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Q91WA3

- HDA11_MOUSE

UniProt

Q91WA3 - HDA11_MOUSE

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Protein

Histone deacetylase 11

Gene

Hdac11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431By similarity

GO - Molecular functioni

  1. histone deacetylase activity Source: UniProtKB
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. chromatin modification Source: UniProtKB
  2. oligodendrocyte development Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 11 (EC:3.5.1.98)
Short name:
HD11
Gene namesi
Name:Hdac11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2385252. Hdac11.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. histone deacetylase complex Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Histone deacetylase 11PRO_0000114717Add
BLAST

Proteomic databases

MaxQBiQ91WA3.
PaxDbiQ91WA3.
PRIDEiQ91WA3.

PTM databases

PhosphoSiteiQ91WA3.

Expressioni

Gene expression databases

BgeeiQ91WA3.
CleanExiMM_HDAC11.
ExpressionAtlasiQ91WA3. baseline and differential.
GenevestigatoriQ91WA3.

Interactioni

Subunit structurei

Interacts with HDAC6.By similarity

Protein-protein interaction databases

BioGridi231232. 3 interactions.
IntActiQ91WA3. 1 interaction.
MINTiMINT-5006804.

Structurei

3D structure databases

ProteinModelPortaliQ91WA3.
SMRiQ91WA3. Positions 19-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 318305Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00390000003411.
HOGENOMiHOG000280018.
HOVERGENiHBG051893.
InParanoidiQ91WA3.
KOiK11418.
OMAiDIIVYNA.
OrthoDBiEOG7J4478.
PhylomeDBiQ91WA3.
TreeFamiTF106176.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q91WA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK
60 70 80 90 100
EEKLLSDGML VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF
110 120 130 140 150
LPNFLVQRKV LRPLRTQTGG TIMAGKLAVE RGWAINVGGG FHHCSSDRGG
160 170 180 190 200
GFCAYADITL AIKFLFERVE GISRATIIDL DAHQGNGHER DFMGDKRVYI
210 220 230 240 250
MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER NVRRSLQEHL
260 270 280 290 300
PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT
310 320 330 340
SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP
Length:347
Mass (Da):39,157
Last modified:December 1, 2001 - v1
Checksum:i7AD91D1B28D57B8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC016208 mRNA. Translation: AAH16208.1.
CCDSiCCDS20366.1.
RefSeqiNP_659168.1. NM_144919.2.
UniGeneiMm.206218.

Genome annotation databases

EnsembliENSMUST00000041736; ENSMUSP00000043828; ENSMUSG00000034245.
GeneIDi232232.
KEGGimmu:232232.
UCSCiuc009cxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC016208 mRNA. Translation: AAH16208.1 .
CCDSi CCDS20366.1.
RefSeqi NP_659168.1. NM_144919.2.
UniGenei Mm.206218.

3D structure databases

ProteinModelPortali Q91WA3.
SMRi Q91WA3. Positions 19-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231232. 3 interactions.
IntActi Q91WA3. 1 interaction.
MINTi MINT-5006804.

Chemistry

BindingDBi Q91WA3.

PTM databases

PhosphoSitei Q91WA3.

Proteomic databases

MaxQBi Q91WA3.
PaxDbi Q91WA3.
PRIDEi Q91WA3.

Protocols and materials databases

DNASUi 232232.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041736 ; ENSMUSP00000043828 ; ENSMUSG00000034245 .
GeneIDi 232232.
KEGGi mmu:232232.
UCSCi uc009cxv.1. mouse.

Organism-specific databases

CTDi 79885.
MGIi MGI:2385252. Hdac11.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00390000003411.
HOGENOMi HOG000280018.
HOVERGENi HBG051893.
InParanoidi Q91WA3.
KOi K11418.
OMAi DIIVYNA.
OrthoDBi EOG7J4478.
PhylomeDBi Q91WA3.
TreeFami TF106176.

Miscellaneous databases

NextBioi 381006.
PROi Q91WA3.
SOURCEi Search...

Gene expression databases

Bgeei Q91WA3.
CleanExi MM_HDAC11.
ExpressionAtlasi Q91WA3. baseline and differential.
Genevestigatori Q91WA3.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiHDA11_MOUSE
AccessioniPrimary (citable) accession number: Q91WA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3