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Q91W64

- CP270_MOUSE

UniProt

Q91W64 - CP270_MOUSE

Protein

Cytochrome P450 2C70

Gene

Cyp2c70

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi434 – 4341Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C70 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC70
    Gene namesi
    Name:Cyp2c70Imported
    Synonyms:Cyp2c-70By similarity, Cyp2c22By similarity
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:2385878. Cyp2c70.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Cytochrome P450 2C70PRO_0000051726Add
    BLAST

    Proteomic databases

    MaxQBiQ91W64.
    PaxDbiQ91W64.
    PRIDEiQ91W64.

    PTM databases

    PhosphoSiteiQ91W64.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

    Gene expression databases

    BgeeiQ91W64.
    GenevestigatoriQ91W64.

    Interactioni

    Protein-protein interaction databases

    IntActiQ91W64. 2 interactions.
    MINTiMINT-1863855.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W64.
    SMRiQ91W64. Positions 28-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiQ91W64.
    KOiK07413.
    OMAiEYANTKE.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ91W64.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91W64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALFIFLGIW LSCFLFLFLW NQHRGRGKLP PGPTPLPIVG NILQVDVKNI    50
    SKSMGMLAKK YGPVFTVYLG MKPTVVLHGY KAMKEALIDQ GDEFSDKTDS 100
    SLLSRTSQGL GIVFSNGETW KQTRRFSLMV LRSMGMGKKT IEDRIQEEIL 150
    YMLDALRKTN GSPCDPSFLL ACVPCNVIST VIFQHRFDYN DQTFQDFMEN 200
    FHRKIEILAS PWSQLCSAYP ILYYLPGIHN RFLKDVTQQK KFILEEINRH 250
    QKSLDLSNPQ DFIDYFLIKM EKEKHNQKSE FTMDNLVVSI GDLFGAGTET 300
    TSSTVKYGLL LLLKYPEVTA KIQEEIAHVI GRHRRPTMQD RNHMPYTDAV 350
    LHEIQRYIDF VPIPSPRKTT QDVEFRGYHI PKGTSVMACL TSVLNDDKEF 400
    PNPEKFDPGH FLDEKGNFKK SDYFVAFSAG RRACIGEGLA RMEMFLILTN 450
    ILQHFTLKPL VKPEDIDTKP VQTGLLHVPP PFELCFIPV 489
    Length:489
    Mass (Da):56,020
    Last modified:December 6, 2005 - v2
    Checksum:i90973D9B05964B1B
    GO

    Sequence cautioni

    The sequence AAH25822.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461D → Y in AAP55509. 1 PublicationCurated
    Sequence conflicti46 – 461D → Y in AAH16494. (PubMed:15489334)Curated
    Sequence conflicti130 – 1301V → A in AAP55509. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227736 mRNA. Translation: AAP55509.1.
    BC016494 mRNA. Translation: AAH16494.1.
    BC022151 mRNA. Translation: AAH22151.1.
    BC023894 mRNA. Translation: AAH23894.2.
    BC025822 mRNA. Translation: AAH25822.1. Different initiation.
    BC034831 mRNA. Translation: AAH34831.1.
    CCDSiCCDS37976.1.
    RefSeqiNP_663474.2. NM_145499.2.
    UniGeneiMm.29119.

    Genome annotation databases

    EnsembliENSMUST00000051846; ENSMUSP00000060584; ENSMUSG00000060613.
    GeneIDi226105.
    KEGGimmu:226105.
    UCSCiuc008hkj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227736 mRNA. Translation: AAP55509.1 .
    BC016494 mRNA. Translation: AAH16494.1 .
    BC022151 mRNA. Translation: AAH22151.1 .
    BC023894 mRNA. Translation: AAH23894.2 .
    BC025822 mRNA. Translation: AAH25822.1 . Different initiation.
    BC034831 mRNA. Translation: AAH34831.1 .
    CCDSi CCDS37976.1.
    RefSeqi NP_663474.2. NM_145499.2.
    UniGenei Mm.29119.

    3D structure databases

    ProteinModelPortali Q91W64.
    SMRi Q91W64. Positions 28-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91W64. 2 interactions.
    MINTi MINT-1863855.

    PTM databases

    PhosphoSitei Q91W64.

    Proteomic databases

    MaxQBi Q91W64.
    PaxDbi Q91W64.
    PRIDEi Q91W64.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051846 ; ENSMUSP00000060584 ; ENSMUSG00000060613 .
    GeneIDi 226105.
    KEGGi mmu:226105.
    UCSCi uc008hkj.2. mouse.

    Organism-specific databases

    CTDi 226105.
    MGIi MGI:2385878. Cyp2c70.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi Q91W64.
    KOi K07413.
    OMAi EYANTKE.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q91W64.
    TreeFami TF352043.

    Miscellaneous databases

    ChiTaRSi Cyp2c70. mouse.
    NextBioi 377994.
    PROi Q91W64.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91W64.
    Genevestigatori Q91W64.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and characterization of four novel mouse cytochrome P450 (CYP) genes (CYP2C65, CYP2C66, CYP2C53 and CYP2C70)."
      Zhao Y., Wang H., Goldstein J.A., Zeldin D.C.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/cImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiCP270_MOUSE
    AccessioniPrimary (citable) accession number: Q91W64
    Secondary accession number(s): Q5GLY9
    , Q80VW0, Q8R120, Q8VC00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3