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Q91W97

- HKDC1_MOUSE

UniProt

Q91W97 - HKDC1_MOUSE

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Protein

Putative hexokinase HKDC1

Gene

Hkdc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei555 – 5551ATPSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 896ATPSequence Analysis
Nucleotide bindingi532 – 5376ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: RefGenome
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: RefGenome
  5. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hexokinase HKDC1 (EC:2.7.1.1)
Alternative name(s):
Hexokinase domain-containing protein 1
Gene namesi
Name:Hkdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2384910. Hkdc1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915Putative hexokinase HKDC1PRO_0000299036Add
BLAST

Proteomic databases

MaxQBiQ91W97.
PaxDbiQ91W97.
PRIDEiQ91W97.

PTM databases

PhosphoSiteiQ91W97.

Expressioni

Gene expression databases

BgeeiQ91W97.
CleanExiMM_HKDC1.
GenevestigatoriQ91W97.

Structurei

3D structure databases

ProteinModelPortaliQ91W97.
SMRiQ91W97. Positions 12-909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 221205Hexokinase type-1 1Add
BLAST
Domaini223 – 462240Hexokinase type-2 1Add
BLAST
Domaini465 – 666202Hexokinase type-1 2Add
BLAST
Domaini668 – 907240Hexokinase type-2 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 17527Glucose-bindingSequence AnalysisAdd
BLAST
Regioni594 – 62027Glucose-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 2 hexokinase type-1 domains.Curated
Contains 2 hexokinase type-2 domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiQ91W97.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
PhylomeDBiQ91W97.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W97 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAVHLVAFY FTKLKEDQIK KVDRFLYHMR LSDETLVDIM ARFQAEMEKG
60 70 80 90 100
LGKDTNPTAS VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSQE
110 120 130 140 150
GQQNVQMESQ FYPMPNEITR GNGTELFDYV ADCLADFMKT KNLTHKKLPL
160 170 180 190 200
GFTFSFPCRQ NKLEEGVLLS WTKKFKARGV QDTDVVNRLA TAMKKHKDLD
210 220 230 240 250
VDILALVNDT VGTMMTCAYD DPNCEVGVII GTGTNACYME DMSNIDLVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL
310 320 330 340 350
YMGELVRLIL LKMAKVGLLF GGAKSSALHT KGKIETQHVA AMEMSKEGLA
360 370 380 390 400
NTREILVDLG LEPSESDCIA VQHVCTIVSF RSANLCAAAL ATILTRLREN
410 420 430 440 450
KKLARLRTTV GMDGTLYKTH PQYPKRLHKV VRRLVPNCDV RFLLSESGST
460 470 480 490 500
KGAAMVTAVA SRVQAQRKQI DKVLALFQLT REQLLGVRDK MRAELEYGLK
510 520 530 540 550
KKTHSLATVK MLPTYVYGMP DGTEKGKFLA LDLGGTNFRV LLVKIRRRSV
560 570 580 590 600
RMYNKIFAIP LEIMQGTGEE LFDHIVQCIA DFLDYMGLKG AQLPLGFTFS
610 620 630 640 650
FPCRQTCIDK GTLVGWTKGF KATDCEGEDV VDMLREAIKR RNEFDLDIVA
660 670 680 690 700
IVNDTVGTMM TCGYEDPRCE IGLIAGTGSN VCYMEEMRNI ELVDGDEGRM
710 720 730 740 750
CVNTEWGGFG DNGCIDDIRT QYDKEVDEGS LNAGKQRYEK MTSGMYLGEI
760 770 780 790 800
VRRILIDLTR QGLLFRGQIS ERLRTRGIFE TKFLSQIESD RLALLQVRRI
810 820 830 840 850
LQQLGLDSTC EDSIVVKEVC GAVSRRAAQM CGAGMAAIVE KRREDQGLQH
860 870 880 890 900
FKVTVGVDGT LYKLHPHFSR ILQETVKELA PQCDVTFMLS EDGSGKGAAL
910
ITAVAKRLQQ PRKDI
Length:915
Mass (Da):102,259
Last modified:December 1, 2001 - v1
Checksum:i1AE1506A9AC0228A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081N → D in BAE26802. (PubMed:16141072)Curated
Sequence conflicti745 – 7451M → T in BAE26802. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145980 mRNA. Translation: BAE26802.1.
BC016235 mRNA. Translation: AAH16235.1.
CCDSiCCDS23888.1.
RefSeqiNP_663394.1. NM_145419.1.
UniGeneiMm.213213.

Genome annotation databases

EnsembliENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080.
GeneIDi216019.
KEGGimmu:216019.
UCSCiuc007fhc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145980 mRNA. Translation: BAE26802.1 .
BC016235 mRNA. Translation: AAH16235.1 .
CCDSi CCDS23888.1.
RefSeqi NP_663394.1. NM_145419.1.
UniGenei Mm.213213.

3D structure databases

ProteinModelPortali Q91W97.
SMRi Q91W97. Positions 12-909.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91W97.

Proteomic databases

MaxQBi Q91W97.
PaxDbi Q91W97.
PRIDEi Q91W97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020277 ; ENSMUSP00000020277 ; ENSMUSG00000020080 .
GeneIDi 216019.
KEGGi mmu:216019.
UCSCi uc007fhc.1. mouse.

Organism-specific databases

CTDi 80201.
MGIi MGI:2384910. Hkdc1.

Phylogenomic databases

eggNOGi COG5026.
GeneTreei ENSGT00390000017159.
HOGENOMi HOG000162671.
HOVERGENi HBG005020.
InParanoidi Q91W97.
KOi K00844.
OMAi MCYMEEM.
OrthoDBi EOG7S21X5.
PhylomeDBi Q91W97.
TreeFami TF314238.

Enzyme and pathway databases

UniPathwayi UPA00242 .

Miscellaneous databases

NextBioi 374947.
PROi Q91W97.
SOURCEi Search...

Gene expression databases

Bgeei Q91W97.
CleanExi MM_HKDC1.
Genevestigatori Q91W97.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiHKDC1_MOUSE
AccessioniPrimary (citable) accession number: Q91W97
Secondary accession number(s): Q3UKJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3