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Protein

Solute carrier family 15 member 4

Gene

Slc15a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-427975. Proton/oligopeptide cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 4
Alternative name(s):
Peptide transporter 4
Peptide/histidine transporter 1
Gene namesi
Name:Slc15a4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2140796. Slc15a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence analysisAdd
BLAST
Transmembranei364 – 38421HelicalSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence analysisAdd
BLAST
Transmembranei536 – 55621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Solute carrier family 15 member 4PRO_0000338600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811PhosphoserineCombined sources
Modified residuei299 – 2991PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91W98.
MaxQBiQ91W98.
PaxDbiQ91W98.
PeptideAtlasiQ91W98.
PRIDEiQ91W98.

PTM databases

iPTMnetiQ91W98.
PhosphoSiteiQ91W98.

Expressioni

Gene expression databases

BgeeiQ91W98.
ExpressionAtlasiQ91W98. baseline and differential.
GenevisibleiQ91W98. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031367.

Structurei

3D structure databases

ProteinModelPortaliQ91W98.
SMRiQ91W98. Positions 23-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ91W98.
KOiK14638.
OMAiMEGERAP.
OrthoDBiEOG7FNC8C.
PhylomeDBiQ91W98.
TreeFamiTF330897.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGERAPLLG SRRPAVSAAS AVFAGRRAAC GAVLLAELLE RAAFYGVTAN
60 70 80 90 100
LVLFLNGAPF DWEGAQASQA LLLFMGLTYL GSPFGGWLAD ARLGRARAIL
110 120 130 140 150
LSLALYLLGL LAFPLLAAPR SRSFLCGDPR PELVRNCSAP FPNGSASCPE
160 170 180 190 200
NAARRCAPAT FAGLVLVGLG VATVKANITP FGADQVKDRG PEATRRFFNW
210 220 230 240 250
FYWSINLGAI LSLGGIAYIQ QNVSFFTGYL IPTVCVAIAF LVFLCGQSVF
260 270 280 290 300
ITKPPDGSAF TDMFRILTYS CCSQRGGQRR SGEGLGVFQQ SSKHSLFDSC
310 320 330 340 350
KMSRGGPFTE DKVEDVKALV KIVPVFLALI PYWTVYFQMQ TTYALQSLHL
360 370 380 390 400
KIPEISSITT THHTLPAAWL TMFDAVLILL LIPLKDKLVD PVLRRHGLLP
410 420 430 440 450
SSLKRIAVGM FFVMCSAFAA GILESKRLDL VKEKTINQTI GGVVYHAADL
460 470 480 490 500
PIWWQIPQYV LIGISEIFAS IAGLEFAYSA APKSMQSAIM GLFFFFSGIG
510 520 530 540 550
SFVGSGLLAL VSLKAIGWMS SHTDFGNINS CHLHYYFFLL AAIQGATLLL
560 570
FLIVSVKYDR QRARTDGGPA STRT
Length:574
Mass (Da):62,256
Last modified:December 1, 2001 - v1
Checksum:i9AE338C1AF56AD05
GO

Sequence cautioni

The sequence AAK95566.1 differs from that shown. Reason: Frameshift at positions 209, 233, 235, 242 and 262. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181Y → I in AAK95566 (Ref. 1) Curated
Sequence conflicti254 – 2541P → L in AAK95566 (Ref. 1) Curated
Sequence conflicti258 – 2581S → G in AAK95566 (Ref. 1) Curated
Sequence conflicti347 – 3471S → N in AAK95566 (Ref. 1) Curated
Sequence conflicti427 – 4271R → K in AAK95566 (Ref. 1) Curated
Sequence conflicti445 – 4451Y → F in AAK95566 (Ref. 1) Curated
Sequence conflicti457 – 4571P → L in AAK95566 (Ref. 1) Curated
Sequence conflicti473 – 4742GL → RQ in AAK95566 (Ref. 1) Curated
Sequence conflicti498 – 4981G → C in AAK95566 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050630 mRNA. Translation: AAK95566.1. Frameshift.
BC016233 mRNA. Translation: AAH16233.1.
CCDSiCCDS19688.1.
RefSeqiNP_598656.1. NM_133895.1.
UniGeneiMm.28506.

Genome annotation databases

EnsembliENSMUST00000031367; ENSMUSP00000031367; ENSMUSG00000029416.
GeneIDi100561.
KEGGimmu:100561.
UCSCiuc008zsb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050630 mRNA. Translation: AAK95566.1. Frameshift.
BC016233 mRNA. Translation: AAH16233.1.
CCDSiCCDS19688.1.
RefSeqiNP_598656.1. NM_133895.1.
UniGeneiMm.28506.

3D structure databases

ProteinModelPortaliQ91W98.
SMRiQ91W98. Positions 23-564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031367.

PTM databases

iPTMnetiQ91W98.
PhosphoSiteiQ91W98.

Proteomic databases

EPDiQ91W98.
MaxQBiQ91W98.
PaxDbiQ91W98.
PeptideAtlasiQ91W98.
PRIDEiQ91W98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031367; ENSMUSP00000031367; ENSMUSG00000029416.
GeneIDi100561.
KEGGimmu:100561.
UCSCiuc008zsb.1. mouse.

Organism-specific databases

CTDi121260.
MGIiMGI:2140796. Slc15a4.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ91W98.
KOiK14638.
OMAiMEGERAP.
OrthoDBiEOG7FNC8C.
PhylomeDBiQ91W98.
TreeFamiTF330897.

Enzyme and pathway databases

ReactomeiR-MMU-427975. Proton/oligopeptide cotransporters.

Miscellaneous databases

PROiQ91W98.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W98.
ExpressionAtlasiQ91W98. baseline and differential.
GenevisibleiQ91W98. MM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a mouse gene encoding a product of peptide/histidine."
    Guo J.H., Yu L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue and Testis.

Entry informationi

Entry nameiS15A4_MOUSE
AccessioniPrimary (citable) accession number: Q91W98
Secondary accession number(s): Q7TPL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.