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Q91W82

- UB2E2_MOUSE

UniProt

Q91W82 - UB2E2_MOUSE

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Protein
Ubiquitin-conjugating enzyme E2 E2
Gene
Ube2e2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination By similarity. Catalyzes the ISGylation of influenza A virus NS1 protein By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ISG15 ligase activity Source: Ensembl
  3. ubiquitin-protein transferase activity Source: Ensembl

GO - Biological processi

  1. ISG15-protein conjugation Source: Ensembl
  2. protein K11-linked ubiquitination Source: Ensembl
  3. protein K48-linked ubiquitination Source: Ensembl
  4. protein K63-linked ubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 E2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein E2
Ubiquitin-protein ligase E2
Gene namesi
Name:Ube2e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2384997. Ube2e2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 201200Ubiquitin-conjugating enzyme E2 E2
PRO_0000082473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei19 – 191Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ91W82.
PRIDEiQ91W82.

PTM databases

PhosphoSiteiQ91W82.

Expressioni

Gene expression databases

ArrayExpressiQ91W82.
BgeeiQ91W82.
GenevestigatoriQ91W82.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115738.

Structurei

3D structure databases

ProteinModelPortaliQ91W82.
SMRiQ91W82. Positions 54-201.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00690000102027.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiQ91W82.
KOiK06689.
OMAiCNINSHG.
PhylomeDBiQ91W82.
TreeFamiTF101117.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W82-1 [UniParc]FASTAAdd to Basket

« Hide

MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA    50
AKLSTSAKRI QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE 100
GGVFFLDITF SPDYPFKPPK VTFRTRIYHC NINSQGVICL DILKDNWSPA 150
LTISKVLLSI CSLLTDCNPA DPLVGSIATQ YMTNRAEHDR MARQWTKRYA 200
T 201
Length:201
Mass (Da):22,241
Last modified:December 1, 2001 - v1
Checksum:i445D00BECA8CD83F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC016265 mRNA. Translation: AAH16265.1.
CCDSiCCDS26838.1.
RefSeqiNP_659088.1. NM_144839.1.
XP_006518076.1. XM_006518013.1.
UniGeneiMm.23551.

Genome annotation databases

EnsembliENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317.
ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
GeneIDi218793.
KEGGimmu:218793.
UCSCiuc007shv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC016265 mRNA. Translation: AAH16265.1 .
CCDSi CCDS26838.1.
RefSeqi NP_659088.1. NM_144839.1.
XP_006518076.1. XM_006518013.1.
UniGenei Mm.23551.

3D structure databases

ProteinModelPortali Q91W82.
SMRi Q91W82. Positions 54-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000115738.

PTM databases

PhosphoSitei Q91W82.

Proteomic databases

PaxDbi Q91W82.
PRIDEi Q91W82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076133 ; ENSMUSP00000075495 ; ENSMUSG00000058317 .
ENSMUST00000150727 ; ENSMUSP00000115738 ; ENSMUSG00000058317 .
GeneIDi 218793.
KEGGi mmu:218793.
UCSCi uc007shv.1. mouse.

Organism-specific databases

CTDi 7325.
MGIi MGI:2384997. Ube2e2.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00690000102027.
HOGENOMi HOG000233455.
HOVERGENi HBG063308.
InParanoidi Q91W82.
KOi K06689.
OMAi CNINSHG.
PhylomeDBi Q91W82.
TreeFami TF101117.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 376413.
PROi Q91W82.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91W82.
Bgeei Q91W82.
Genevestigatori Q91W82.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiUB2E2_MOUSE
AccessioniPrimary (citable) accession number: Q91W82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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