Q91W90 (TXND5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin domain-containing protein 5

Alternative name(s):
Endoplasmic reticulum resident protein 46
Short name=ER protein 46
Short name=ERp46
Plasma cell-specific thioredoxin-related protein
Short name=PC-TRP
Thioredoxin-like protein p46

Gene names

Name:	Txndc5
Synonyms:	Tlp46

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast. Ref.1 Ref.2
Subcellular location	Endoplasmic reticulum lumen Ref.1.
Tissue specificity	Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level). Ref.2
Sequence similarities	Belongs to the protein disulfide isomerase family. Contains 3 thioredoxin domains.
Mass spectrometry	Molecular mass is 51200 Da from positions 34 - 417. Determined by MALDI. Ref.1

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Redox-active center Repeat Signal
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro isomerase activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 417	384	Thioredoxin domain-containing protein 5		PRO_0000034184
Regions
	Domain	35 – 155	121	Thioredoxin 1
	Domain	156 – 281	126	Thioredoxin 2
	Domain	289 – 417	129	Thioredoxin 3
	Motif	414 – 417	4	Prevents secretion from ER Potential
Amino acid modifications
	Disulfide bond	75 ↔ 78		Redox-active Potential
	Disulfide bond	203 ↔ 206		Redox-active Potential
	Disulfide bond	335 ↔ 338		Redox-active Potential
Experimental info
	Sequence conflict	171	1	P → L in AAP68841. Ref.2
	Sequence conflict	171	1	P → L in AAH16252. Ref.3
	Sequence conflict	280	1	L → Q in AAP68841. Ref.2
	Sequence conflict	280	1	L → Q in AAH16252. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q91W90 [UniParc]. Last modified April 11, 2003. Version 2. Checksum: 0F2811DA5F5804AA	FASTA	417	46,415
	10 20 30 40 50 60 MPPRPGRLLQ PLAGLPALAT LLLLLGARKG ARAQEVEADS GVEQDPHAKH LYTADMFTHG 70 80 90 100 110 120 IQSAAHFVMF FAPWCGHCQR LQPTWNDLGD KYNSMEDAKV YVAKVDCTAD SDVCSAQGVR 130 140 150 160 170 180 GYPTLKFFKP GQEAVKYQGP RDFETLENWM LQTLNEEPAT PEPEAEPPRA PELKQGLYEL 190 200 210 220 230 240 SANNFELHVS QGNHFIKFFA PWCGHCKALA PTWEQLALGL EHSETVKIGK VDCTQHYAVC 250 260 270 280 290 300 SEHQVRGYPT LLWFRDGKKV DQYKGKRDLE SLRDYVQSQL QGSEAAPETV EPSEAPVMAA 310 320 330 340 350 360 EPTGDKGTVL ALTEKSFEDT IAQGITFVKF YAPWCGHCKN LAPTWEELSK KEFPGLSDVT 370 380 390 400 410 IAEVDCTAER NVCSKYSVRG YPTLLLFRGG EKVGEHNGGR DLDSLHSFVL RQAKDEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins." Knoblach B., Keller B.O., Groenendyk J., Aldred S., Zheng J., Lemire B.D., Li L., Michalak M. Mol. Cell. Proteomics 2:1104-1119(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 316-329 AND 401-411, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY. Strain: BALB/c.
[2]	"Identification of a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells." Wrammert J., Kallberg E., Leanderson T. Eur. J. Immunol. 34:137-146(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: C57BL/6. Tissue: B-cell.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and FVB/N. Tissue: Brain, Colon and Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY548112 mRNA. Translation: AAS55652.1. AY243534 mRNA. Translation: AAP68841.1. BC016252 mRNA. Translation: AAH16252.2. BC024505 mRNA. Translation: AAH24505.1. BC046789 mRNA. Translation: AAH46789.3.
IPI	IPI00163011.
RefSeq	NP_663342.3. NM_145367.3.
UniGene	Mm.28622.
3D structure databases
ProteinModelPortal	Q91W90.
SMR	Q91W90. Positions 67-413.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000041839.
PTM databases
PhosphoSite	Q91W90.
2D gel databases
REPRODUCTION-2DPAGE	Q91W90.
Proteomic databases
PaxDb	Q91W90.
PRIDE	Q91W90.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000035988; ENSMUSP00000041839; ENSMUSG00000038991. ENSMUST00000162075; ENSMUSP00000124516; ENSMUSG00000038991.
GeneID	105245.
KEGG	mmu:105245.
Organism-specific databases
CTD	81567.
MGI	MGI:2145316. Txndc5.
Phylogenomic databases
eggNOG	COG0526.
GeneTree	ENSGT00700000104218.
HOGENOM	HOG000007899.
HOVERGEN	HBG058611.
InParanoid	Q91W90.
KO	K13984.
OMA	SNFELHV.
OrthoDB	EOG40K804.
Gene expression databases
ArrayExpress	Q91W90.
Bgee	Q91W90.
CleanEx	MM_TXNDC5.
Genevestigator	Q91W90.
GermOnline	ENSMUSG00000038991. Mus musculus.
Family and domain databases
Gene3D	3.40.30.10. 3 hits.
InterPro	IPR005788. Disulphide_isomerase. IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. [Graphical view]
Pfam	PF00085. Thioredoxin. 3 hits. [Graphical view]
PRINTS	PR00421. THIOREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 3 hits.
TIGRFAMs	TIGR01126. pdi_dom. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 3 hits. PS51352. THIOREDOXIN_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	357552.
SOURCE	Search...

Entry information

Entry name

TXND5_MOUSE

Accession

Primary (citable) accession number: Q91W90
Secondary accession number(s): Q8R1I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	April 11, 2003
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program