SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91W97

- HKDC1_MOUSE

UniProt

Q91W97 - HKDC1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative hexokinase HKDC1

Gene
Hkdc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei555 – 5551ATP Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 896ATP Reviewed prediction
Nucleotide bindingi532 – 5376ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: RefGenome
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: RefGenome
  5. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hexokinase HKDC1 (EC:2.7.1.1)
Alternative name(s):
Hexokinase domain-containing protein 1
Gene namesi
Name:Hkdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2384910. Hkdc1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
  2. mitochondrion Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915Putative hexokinase HKDC1PRO_0000299036Add
BLAST

Proteomic databases

MaxQBiQ91W97.
PaxDbiQ91W97.
PRIDEiQ91W97.

PTM databases

PhosphoSiteiQ91W97.

Expressioni

Gene expression databases

BgeeiQ91W97.
CleanExiMM_HKDC1.
GenevestigatoriQ91W97.

Structurei

3D structure databases

ProteinModelPortaliQ91W97.
SMRiQ91W97. Positions 12-909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 221205Hexokinase type-1 1Add
BLAST
Domaini223 – 462240Hexokinase type-2 1Add
BLAST
Domaini465 – 666202Hexokinase type-1 2Add
BLAST
Domaini668 – 907240Hexokinase type-2 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 17527Glucose-binding Reviewed predictionAdd
BLAST
Regioni594 – 62027Glucose-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiQ91W97.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
PhylomeDBiQ91W97.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W97-1 [UniParc]FASTAAdd to Basket

« Hide

MFAVHLVAFY FTKLKEDQIK KVDRFLYHMR LSDETLVDIM ARFQAEMEKG    50
LGKDTNPTAS VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSQE 100
GQQNVQMESQ FYPMPNEITR GNGTELFDYV ADCLADFMKT KNLTHKKLPL 150
GFTFSFPCRQ NKLEEGVLLS WTKKFKARGV QDTDVVNRLA TAMKKHKDLD 200
VDILALVNDT VGTMMTCAYD DPNCEVGVII GTGTNACYME DMSNIDLVEG 250
DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL 300
YMGELVRLIL LKMAKVGLLF GGAKSSALHT KGKIETQHVA AMEMSKEGLA 350
NTREILVDLG LEPSESDCIA VQHVCTIVSF RSANLCAAAL ATILTRLREN 400
KKLARLRTTV GMDGTLYKTH PQYPKRLHKV VRRLVPNCDV RFLLSESGST 450
KGAAMVTAVA SRVQAQRKQI DKVLALFQLT REQLLGVRDK MRAELEYGLK 500
KKTHSLATVK MLPTYVYGMP DGTEKGKFLA LDLGGTNFRV LLVKIRRRSV 550
RMYNKIFAIP LEIMQGTGEE LFDHIVQCIA DFLDYMGLKG AQLPLGFTFS 600
FPCRQTCIDK GTLVGWTKGF KATDCEGEDV VDMLREAIKR RNEFDLDIVA 650
IVNDTVGTMM TCGYEDPRCE IGLIAGTGSN VCYMEEMRNI ELVDGDEGRM 700
CVNTEWGGFG DNGCIDDIRT QYDKEVDEGS LNAGKQRYEK MTSGMYLGEI 750
VRRILIDLTR QGLLFRGQIS ERLRTRGIFE TKFLSQIESD RLALLQVRRI 800
LQQLGLDSTC EDSIVVKEVC GAVSRRAAQM CGAGMAAIVE KRREDQGLQH 850
FKVTVGVDGT LYKLHPHFSR ILQETVKELA PQCDVTFMLS EDGSGKGAAL 900
ITAVAKRLQQ PRKDI 915
Length:915
Mass (Da):102,259
Last modified:December 1, 2001 - v1
Checksum:i1AE1506A9AC0228A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081N → D in BAE26802. 1 Publication
Sequence conflicti745 – 7451M → T in BAE26802. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145980 mRNA. Translation: BAE26802.1.
BC016235 mRNA. Translation: AAH16235.1.
CCDSiCCDS23888.1.
RefSeqiNP_663394.1. NM_145419.1.
UniGeneiMm.213213.

Genome annotation databases

EnsembliENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080.
GeneIDi216019.
KEGGimmu:216019.
UCSCiuc007fhc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145980 mRNA. Translation: BAE26802.1 .
BC016235 mRNA. Translation: AAH16235.1 .
CCDSi CCDS23888.1.
RefSeqi NP_663394.1. NM_145419.1.
UniGenei Mm.213213.

3D structure databases

ProteinModelPortali Q91W97.
SMRi Q91W97. Positions 12-909.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91W97.

Proteomic databases

MaxQBi Q91W97.
PaxDbi Q91W97.
PRIDEi Q91W97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020277 ; ENSMUSP00000020277 ; ENSMUSG00000020080 .
GeneIDi 216019.
KEGGi mmu:216019.
UCSCi uc007fhc.1. mouse.

Organism-specific databases

CTDi 80201.
MGIi MGI:2384910. Hkdc1.

Phylogenomic databases

eggNOGi COG5026.
GeneTreei ENSGT00390000017159.
HOGENOMi HOG000162671.
HOVERGENi HBG005020.
InParanoidi Q91W97.
KOi K00844.
OMAi MCYMEEM.
OrthoDBi EOG7S21X5.
PhylomeDBi Q91W97.
TreeFami TF314238.

Enzyme and pathway databases

UniPathwayi UPA00242 .

Miscellaneous databases

NextBioi 374947.
PROi Q91W97.
SOURCEi Search...

Gene expression databases

Bgeei Q91W97.
CleanExi MM_HKDC1.
Genevestigatori Q91W97.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiHKDC1_MOUSE
AccessioniPrimary (citable) accession number: Q91W97
Secondary accession number(s): Q3UKJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi