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Q91W89 (MA2C1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-mannosidase 2C1

EC=3.2.1.24
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1
Gene names
Name:Man2c1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1039 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 38 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10391039Alpha-mannosidase 2C1
PRO_0000206908

Sites

Active site3711Nucleophile By similarity
Metal binding2591Zinc By similarity
Metal binding2611Zinc By similarity
Metal binding3711Zinc By similarity
Metal binding5761Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91W89 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 308F2F841590F9E8

FASTA1,039115,688
        10         20         30         40         50         60 
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC SVTLSSFLTP ERLPYEKAVQ 

        70         80         90        100        110        120 
QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGQEVHLCW ESDGESLVWR DGEPVQGLTK 

       130        140        150        160        170        180 
EGEKTSYVLS ERLRASDPRS LTLYVEVACN GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF 

       190        200        210        220        230        240 
HRDVHSLLVD LELLLGVAKG LGEDSQRSFQ ALHTANQMVN ICDPAQPETY PAAKALASKF 

       250        260        270        280        290        300 
FGQHGGESQH TIHAMGHCHI DTAWLWPFKE TVRKCARSWS TAVTLMEQNT DFIFACSQAQ 

       310        320        330        340        350        360 
QLEWVKSQYP GLHARLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL QGQNFFLQEF 

       370        380        390        400        410        420 
GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL VNSFPHHTFF WEGLDGSRVL 

       430        440        450        460        470        480 
VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR TNHSGFLFGF GDGGGGPTQT MLDRLKRLSN 

       490        500        510        520        530        540 
TDGLPRVQLS SPGQLFTALE RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH 

       550        560        570        580        590        600 
DVEVLSSLAL ARSAQFLYPA AQLQHLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS 

       610        620        630        640        650        660 
HGNPLLSAAA AALCAGEPGP KGLLIINTLP WKRTEVLALP KPCGAHSLAL VTVPSIGYAP 

       670        680        690        700        710        720 
APTPTSLQPL LPQQPVFVMQ ETDGSVTLDN GIIRVRLDPT GCLTSLVLVA SGREAIAEGA 

       730        740        750        760        770        780 
LGNQFVLFDD VPLYWDAWDV MDYHLETRKP VLGQAGTLAV GTEGGLRGSA WFLLQISPNS 

       790        800        810        820        830        840 
RLSQEVVLDV GCPYVRFHTE VHWHEAHKFL KVEFPARIRS PQATYEIQFG HLQRPTHNNT 

       850        860        870        880        890        900 
SWDWARYEVW AHRWIDLSEC DFGLALLNNC KYGASVRGNV LSLSLLRAPK APDATADMGR 

       910        920        930        940        950        960 
HEFTYALMPH KGSFQEAGVI HAAYNLNFPL LALPAPGPAP DTTWSAFSVS SPAVVLETIK 

       970        980        990       1000       1010       1020 
QAERCHQHRT LVLRLYEAHG SHVDCWLHTS LPVQEATLCD LLEQRDPTGH LSLQDNRLKL 

      1030 
TFSPFQVRSL LLVLQSPPN 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016253 mRNA. Translation: AAH16253.1.
CCDSCCDS40646.1.
RefSeqNP_082912.1. NM_028636.2.
UniGeneMm.30110.
Mm.474792.

3D structure databases

ProteinModelPortalQ91W89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91W89. 1 interaction.
MINTMINT-4100968.

Protein family/group databases

CAZyGH38. Glycoside Hydrolase Family 38.

PTM databases

PhosphoSiteQ91W89.

Proteomic databases

MaxQBQ91W89.
PaxDbQ91W89.
PRIDEQ91W89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000160147; ENSMUSP00000125478; ENSMUSG00000032295.
GeneID73744.
KEGGmmu:73744.
UCSCuc009pud.1. mouse.

Organism-specific databases

CTD4123.
MGIMGI:1920994. Man2c1.

Phylogenomic databases

eggNOGCOG0383.
GeneTreeENSGT00390000006338.
HOGENOMHOG000048425.
HOVERGENHBG055567.
InParanoidQ91W89.
KOK01191.
OMACHMAPSE.
OrthoDBEOG78M015.
PhylomeDBQ91W89.
TreeFamTF300335.

Gene expression databases

ArrayExpressQ91W89.
BgeeQ91W89.
CleanExMM_MAN2C1.
GenevestigatorQ91W89.

Family and domain databases

Gene3D1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMAN2C1. mouse.
NextBio338957.
PROQ91W89.
SOURCESearch...

Entry information

Entry nameMA2C1_MOUSE
AccessionPrimary (citable) accession number: Q91W89
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries