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Reviewed, UniProtKB/Swiss-Prot Q91WA3 (HDA11_MOUSE)

Last modified January 19, 2010. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histone deacetylase 11
      Short name=HD11
    EC=3.5.1.98
Gene names
Name: Hdac11
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Interacts with HDAC6 By similarity.

Subcellular location

Nucleus By similarity.

Miscellaneous

Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor By similarity.

Sequence similarities

Belongs to the histone deacetylase family.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
Gene Ontology (GO)
   Biological processregulation of transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Traceable author statement. Source: UniProtKB

histone deacetylase complex

Traceable author statement. Source: UniProtKB

   Molecular functionhistone deacetylase activity

Traceable author statement. Source: UniProtKB

transcription factor binding

Traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Histone deacetylase 11
PRO_0000114717

Regions

Region14 – 318305Histone deacetylase

Sites

Active site1431 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q91WA3-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7AD91D1B28D57B8E

FASTA34739,157
        10         20         30         40         50         60 
MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDGML 

        70         80         90        100        110        120 
VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG 

       130        140        150        160        170        180 
TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL 

       190        200        210        220        230        240 
DAHQGNGHER DFMGDKRVYI MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER 

       250        260        270        280        290        300 
NVRRSLQEHL PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT 

       310        320        330        340 
SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP

« Hide

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC016208 mRNA. Translation: AAH16208.1.
IPIIPI00127900.
RefSeqNP_659168.1.
UniGeneMm.206218

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ91WA3.

Proteomic databases

PRIDEQ91WA3.

Genome annotation databases

EnsemblENSMUST00000041736; ENSMUSP00000043828; ENSMUSG00000034245; Mus musculus. [Genome view]
GeneID232232.
KEGGmmu:232232.
NMPDRfig|10090.3.peg.14872.
UCSCuc009cxv.1. mouse.

Organism-specific databases

CTD232232.
MGIMGI:2385252. Hdac11.

Phylogenomic databases

HOGENOMHBG316647.
HOVERGENQ91WA3.
InParanoidQ91WA3.
OMAKLHPFDS.
OrthoDBEOG9K6JPG.
PhylomeDBQ91WA3.

Gene expression databases

ArrayExpressQ91WA3.
BgeeQ91WA3.
CleanExMM_HDAC11.
GenevestigatorQ91WA3.
GermOnlineENSMUSG00000034245. Mus musculus.

Family and domain databases

InterProIPR000286. His_deacetylse.
[Graphical view]
Gene3DG3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHERPTHR10625. His_deacetylse. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other Resources

NextBio381006.
SOURCESearch...

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Entry information

Entry nameHDA11_MOUSE
AccessionPrimary (citable) accession number: Q91WA3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: January 19, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents