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Q91W89

- MA2C1_MOUSE

UniProt

Q91W89 - MA2C1_MOUSE

Protein

Alpha-mannosidase 2C1

Gene

Man2c1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi259 – 2591ZincBy similarity
    Metal bindingi261 – 2611ZincBy similarity
    Active sitei371 – 3711NucleophileBy similarity
    Metal bindingi371 – 3711ZincBy similarity
    Metal bindingi576 – 5761ZincBy similarity

    GO - Molecular functioni

    1. alpha-mannosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. mannose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    CAZyiGH38. Glycoside Hydrolase Family 38.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-mannosidase 2C1 (EC:3.2.1.24)
    Alternative name(s):
    Alpha-D-mannoside mannohydrolase
    Mannosidase alpha class 2C member 1
    Gene namesi
    Name:Man2c1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1920994. Man2c1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10391039Alpha-mannosidase 2C1PRO_0000206908Add
    BLAST

    Proteomic databases

    MaxQBiQ91W89.
    PaxDbiQ91W89.
    PRIDEiQ91W89.

    PTM databases

    PhosphoSiteiQ91W89.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91W89.
    BgeeiQ91W89.
    CleanExiMM_MAN2C1.
    GenevestigatoriQ91W89.

    Interactioni

    Protein-protein interaction databases

    IntActiQ91W89. 1 interaction.
    MINTiMINT-4100968.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 38 family.Curated

    Phylogenomic databases

    eggNOGiCOG0383.
    GeneTreeiENSGT00390000006338.
    HOGENOMiHOG000048425.
    HOVERGENiHBG055567.
    InParanoidiQ91W89.
    KOiK01191.
    OMAiCHMAPSE.
    OrthoDBiEOG78M015.
    PhylomeDBiQ91W89.
    TreeFamiTF300335.

    Family and domain databases

    Gene3Di1.20.1270.50. 1 hit.
    3.20.110.10. 1 hit.
    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view]
    PfamiPF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view]
    SMARTiSM00872. Alpha-mann_mid. 1 hit.
    [Graphical view]
    SUPFAMiSSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91W89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC SVTLSSFLTP     50
    ERLPYEKAVQ QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGQEVHLCW 100
    ESDGESLVWR DGEPVQGLTK EGEKTSYVLS ERLRASDPRS LTLYVEVACN 150
    GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF HRDVHSLLVD LELLLGVAKG 200
    LGEDSQRSFQ ALHTANQMVN ICDPAQPETY PAAKALASKF FGQHGGESQH 250
    TIHAMGHCHI DTAWLWPFKE TVRKCARSWS TAVTLMEQNT DFIFACSQAQ 300
    QLEWVKSQYP GLHARLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL 350
    QGQNFFLQEF GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL 400
    VNSFPHHTFF WEGLDGSRVL VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR 450
    TNHSGFLFGF GDGGGGPTQT MLDRLKRLSN TDGLPRVQLS SPGQLFTALE 500
    RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH DVEVLSSLAL 550
    ARSAQFLYPA AQLQHLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS 600
    HGNPLLSAAA AALCAGEPGP KGLLIINTLP WKRTEVLALP KPCGAHSLAL 650
    VTVPSIGYAP APTPTSLQPL LPQQPVFVMQ ETDGSVTLDN GIIRVRLDPT 700
    GCLTSLVLVA SGREAIAEGA LGNQFVLFDD VPLYWDAWDV MDYHLETRKP 750
    VLGQAGTLAV GTEGGLRGSA WFLLQISPNS RLSQEVVLDV GCPYVRFHTE 800
    VHWHEAHKFL KVEFPARIRS PQATYEIQFG HLQRPTHNNT SWDWARYEVW 850
    AHRWIDLSEC DFGLALLNNC KYGASVRGNV LSLSLLRAPK APDATADMGR 900
    HEFTYALMPH KGSFQEAGVI HAAYNLNFPL LALPAPGPAP DTTWSAFSVS 950
    SPAVVLETIK QAERCHQHRT LVLRLYEAHG SHVDCWLHTS LPVQEATLCD 1000
    LLEQRDPTGH LSLQDNRLKL TFSPFQVRSL LLVLQSPPN 1039
    Length:1,039
    Mass (Da):115,688
    Last modified:December 1, 2001 - v1
    Checksum:i308F2F841590F9E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016253 mRNA. Translation: AAH16253.1.
    CCDSiCCDS40646.1.
    RefSeqiNP_082912.1. NM_028636.2.
    UniGeneiMm.30110.
    Mm.474792.

    Genome annotation databases

    EnsembliENSMUST00000160147; ENSMUSP00000125478; ENSMUSG00000032295.
    GeneIDi73744.
    KEGGimmu:73744.
    UCSCiuc009pud.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016253 mRNA. Translation: AAH16253.1 .
    CCDSi CCDS40646.1.
    RefSeqi NP_082912.1. NM_028636.2.
    UniGenei Mm.30110.
    Mm.474792.

    3D structure databases

    ProteinModelPortali Q91W89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91W89. 1 interaction.
    MINTi MINT-4100968.

    Protein family/group databases

    CAZyi GH38. Glycoside Hydrolase Family 38.

    PTM databases

    PhosphoSitei Q91W89.

    Proteomic databases

    MaxQBi Q91W89.
    PaxDbi Q91W89.
    PRIDEi Q91W89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000160147 ; ENSMUSP00000125478 ; ENSMUSG00000032295 .
    GeneIDi 73744.
    KEGGi mmu:73744.
    UCSCi uc009pud.1. mouse.

    Organism-specific databases

    CTDi 4123.
    MGIi MGI:1920994. Man2c1.

    Phylogenomic databases

    eggNOGi COG0383.
    GeneTreei ENSGT00390000006338.
    HOGENOMi HOG000048425.
    HOVERGENi HBG055567.
    InParanoidi Q91W89.
    KOi K01191.
    OMAi CHMAPSE.
    OrthoDBi EOG78M015.
    PhylomeDBi Q91W89.
    TreeFami TF300335.

    Miscellaneous databases

    ChiTaRSi MAN2C1. mouse.
    NextBioi 338957.
    PROi Q91W89.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91W89.
    Bgeei Q91W89.
    CleanExi MM_MAN2C1.
    Genevestigatori Q91W89.

    Family and domain databases

    Gene3Di 1.20.1270.50. 1 hit.
    3.20.110.10. 1 hit.
    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view ]
    Pfami PF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view ]
    SMARTi SM00872. Alpha-mann_mid. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiMA2C1_MOUSE
    AccessioniPrimary (citable) accession number: Q91W89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3