Reviewed, UniProtKB/Swiss-Prot Q91W64 (CP270_MOUSE)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2C70
    EC=1.14.14.1
Alternative name(s):
    CYPIIC70

Gene names

Name:	Cyp2c70
Synonyms:	Cyp2c-70, Cyp2c22

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity. UniProtKB P19225
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. UniProtKB P19225
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Cytochrome P450 2C70		PRO_0000051726
Sites
	Metal binding	434	1	Iron (heme axial ligand) By similarity UniProtKB P19225
Experimental info
	Sequence conflict	46	1	D → Y in AAP55509. Ref.1
	Sequence conflict	46	1	D → Y in AAH16494. Ref.2
	Sequence conflict	130	1	V → A in AAP55509. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q91W64-1 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 90973D9B05964B1B	FASTA	489	56,020
	10 20 30 40 50 60 MALFIFLGIW LSCFLFLFLW NQHRGRGKLP PGPTPLPIVG NILQVDVKNI SKSMGMLAKK 70 80 90 100 110 120 YGPVFTVYLG MKPTVVLHGY KAMKEALIDQ GDEFSDKTDS SLLSRTSQGL GIVFSNGETW 130 140 150 160 170 180 KQTRRFSLMV LRSMGMGKKT IEDRIQEEIL YMLDALRKTN GSPCDPSFLL ACVPCNVIST 190 200 210 220 230 240 VIFQHRFDYN DQTFQDFMEN FHRKIEILAS PWSQLCSAYP ILYYLPGIHN RFLKDVTQQK 250 260 270 280 290 300 KFILEEINRH QKSLDLSNPQ DFIDYFLIKM EKEKHNQKSE FTMDNLVVSI GDLFGAGTET 310 320 330 340 350 360 TSSTVKYGLL LLLKYPEVTA KIQEEIAHVI GRHRRPTMQD RNHMPYTDAV LHEIQRYIDF 370 380 390 400 410 420 VPIPSPRKTT QDVEFRGYHI PKGTSVMACL TSVLNDDKEF PNPEKFDPGH FLDEKGNFKK 430 440 450 460 470 480 SDYFVAFSAG RRACIGEGLA RMEMFLILTN ILQHFTLKPL VKPEDIDTKP VQTGLLHVPP PFELCFIPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, expression, and characterization of four novel mouse cytochrome P450 (CYP) genes (CYP2C65, CYP2C66, CYP2C53 and CYP2C70)." Zhao Y., Wang H., Goldstein J.A., Zeldin D.C. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY227736 mRNA. Translation: AAP55509.1. BC016494 mRNA. Translation: AAH16494.1. BC022151 mRNA. Translation: AAH22151.1. BC023894 mRNA. Translation: AAH23894.2. BC025822 mRNA. Translation: AAH25822.1. Different initiation. BC034831 mRNA. Translation: AAH34831.1.
IPI	IPI00269265.
RefSeq	NP_663474.1.
UniGene	Mm.29119
3D structure databases
HSSP	HSSP built from PDB template 1OG2 based on UniProtKB P11712.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91W64.
Proteomic databases
PRIDE	Q91W64.
Genome annotation databases
Ensembl	ENSMUST00000051846; ENSMUSP00000060584; ENSMUSG00000060613; Mus musculus. [Genome view]
GeneID	226105.
KEGG	mmu:226105.
UCSC	uc008hkj.1. mouse.
Organism-specific databases
CTD	226105.
MGI	MGI:2385878. Cyp2c70.
Phylogenomic databases
HOGENOM	Q91W64.
HOVERGEN	Q91W64.
OMA	EILASPW.
Enzyme and pathway databases
BRENDA	1.14.14.1. 244.
Gene expression databases
ArrayExpress	Q91W64.
Bgee	Q91W64.
Genevestigator	Q91W64.
GermOnline	ENSMUSG00000060613. Mus musculus.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	377994.
SOURCE	Search...

Entry information

Entry name

CP270_MOUSE

Accession

Primary (citable) accession number: Q91W64
Secondary accession number(s): Q5GLY9 , Q80VW0, Q8R120, Q8VC00

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	November 3, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)