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Protein

Alpha-mannosidase 2C1

Gene

Man2c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi259 – 2591ZincBy similarity
Metal bindingi261 – 2611ZincBy similarity
Active sitei371 – 3711NucleophileBy similarity
Metal bindingi371 – 3711ZincBy similarity
Metal bindingi576 – 5761ZincBy similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase 2C1 (EC:3.2.1.24)
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1
Gene namesi
Name:Man2c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920994. Man2c1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10391039Alpha-mannosidase 2C1PRO_0000206908Add
BLAST

Proteomic databases

MaxQBiQ91W89.
PaxDbiQ91W89.
PRIDEiQ91W89.

PTM databases

PhosphoSiteiQ91W89.

Expressioni

Gene expression databases

BgeeiQ91W89.
CleanExiMM_MAN2C1.
ExpressionAtlasiQ91W89. baseline and differential.
GenevestigatoriQ91W89.

Interactioni

Protein-protein interaction databases

IntActiQ91W89. 1 interaction.
MINTiMINT-4100968.

Structurei

3D structure databases

ProteinModelPortaliQ91W89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Phylogenomic databases

eggNOGiCOG0383.
GeneTreeiENSGT00390000006338.
HOGENOMiHOG000048425.
HOVERGENiHBG055567.
InParanoidiQ91W89.
KOiK01191.
OMAiKRSVTQH.
OrthoDBiEOG78M015.
PhylomeDBiQ91W89.
TreeFamiTF300335.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91W89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC SVTLSSFLTP
60 70 80 90 100
ERLPYEKAVQ QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGQEVHLCW
110 120 130 140 150
ESDGESLVWR DGEPVQGLTK EGEKTSYVLS ERLRASDPRS LTLYVEVACN
160 170 180 190 200
GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF HRDVHSLLVD LELLLGVAKG
210 220 230 240 250
LGEDSQRSFQ ALHTANQMVN ICDPAQPETY PAAKALASKF FGQHGGESQH
260 270 280 290 300
TIHAMGHCHI DTAWLWPFKE TVRKCARSWS TAVTLMEQNT DFIFACSQAQ
310 320 330 340 350
QLEWVKSQYP GLHARLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL
360 370 380 390 400
QGQNFFLQEF GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL
410 420 430 440 450
VNSFPHHTFF WEGLDGSRVL VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR
460 470 480 490 500
TNHSGFLFGF GDGGGGPTQT MLDRLKRLSN TDGLPRVQLS SPGQLFTALE
510 520 530 540 550
RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH DVEVLSSLAL
560 570 580 590 600
ARSAQFLYPA AQLQHLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS
610 620 630 640 650
HGNPLLSAAA AALCAGEPGP KGLLIINTLP WKRTEVLALP KPCGAHSLAL
660 670 680 690 700
VTVPSIGYAP APTPTSLQPL LPQQPVFVMQ ETDGSVTLDN GIIRVRLDPT
710 720 730 740 750
GCLTSLVLVA SGREAIAEGA LGNQFVLFDD VPLYWDAWDV MDYHLETRKP
760 770 780 790 800
VLGQAGTLAV GTEGGLRGSA WFLLQISPNS RLSQEVVLDV GCPYVRFHTE
810 820 830 840 850
VHWHEAHKFL KVEFPARIRS PQATYEIQFG HLQRPTHNNT SWDWARYEVW
860 870 880 890 900
AHRWIDLSEC DFGLALLNNC KYGASVRGNV LSLSLLRAPK APDATADMGR
910 920 930 940 950
HEFTYALMPH KGSFQEAGVI HAAYNLNFPL LALPAPGPAP DTTWSAFSVS
960 970 980 990 1000
SPAVVLETIK QAERCHQHRT LVLRLYEAHG SHVDCWLHTS LPVQEATLCD
1010 1020 1030
LLEQRDPTGH LSLQDNRLKL TFSPFQVRSL LLVLQSPPN
Length:1,039
Mass (Da):115,688
Last modified:December 1, 2001 - v1
Checksum:i308F2F841590F9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016253 mRNA. Translation: AAH16253.1.
CCDSiCCDS40646.1.
RefSeqiNP_082912.1. NM_028636.2.
UniGeneiMm.30110.
Mm.474792.

Genome annotation databases

EnsembliENSMUST00000160147; ENSMUSP00000125478; ENSMUSG00000032295.
GeneIDi73744.
KEGGimmu:73744.
UCSCiuc009pud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016253 mRNA. Translation: AAH16253.1.
CCDSiCCDS40646.1.
RefSeqiNP_082912.1. NM_028636.2.
UniGeneiMm.30110.
Mm.474792.

3D structure databases

ProteinModelPortaliQ91W89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91W89. 1 interaction.
MINTiMINT-4100968.

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

PTM databases

PhosphoSiteiQ91W89.

Proteomic databases

MaxQBiQ91W89.
PaxDbiQ91W89.
PRIDEiQ91W89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160147; ENSMUSP00000125478; ENSMUSG00000032295.
GeneIDi73744.
KEGGimmu:73744.
UCSCiuc009pud.1. mouse.

Organism-specific databases

CTDi4123.
MGIiMGI:1920994. Man2c1.

Phylogenomic databases

eggNOGiCOG0383.
GeneTreeiENSGT00390000006338.
HOGENOMiHOG000048425.
HOVERGENiHBG055567.
InParanoidiQ91W89.
KOiK01191.
OMAiKRSVTQH.
OrthoDBiEOG78M015.
PhylomeDBiQ91W89.
TreeFamiTF300335.

Miscellaneous databases

ChiTaRSiMan2c1. mouse.
NextBioi338957.
PROiQ91W89.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W89.
CleanExiMM_MAN2C1.
ExpressionAtlasiQ91W89. baseline and differential.
GenevestigatoriQ91W89.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiMA2C1_MOUSE
AccessioniPrimary (citable) accession number: Q91W89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.