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Q91W89

- MA2C1_MOUSE

UniProt

Q91W89 - MA2C1_MOUSE

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Protein

Alpha-mannosidase 2C1

Gene

Man2c1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi259 – 2591ZincBy similarity
Metal bindingi261 – 2611ZincBy similarity
Active sitei371 – 3711NucleophileBy similarity
Metal bindingi371 – 3711ZincBy similarity
Metal bindingi576 – 5761ZincBy similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase 2C1 (EC:3.2.1.24)
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1
Gene namesi
Name:Man2c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1920994. Man2c1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10391039Alpha-mannosidase 2C1PRO_0000206908Add
BLAST

Proteomic databases

MaxQBiQ91W89.
PaxDbiQ91W89.
PRIDEiQ91W89.

PTM databases

PhosphoSiteiQ91W89.

Expressioni

Gene expression databases

BgeeiQ91W89.
CleanExiMM_MAN2C1.
ExpressionAtlasiQ91W89. baseline and differential.
GenevestigatoriQ91W89.

Interactioni

Protein-protein interaction databases

IntActiQ91W89. 1 interaction.
MINTiMINT-4100968.

Structurei

3D structure databases

ProteinModelPortaliQ91W89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Phylogenomic databases

eggNOGiCOG0383.
GeneTreeiENSGT00390000006338.
HOGENOMiHOG000048425.
HOVERGENiHBG055567.
InParanoidiQ91W89.
KOiK01191.
OMAiCHMAPSE.
OrthoDBiEOG78M015.
PhylomeDBiQ91W89.
TreeFamiTF300335.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91W89-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC SVTLSSFLTP
60 70 80 90 100
ERLPYEKAVQ QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGQEVHLCW
110 120 130 140 150
ESDGESLVWR DGEPVQGLTK EGEKTSYVLS ERLRASDPRS LTLYVEVACN
160 170 180 190 200
GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF HRDVHSLLVD LELLLGVAKG
210 220 230 240 250
LGEDSQRSFQ ALHTANQMVN ICDPAQPETY PAAKALASKF FGQHGGESQH
260 270 280 290 300
TIHAMGHCHI DTAWLWPFKE TVRKCARSWS TAVTLMEQNT DFIFACSQAQ
310 320 330 340 350
QLEWVKSQYP GLHARLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL
360 370 380 390 400
QGQNFFLQEF GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL
410 420 430 440 450
VNSFPHHTFF WEGLDGSRVL VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR
460 470 480 490 500
TNHSGFLFGF GDGGGGPTQT MLDRLKRLSN TDGLPRVQLS SPGQLFTALE
510 520 530 540 550
RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH DVEVLSSLAL
560 570 580 590 600
ARSAQFLYPA AQLQHLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS
610 620 630 640 650
HGNPLLSAAA AALCAGEPGP KGLLIINTLP WKRTEVLALP KPCGAHSLAL
660 670 680 690 700
VTVPSIGYAP APTPTSLQPL LPQQPVFVMQ ETDGSVTLDN GIIRVRLDPT
710 720 730 740 750
GCLTSLVLVA SGREAIAEGA LGNQFVLFDD VPLYWDAWDV MDYHLETRKP
760 770 780 790 800
VLGQAGTLAV GTEGGLRGSA WFLLQISPNS RLSQEVVLDV GCPYVRFHTE
810 820 830 840 850
VHWHEAHKFL KVEFPARIRS PQATYEIQFG HLQRPTHNNT SWDWARYEVW
860 870 880 890 900
AHRWIDLSEC DFGLALLNNC KYGASVRGNV LSLSLLRAPK APDATADMGR
910 920 930 940 950
HEFTYALMPH KGSFQEAGVI HAAYNLNFPL LALPAPGPAP DTTWSAFSVS
960 970 980 990 1000
SPAVVLETIK QAERCHQHRT LVLRLYEAHG SHVDCWLHTS LPVQEATLCD
1010 1020 1030
LLEQRDPTGH LSLQDNRLKL TFSPFQVRSL LLVLQSPPN
Length:1,039
Mass (Da):115,688
Last modified:December 1, 2001 - v1
Checksum:i308F2F841590F9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016253 mRNA. Translation: AAH16253.1.
CCDSiCCDS40646.1.
RefSeqiNP_082912.1. NM_028636.2.
UniGeneiMm.30110.
Mm.474792.

Genome annotation databases

EnsembliENSMUST00000160147; ENSMUSP00000125478; ENSMUSG00000032295.
GeneIDi73744.
KEGGimmu:73744.
UCSCiuc009pud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016253 mRNA. Translation: AAH16253.1 .
CCDSi CCDS40646.1.
RefSeqi NP_082912.1. NM_028636.2.
UniGenei Mm.30110.
Mm.474792.

3D structure databases

ProteinModelPortali Q91W89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91W89. 1 interaction.
MINTi MINT-4100968.

Protein family/group databases

CAZyi GH38. Glycoside Hydrolase Family 38.

PTM databases

PhosphoSitei Q91W89.

Proteomic databases

MaxQBi Q91W89.
PaxDbi Q91W89.
PRIDEi Q91W89.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000160147 ; ENSMUSP00000125478 ; ENSMUSG00000032295 .
GeneIDi 73744.
KEGGi mmu:73744.
UCSCi uc009pud.1. mouse.

Organism-specific databases

CTDi 4123.
MGIi MGI:1920994. Man2c1.

Phylogenomic databases

eggNOGi COG0383.
GeneTreei ENSGT00390000006338.
HOGENOMi HOG000048425.
HOVERGENi HBG055567.
InParanoidi Q91W89.
KOi K01191.
OMAi CHMAPSE.
OrthoDBi EOG78M015.
PhylomeDBi Q91W89.
TreeFami TF300335.

Miscellaneous databases

ChiTaRSi Man2c1. mouse.
NextBioi 338957.
PROi Q91W89.
SOURCEi Search...

Gene expression databases

Bgeei Q91W89.
CleanExi MM_MAN2C1.
ExpressionAtlasi Q91W89. baseline and differential.
Genevestigatori Q91W89.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiMA2C1_MOUSE
AccessioniPrimary (citable) accession number: Q91W89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3