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Q91W82 (UB2E2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 E2

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein E2
Ubiquitin-protein ligase E2
Gene names
Name:Ube2e2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination By similarity. Catalyzes the ISGylation of influenza A virus NS1 protein By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 201200Ubiquitin-conjugating enzyme E2 E2
PRO_0000082473

Sites

Active site1391Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue191Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91W82 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 445D00BECA8CD83F

FASTA20122,241
        10         20         30         40         50         60 
MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA AKLSTSAKRI 

        70         80         90        100        110        120 
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 

       130        140        150        160        170        180 
VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ 

       190        200 
YMTNRAEHDR MARQWTKRYA T 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016265 mRNA. Translation: AAH16265.1.
CCDSCCDS26838.1.
RefSeqNP_659088.1. NM_144839.1.
XP_006518076.1. XM_006518013.1.
UniGeneMm.23551.

3D structure databases

ProteinModelPortalQ91W82.
SMRQ91W82. Positions 54-201.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000115738.

PTM databases

PhosphoSiteQ91W82.

Proteomic databases

PaxDbQ91W82.
PRIDEQ91W82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317.
ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
GeneID218793.
KEGGmmu:218793.
UCSCuc007shv.1. mouse.

Organism-specific databases

CTD7325.
MGIMGI:2384997. Ube2e2.

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00690000102027.
HOGENOMHOG000233455.
HOVERGENHBG063308.
InParanoidQ91W82.
KOK06689.
OMACNINSHG.
PhylomeDBQ91W82.
TreeFamTF101117.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ91W82.
BgeeQ91W82.
GenevestigatorQ91W82.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio376413.
PROQ91W82.
SOURCESearch...

Entry information

Entry nameUB2E2_MOUSE
AccessionPrimary (citable) accession number: Q91W82
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot