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Protein

Solute carrier family 15 member 4

Gene

Slc15a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-427975. Proton/oligopeptide cotransporters.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 4
Alternative name(s):
Peptide transporter 4
Peptide/histidine transporter 1
Gene namesi
Name:Slc15a4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2140796. Slc15a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386001 – 574Solute carrier family 15 member 4Add BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91W98.
MaxQBiQ91W98.
PaxDbiQ91W98.
PeptideAtlasiQ91W98.
PRIDEiQ91W98.

PTM databases

iPTMnetiQ91W98.
PhosphoSitePlusiQ91W98.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029416.
ExpressionAtlasiQ91W98. baseline and differential.
GenevisibleiQ91W98. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031367.

Structurei

3D structure databases

ProteinModelPortaliQ91W98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ91W98.
KOiK14638.
OMAiMEGERAP.
OrthoDBiEOG091G0GF9.
PhylomeDBiQ91W98.
TreeFamiTF330897.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGERAPLLG SRRPAVSAAS AVFAGRRAAC GAVLLAELLE RAAFYGVTAN
60 70 80 90 100
LVLFLNGAPF DWEGAQASQA LLLFMGLTYL GSPFGGWLAD ARLGRARAIL
110 120 130 140 150
LSLALYLLGL LAFPLLAAPR SRSFLCGDPR PELVRNCSAP FPNGSASCPE
160 170 180 190 200
NAARRCAPAT FAGLVLVGLG VATVKANITP FGADQVKDRG PEATRRFFNW
210 220 230 240 250
FYWSINLGAI LSLGGIAYIQ QNVSFFTGYL IPTVCVAIAF LVFLCGQSVF
260 270 280 290 300
ITKPPDGSAF TDMFRILTYS CCSQRGGQRR SGEGLGVFQQ SSKHSLFDSC
310 320 330 340 350
KMSRGGPFTE DKVEDVKALV KIVPVFLALI PYWTVYFQMQ TTYALQSLHL
360 370 380 390 400
KIPEISSITT THHTLPAAWL TMFDAVLILL LIPLKDKLVD PVLRRHGLLP
410 420 430 440 450
SSLKRIAVGM FFVMCSAFAA GILESKRLDL VKEKTINQTI GGVVYHAADL
460 470 480 490 500
PIWWQIPQYV LIGISEIFAS IAGLEFAYSA APKSMQSAIM GLFFFFSGIG
510 520 530 540 550
SFVGSGLLAL VSLKAIGWMS SHTDFGNINS CHLHYYFFLL AAIQGATLLL
560 570
FLIVSVKYDR QRARTDGGPA STRT
Length:574
Mass (Da):62,256
Last modified:December 1, 2001 - v1
Checksum:i9AE338C1AF56AD05
GO

Sequence cautioni

The sequence AAK95566 differs from that shown. Reason: Frameshift at positions 209, 233, 235, 242 and 262.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218Y → I in AAK95566 (Ref. 1) Curated1
Sequence conflicti254P → L in AAK95566 (Ref. 1) Curated1
Sequence conflicti258S → G in AAK95566 (Ref. 1) Curated1
Sequence conflicti347S → N in AAK95566 (Ref. 1) Curated1
Sequence conflicti427R → K in AAK95566 (Ref. 1) Curated1
Sequence conflicti445Y → F in AAK95566 (Ref. 1) Curated1
Sequence conflicti457P → L in AAK95566 (Ref. 1) Curated1
Sequence conflicti473 – 474GL → RQ in AAK95566 (Ref. 1) Curated2
Sequence conflicti498G → C in AAK95566 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050630 mRNA. Translation: AAK95566.1. Frameshift.
BC016233 mRNA. Translation: AAH16233.1.
CCDSiCCDS19688.1.
RefSeqiNP_598656.1. NM_133895.1.
UniGeneiMm.28506.

Genome annotation databases

EnsembliENSMUST00000031367; ENSMUSP00000031367; ENSMUSG00000029416.
GeneIDi100561.
KEGGimmu:100561.
UCSCiuc008zsb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050630 mRNA. Translation: AAK95566.1. Frameshift.
BC016233 mRNA. Translation: AAH16233.1.
CCDSiCCDS19688.1.
RefSeqiNP_598656.1. NM_133895.1.
UniGeneiMm.28506.

3D structure databases

ProteinModelPortaliQ91W98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031367.

PTM databases

iPTMnetiQ91W98.
PhosphoSitePlusiQ91W98.

Proteomic databases

EPDiQ91W98.
MaxQBiQ91W98.
PaxDbiQ91W98.
PeptideAtlasiQ91W98.
PRIDEiQ91W98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031367; ENSMUSP00000031367; ENSMUSG00000029416.
GeneIDi100561.
KEGGimmu:100561.
UCSCiuc008zsb.1. mouse.

Organism-specific databases

CTDi121260.
MGIiMGI:2140796. Slc15a4.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ91W98.
KOiK14638.
OMAiMEGERAP.
OrthoDBiEOG091G0GF9.
PhylomeDBiQ91W98.
TreeFamiTF330897.

Enzyme and pathway databases

ReactomeiR-MMU-427975. Proton/oligopeptide cotransporters.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ91W98.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029416.
ExpressionAtlasiQ91W98. baseline and differential.
GenevisibleiQ91W98. MM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS15A4_MOUSE
AccessioniPrimary (citable) accession number: Q91W98
Secondary accession number(s): Q7TPL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.