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Protein

Ubiquitin-conjugating enzyme E2 E2

Gene

Ube2e2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationBy similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 E2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme E2
Ubiquitin carrier protein E2
Ubiquitin-protein ligase E2
Gene namesi
Name:Ube2e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2384997 Ube2e2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000824732 – 201Ubiquitin-conjugating enzyme E2 E2Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91W82
MaxQBiQ91W82
PaxDbiQ91W82
PRIDEiQ91W82

PTM databases

iPTMnetiQ91W82
PhosphoSitePlusiQ91W82
SwissPalmiQ91W82

Expressioni

Gene expression databases

BgeeiENSMUSG00000058317
ExpressionAtlasiQ91W82 baseline and differential
GenevisibleiQ91W82 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075495

Structurei

3D structure databases

ProteinModelPortaliQ91W82
SMRiQ91W82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiQ91W82
KOiK20217
OMAiKFLFNQR
OrthoDBiEOG091G0GF8
PhylomeDBiQ91W82
TreeFamiTF101117

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA
60 70 80 90 100
AKLSTSAKRI QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE
110 120 130 140 150
GGVFFLDITF SPDYPFKPPK VTFRTRIYHC NINSQGVICL DILKDNWSPA
160 170 180 190 200
LTISKVLLSI CSLLTDCNPA DPLVGSIATQ YMTNRAEHDR MARQWTKRYA

T
Length:201
Mass (Da):22,241
Last modified:December 1, 2001 - v1
Checksum:i445D00BECA8CD83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016265 mRNA Translation: AAH16265.1
CCDSiCCDS26838.1
RefSeqiNP_659088.1, NM_144839.1
XP_006518076.1, XM_006518013.1
UniGeneiMm.23551

Genome annotation databases

EnsembliENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317
ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317
GeneIDi218793
KEGGimmu:218793
UCSCiuc007shv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiUB2E2_MOUSE
AccessioniPrimary (citable) accession number: Q91W82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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