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Q91W64 (CP270_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C70

EC=1.14.14.1
Alternative name(s):
CYPIIC70
Gene names
Name:Cyp2c70
Synonyms:Cyp2c-70, Cyp2c22
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity. UniProtKB P19225

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. UniProtKB P19225

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AAH25822.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Cytochrome P450 2C70
PRO_0000051726

Sites

Metal binding4341Iron (heme axial ligand) By similarity UniProtKB P19225

Experimental info

Sequence conflict461D → Y in AAP55509. Ref.1
Sequence conflict461D → Y in AAH16494. Ref.2
Sequence conflict1301V → A in AAP55509. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91W64 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 90973D9B05964B1B

FASTA48956,020
        10         20         30         40         50         60 
MALFIFLGIW LSCFLFLFLW NQHRGRGKLP PGPTPLPIVG NILQVDVKNI SKSMGMLAKK 

        70         80         90        100        110        120 
YGPVFTVYLG MKPTVVLHGY KAMKEALIDQ GDEFSDKTDS SLLSRTSQGL GIVFSNGETW 

       130        140        150        160        170        180 
KQTRRFSLMV LRSMGMGKKT IEDRIQEEIL YMLDALRKTN GSPCDPSFLL ACVPCNVIST 

       190        200        210        220        230        240 
VIFQHRFDYN DQTFQDFMEN FHRKIEILAS PWSQLCSAYP ILYYLPGIHN RFLKDVTQQK 

       250        260        270        280        290        300 
KFILEEINRH QKSLDLSNPQ DFIDYFLIKM EKEKHNQKSE FTMDNLVVSI GDLFGAGTET 

       310        320        330        340        350        360 
TSSTVKYGLL LLLKYPEVTA KIQEEIAHVI GRHRRPTMQD RNHMPYTDAV LHEIQRYIDF 

       370        380        390        400        410        420 
VPIPSPRKTT QDVEFRGYHI PKGTSVMACL TSVLNDDKEF PNPEKFDPGH FLDEKGNFKK 

       430        440        450        460        470        480 
SDYFVAFSAG RRACIGEGLA RMEMFLILTN ILQHFTLKPL VKPEDIDTKP VQTGLLHVPP 


PFELCFIPV 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, expression, and characterization of four novel mouse cytochrome P450 (CYP) genes (CYP2C65, CYP2C66, CYP2C53 and CYP2C70)."
Zhao Y., Wang H., Goldstein J.A., Zeldin D.C.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY227736 mRNA. Translation: AAP55509.1.
BC016494 mRNA. Translation: AAH16494.1.
BC022151 mRNA. Translation: AAH22151.1.
BC023894 mRNA. Translation: AAH23894.2.
BC025822 mRNA. Translation: AAH25822.1. Different initiation.
BC034831 mRNA. Translation: AAH34831.1.
CCDSCCDS37976.1.
RefSeqNP_663474.2. NM_145499.2.
UniGeneMm.29119.

3D structure databases

ProteinModelPortalQ91W64.
SMRQ91W64. Positions 28-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91W64. 2 interactions.
MINTMINT-1863855.

PTM databases

PhosphoSiteQ91W64.

Proteomic databases

MaxQBQ91W64.
PaxDbQ91W64.
PRIDEQ91W64.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000051846; ENSMUSP00000060584; ENSMUSG00000060613.
GeneID226105.
KEGGmmu:226105.
UCSCuc008hkj.2. mouse.

Organism-specific databases

CTD226105.
MGIMGI:2385878. Cyp2c70.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidQ91W64.
KOK07413.
OMAEYANTKE.
OrthoDBEOG7RBZ85.
PhylomeDBQ91W64.
TreeFamTF352043.

Gene expression databases

BgeeQ91W64.
GenevestigatorQ91W64.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCyp2c70. mouse.
NextBio377994.
PROQ91W64.
SOURCESearch...

Entry information

Entry nameCP270_MOUSE
AccessionPrimary (citable) accession number: Q91W64
Secondary accession number(s): Q5GLY9 expand/collapse secondary AC list , Q80VW0, Q8R120, Q8VC00
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot