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Protein

Thioredoxin domain-containing protein 5

Gene

Txndc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.2 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 5
Alternative name(s):
Endoplasmic reticulum resident protein 46
Short name:
ER protein 46
Short name:
ERp46
Plasma cell-specific thioredoxin-related protein
Short name:
PC-TRP
Thioredoxin-like protein p46
Gene namesi
Name:Txndc5
Synonyms:Tlp46
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145316. Txndc5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000003418434 – 417Thioredoxin domain-containing protein 5Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 78Redox-activePROSITE-ProRule annotation
Disulfide bondi203 ↔ 206Redox-activePROSITE-ProRule annotation
Disulfide bondi335 ↔ 338Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ91W90.
MaxQBiQ91W90.
PaxDbiQ91W90.
PeptideAtlasiQ91W90.
PRIDEiQ91W90.

2D gel databases

REPRODUCTION-2DPAGEiQ91W90.

PTM databases

iPTMnetiQ91W90.
PhosphoSitePlusiQ91W90.
SwissPalmiQ91W90.

Expressioni

Tissue specificityi

Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000038991.
CleanExiMM_TXNDC5.
ExpressionAtlasiQ91W90. baseline and differential.
GenevisibleiQ91W90. MM.

Interactioni

Protein-protein interaction databases

BioGridi222795. 1 interactor.
IntActiQ91W90. 4 interactors.
MINTiMINT-4138849.
STRINGi10090.ENSMUSP00000041839.

Structurei

3D structure databases

ProteinModelPortaliQ91W90.
SMRiQ91W90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 155Thioredoxin 1PROSITE-ProRule annotationAdd BLAST121
Domaini156 – 281Thioredoxin 2PROSITE-ProRule annotationAdd BLAST126
Domaini289 – 417Thioredoxin 3PROSITE-ProRule annotationAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 417Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133723.
HOGENOMiHOG000007899.
HOVERGENiHBG058611.
InParanoidiQ91W90.
KOiK13984.
OMAiHFVKFFA.
OrthoDBiEOG091G08PT.
PhylomeDBiQ91W90.
TreeFamiTF106379.

Family and domain databases

InterProiView protein in InterPro
IPR005788. Disulphide_isomerase.
IPR036249. Thioredoxin-like_sf.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF00085. Thioredoxin. 3 hits.
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiView protein in PROSITE
PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRPGRLLQ PLAGLPALAT LLLLLGARKG ARAQEVEADS GVEQDPHAKH
60 70 80 90 100
LYTADMFTHG IQSAAHFVMF FAPWCGHCQR LQPTWNDLGD KYNSMEDAKV
110 120 130 140 150
YVAKVDCTAD SDVCSAQGVR GYPTLKFFKP GQEAVKYQGP RDFETLENWM
160 170 180 190 200
LQTLNEEPAT PEPEAEPPRA PELKQGLYEL SANNFELHVS QGNHFIKFFA
210 220 230 240 250
PWCGHCKALA PTWEQLALGL EHSETVKIGK VDCTQHYAVC SEHQVRGYPT
260 270 280 290 300
LLWFRDGKKV DQYKGKRDLE SLRDYVQSQL QGSEAAPETV EPSEAPVMAA
310 320 330 340 350
EPTGDKGTVL ALTEKSFEDT IAQGITFVKF YAPWCGHCKN LAPTWEELSK
360 370 380 390 400
KEFPGLSDVT IAEVDCTAER NVCSKYSVRG YPTLLLFRGG EKVGEHNGGR
410
DLDSLHSFVL RQAKDEL
Length:417
Mass (Da):46,415
Last modified:April 11, 2003 - v2
Checksum:i0F2811DA5F5804AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171P → L in AAP68841 (PubMed:14971039).Curated1
Sequence conflicti171P → L in AAH16252 (PubMed:15489334).Curated1
Sequence conflicti280L → Q in AAP68841 (PubMed:14971039).Curated1
Sequence conflicti280L → Q in AAH16252 (PubMed:15489334).Curated1

Mass spectrometryi

Molecular mass is 51200 Da from positions 34 - 417. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548112 mRNA. Translation: AAS55652.1.
AY243534 mRNA. Translation: AAP68841.1.
BC016252 mRNA. Translation: AAH16252.2.
BC024505 mRNA. Translation: AAH24505.1.
BC046789 mRNA. Translation: AAH46789.3.
CCDSiCCDS26463.1.
RefSeqiNP_001276527.1. NM_001289598.1.
NP_001276528.1. NM_001289599.1.
NP_663342.3. NM_145367.4.
UniGeneiMm.28622.

Genome annotation databases

EnsembliENSMUST00000035988; ENSMUSP00000041839; ENSMUSG00000038991.
GeneIDi105245.
KEGGimmu:105245.
UCSCiuc007qdq.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTXND5_MOUSE
AccessioniPrimary (citable) accession number: Q91W90
Secondary accession number(s): Q8R1I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: November 22, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families