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Protein

Thioredoxin domain-containing protein 5

Gene

Txndc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.2 Publications

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: GO_Central

GO - Biological processi

  1. apoptotic cell clearance Source: GO_Central
  2. cell redox homeostasis Source: InterPro
  3. protein folding Source: GO_Central
  4. response to endoplasmic reticulum stress Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_231722. Lysosome Vesicle Biogenesis.
REACT_232671. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 5
Alternative name(s):
Endoplasmic reticulum resident protein 46
Short name:
ER protein 46
Short name:
ERp46
Plasma cell-specific thioredoxin-related protein
Short name:
PC-TRP
Thioredoxin-like protein p46
Gene namesi
Name:Txndc5
Synonyms:Tlp46
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:2145316. Txndc5.

Subcellular locationi

Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 417384Thioredoxin domain-containing protein 5PRO_0000034184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 78Redox-activePROSITE-ProRule annotation
Disulfide bondi203 ↔ 206Redox-activePROSITE-ProRule annotation
Disulfide bondi335 ↔ 338Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ91W90.
PaxDbiQ91W90.
PRIDEiQ91W90.

2D gel databases

REPRODUCTION-2DPAGEQ91W90.

PTM databases

PhosphoSiteiQ91W90.

Expressioni

Tissue specificityi

Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level).1 Publication

Gene expression databases

BgeeiQ91W90.
CleanExiMM_TXNDC5.
ExpressionAtlasiQ91W90. baseline and differential.
GenevestigatoriQ91W90.

Interactioni

Protein-protein interaction databases

BioGridi222795. 1 interaction.
IntActiQ91W90. 4 interactions.
MINTiMINT-4138849.
STRINGi10090.ENSMUSP00000041839.

Structurei

3D structure databases

ProteinModelPortaliQ91W90.
SMRiQ91W90. Positions 48-156, 176-281, 308-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 155121Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 281126Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 417129Thioredoxin 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi414 – 4174Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 3 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00730000110455.
HOGENOMiHOG000007899.
HOVERGENiHBG058611.
InParanoidiQ91W90.
KOiK13984.
OMAiCTQHYEV.
OrthoDBiEOG75F4DK.
PhylomeDBiQ91W90.
TreeFamiTF106379.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W90-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPRPGRLLQ PLAGLPALAT LLLLLGARKG ARAQEVEADS GVEQDPHAKH
60 70 80 90 100
LYTADMFTHG IQSAAHFVMF FAPWCGHCQR LQPTWNDLGD KYNSMEDAKV
110 120 130 140 150
YVAKVDCTAD SDVCSAQGVR GYPTLKFFKP GQEAVKYQGP RDFETLENWM
160 170 180 190 200
LQTLNEEPAT PEPEAEPPRA PELKQGLYEL SANNFELHVS QGNHFIKFFA
210 220 230 240 250
PWCGHCKALA PTWEQLALGL EHSETVKIGK VDCTQHYAVC SEHQVRGYPT
260 270 280 290 300
LLWFRDGKKV DQYKGKRDLE SLRDYVQSQL QGSEAAPETV EPSEAPVMAA
310 320 330 340 350
EPTGDKGTVL ALTEKSFEDT IAQGITFVKF YAPWCGHCKN LAPTWEELSK
360 370 380 390 400
KEFPGLSDVT IAEVDCTAER NVCSKYSVRG YPTLLLFRGG EKVGEHNGGR
410
DLDSLHSFVL RQAKDEL
Length:417
Mass (Da):46,415
Last modified:April 11, 2003 - v2
Checksum:i0F2811DA5F5804AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711P → L in AAP68841. (PubMed:14971039)Curated
Sequence conflicti171 – 1711P → L in AAH16252. (PubMed:15489334)Curated
Sequence conflicti280 – 2801L → Q in AAP68841. (PubMed:14971039)Curated
Sequence conflicti280 – 2801L → Q in AAH16252. (PubMed:15489334)Curated

Mass spectrometryi

Molecular mass is 51200 Da from positions 34 - 417. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548112 mRNA. Translation: AAS55652.1.
AY243534 mRNA. Translation: AAP68841.1.
BC016252 mRNA. Translation: AAH16252.2.
BC024505 mRNA. Translation: AAH24505.1.
BC046789 mRNA. Translation: AAH46789.3.
CCDSiCCDS26463.1.
RefSeqiNP_001276527.1. NM_001289598.1.
NP_001276528.1. NM_001289599.1.
NP_663342.3. NM_145367.4.
UniGeneiMm.28622.

Genome annotation databases

EnsembliENSMUST00000035988; ENSMUSP00000041839; ENSMUSG00000038991.
ENSMUST00000162075; ENSMUSP00000124516; ENSMUSG00000038991.
GeneIDi105245.
KEGGimmu:105245.
UCSCiuc007qdq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548112 mRNA. Translation: AAS55652.1.
AY243534 mRNA. Translation: AAP68841.1.
BC016252 mRNA. Translation: AAH16252.2.
BC024505 mRNA. Translation: AAH24505.1.
BC046789 mRNA. Translation: AAH46789.3.
CCDSiCCDS26463.1.
RefSeqiNP_001276527.1. NM_001289598.1.
NP_001276528.1. NM_001289599.1.
NP_663342.3. NM_145367.4.
UniGeneiMm.28622.

3D structure databases

ProteinModelPortaliQ91W90.
SMRiQ91W90. Positions 48-156, 176-281, 308-413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222795. 1 interaction.
IntActiQ91W90. 4 interactions.
MINTiMINT-4138849.
STRINGi10090.ENSMUSP00000041839.

PTM databases

PhosphoSiteiQ91W90.

2D gel databases

REPRODUCTION-2DPAGEQ91W90.

Proteomic databases

MaxQBiQ91W90.
PaxDbiQ91W90.
PRIDEiQ91W90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035988; ENSMUSP00000041839; ENSMUSG00000038991.
ENSMUST00000162075; ENSMUSP00000124516; ENSMUSG00000038991.
GeneIDi105245.
KEGGimmu:105245.
UCSCiuc007qdq.1. mouse.

Organism-specific databases

CTDi81567.
MGIiMGI:2145316. Txndc5.

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00730000110455.
HOGENOMiHOG000007899.
HOVERGENiHBG058611.
InParanoidiQ91W90.
KOiK13984.
OMAiCTQHYEV.
OrthoDBiEOG75F4DK.
PhylomeDBiQ91W90.
TreeFamiTF106379.

Enzyme and pathway databases

ReactomeiREACT_231722. Lysosome Vesicle Biogenesis.
REACT_232671. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSiTxndc5. mouse.
NextBioi357552.
PROiQ91W90.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W90.
CleanExiMM_TXNDC5.
ExpressionAtlasiQ91W90. baseline and differential.
GenevestigatoriQ91W90.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins."
    Knoblach B., Keller B.O., Groenendyk J., Aldred S., Zheng J., Lemire B.D., Li L., Michalak M.
    Mol. Cell. Proteomics 2:1104-1119(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 316-329 AND 401-411, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
    Strain: BALB/c.
  2. "Identification of a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells."
    Wrammert J., Kallberg E., Leanderson T.
    Eur. J. Immunol. 34:137-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: B-cell.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain, Colon and Salivary gland.

Entry informationi

Entry nameiTXND5_MOUSE
AccessioniPrimary (citable) accession number: Q91W90
Secondary accession number(s): Q8R1I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: February 4, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.