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Q91W82 (UB2E2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 E2

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein E2
Ubiquitin-protein ligase E2
Gene names
Name:Ube2e2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Ubiquitin-conjugating enzyme E2 E2
PRO_0000082473

Sites

Active site1391Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue191Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91W82 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 445D00BECA8CD83F

FASTA20122,241
        10         20         30         40         50         60 
MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA AKLSTSAKRI 

        70         80         90        100        110        120 
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 

       130        140        150        160        170        180 
VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ 

       190        200 
YMTNRAEHDR MARQWTKRYA T 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016265 mRNA. Translation: AAH16265.1.
IPIIPI00127440.
RefSeqNP_659088.1. NM_144839.1.
UniGeneMm.23551.

3D structure databases

ProteinModelPortalQ91W82.
SMRQ91W82. Positions 54-201.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ91W82.

PTM databases

PhosphoSiteQ91W82.

Proteomic databases

PRIDEQ91W82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076133; ENSMUSP00000075495; ENSMUSG00000058317.
ENSMUST00000150727; ENSMUSP00000115738; ENSMUSG00000058317.
GeneID218793.
KEGGmmu:218793.
UCSCuc007shv.1. mouse.

Organism-specific databases

CTD7325.
MGIMGI:2384997. Ube2e2.

Phylogenomic databases

eggNOGroNOG15669.
GeneTreeENSGT00590000082778.
HOGENOMHBG756483.
HOVERGENHBG063308.
InParanoidQ91W82.
OMAVIARLYL.
OrthoDBEOG48SGV9.
PhylomeDBQ91W82.

Gene expression databases

ArrayExpressQ91W82.
BgeeQ91W82.
GenevestigatorQ91W82.
GermOnlineENSMUSG00000058317. Mus musculus.

Family and domain databases

InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
KOK06689.
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio376413.
SOURCESearch...

Entry information

Entry nameUB2E2_MOUSE
AccessionPrimary (citable) accession number: Q91W82
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families