Reviewed, UniProtKB/Swiss-Prot Q91W97 (HKDC1_MOUSE)

Names and origin

Protein names

Recommended name:
    Putative hexokinase HKDC1
    EC=2.7.1.1
Alternative name(s):
    Hexokinase domain-containing protein 1

Gene names

Name:

Hkdc1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	915 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Pathway	Carbohydrate metabolism; hexose metabolism.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 915	915	Putative hexokinase HKDC1		PRO_0000299036
Regions
	Nucleotide binding	84 – 89	6	ATP Potential
	Nucleotide binding	532 – 537	6	ATP Potential
	Region	149 – 175	27	Glucose-binding Potential
	Region	594 – 620	27	Glucose-binding Potential
Sites
	Binding site	555	1	ATP Potential
Experimental info
	Sequence conflict	208	1	N → D in BAE26802. Ref.1
	Sequence conflict	745	1	M → T in BAE26802. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q91W97-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1AE1506A9AC0228A	FASTA	915	102,259
	10 20 30 40 50 60 MFAVHLVAFY FTKLKEDQIK KVDRFLYHMR LSDETLVDIM ARFQAEMEKG LGKDTNPTAS 70 80 90 100 110 120 VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSQE GQQNVQMESQ FYPMPNEITR 130 140 150 160 170 180 GNGTELFDYV ADCLADFMKT KNLTHKKLPL GFTFSFPCRQ NKLEEGVLLS WTKKFKARGV 190 200 210 220 230 240 QDTDVVNRLA TAMKKHKDLD VDILALVNDT VGTMMTCAYD DPNCEVGVII GTGTNACYME 250 260 270 280 290 300 DMSNIDLVEG DEGRMCINTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL 310 320 330 340 350 360 YMGELVRLIL LKMAKVGLLF GGAKSSALHT KGKIETQHVA AMEMSKEGLA NTREILVDLG 370 380 390 400 410 420 LEPSESDCIA VQHVCTIVSF RSANLCAAAL ATILTRLREN KKLARLRTTV GMDGTLYKTH 430 440 450 460 470 480 PQYPKRLHKV VRRLVPNCDV RFLLSESGST KGAAMVTAVA SRVQAQRKQI DKVLALFQLT 490 500 510 520 530 540 REQLLGVRDK MRAELEYGLK KKTHSLATVK MLPTYVYGMP DGTEKGKFLA LDLGGTNFRV 550 560 570 580 590 600 LLVKIRRRSV RMYNKIFAIP LEIMQGTGEE LFDHIVQCIA DFLDYMGLKG AQLPLGFTFS 610 620 630 640 650 660 FPCRQTCIDK GTLVGWTKGF KATDCEGEDV VDMLREAIKR RNEFDLDIVA IVNDTVGTMM 670 680 690 700 710 720 TCGYEDPRCE IGLIAGTGSN VCYMEEMRNI ELVDGDEGRM CVNTEWGGFG DNGCIDDIRT 730 740 750 760 770 780 QYDKEVDEGS LNAGKQRYEK MTSGMYLGEI VRRILIDLTR QGLLFRGQIS ERLRTRGIFE 790 800 810 820 830 840 TKFLSQIESD RLALLQVRRI LQQLGLDSTC EDSIVVKEVC GAVSRRAAQM CGAGMAAIVE 850 860 870 880 890 900 KRREDQGLQH FKVTVGVDGT LYKLHPHFSR ILQETVKELA PQCDVTFMLS EDGSGKGAAL 910 ITAVAKRLQQ PRKDI

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK145980 mRNA. Translation: BAE26802.1. BC016235 mRNA. Translation: AAH16235.1.
IPI	IPI00127495.
RefSeq	NP_663394.1.
UniGene	Mm.213213
3D structure databases
HSSP	HSSP built from PDB template 1BG3 based on UniProtKB P05708.
SMR	Q91W97. Positions 16-909.
ModBase	Search...
Proteomic databases
PRIDE	Q91W97.
Genome annotation databases
Ensembl	ENSMUST00000020277; ENSMUSP00000020277; ENSMUSG00000020080; Mus musculus. [Genome view]
GeneID	216019.
KEGG	mmu:216019.
UCSC	uc007fhc.1. mouse.
Organism-specific databases
CTD	216019.
MGI	MGI:2384910. Hkdc1.
Phylogenomic databases
eggNOG	roNOG09167.
HOGENOM	HBG446386.
HOVERGEN	Q91W97.
InParanoid	Q91W97.
OMA	CYMEDMS.
OrthoDB	EOG9SBHH8.
PhylomeDB	Q91W97.
Enzyme and pathway databases
BRENDA	2.7.1.1. 244.
Gene expression databases
ArrayExpress	Q91W97.
Bgee	Q91W97.
CleanEx	MM_HKDC1.
Genevestigator	Q91W97.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR019807. Hexokinase_CS. [Graphical view]
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 2 hits. PF03727. Hexokinase_2. 2 hits. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	374947.
SOURCE	Search...

Entry information

Entry name

HKDC1_MOUSE

Accession

Primary (citable) accession number: Q91W97
Secondary accession number(s): Q3UKJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)