Q91W82 (UB2E2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-conjugating enzyme E2 E2
EC=6.3.2.19

Alternative name(s):
Ubiquitin carrier protein E2
Ubiquitin-protein ligase E2

Gene names

Name:

Ube2e2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Ubiquitin-conjugating enzyme E2 E2		PRO_0000082473
Sites
	Active site	139	1	Glycyl thioester intermediate By similarity
Amino acid modifications
	Modified residue	19	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91W82 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 445D00BECA8CD83F	FASTA	201	22,241
	10 20 30 40 50 60 MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA AKLSTSAKRI 70 80 90 100 110 120 QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 130 140 150 160 170 180 VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ 190 200 YMTNRAEHDR MARQWTKRYA T

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC016265 mRNA. Translation: AAH16265.1.
IPI	IPI00127440.
RefSeq	NP_659088.1. NM_144839.1.
UniGene	Mm.23551.
3D structure databases
ProteinModelPortal	Q91W82.
SMR	Q91W82. Positions 54-201.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91W82.
PTM databases
PhosphoSite	Q91W82.
Proteomic databases
PRIDE	Q91W82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317. ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
GeneID	218793.
KEGG	mmu:218793.
UCSC	uc007shv.1. mouse.
Organism-specific databases
CTD	7325.
MGI	MGI:2384997. Ube2e2.
Phylogenomic databases
eggNOG	roNOG15669.
GeneTree	ENSGT00590000082778.
HOGENOM	HBG756483.
HOVERGEN	HBG063308.
InParanoid	Q91W82.
OMA	VIARLYL.
OrthoDB	EOG48SGV9.
PhylomeDB	Q91W82.
Gene expression databases
ArrayExpress	Q91W82.
Bgee	Q91W82.
Genevestigator	Q91W82.
GermOnline	ENSMUSG00000058317. Mus musculus.
Family and domain databases
InterPro	IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
KO	K06689.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	376413.
SOURCE	Search...

Entry information

Entry name

UB2E2_MOUSE

Accession

Primary (citable) accession number: Q91W82

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program