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Q91WA3 (HDA11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 11

Short name=HD11
EC=3.5.1.98
Gene names
Name:Hdac11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Interacts with HDAC6 By similarity.

Subcellular location

Nucleus By similarity.

Miscellaneous

Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor By similarity.

Sequence similarities

Belongs to the histone deacetylase family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchromatin modification

Traceable author statement PubMed 12711221. Source: UniProtKB

oligodendrocyte development

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Traceable author statement PubMed 12711221. Source: UniProtKB

histone deacetylase complex

Traceable author statement PubMed 12711221. Source: UniProtKB

nucleus

Traceable author statement PubMed 12711221. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

histone deacetylase activity

Traceable author statement PubMed 12711221. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 17568773. Source: MGI

transcription factor binding

Traceable author statement PubMed 12711221. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Histone deacetylase 11
PRO_0000114717

Regions

Region14 – 318305Histone deacetylase

Sites

Active site1431 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91WA3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7AD91D1B28D57B8E

FASTA34739,157
        10         20         30         40         50         60 
MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDGML 

        70         80         90        100        110        120 
VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG 

       130        140        150        160        170        180 
TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL 

       190        200        210        220        230        240 
DAHQGNGHER DFMGDKRVYI MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER 

       250        260        270        280        290        300 
NVRRSLQEHL PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT 

       310        320        330        340 
SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
[2]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016208 mRNA. Translation: AAH16208.1.
CCDSCCDS20366.1.
RefSeqNP_659168.1. NM_144919.2.
UniGeneMm.206218.

3D structure databases

ProteinModelPortalQ91WA3.
SMRQ91WA3. Positions 19-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231232. 3 interactions.
IntActQ91WA3. 1 interaction.
MINTMINT-5006804.

Chemistry

BindingDBQ91WA3.

PTM databases

PhosphoSiteQ91WA3.

Proteomic databases

PaxDbQ91WA3.
PRIDEQ91WA3.

Protocols and materials databases

DNASU232232.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041736; ENSMUSP00000043828; ENSMUSG00000034245.
GeneID232232.
KEGGmmu:232232.
UCSCuc009cxv.1. mouse.

Organism-specific databases

CTD79885.
MGIMGI:2385252. Hdac11.

Phylogenomic databases

eggNOGCOG0123.
GeneTreeENSGT00390000003411.
HOGENOMHOG000280018.
HOVERGENHBG051893.
InParanoidQ91WA3.
KOK11418.
OMADIIVYNA.
OrthoDBEOG7J4478.
PhylomeDBQ91WA3.
TreeFamTF106176.

Gene expression databases

ArrayExpressQ91WA3.
BgeeQ91WA3.
CleanExMM_HDAC11.
GenevestigatorQ91WA3.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other

NextBio381006.
PROQ91WA3.
SOURCESearch...

Entry information

Entry nameHDA11_MOUSE
AccessionPrimary (citable) accession number: Q91WA3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot