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Q91W90

- TXND5_MOUSE

UniProt

Q91W90 - TXND5_MOUSE

Protein

Thioredoxin domain-containing protein 5

Gene

Txndc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.2 Publications

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. apoptotic cell clearance Source: RefGenome
    2. cell redox homeostasis Source: InterPro
    3. protein folding Source: RefGenome
    4. response to endoplasmic reticulum stress Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin domain-containing protein 5
    Alternative name(s):
    Endoplasmic reticulum resident protein 46
    Short name:
    ER protein 46
    Short name:
    ERp46
    Plasma cell-specific thioredoxin-related protein
    Short name:
    PC-TRP
    Thioredoxin-like protein p46
    Gene namesi
    Name:Txndc5
    Synonyms:Tlp46
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2145316. Txndc5.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 417384Thioredoxin domain-containing protein 5PRO_0000034184Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 78Redox-activePROSITE-ProRule annotation
    Disulfide bondi203 ↔ 206Redox-activePROSITE-ProRule annotation
    Disulfide bondi335 ↔ 338Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ91W90.
    PaxDbiQ91W90.
    PRIDEiQ91W90.

    2D gel databases

    REPRODUCTION-2DPAGEQ91W90.

    PTM databases

    PhosphoSiteiQ91W90.

    Expressioni

    Tissue specificityi

    Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ91W90.
    BgeeiQ91W90.
    CleanExiMM_TXNDC5.
    GenevestigatoriQ91W90.

    Interactioni

    Protein-protein interaction databases

    BioGridi222795. 1 interaction.
    IntActiQ91W90. 4 interactions.
    MINTiMINT-4138849.
    STRINGi10090.ENSMUSP00000041839.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W90.
    SMRiQ91W90. Positions 67-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 155121Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 281126Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini289 – 417129Thioredoxin 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi414 – 4174Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 3 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00730000110455.
    HOGENOMiHOG000007899.
    HOVERGENiHBG058611.
    InParanoidiQ91W90.
    KOiK13984.
    OMAiHFVKFFA.
    OrthoDBiEOG75F4DK.
    PhylomeDBiQ91W90.
    TreeFamiTF106379.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 3 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 3 hits.
    TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 3 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91W90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPRPGRLLQ PLAGLPALAT LLLLLGARKG ARAQEVEADS GVEQDPHAKH    50
    LYTADMFTHG IQSAAHFVMF FAPWCGHCQR LQPTWNDLGD KYNSMEDAKV 100
    YVAKVDCTAD SDVCSAQGVR GYPTLKFFKP GQEAVKYQGP RDFETLENWM 150
    LQTLNEEPAT PEPEAEPPRA PELKQGLYEL SANNFELHVS QGNHFIKFFA 200
    PWCGHCKALA PTWEQLALGL EHSETVKIGK VDCTQHYAVC SEHQVRGYPT 250
    LLWFRDGKKV DQYKGKRDLE SLRDYVQSQL QGSEAAPETV EPSEAPVMAA 300
    EPTGDKGTVL ALTEKSFEDT IAQGITFVKF YAPWCGHCKN LAPTWEELSK 350
    KEFPGLSDVT IAEVDCTAER NVCSKYSVRG YPTLLLFRGG EKVGEHNGGR 400
    DLDSLHSFVL RQAKDEL 417
    Length:417
    Mass (Da):46,415
    Last modified:April 11, 2003 - v2
    Checksum:i0F2811DA5F5804AA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711P → L in AAP68841. (PubMed:14971039)Curated
    Sequence conflicti171 – 1711P → L in AAH16252. (PubMed:15489334)Curated
    Sequence conflicti280 – 2801L → Q in AAP68841. (PubMed:14971039)Curated
    Sequence conflicti280 – 2801L → Q in AAH16252. (PubMed:15489334)Curated

    Mass spectrometryi

    Molecular mass is 51200 Da from positions 34 - 417. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548112 mRNA. Translation: AAS55652.1.
    AY243534 mRNA. Translation: AAP68841.1.
    BC016252 mRNA. Translation: AAH16252.2.
    BC024505 mRNA. Translation: AAH24505.1.
    BC046789 mRNA. Translation: AAH46789.3.
    CCDSiCCDS26463.1.
    RefSeqiNP_001276527.1. NM_001289598.1.
    NP_001276528.1. NM_001289599.1.
    NP_663342.3. NM_145367.4.
    UniGeneiMm.28622.

    Genome annotation databases

    EnsembliENSMUST00000035988; ENSMUSP00000041839; ENSMUSG00000038991.
    ENSMUST00000162075; ENSMUSP00000124516; ENSMUSG00000038991.
    GeneIDi105245.
    KEGGimmu:105245.
    UCSCiuc007qdq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548112 mRNA. Translation: AAS55652.1 .
    AY243534 mRNA. Translation: AAP68841.1 .
    BC016252 mRNA. Translation: AAH16252.2 .
    BC024505 mRNA. Translation: AAH24505.1 .
    BC046789 mRNA. Translation: AAH46789.3 .
    CCDSi CCDS26463.1.
    RefSeqi NP_001276527.1. NM_001289598.1.
    NP_001276528.1. NM_001289599.1.
    NP_663342.3. NM_145367.4.
    UniGenei Mm.28622.

    3D structure databases

    ProteinModelPortali Q91W90.
    SMRi Q91W90. Positions 67-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222795. 1 interaction.
    IntActi Q91W90. 4 interactions.
    MINTi MINT-4138849.
    STRINGi 10090.ENSMUSP00000041839.

    PTM databases

    PhosphoSitei Q91W90.

    2D gel databases

    REPRODUCTION-2DPAGE Q91W90.

    Proteomic databases

    MaxQBi Q91W90.
    PaxDbi Q91W90.
    PRIDEi Q91W90.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035988 ; ENSMUSP00000041839 ; ENSMUSG00000038991 .
    ENSMUST00000162075 ; ENSMUSP00000124516 ; ENSMUSG00000038991 .
    GeneIDi 105245.
    KEGGi mmu:105245.
    UCSCi uc007qdq.1. mouse.

    Organism-specific databases

    CTDi 81567.
    MGIi MGI:2145316. Txndc5.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00730000110455.
    HOGENOMi HOG000007899.
    HOVERGENi HBG058611.
    InParanoidi Q91W90.
    KOi K13984.
    OMAi HFVKFFA.
    OrthoDBi EOG75F4DK.
    PhylomeDBi Q91W90.
    TreeFami TF106379.

    Miscellaneous databases

    NextBioi 357552.
    PROi Q91W90.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91W90.
    Bgeei Q91W90.
    CleanExi MM_TXNDC5.
    Genevestigatori Q91W90.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 3 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 3 hits.
    TIGRFAMsi TIGR01126. pdi_dom. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 3 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins."
      Knoblach B., Keller B.O., Groenendyk J., Aldred S., Zheng J., Lemire B.D., Li L., Michalak M.
      Mol. Cell. Proteomics 2:1104-1119(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 316-329 AND 401-411, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
      Strain: BALB/c.
    2. "Identification of a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells."
      Wrammert J., Kallberg E., Leanderson T.
      Eur. J. Immunol. 34:137-146(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: B-cell.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain, Colon and Salivary gland.

    Entry informationi

    Entry nameiTXND5_MOUSE
    AccessioniPrimary (citable) accession number: Q91W90
    Secondary accession number(s): Q8R1I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3