Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase 11

Gene

Hdac11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431By similarity

GO - Molecular functioni

  • histone deacetylase activity Source: UniProtKB
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 11 (EC:3.5.1.98)
Short name:
HD11
Gene namesi
Name:Hdac11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2385252. Hdac11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • histone deacetylase complex Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Histone deacetylase 11PRO_0000114717Add
BLAST

Proteomic databases

MaxQBiQ91WA3.
PaxDbiQ91WA3.
PRIDEiQ91WA3.

PTM databases

PhosphoSiteiQ91WA3.

Expressioni

Gene expression databases

BgeeiQ91WA3.
CleanExiMM_HDAC11.
ExpressionAtlasiQ91WA3. baseline and differential.
GenevisibleiQ91WA3. MM.

Interactioni

Subunit structurei

Interacts with HDAC6.By similarity

Protein-protein interaction databases

BioGridi231232. 3 interactions.
IntActiQ91WA3. 1 interaction.
MINTiMINT-5006804.
STRINGi10090.ENSMUSP00000043828.

Structurei

3D structure databases

ProteinModelPortaliQ91WA3.
SMRiQ91WA3. Positions 19-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 318305Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00390000003411.
HOGENOMiHOG000280018.
HOVERGENiHBG051893.
InParanoidiQ91WA3.
KOiK11418.
OMAiGWAINLG.
OrthoDBiEOG7J4478.
PhylomeDBiQ91WA3.
TreeFamiTF106176.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q91WA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK
60 70 80 90 100
EEKLLSDGML VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF
110 120 130 140 150
LPNFLVQRKV LRPLRTQTGG TIMAGKLAVE RGWAINVGGG FHHCSSDRGG
160 170 180 190 200
GFCAYADITL AIKFLFERVE GISRATIIDL DAHQGNGHER DFMGDKRVYI
210 220 230 240 250
MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER NVRRSLQEHL
260 270 280 290 300
PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT
310 320 330 340
SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP
Length:347
Mass (Da):39,157
Last modified:December 1, 2001 - v1
Checksum:i7AD91D1B28D57B8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016208 mRNA. Translation: AAH16208.1.
CCDSiCCDS20366.1.
RefSeqiNP_659168.1. NM_144919.2.
UniGeneiMm.206218.

Genome annotation databases

EnsembliENSMUST00000041736; ENSMUSP00000043828; ENSMUSG00000034245.
GeneIDi232232.
KEGGimmu:232232.
UCSCiuc009cxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016208 mRNA. Translation: AAH16208.1.
CCDSiCCDS20366.1.
RefSeqiNP_659168.1. NM_144919.2.
UniGeneiMm.206218.

3D structure databases

ProteinModelPortaliQ91WA3.
SMRiQ91WA3. Positions 19-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231232. 3 interactions.
IntActiQ91WA3. 1 interaction.
MINTiMINT-5006804.
STRINGi10090.ENSMUSP00000043828.

PTM databases

PhosphoSiteiQ91WA3.

Proteomic databases

MaxQBiQ91WA3.
PaxDbiQ91WA3.
PRIDEiQ91WA3.

Protocols and materials databases

DNASUi232232.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041736; ENSMUSP00000043828; ENSMUSG00000034245.
GeneIDi232232.
KEGGimmu:232232.
UCSCiuc009cxv.1. mouse.

Organism-specific databases

CTDi79885.
MGIiMGI:2385252. Hdac11.

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00390000003411.
HOGENOMiHOG000280018.
HOVERGENiHBG051893.
InParanoidiQ91WA3.
KOiK11418.
OMAiGWAINLG.
OrthoDBiEOG7J4478.
PhylomeDBiQ91WA3.
TreeFamiTF106176.

Miscellaneous databases

NextBioi381006.
PROiQ91WA3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WA3.
CleanExiMM_HDAC11.
ExpressionAtlasiQ91WA3. baseline and differential.
GenevisibleiQ91WA3. MM.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiHDA11_MOUSE
AccessioniPrimary (citable) accession number: Q91WA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.