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Q91WA9

- Q91WA9_MOUSE

UniProt

Q91WA9 - Q91WA9_MOUSE

Protein
Submitted name:

ATP-binding cassette transporter ABCG4

Gene

Abcg4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-bindingUniRule annotationImported, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP-binding cassette transporter ABCG4Imported
    Submitted name:
    ATP-binding cassette transporter White2Imported
    Submitted name:
    ATP-binding cassette transporter sub-family G member 4Imported
    Submitted name:
    ATP-binding cassette, sub-family G (WHITE), member 4Imported
    Submitted name:
    Protein Abcg4Imported
    Submitted name:
    Putative white family ABC-transporterImported
    Gene namesi
    Name:Abcg4Imported
    Synonyms:ABCG4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1890594. Abcg4.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ91WA9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034648.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114855.
    HOVERGENiHBG103052.
    InParanoidiQ91WA9.
    KOiK05680.
    OMAiCLEEHCP.
    TreeFamiTF105210.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91WA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKALEAVG CGLGPGAVAM AVTLEDGAEP PVLTTHLKKV ENHITEAQRF    50
    SHLPKRSAVD IEFVELSYSV REGPCWRKRG YKTLLKCLSG KFCRRELIGI 100
    MGPSGAGKST FMNILAGYRE SGMKGQILVN GRPRELRTFR KMSCYIMQDD 150
    MLLPHLTVLE AMMVSANLKL SEKQEVKKEL VTEILTALGL MSCSHTRTAL 200
    LSGGQRKRLA IALELVNNPP VMFFDEPTSG LDSASCFQVV SLMKSLAHGG 250
    RTVICTIHQP SAKLFEMFDK LYILSQGQCI FKGVVTNLIP YLKGLGLHCP 300
    TYHNPADFII EVASGEYGDL NPMLFRAVQN GLCTMAEKKS SPGKNELPAH 350
    CPTCPPELDP IESHTFATST LTQFCILFRR TFLSILRDTV LTHLRFMSHV 400
    LIGVLIGLLY LHIGDDASKV FNNTGFLFFS MLFLMFAALM PTVLTFPLEM 450
    AVFMREHLNY WYTLKAYYLA KTMADVPFQV VCPVVYCSIV YWMTGQPAET 500
    SRFLLFSALA IATALVAQSL GLLIGAASTS LQVATFVGPV TAIPVLLFSG 550
    FFVSFKTIPT YLQWSSYLSY VRYGFEGLIL TIYGMERGHL TCLDEQCPFR 600
    DPQIILRELD VEEAKLYMDF LVLGIFFLAL RLLAYLVLRY RVKSER 646
    Length:646
    Mass (Da):72,098
    Last modified:March 1, 2004 - v2
    Checksum:iED83A4C4301ED6FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124577 Genomic DNA. No translation available.
    BC016200 mRNA. Translation: AAH16200.2.
    AY040865 mRNA. Translation: AAK91781.1.
    AF411084 mRNA. Translation: AAL57369.1.
    AF378330 mRNA. Translation: AAO13805.1.
    AJ426047 mRNA. Translation: CAD19779.2.
    RefSeqiNP_620405.3. NM_138955.3.
    UniGeneiMm.101876.

    Genome annotation databases

    EnsembliENSMUST00000034648; ENSMUSP00000034648; ENSMUSG00000032131.
    ENSMUST00000161354; ENSMUSP00000124647; ENSMUSG00000032131.
    GeneIDi192663.
    KEGGimmu:192663.
    UCSCiuc009pcp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124577 Genomic DNA. No translation available.
    BC016200 mRNA. Translation: AAH16200.2 .
    AY040865 mRNA. Translation: AAK91781.1 .
    AF411084 mRNA. Translation: AAL57369.1 .
    AF378330 mRNA. Translation: AAO13805.1 .
    AJ426047 mRNA. Translation: CAD19779.2 .
    RefSeqi NP_620405.3. NM_138955.3.
    UniGenei Mm.101876.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034648.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034648 ; ENSMUSP00000034648 ; ENSMUSG00000032131 .
    ENSMUST00000161354 ; ENSMUSP00000124647 ; ENSMUSG00000032131 .
    GeneIDi 192663.
    KEGGi mmu:192663.
    UCSCi uc009pcp.1. mouse.

    Organism-specific databases

    CTDi 64137.
    MGIi MGI:1890594. Abcg4.

    Phylogenomic databases

    GeneTreei ENSGT00740000114855.
    HOVERGENi HBG103052.
    InParanoidi Q91WA9.
    KOi K05680.
    OMAi CLEEHCP.
    TreeFami TF105210.

    Enzyme and pathway databases

    Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

    Miscellaneous databases

    ChiTaRSi ABCG4. mouse.
    NextBioi 371342.
    PROi Q91WA9.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q91WA9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4."
      Annilo T., Tammur J., Hutchinson A., Rzhetsky A., Dean M., Allikmets R.
      Cytogenet. Cell Genet. 94:196-201(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Cloning and expression analysis of a novel ABC transporter, White2, that is expressed in the mouse retina."
      Kameya S., Naggert J.K., Nishina P.M.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    3. "ABCG4: a novel human white family ABC-transporter expressed in the brain and eye."
      Oldfield S., Lowry C., Ruddick J., Lightman S.
      Biochim. Biophys. Acta 1591:175-179(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: RetinaImported.
    4. "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4."
      Yoshikawa M., Yabuuchi H., Kuroiwa A., Ikegami Y., Sai Y., Tamai I., Tsuji A., Matsuda Y., Yoshida H., Ishikawa T.
      Gene 293:67-75(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/cImported.
      Tissue: BrainImported.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EyeImported.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    7. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ91WA9_MOUSE
    AccessioniPrimary (citable) accession number: Q91WA9
    Secondary accession number(s): Q8VBS9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3