Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91W82

- UB2E2_MOUSE

UniProt

Q91W82 - UB2E2_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 E2

Gene

Ube2e2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination By similarity. Catalyzes the ISGylation of influenza A virus NS1 protein By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei139 – 1391Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ISG15 ligase activity Source: Ensembl
    3. ubiquitin-protein transferase activity Source: Ensembl

    GO - Biological processi

    1. ISG15-protein conjugation Source: Ensembl
    2. protein K11-linked ubiquitination Source: Ensembl
    3. protein K48-linked ubiquitination Source: Ensembl
    4. protein K63-linked ubiquitination Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 E2 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein E2
    Ubiquitin-protein ligase E2
    Gene namesi
    Name:Ube2e2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:2384997. Ube2e2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 201200Ubiquitin-conjugating enzyme E2 E2PRO_0000082473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei19 – 191PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ91W82.
    PRIDEiQ91W82.

    PTM databases

    PhosphoSiteiQ91W82.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91W82.
    BgeeiQ91W82.
    GenevestigatoriQ91W82.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000115738.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W82.
    SMRiQ91W82. Positions 54-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00690000102027.
    HOGENOMiHOG000233455.
    HOVERGENiHBG063308.
    InParanoidiQ91W82.
    KOiK06689.
    OMAiCNINSHG.
    PhylomeDBiQ91W82.
    TreeFamiTF101117.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91W82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA    50
    AKLSTSAKRI QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE 100
    GGVFFLDITF SPDYPFKPPK VTFRTRIYHC NINSQGVICL DILKDNWSPA 150
    LTISKVLLSI CSLLTDCNPA DPLVGSIATQ YMTNRAEHDR MARQWTKRYA 200
    T 201
    Length:201
    Mass (Da):22,241
    Last modified:December 1, 2001 - v1
    Checksum:i445D00BECA8CD83F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016265 mRNA. Translation: AAH16265.1.
    CCDSiCCDS26838.1.
    RefSeqiNP_659088.1. NM_144839.1.
    XP_006518076.1. XM_006518013.1.
    UniGeneiMm.23551.

    Genome annotation databases

    EnsembliENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317.
    ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
    GeneIDi218793.
    KEGGimmu:218793.
    UCSCiuc007shv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016265 mRNA. Translation: AAH16265.1 .
    CCDSi CCDS26838.1.
    RefSeqi NP_659088.1. NM_144839.1.
    XP_006518076.1. XM_006518013.1.
    UniGenei Mm.23551.

    3D structure databases

    ProteinModelPortali Q91W82.
    SMRi Q91W82. Positions 54-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000115738.

    PTM databases

    PhosphoSitei Q91W82.

    Proteomic databases

    PaxDbi Q91W82.
    PRIDEi Q91W82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076133 ; ENSMUSP00000075495 ; ENSMUSG00000058317 .
    ENSMUST00000150727 ; ENSMUSP00000115738 ; ENSMUSG00000058317 .
    GeneIDi 218793.
    KEGGi mmu:218793.
    UCSCi uc007shv.1. mouse.

    Organism-specific databases

    CTDi 7325.
    MGIi MGI:2384997. Ube2e2.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00690000102027.
    HOGENOMi HOG000233455.
    HOVERGENi HBG063308.
    InParanoidi Q91W82.
    KOi K06689.
    OMAi CNINSHG.
    PhylomeDBi Q91W82.
    TreeFami TF101117.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 376413.
    PROi Q91W82.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91W82.
    Bgeei Q91W82.
    Genevestigatori Q91W82.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiUB2E2_MOUSE
    AccessioniPrimary (citable) accession number: Q91W82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3