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Protein

Cdc42 effector protein 1

Gene

Cdc42ep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 1
Alternative name(s):
Binder of Rho GTPases 5
Gene namesi
Name:Cdc42ep1
Synonyms:Borg5, Cep1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929763. Cdc42ep1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: MGI
  • focal adhesion Source: MGI
  • Golgi apparatus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Cdc42 effector protein 1PRO_0000212658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei34 – 341PhosphothreonineCombined sources
Modified residuei39 – 391PhosphoserineCombined sources
Modified residuei65 – 651PhosphoserineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei101 – 1011PhosphoserineBy similarity
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei121 – 1211PhosphoserineCombined sources
Modified residuei139 – 1391PhosphoserineCombined sources
Modified residuei191 – 1911PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei207 – 2071PhosphoserineCombined sources
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei312 – 3121PhosphoserineBy similarity
Modified residuei332 – 3321PhosphoserineBy similarity
Modified residuei368 – 3681PhosphoserineCombined sources
Modified residuei371 – 3711PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91W92.
PaxDbiQ91W92.
PeptideAtlasiQ91W92.
PRIDEiQ91W92.

PTM databases

iPTMnetiQ91W92.
PhosphoSiteiQ91W92.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049521.
CleanExiMM_CDC42EP1.

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91W92. 1 interaction.
STRINGi10090.ENSMUSP00000060930.

Structurei

3D structure databases

ProteinModelPortaliQ91W92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 5215CRIBPROSITE-ProRule annotationAdd
BLAST
Repeati235 – 24171
Repeati242 – 24872
Repeati255 – 26173

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 284503 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Add
BLAST

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGPN. Eukaryota.
ENOG4111PPX. LUCA.
HOGENOMiHOG000095252.
HOVERGENiHBG080906.
InParanoidiQ91W92.
PhylomeDBiQ91W92.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPQGGTGA PTMSLGKLSP VGWVSSSHGK RRLTADMISP PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGR SGNTHRSPRS FLARKLQQVR RVGVPPRRMA
110 120 130 140 150
SPAAPSPAPP PISPIIKNAI SLPQLNQATY DSLVMGKLSF DSTPASSTDG
160 170 180 190 200
HSGYGLESGF CTISRLPRVE KHSNRDRDRD PDHSQDREQS SFPSEPTPNP
210 220 230 240 250
ELRRSDSLLS FRFDLDLGPS LLSELLGVMS LSEAPAAETP VPTANPPAPA
260 270 280 290 300
ANPAPTAKPP AHAITTLDAV TSLPASAVTS LPAPAAASSP SRGHFPNGVT
310 320 330 340 350
SVLGPAAEAK PSPVGEGPQV PSNMTFDRHG ASWGASRASW GASRASRHYT
360 370 380 390 400
EMDARRELAG VLPQVHGSWE SLNEDWSTPP ASVRAPVPTS VQVNAFEFAD

AEEDDEVKV
Length:409
Mass (Da):43,096
Last modified:December 1, 2001 - v1
Checksum:i1794FD0850171F0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861A → V in BAB25335 (PubMed:16141072).Curated
Sequence conflicti325 – 3251T → A in BAB25335 (PubMed:16141072).Curated
Sequence conflicti378 – 3781T → A in BAB25335 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007896 mRNA. Translation: BAB25335.1.
BC016250 mRNA. Translation: AAH16250.1.
BC083130 mRNA. Translation: AAH83130.1.
CCDSiCCDS27624.1.
RefSeqiNP_081495.1. NM_027219.3.
UniGeneiMm.307488.

Genome annotation databases

GeneIDi104445.
KEGGimmu:104445.
UCSCiuc007wrl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007896 mRNA. Translation: BAB25335.1.
BC016250 mRNA. Translation: AAH16250.1.
BC083130 mRNA. Translation: AAH83130.1.
CCDSiCCDS27624.1.
RefSeqiNP_081495.1. NM_027219.3.
UniGeneiMm.307488.

3D structure databases

ProteinModelPortaliQ91W92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91W92. 1 interaction.
STRINGi10090.ENSMUSP00000060930.

PTM databases

iPTMnetiQ91W92.
PhosphoSiteiQ91W92.

Proteomic databases

MaxQBiQ91W92.
PaxDbiQ91W92.
PeptideAtlasiQ91W92.
PRIDEiQ91W92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi104445.
KEGGimmu:104445.
UCSCiuc007wrl.1. mouse.

Organism-specific databases

CTDi11135.
MGIiMGI:1929763. Cdc42ep1.

Phylogenomic databases

eggNOGiENOG410IGPN. Eukaryota.
ENOG4111PPX. LUCA.
HOGENOMiHOG000095252.
HOVERGENiHBG080906.
InParanoidiQ91W92.
PhylomeDBiQ91W92.
TreeFamiTF331725.

Miscellaneous databases

ChiTaRSiCdc42ep1. mouse.
PROiQ91W92.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049521.
CleanExiMM_CDC42EP1.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBORG5_MOUSE
AccessioniPrimary (citable) accession number: Q91W92
Secondary accession number(s): Q9D8M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.