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Protein

Cytochrome P450 2C70

Gene

Cyp2c70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi434Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Chemistry databases

SwissLipidsiSLP:000001666

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C70 (EC:1.14.14.1)
Alternative name(s):
CYPIIC70
Gene namesi
Name:Cyp2c70Imported
Synonyms:Cyp2c-70By similarity, Cyp2c22By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2385878 Cyp2c70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517261 – 489Cytochrome P450 2C70Add BLAST489

Proteomic databases

MaxQBiQ91W64
PaxDbiQ91W64
PeptideAtlasiQ91W64
PRIDEiQ91W64

PTM databases

iPTMnetiQ91W64
PhosphoSitePlusiQ91W64
SwissPalmiQ91W64

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiENSMUSG00000060613
ExpressionAtlasiQ91W64 baseline and differential
GenevisibleiQ91W64 MM

Interactioni

Protein-protein interaction databases

IntActiQ91W64, 2 interactors
MINTiQ91W64
STRINGi10090.ENSMUSP00000060584

Structurei

3D structure databases

ProteinModelPortaliQ91W64
SMRiQ91W64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ91W64
KOiK07413
OMAiHANQWAI
OrthoDBiEOG091G0BT8
PhylomeDBiQ91W64
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q91W64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFIFLGIW LSCFLFLFLW NQHRGRGKLP PGPTPLPIVG NILQVDVKNI
60 70 80 90 100
SKSMGMLAKK YGPVFTVYLG MKPTVVLHGY KAMKEALIDQ GDEFSDKTDS
110 120 130 140 150
SLLSRTSQGL GIVFSNGETW KQTRRFSLMV LRSMGMGKKT IEDRIQEEIL
160 170 180 190 200
YMLDALRKTN GSPCDPSFLL ACVPCNVIST VIFQHRFDYN DQTFQDFMEN
210 220 230 240 250
FHRKIEILAS PWSQLCSAYP ILYYLPGIHN RFLKDVTQQK KFILEEINRH
260 270 280 290 300
QKSLDLSNPQ DFIDYFLIKM EKEKHNQKSE FTMDNLVVSI GDLFGAGTET
310 320 330 340 350
TSSTVKYGLL LLLKYPEVTA KIQEEIAHVI GRHRRPTMQD RNHMPYTDAV
360 370 380 390 400
LHEIQRYIDF VPIPSPRKTT QDVEFRGYHI PKGTSVMACL TSVLNDDKEF
410 420 430 440 450
PNPEKFDPGH FLDEKGNFKK SDYFVAFSAG RRACIGEGLA RMEMFLILTN
460 470 480
ILQHFTLKPL VKPEDIDTKP VQTGLLHVPP PFELCFIPV
Length:489
Mass (Da):56,020
Last modified:December 6, 2005 - v2
Checksum:i90973D9B05964B1B
GO

Sequence cautioni

The sequence AAH25822 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46D → Y in AAP55509 (Ref. 1) Curated1
Sequence conflicti46D → Y in AAH16494 (PubMed:15489334).Curated1
Sequence conflicti130V → A in AAP55509 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227736 mRNA Translation: AAP55509.1
BC016494 mRNA Translation: AAH16494.1
BC022151 mRNA Translation: AAH22151.1
BC023894 mRNA Translation: AAH23894.2
BC025822 mRNA Translation: AAH25822.1 Different initiation.
BC034831 mRNA Translation: AAH34831.1
CCDSiCCDS37976.1
RefSeqiNP_663474.2, NM_145499.2
UniGeneiMm.29119

Genome annotation databases

EnsembliENSMUST00000051846; ENSMUSP00000060584; ENSMUSG00000060613
GeneIDi226105
KEGGimmu:226105
UCSCiuc008hkj.2 mouse

Entry informationi

Entry nameiCP270_MOUSE
AccessioniPrimary (citable) accession number: Q91W64
Secondary accession number(s): Q5GLY9
, Q80VW0, Q8R120, Q8VC00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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