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Q91W82

- UB2E2_MOUSE

UniProt

Q91W82 - UB2E2_MOUSE

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Protein

Ubiquitin-conjugating enzyme E2 E2

Gene

Ube2e2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Catalyzes the ISGylation of influenza A virus NS1 protein (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ISG15 ligase activity Source: Ensembl
  3. ubiquitin-protein transferase activity Source: Ensembl

GO - Biological processi

  1. ISG15-protein conjugation Source: Ensembl
  2. protein K11-linked ubiquitination Source: Ensembl
  3. protein K48-linked ubiquitination Source: Ensembl
  4. protein K63-linked ubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 E2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein E2
Ubiquitin-protein ligase E2
Gene namesi
Name:Ube2e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2384997. Ube2e2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 201200Ubiquitin-conjugating enzyme E2 E2PRO_0000082473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei19 – 191PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91W82.
PaxDbiQ91W82.
PRIDEiQ91W82.

PTM databases

PhosphoSiteiQ91W82.

Expressioni

Gene expression databases

BgeeiQ91W82.
ExpressionAtlasiQ91W82. baseline and differential.
GenevestigatoriQ91W82.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115738.

Structurei

3D structure databases

ProteinModelPortaliQ91W82.
SMRiQ91W82. Positions 54-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiQ91W82.
KOiK06689.
OMAiCNINSHG.
PhylomeDBiQ91W82.
TreeFamiTF101117.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA
60 70 80 90 100
AKLSTSAKRI QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE
110 120 130 140 150
GGVFFLDITF SPDYPFKPPK VTFRTRIYHC NINSQGVICL DILKDNWSPA
160 170 180 190 200
LTISKVLLSI CSLLTDCNPA DPLVGSIATQ YMTNRAEHDR MARQWTKRYA

T
Length:201
Mass (Da):22,241
Last modified:December 1, 2001 - v1
Checksum:i445D00BECA8CD83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016265 mRNA. Translation: AAH16265.1.
CCDSiCCDS26838.1.
RefSeqiNP_659088.1. NM_144839.1.
XP_006518076.1. XM_006518013.1.
UniGeneiMm.23551.

Genome annotation databases

EnsembliENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317.
ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
GeneIDi218793.
KEGGimmu:218793.
UCSCiuc007shv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016265 mRNA. Translation: AAH16265.1 .
CCDSi CCDS26838.1.
RefSeqi NP_659088.1. NM_144839.1.
XP_006518076.1. XM_006518013.1.
UniGenei Mm.23551.

3D structure databases

ProteinModelPortali Q91W82.
SMRi Q91W82. Positions 54-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000115738.

PTM databases

PhosphoSitei Q91W82.

Proteomic databases

MaxQBi Q91W82.
PaxDbi Q91W82.
PRIDEi Q91W82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076133 ; ENSMUSP00000075495 ; ENSMUSG00000058317 .
ENSMUST00000150727 ; ENSMUSP00000115738 ; ENSMUSG00000058317 .
GeneIDi 218793.
KEGGi mmu:218793.
UCSCi uc007shv.1. mouse.

Organism-specific databases

CTDi 7325.
MGIi MGI:2384997. Ube2e2.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00760000119012.
HOGENOMi HOG000233455.
HOVERGENi HBG063308.
InParanoidi Q91W82.
KOi K06689.
OMAi CNINSHG.
PhylomeDBi Q91W82.
TreeFami TF101117.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 376413.
PROi Q91W82.
SOURCEi Search...

Gene expression databases

Bgeei Q91W82.
ExpressionAtlasi Q91W82. baseline and differential.
Genevestigatori Q91W82.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiUB2E2_MOUSE
AccessioniPrimary (citable) accession number: Q91W82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3