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Q91W97

- HKDC1_MOUSE

UniProt

Q91W97 - HKDC1_MOUSE

Protein

Putative hexokinase HKDC1

Gene

Hkdc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei555 – 5551ATPSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi84 – 896ATPSequence Analysis
    Nucleotide bindingi532 – 5376ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: RefGenome
    3. glucokinase activity Source: RefGenome
    4. mannokinase activity Source: RefGenome

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. cellular glucose homeostasis Source: RefGenome
    3. glucose 6-phosphate metabolic process Source: GOC
    4. glycolytic process Source: RefGenome
    5. hexose metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative hexokinase HKDC1 (EC:2.7.1.1)
    Alternative name(s):
    Hexokinase domain-containing protein 1
    Gene namesi
    Name:Hkdc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2384910. Hkdc1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome
    2. mitochondrion Source: Ensembl
    3. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 915915Putative hexokinase HKDC1PRO_0000299036Add
    BLAST

    Proteomic databases

    MaxQBiQ91W97.
    PaxDbiQ91W97.
    PRIDEiQ91W97.

    PTM databases

    PhosphoSiteiQ91W97.

    Expressioni

    Gene expression databases

    BgeeiQ91W97.
    CleanExiMM_HKDC1.
    GenevestigatoriQ91W97.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W97.
    SMRiQ91W97. Positions 12-909.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 221205Hexokinase type-1 1Add
    BLAST
    Domaini223 – 462240Hexokinase type-2 1Add
    BLAST
    Domaini465 – 666202Hexokinase type-1 2Add
    BLAST
    Domaini668 – 907240Hexokinase type-2 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni149 – 17527Glucose-bindingSequence AnalysisAdd
    BLAST
    Regioni594 – 62027Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 2 hexokinase type-1 domains.Curated
    Contains 2 hexokinase type-2 domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5026.
    GeneTreeiENSGT00390000017159.
    HOGENOMiHOG000162671.
    HOVERGENiHBG005020.
    InParanoidiQ91W97.
    KOiK00844.
    OMAiMCYMEEM.
    OrthoDBiEOG7S21X5.
    PhylomeDBiQ91W97.
    TreeFamiTF314238.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91W97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAVHLVAFY FTKLKEDQIK KVDRFLYHMR LSDETLVDIM ARFQAEMEKG    50
    LGKDTNPTAS VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSQE 100
    GQQNVQMESQ FYPMPNEITR GNGTELFDYV ADCLADFMKT KNLTHKKLPL 150
    GFTFSFPCRQ NKLEEGVLLS WTKKFKARGV QDTDVVNRLA TAMKKHKDLD 200
    VDILALVNDT VGTMMTCAYD DPNCEVGVII GTGTNACYME DMSNIDLVEG 250
    DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL 300
    YMGELVRLIL LKMAKVGLLF GGAKSSALHT KGKIETQHVA AMEMSKEGLA 350
    NTREILVDLG LEPSESDCIA VQHVCTIVSF RSANLCAAAL ATILTRLREN 400
    KKLARLRTTV GMDGTLYKTH PQYPKRLHKV VRRLVPNCDV RFLLSESGST 450
    KGAAMVTAVA SRVQAQRKQI DKVLALFQLT REQLLGVRDK MRAELEYGLK 500
    KKTHSLATVK MLPTYVYGMP DGTEKGKFLA LDLGGTNFRV LLVKIRRRSV 550
    RMYNKIFAIP LEIMQGTGEE LFDHIVQCIA DFLDYMGLKG AQLPLGFTFS 600
    FPCRQTCIDK GTLVGWTKGF KATDCEGEDV VDMLREAIKR RNEFDLDIVA 650
    IVNDTVGTMM TCGYEDPRCE IGLIAGTGSN VCYMEEMRNI ELVDGDEGRM 700
    CVNTEWGGFG DNGCIDDIRT QYDKEVDEGS LNAGKQRYEK MTSGMYLGEI 750
    VRRILIDLTR QGLLFRGQIS ERLRTRGIFE TKFLSQIESD RLALLQVRRI 800
    LQQLGLDSTC EDSIVVKEVC GAVSRRAAQM CGAGMAAIVE KRREDQGLQH 850
    FKVTVGVDGT LYKLHPHFSR ILQETVKELA PQCDVTFMLS EDGSGKGAAL 900
    ITAVAKRLQQ PRKDI 915
    Length:915
    Mass (Da):102,259
    Last modified:December 1, 2001 - v1
    Checksum:i1AE1506A9AC0228A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081N → D in BAE26802. (PubMed:16141072)Curated
    Sequence conflicti745 – 7451M → T in BAE26802. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145980 mRNA. Translation: BAE26802.1.
    BC016235 mRNA. Translation: AAH16235.1.
    CCDSiCCDS23888.1.
    RefSeqiNP_663394.1. NM_145419.1.
    UniGeneiMm.213213.

    Genome annotation databases

    EnsembliENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080.
    GeneIDi216019.
    KEGGimmu:216019.
    UCSCiuc007fhc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145980 mRNA. Translation: BAE26802.1 .
    BC016235 mRNA. Translation: AAH16235.1 .
    CCDSi CCDS23888.1.
    RefSeqi NP_663394.1. NM_145419.1.
    UniGenei Mm.213213.

    3D structure databases

    ProteinModelPortali Q91W97.
    SMRi Q91W97. Positions 12-909.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91W97.

    Proteomic databases

    MaxQBi Q91W97.
    PaxDbi Q91W97.
    PRIDEi Q91W97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020277 ; ENSMUSP00000020277 ; ENSMUSG00000020080 .
    GeneIDi 216019.
    KEGGi mmu:216019.
    UCSCi uc007fhc.1. mouse.

    Organism-specific databases

    CTDi 80201.
    MGIi MGI:2384910. Hkdc1.

    Phylogenomic databases

    eggNOGi COG5026.
    GeneTreei ENSGT00390000017159.
    HOGENOMi HOG000162671.
    HOVERGENi HBG005020.
    InParanoidi Q91W97.
    KOi K00844.
    OMAi MCYMEEM.
    OrthoDBi EOG7S21X5.
    PhylomeDBi Q91W97.
    TreeFami TF314238.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .

    Miscellaneous databases

    NextBioi 374947.
    PROi Q91W97.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91W97.
    CleanExi MM_HKDC1.
    Genevestigatori Q91W97.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiHKDC1_MOUSE
    AccessioniPrimary (citable) accession number: Q91W97
    Secondary accession number(s): Q3UKJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3