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Q91W90 (TXND5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin domain-containing protein 5
Alternative name(s):
Endoplasmic reticulum resident protein 46
Short name=ER protein 46
Short name=ERp46
Plasma cell-specific thioredoxin-related protein
Short name=PC-TRP
Thioredoxin-like protein p46
Gene names
Name:Txndc5
Synonyms:Tlp46
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast. Ref.1 Ref.2

Subcellular location

Endoplasmic reticulum lumen Ref.1.

Tissue specificity

Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level). Ref.2

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 3 thioredoxin domains.

Mass spectrometry

Molecular mass is 51200 Da from positions 34 - 417. Determined by MALDI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 417384Thioredoxin domain-containing protein 5
PRO_0000034184

Regions

Domain35 – 155121Thioredoxin 1
Domain156 – 281126Thioredoxin 2
Domain289 – 417129Thioredoxin 3
Motif414 – 4174Prevents secretion from ER Potential

Amino acid modifications

Disulfide bond75 ↔ 78Redox-active Potential
Disulfide bond203 ↔ 206Redox-active Potential
Disulfide bond335 ↔ 338Redox-active Potential

Experimental info

Sequence conflict1711P → L in AAP68841. Ref.2
Sequence conflict1711P → L in AAH16252. Ref.3
Sequence conflict2801L → Q in AAP68841. Ref.2
Sequence conflict2801L → Q in AAH16252. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q91W90 [UniParc].

Last modified April 11, 2003. Version 2.
Checksum: 0F2811DA5F5804AA

FASTA41746,415
        10         20         30         40         50         60 
MPPRPGRLLQ PLAGLPALAT LLLLLGARKG ARAQEVEADS GVEQDPHAKH LYTADMFTHG 

        70         80         90        100        110        120 
IQSAAHFVMF FAPWCGHCQR LQPTWNDLGD KYNSMEDAKV YVAKVDCTAD SDVCSAQGVR 

       130        140        150        160        170        180 
GYPTLKFFKP GQEAVKYQGP RDFETLENWM LQTLNEEPAT PEPEAEPPRA PELKQGLYEL 

       190        200        210        220        230        240 
SANNFELHVS QGNHFIKFFA PWCGHCKALA PTWEQLALGL EHSETVKIGK VDCTQHYAVC 

       250        260        270        280        290        300 
SEHQVRGYPT LLWFRDGKKV DQYKGKRDLE SLRDYVQSQL QGSEAAPETV EPSEAPVMAA 

       310        320        330        340        350        360 
EPTGDKGTVL ALTEKSFEDT IAQGITFVKF YAPWCGHCKN LAPTWEELSK KEFPGLSDVT 

       370        380        390        400        410 
IAEVDCTAER NVCSKYSVRG YPTLLLFRGG EKVGEHNGGR DLDSLHSFVL RQAKDEL 

« Hide

References

« Hide 'large scale' references
[1]"ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins."
Knoblach B., Keller B.O., Groenendyk J., Aldred S., Zheng J., Lemire B.D., Li L., Michalak M.
Mol. Cell. Proteomics 2:1104-1119(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 316-329 AND 401-411, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
Strain: BALB/c.
[2]"Identification of a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells."
Wrammert J., Kallberg E., Leanderson T.
Eur. J. Immunol. 34:137-146(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: B-cell.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Brain, Colon and Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY548112 mRNA. Translation: AAS55652.1.
AY243534 mRNA. Translation: AAP68841.1.
BC016252 mRNA. Translation: AAH16252.2.
BC024505 mRNA. Translation: AAH24505.1.
BC046789 mRNA. Translation: AAH46789.3.
CCDSCCDS26463.1.
RefSeqNP_001276527.1. NM_001289598.1.
NP_001276528.1. NM_001289599.1.
NP_663342.3. NM_145367.4.
UniGeneMm.28622.

3D structure databases

ProteinModelPortalQ91W90.
SMRQ91W90. Positions 67-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid222795. 1 interaction.
IntActQ91W90. 4 interactions.
MINTMINT-4138849.
STRING10090.ENSMUSP00000041839.

PTM databases

PhosphoSiteQ91W90.

2D gel databases

REPRODUCTION-2DPAGEQ91W90.

Proteomic databases

MaxQBQ91W90.
PaxDbQ91W90.
PRIDEQ91W90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035988; ENSMUSP00000041839; ENSMUSG00000038991.
ENSMUST00000162075; ENSMUSP00000124516; ENSMUSG00000038991.
GeneID105245.
KEGGmmu:105245.
UCSCuc007qdq.1. mouse.

Organism-specific databases

CTD81567.
MGIMGI:2145316. Txndc5.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00730000110455.
HOGENOMHOG000007899.
HOVERGENHBG058611.
InParanoidQ91W90.
KOK13984.
OMAHFVKFFA.
OrthoDBEOG75F4DK.
PhylomeDBQ91W90.
TreeFamTF106379.

Gene expression databases

ArrayExpressQ91W90.
BgeeQ91W90.
CleanExMM_TXNDC5.
GenevestigatorQ91W90.

Family and domain databases

Gene3D3.40.30.10. 3 hits.
InterProIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMSSF52833. SSF52833. 3 hits.
TIGRFAMsTIGR01126. pdi_dom. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio357552.
PROQ91W90.
SOURCESearch...

Entry information

Entry nameTXND5_MOUSE
AccessionPrimary (citable) accession number: Q91W90
Secondary accession number(s): Q8R1I6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot