Alpha-mannosidase 2C1 - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Alpha-mannosidase 2C1
EC=3.2.1.24

Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1

Gene names

Name:

Man2c1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1039 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 38 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Glycosidase Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mannose metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	alpha-mannosidase activity Inferred from electronic annotation. Source: EC carbohydrate binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1039

1039

Alpha-mannosidase 2C1

PRO_0000206908

Sites

Active site

371

1

Nucleophile By similarity

Metal binding

259

1

Zinc By similarity

Metal binding

261

1

Zinc By similarity

Metal binding

371

1

Zinc By similarity

Metal binding

576

1

Zinc By similarity

Amino acid modifications

Modified residue

479

1

Phosphoserine Ref.2

Modified residue

481

1

Phosphothreonine Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q91W89 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 308F2F841590F9E8
Show »

FASTA

1,039

115,688

        10         20         30         40         50         60 
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC SVTLSSFLTP ERLPYEKAVQ 

        70         80         90        100        110        120 
QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGQEVHLCW ESDGESLVWR DGEPVQGLTK 

       130        140        150        160        170        180 
EGEKTSYVLS ERLRASDPRS LTLYVEVACN GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF 

       190        200        210        220        230        240 
HRDVHSLLVD LELLLGVAKG LGEDSQRSFQ ALHTANQMVN ICDPAQPETY PAAKALASKF 

       250        260        270        280        290        300 
FGQHGGESQH TIHAMGHCHI DTAWLWPFKE TVRKCARSWS TAVTLMEQNT DFIFACSQAQ 

       310        320        330        340        350        360 
QLEWVKSQYP GLHARLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL QGQNFFLQEF 

       370        380        390        400        410        420 
GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL VNSFPHHTFF WEGLDGSRVL 

       430        440        450        460        470        480 
VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR TNHSGFLFGF GDGGGGPTQT MLDRLKRLSN 

       490        500        510        520        530        540 
TDGLPRVQLS SPGQLFTALE RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH 

       550        560        570        580        590        600 
DVEVLSSLAL ARSAQFLYPA AQLQHLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS 

       610        620        630        640        650        660 
HGNPLLSAAA AALCAGEPGP KGLLIINTLP WKRTEVLALP KPCGAHSLAL VTVPSIGYAP 

       670        680        690        700        710        720 
APTPTSLQPL LPQQPVFVMQ ETDGSVTLDN GIIRVRLDPT GCLTSLVLVA SGREAIAEGA 

       730        740        750        760        770        780 
LGNQFVLFDD VPLYWDAWDV MDYHLETRKP VLGQAGTLAV GTEGGLRGSA WFLLQISPNS 

       790        800        810        820        830        840 
RLSQEVVLDV GCPYVRFHTE VHWHEAHKFL KVEFPARIRS PQATYEIQFG HLQRPTHNNT 

       850        860        870        880        890        900 
SWDWARYEVW AHRWIDLSEC DFGLALLNNC KYGASVRGNV LSLSLLRAPK APDATADMGR 

       910        920        930        940        950        960 
HEFTYALMPH KGSFQEAGVI HAAYNLNFPL LALPAPGPAP DTTWSAFSVS SPAVVLETIK 

       970        980        990       1000       1010       1020 
QAERCHQHRT LVLRLYEAHG SHVDCWLHTS LPVQEATLCD LLEQRDPTGH LSLQDNRLKL 

      1030 
TFSPFQVRSL LLVLQSPPN

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References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Salivary gland.
[2]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479 AND THR-481, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC016253 mRNA. Translation: AAH16253.1.
IPI	IPI00127450.
RefSeq	NP_082912.1. NM_028636.2.
UniGene	Mm.30110. Mm.474792.
3D structure databases
ProteinModelPortal	Q91W89.
ModBase	Search...
Protein family/group databases
CAZy	GH38. Glycoside Hydrolase Family 38.
PTM databases
PhosphoSite	Q91W89.
Proteomic databases
PaxDb	Q91W89.
PRIDE	Q91W89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000160147; ENSMUSP00000125478; ENSMUSG00000032295.
GeneID	73744.
KEGG	mmu:73744.
Organism-specific databases
CTD	4123.
MGI	MGI:1920994. Man2c1.
Phylogenomic databases
eggNOG	COG0383.
GeneTree	ENSGT00390000006338.
HOGENOM	HOG000048425.
HOVERGEN	HBG055567.
InParanoid	Q91W89.
KO	K01191.
OMA	DPEKMFQ.
OrthoDB	EOG4CNQQB.
Gene expression databases
ArrayExpress	Q91W89.
Bgee	Q91W89.
CleanEx	MM_MAN2C1.
Genevestigator	Q91W89.
GermOnline	ENSMUSG00000032295. Mus musculus.
Family and domain databases
Gene3D	3.20.110.10. 1 hit.
InterPro	IPR011013. Gal_mutarotase_SF_dom. IPR011330. Glyco_hydro/deAcase_b/a-brl. IPR027291. Glyco_hydro_38/57_N. IPR011682. Glyco_hydro_38_C. IPR015341. Glyco_hydro_38_cen_dom. IPR000602. Glyco_hydro_38_N. [Graphical view]
Pfam	PF09261. Alpha-mann_mid. 1 hit. PF01074. Glyco_hydro_38. 1 hit. PF07748. Glyco_hydro_38C. 1 hit. [Graphical view]
SMART	SM00872. Alpha-mann_mid. 1 hit. [Graphical view]
SUPFAM	SSF74650. Gal_mut_like. 1 hit. SSF88713. Glyco_hydro/deAcase_b/a-brl. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MAN2C1. mouse.
NextBio	338957.
SOURCE	Search...

Entry information

Entry name

MA2C1_MOUSE

Accession

Primary (citable) accession number: Q91W89

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents