 mRNA. Translation: AAH16200.2.
AY040865 mRNA. Translation: AAK91781.1.
AF411084 mRNA. Translation: AAL57369.1.
AF378330 mRNA. Translation: AAO13805.1.
AJ426047 mRNA. Translation: CAD19779.2.
RefSeqiNP_620405.3. NM_138955.3.
XP_011240723.1. XM_011242421.2.
UniGeneiMm.101876.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034648; ENSMUSP00000034648; ENSMUSG00000032131.
ENSMUST00000161354; ENSMUSP00000124647; ENSMUSG00000032131.
GeneIDi192663.
KEGGimmu:192663.
UCSCiuc009pcp.1. mouse.

Organism-specific databases

CTDi64137.
MGIiMGI:1890594. Abcg4.

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG103052.
KOiK05680.
OMAiAPCPTCP.
OrthoDBiEOG091G050S.
TreeFamiTF105210.

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.

Miscellaneous databases

ChiTaRSiAbcg4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032131.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91WA9_MOUSE
AccessioniPrimary (citable) accession number: Q91WA9
Secondary accession number(s): Q8VBS9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: March 1, 2004
Last modified: October 5, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.