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Protein

Putative hexokinase HKDC1

Gene

Hkdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei555 – 5551ATPSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 896ATPSequence Analysis
Nucleotide bindingi532 – 5376ATPSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hexokinase HKDC1 (EC:2.7.1.1)
Alternative name(s):
Hexokinase domain-containing protein 1
Gene namesi
Name:Hkdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384910. Hkdc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915Putative hexokinase HKDC1PRO_0000299036Add
BLAST

Proteomic databases

MaxQBiQ91W97.
PaxDbiQ91W97.
PRIDEiQ91W97.

PTM databases

PhosphoSiteiQ91W97.

Expressioni

Gene expression databases

BgeeiQ91W97.
CleanExiMM_HKDC1.
GenevisibleiQ91W97. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020277.

Structurei

3D structure databases

ProteinModelPortaliQ91W97.
SMRiQ91W97. Positions 12-909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 458443Hexokinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini464 – 903440Hexokinase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 207135Hexokinase small subdomain 1PROSITE-ProRule annotationAdd
BLAST
Regioni149 – 17527Glucose-bindingSequence AnalysisAdd
BLAST
Regioni208 – 447240Hexokinase large subdomain 1PROSITE-ProRule annotationAdd
BLAST
Regioni521 – 652132Hexokinase small subdomain 2PROSITE-ProRule annotationAdd
BLAST
Regioni594 – 62027Glucose-bindingSequence AnalysisAdd
BLAST
Regioni653 – 892240Hexokinase large subdomain 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 2 hexokinase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiQ91W97.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
PhylomeDBiQ91W97.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAVHLVAFY FTKLKEDQIK KVDRFLYHMR LSDETLVDIM ARFQAEMEKG
60 70 80 90 100
LGKDTNPTAS VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSQE
110 120 130 140 150
GQQNVQMESQ FYPMPNEITR GNGTELFDYV ADCLADFMKT KNLTHKKLPL
160 170 180 190 200
GFTFSFPCRQ NKLEEGVLLS WTKKFKARGV QDTDVVNRLA TAMKKHKDLD
210 220 230 240 250
VDILALVNDT VGTMMTCAYD DPNCEVGVII GTGTNACYME DMSNIDLVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL
310 320 330 340 350
YMGELVRLIL LKMAKVGLLF GGAKSSALHT KGKIETQHVA AMEMSKEGLA
360 370 380 390 400
NTREILVDLG LEPSESDCIA VQHVCTIVSF RSANLCAAAL ATILTRLREN
410 420 430 440 450
KKLARLRTTV GMDGTLYKTH PQYPKRLHKV VRRLVPNCDV RFLLSESGST
460 470 480 490 500
KGAAMVTAVA SRVQAQRKQI DKVLALFQLT REQLLGVRDK MRAELEYGLK
510 520 530 540 550
KKTHSLATVK MLPTYVYGMP DGTEKGKFLA LDLGGTNFRV LLVKIRRRSV
560 570 580 590 600
RMYNKIFAIP LEIMQGTGEE LFDHIVQCIA DFLDYMGLKG AQLPLGFTFS
610 620 630 640 650
FPCRQTCIDK GTLVGWTKGF KATDCEGEDV VDMLREAIKR RNEFDLDIVA
660 670 680 690 700
IVNDTVGTMM TCGYEDPRCE IGLIAGTGSN VCYMEEMRNI ELVDGDEGRM
710 720 730 740 750
CVNTEWGGFG DNGCIDDIRT QYDKEVDEGS LNAGKQRYEK MTSGMYLGEI
760 770 780 790 800
VRRILIDLTR QGLLFRGQIS ERLRTRGIFE TKFLSQIESD RLALLQVRRI
810 820 830 840 850
LQQLGLDSTC EDSIVVKEVC GAVSRRAAQM CGAGMAAIVE KRREDQGLQH
860 870 880 890 900
FKVTVGVDGT LYKLHPHFSR ILQETVKELA PQCDVTFMLS EDGSGKGAAL
910
ITAVAKRLQQ PRKDI
Length:915
Mass (Da):102,259
Last modified:December 1, 2001 - v1
Checksum:i1AE1506A9AC0228A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081N → D in BAE26802 (PubMed:16141072).Curated
Sequence conflicti745 – 7451M → T in BAE26802 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145980 mRNA. Translation: BAE26802.1.
BC016235 mRNA. Translation: AAH16235.1.
CCDSiCCDS23888.1.
RefSeqiNP_663394.1. NM_145419.1.
UniGeneiMm.213213.

Genome annotation databases

EnsembliENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080.
GeneIDi216019.
KEGGimmu:216019.
UCSCiuc007fhc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145980 mRNA. Translation: BAE26802.1.
BC016235 mRNA. Translation: AAH16235.1.
CCDSiCCDS23888.1.
RefSeqiNP_663394.1. NM_145419.1.
UniGeneiMm.213213.

3D structure databases

ProteinModelPortaliQ91W97.
SMRiQ91W97. Positions 12-909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020277.

PTM databases

PhosphoSiteiQ91W97.

Proteomic databases

MaxQBiQ91W97.
PaxDbiQ91W97.
PRIDEiQ91W97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080.
GeneIDi216019.
KEGGimmu:216019.
UCSCiuc007fhc.1. mouse.

Organism-specific databases

CTDi80201.
MGIiMGI:2384910. Hkdc1.

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiQ91W97.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
PhylomeDBiQ91W97.
TreeFamiTF314238.

Enzyme and pathway databases

UniPathwayiUPA00242.

Miscellaneous databases

NextBioi374947.
PROiQ91W97.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W97.
CleanExiMM_HKDC1.
GenevisibleiQ91W97. MM.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiHKDC1_MOUSE
AccessioniPrimary (citable) accession number: Q91W97
Secondary accession number(s): Q3UKJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.