Reviewed,
UniProtKB/Swiss-Prot Q91W97 (HKDC1_MOUSE)
Last modified
January 19, 2010.
Version 57.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative hexokinase HKDC1 EC=2.7.1.1 Alternative name(s): Hexokinase domain-containing protein 1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 915 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + D-hexose = ADP + D-hexose 6-phosphate. |
| Pathway | |
| Sequence similarities | Belongs to the hexokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Domain | Repeat |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 915 | 915 | Putative hexokinase HKDC1 | PRO_0000299036 | |||||
Regions | |||||||||
| Nucleotide binding | 84 – 89 | 6 | ATP Potential | ||||||
| Nucleotide binding | 532 – 537 | 6 | ATP Potential | ||||||
| Region | 149 – 175 | 27 | Glucose-binding Potential | ||||||
| Region | 594 – 620 | 27 | Glucose-binding Potential | ||||||
Sites | |||||||||
| Binding site | 555 | 1 | ATP Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 208 | 1 | N → D in BAE26802. Ref.1 | ||||||
| Sequence conflict | 745 | 1 | M → T in BAE26802. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Placenta. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK145980 mRNA. Translation: BAE26802.1. BC016235 mRNA. Translation: AAH16235.1. |
| IPI | IPI00127495. |
| RefSeq | NP_663394.1. |
| UniGene | Mm.213213 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BG3 based on UniProtKB P05708. |
| SMR | Q91W97. Positions 16-909. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q91W97. |
Genome annotation databases | |
| Ensembl | ENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080; Mus musculus. [Genome view] |
| GeneID | 216019. |
| KEGG | mmu:216019. |
| UCSC | uc007fhc.1. mouse. |
Organism-specific databases | |
| CTD | 216019. |
| MGI | MGI:2384910. Hkdc1. |
Phylogenomic databases | |
| eggNOG | roNOG09167. |
| HOGENOM | HBG446386. |
| HOVERGEN | Q91W97. |
| InParanoid | Q91W97. |
| OMA | CYMEDMS. |
| OrthoDB | EOG9SBHH8. |
| PhylomeDB | Q91W97. |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.1. 244. |
Gene expression databases | |
| ArrayExpress | Q91W97. |
| Bgee | Q91W97. |
| CleanEx | MM_HKDC1. |
| Genevestigator | Q91W97. |
Family and domain databases | |
| InterPro | IPR001312. Hexokinase. IPR019807. Hexokinase_CS. [Graphical view] |
| PANTHER | PTHR19443. Hexokinase. 1 hit. |
| Pfam | PF00349. Hexokinase_1. 2 hits. PF03727. Hexokinase_2. 2 hits. [Graphical view] |
| PRINTS | PR00475. HEXOKINASE. |
| PROSITE | PS00378. HEXOKINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 374947. |
| SOURCE | Search... |
Entry information
| Entry name | HKDC1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q91W97 Secondary accession number(s): Q3UKJ9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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