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Q91W97 (HKDC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative hexokinase HKDC1

EC=2.7.1.1
Alternative name(s):
Hexokinase domain-containing protein 1
Gene names
Name:Hkdc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length915 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway

Carbohydrate metabolism; hexose metabolism.

Sequence similarities

Belongs to the hexokinase family.

Contains 2 hexokinase type-1 domains.

Contains 2 hexokinase type-2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 915915Putative hexokinase HKDC1
PRO_0000299036

Regions

Domain17 – 221205Hexokinase type-1 1
Domain223 – 462240Hexokinase type-2 1
Domain465 – 666202Hexokinase type-1 2
Domain668 – 907240Hexokinase type-2 2
Nucleotide binding84 – 896ATP Potential
Nucleotide binding532 – 5376ATP Potential
Region149 – 17527Glucose-binding Potential
Region594 – 62027Glucose-binding Potential

Sites

Binding site5551ATP Potential

Experimental info

Sequence conflict2081N → D in BAE26802. Ref.1
Sequence conflict7451M → T in BAE26802. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91W97 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1AE1506A9AC0228A

FASTA915102,259
        10         20         30         40         50         60 
MFAVHLVAFY FTKLKEDQIK KVDRFLYHMR LSDETLVDIM ARFQAEMEKG LGKDTNPTAS 

        70         80         90        100        110        120 
VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSQE GQQNVQMESQ FYPMPNEITR 

       130        140        150        160        170        180 
GNGTELFDYV ADCLADFMKT KNLTHKKLPL GFTFSFPCRQ NKLEEGVLLS WTKKFKARGV 

       190        200        210        220        230        240 
QDTDVVNRLA TAMKKHKDLD VDILALVNDT VGTMMTCAYD DPNCEVGVII GTGTNACYME 

       250        260        270        280        290        300 
DMSNIDLVEG DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL 

       310        320        330        340        350        360 
YMGELVRLIL LKMAKVGLLF GGAKSSALHT KGKIETQHVA AMEMSKEGLA NTREILVDLG 

       370        380        390        400        410        420 
LEPSESDCIA VQHVCTIVSF RSANLCAAAL ATILTRLREN KKLARLRTTV GMDGTLYKTH 

       430        440        450        460        470        480 
PQYPKRLHKV VRRLVPNCDV RFLLSESGST KGAAMVTAVA SRVQAQRKQI DKVLALFQLT 

       490        500        510        520        530        540 
REQLLGVRDK MRAELEYGLK KKTHSLATVK MLPTYVYGMP DGTEKGKFLA LDLGGTNFRV 

       550        560        570        580        590        600 
LLVKIRRRSV RMYNKIFAIP LEIMQGTGEE LFDHIVQCIA DFLDYMGLKG AQLPLGFTFS 

       610        620        630        640        650        660 
FPCRQTCIDK GTLVGWTKGF KATDCEGEDV VDMLREAIKR RNEFDLDIVA IVNDTVGTMM 

       670        680        690        700        710        720 
TCGYEDPRCE IGLIAGTGSN VCYMEEMRNI ELVDGDEGRM CVNTEWGGFG DNGCIDDIRT 

       730        740        750        760        770        780 
QYDKEVDEGS LNAGKQRYEK MTSGMYLGEI VRRILIDLTR QGLLFRGQIS ERLRTRGIFE 

       790        800        810        820        830        840 
TKFLSQIESD RLALLQVRRI LQQLGLDSTC EDSIVVKEVC GAVSRRAAQM CGAGMAAIVE 

       850        860        870        880        890        900 
KRREDQGLQH FKVTVGVDGT LYKLHPHFSR ILQETVKELA PQCDVTFMLS EDGSGKGAAL 

       910 
ITAVAKRLQQ PRKDI 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Placenta.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK145980 mRNA. Translation: BAE26802.1.
BC016235 mRNA. Translation: AAH16235.1.
RefSeqNP_663394.1. NM_145419.1.
UniGeneMm.213213.

3D structure databases

ProteinModelPortalQ91W97.
SMRQ91W97. Positions 12-909.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91W97.

Proteomic databases

PaxDbQ91W97.
PRIDEQ91W97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080.
GeneID216019.
KEGGmmu:216019.
UCSCuc007fhc.1. mouse.

Organism-specific databases

CTD80201.
MGIMGI:2384910. Hkdc1.

Phylogenomic databases

eggNOGCOG5026.
GeneTreeENSGT00390000017159.
HOGENOMHOG000162671.
HOVERGENHBG005020.
InParanoidQ91W97.
KOK00844.
OMAMCYMEEM.
OrthoDBEOG7S21X5.
PhylomeDBQ91W97.
TreeFamTF314238.

Enzyme and pathway databases

UniPathwayUPA00242.

Gene expression databases

BgeeQ91W97.
CleanExMM_HKDC1.
GenevestigatorQ91W97.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374947.
PROQ91W97.
SOURCESearch...

Entry information

Entry nameHKDC1_MOUSE
AccessionPrimary (citable) accession number: Q91W97
Secondary accession number(s): Q3UKJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot