Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-conjugating enzyme E2 E2

Gene

Ube2e2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Catalyzes the ISGylation of influenza A virus NS1 protein (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 E2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein E2
Ubiquitin-protein ligase E2
Gene namesi
Name:Ube2e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2384997. Ube2e2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 201200Ubiquitin-conjugating enzyme E2 E2PRO_0000082473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei19 – 191PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91W82.
PaxDbiQ91W82.
PRIDEiQ91W82.

PTM databases

PhosphoSiteiQ91W82.

Expressioni

Gene expression databases

BgeeiQ91W82.
ExpressionAtlasiQ91W82. baseline and differential.
GenevisibleiQ91W82. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075495.

Structurei

3D structure databases

ProteinModelPortaliQ91W82.
SMRiQ91W82. Positions 54-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiQ91W82.
KOiK06689.
OMAiCNINSHG.
PhylomeDBiQ91W82.
TreeFamiTF101117.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA
60 70 80 90 100
AKLSTSAKRI QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE
110 120 130 140 150
GGVFFLDITF SPDYPFKPPK VTFRTRIYHC NINSQGVICL DILKDNWSPA
160 170 180 190 200
LTISKVLLSI CSLLTDCNPA DPLVGSIATQ YMTNRAEHDR MARQWTKRYA

T
Length:201
Mass (Da):22,241
Last modified:December 1, 2001 - v1
Checksum:i445D00BECA8CD83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016265 mRNA. Translation: AAH16265.1.
CCDSiCCDS26838.1.
RefSeqiNP_659088.1. NM_144839.1.
XP_006518076.1. XM_006518013.1.
UniGeneiMm.23551.

Genome annotation databases

EnsembliENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317.
ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
GeneIDi218793.
KEGGimmu:218793.
UCSCiuc007shv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016265 mRNA. Translation: AAH16265.1.
CCDSiCCDS26838.1.
RefSeqiNP_659088.1. NM_144839.1.
XP_006518076.1. XM_006518013.1.
UniGeneiMm.23551.

3D structure databases

ProteinModelPortaliQ91W82.
SMRiQ91W82. Positions 54-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075495.

PTM databases

PhosphoSiteiQ91W82.

Proteomic databases

MaxQBiQ91W82.
PaxDbiQ91W82.
PRIDEiQ91W82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317.
ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
GeneIDi218793.
KEGGimmu:218793.
UCSCiuc007shv.1. mouse.

Organism-specific databases

CTDi7325.
MGIiMGI:2384997. Ube2e2.

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiQ91W82.
KOiK06689.
OMAiCNINSHG.
PhylomeDBiQ91W82.
TreeFamiTF101117.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi376413.
PROiQ91W82.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W82.
ExpressionAtlasiQ91W82. baseline and differential.
GenevisibleiQ91W82. MM.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiUB2E2_MOUSE
AccessioniPrimary (citable) accession number: Q91W82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.