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Q91WA3

- HDA11_MOUSE

UniProt

Q91WA3 - HDA11_MOUSE

Protein

Histone deacetylase 11

Gene

Hdac11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei143 – 1431By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: UniProtKB
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. protein binding Source: MGI
    7. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. chromatin modification Source: UniProtKB
    2. oligodendrocyte development Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 11 (EC:3.5.1.98)
    Short name:
    HD11
    Gene namesi
    Name:Hdac11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2385252. Hdac11.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. histone deacetylase complex Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Histone deacetylase 11PRO_0000114717Add
    BLAST

    Proteomic databases

    PaxDbiQ91WA3.
    PRIDEiQ91WA3.

    PTM databases

    PhosphoSiteiQ91WA3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91WA3.
    BgeeiQ91WA3.
    CleanExiMM_HDAC11.
    GenevestigatoriQ91WA3.

    Interactioni

    Subunit structurei

    Interacts with HDAC6.By similarity

    Protein-protein interaction databases

    BioGridi231232. 3 interactions.
    IntActiQ91WA3. 1 interaction.
    MINTiMINT-5006804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WA3.
    SMRiQ91WA3. Positions 19-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 318305Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the histone deacetylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00390000003411.
    HOGENOMiHOG000280018.
    HOVERGENiHBG051893.
    InParanoidiQ91WA3.
    KOiK11418.
    OMAiDIIVYNA.
    OrthoDBiEOG7J4478.
    PhylomeDBiQ91WA3.
    TreeFamiTF106176.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q91WA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK    50
    EEKLLSDGML VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF 100
    LPNFLVQRKV LRPLRTQTGG TIMAGKLAVE RGWAINVGGG FHHCSSDRGG 150
    GFCAYADITL AIKFLFERVE GISRATIIDL DAHQGNGHER DFMGDKRVYI 200
    MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER NVRRSLQEHL 250
    PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT 300
    SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP 347
    Length:347
    Mass (Da):39,157
    Last modified:December 1, 2001 - v1
    Checksum:i7AD91D1B28D57B8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016208 mRNA. Translation: AAH16208.1.
    CCDSiCCDS20366.1.
    RefSeqiNP_659168.1. NM_144919.2.
    UniGeneiMm.206218.

    Genome annotation databases

    EnsembliENSMUST00000041736; ENSMUSP00000043828; ENSMUSG00000034245.
    GeneIDi232232.
    KEGGimmu:232232.
    UCSCiuc009cxv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016208 mRNA. Translation: AAH16208.1 .
    CCDSi CCDS20366.1.
    RefSeqi NP_659168.1. NM_144919.2.
    UniGenei Mm.206218.

    3D structure databases

    ProteinModelPortali Q91WA3.
    SMRi Q91WA3. Positions 19-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231232. 3 interactions.
    IntActi Q91WA3. 1 interaction.
    MINTi MINT-5006804.

    Chemistry

    BindingDBi Q91WA3.

    PTM databases

    PhosphoSitei Q91WA3.

    Proteomic databases

    PaxDbi Q91WA3.
    PRIDEi Q91WA3.

    Protocols and materials databases

    DNASUi 232232.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041736 ; ENSMUSP00000043828 ; ENSMUSG00000034245 .
    GeneIDi 232232.
    KEGGi mmu:232232.
    UCSCi uc009cxv.1. mouse.

    Organism-specific databases

    CTDi 79885.
    MGIi MGI:2385252. Hdac11.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00390000003411.
    HOGENOMi HOG000280018.
    HOVERGENi HBG051893.
    InParanoidi Q91WA3.
    KOi K11418.
    OMAi DIIVYNA.
    OrthoDBi EOG7J4478.
    PhylomeDBi Q91WA3.
    TreeFami TF106176.

    Miscellaneous databases

    NextBioi 381006.
    PROi Q91WA3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91WA3.
    Bgeei Q91WA3.
    CleanExi MM_HDAC11.
    Genevestigatori Q91WA3.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.
    2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiHDA11_MOUSE
    AccessioniPrimary (citable) accession number: Q91WA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3