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Protein

CXXC-type zinc finger protein 5

Gene

Cxxc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 292CXXC-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 5
Gene namesi
Name:Cxxc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914643. Cxxc5.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175491 – 317CXXC-type zinc finger protein 5Add BLAST317

Proteomic databases

MaxQBiQ91WA4.
PaxDbiQ91WA4.
PeptideAtlasiQ91WA4.
PRIDEiQ91WA4.

PTM databases

PhosphoSitePlusiQ91WA4.

Expressioni

Developmental stagei

Expressed in dorsal pallium and in and around the developing choroid plexus at 10.5 and 12.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000046668.
CleanExiMM_CXXC5.
GenevisibleiQ91WA4. MM.

Interactioni

Subunit structurei

Interacts with DVL1. Interacts with RBPJ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212157. 7 interactors.
IntActiQ91WA4. 7 interactors.
STRINGi10090.ENSMUSP00000054307.

Structurei

3D structure databases

ProteinModelPortaliQ91WA4.
SMRiQ91WA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi252 – 257Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 18Poly-Ser5

Sequence similaritiesi

Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 292CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGNJ. Eukaryota.
ENOG4110UND. LUCA.
GeneTreeiENSGT00510000046972.
HOGENOMiHOG000112118.
HOVERGENiHBG095668.
InParanoidiQ91WA4.
OMAiRAGMEHM.
OrthoDBiEOG091G0FYR.
PhylomeDBiQ91WA4.
TreeFamiTF326617.

Family and domain databases

InterProiIPR002857. Znf_CXXC.
[Graphical view]
PfamiPF02008. zf-CXXC. 1 hit.
[Graphical view]
PROSITEiPS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLGGGSQD AGGSSSSSNT NSSSGSGQKA GGTDKSTAVA ATTAPTSVAD
60 70 80 90 100
DAPPPERRNK SGIISEPLNK SLRRSRPLSH YSSFGSSGGG GSMMGVESAD
110 120 130 140 150
KAAAAAASLL ANGHDLAAAM AVDKSNPTSK HKSGAVASLL SKAERATELA
160 170 180 190 200
AEGQLTLQQF AQSTEMLKRV VQEHLPLMSE AGAGLPDMEA VAGAEALNGQ
210 220 230 240 250
SDFPYLGAFP INPGLFIMTP AGVFLAESAL HMAGLAEYPM QGELASAISS
260 270 280 290 300
GKKKRKRCGM CAPCRRRINC EQCSSCRNRK TGHQICKFRK CEELKKKPSA
310
ALEKVMLPSG AAFRWFQ
Length:317
Mass (Da):32,812
Last modified:December 1, 2001 - v1
Checksum:i215B73C8BA2AE031
GO

Sequence cautioni

The sequence BAC25113 differs from that shown. Reason: Frameshift at position 245.Curated
The sequence BAC25458 differs from that shown. Reason: Frameshift at position 245.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10D → G in BAE21439 (PubMed:16141072).Curated1
Sequence conflicti105A → G in BAC25458 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005364 mRNA. Translation: BAC25113.1. Frameshift.
AK015150 mRNA. Translation: BAC25458.1. Frameshift.
AK132950 mRNA. Translation: BAE21439.1.
BC016207 mRNA. Translation: AAH16207.1.
BC089314 mRNA. Translation: AAH89314.1.
CCDSiCCDS29150.1.
RefSeqiNP_598448.1. NM_133687.2.
XP_006526239.1. XM_006526176.3.
XP_006526240.1. XM_006526177.3.
XP_006526241.1. XM_006526178.3.
XP_006526243.1. XM_006526180.2.
XP_006526244.1. XM_006526181.3.
UniGeneiMm.94560.

Genome annotation databases

EnsembliENSMUST00000060722; ENSMUSP00000054307; ENSMUSG00000046668.
GeneIDi67393.
KEGGimmu:67393.
UCSCiuc008emx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005364 mRNA. Translation: BAC25113.1. Frameshift.
AK015150 mRNA. Translation: BAC25458.1. Frameshift.
AK132950 mRNA. Translation: BAE21439.1.
BC016207 mRNA. Translation: AAH16207.1.
BC089314 mRNA. Translation: AAH89314.1.
CCDSiCCDS29150.1.
RefSeqiNP_598448.1. NM_133687.2.
XP_006526239.1. XM_006526176.3.
XP_006526240.1. XM_006526177.3.
XP_006526241.1. XM_006526178.3.
XP_006526243.1. XM_006526180.2.
XP_006526244.1. XM_006526181.3.
UniGeneiMm.94560.

3D structure databases

ProteinModelPortaliQ91WA4.
SMRiQ91WA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212157. 7 interactors.
IntActiQ91WA4. 7 interactors.
STRINGi10090.ENSMUSP00000054307.

PTM databases

PhosphoSitePlusiQ91WA4.

Proteomic databases

MaxQBiQ91WA4.
PaxDbiQ91WA4.
PeptideAtlasiQ91WA4.
PRIDEiQ91WA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060722; ENSMUSP00000054307; ENSMUSG00000046668.
GeneIDi67393.
KEGGimmu:67393.
UCSCiuc008emx.1. mouse.

Organism-specific databases

CTDi51523.
MGIiMGI:1914643. Cxxc5.

Phylogenomic databases

eggNOGiENOG410IGNJ. Eukaryota.
ENOG4110UND. LUCA.
GeneTreeiENSGT00510000046972.
HOGENOMiHOG000112118.
HOVERGENiHBG095668.
InParanoidiQ91WA4.
OMAiRAGMEHM.
OrthoDBiEOG091G0FYR.
PhylomeDBiQ91WA4.
TreeFamiTF326617.

Miscellaneous databases

ChiTaRSiCxxc5. mouse.
PROiQ91WA4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046668.
CleanExiMM_CXXC5.
GenevisibleiQ91WA4. MM.

Family and domain databases

InterProiIPR002857. Znf_CXXC.
[Graphical view]
PfamiPF02008. zf-CXXC. 1 hit.
[Graphical view]
PROSITEiPS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXXC5_MOUSE
AccessioniPrimary (citable) accession number: Q91WA4
Secondary accession number(s): Q3V0R4, Q8CES6, Q8CF49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.