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Protein

Cytochrome P450 2C70

Gene

Cyp2c70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi434 – 4341Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: GO_Central
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: GO_Central
  4. iron ion binding Source: InterPro
  5. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  6. oxygen binding Source: GO_Central
  7. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. epoxygenase P450 pathway Source: GO_Central
  2. exogenous drug catabolic process Source: GO_Central
  3. oxidation-reduction process Source: GO_Central
  4. xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C70 (EC:1.14.14.1)
Alternative name(s):
CYPIIC70
Gene namesi
Name:Cyp2c70Imported
Synonyms:Cyp2c-70By similarity, Cyp2c22By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2385878. Cyp2c70.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Cytochrome P450 2C70PRO_0000051726Add
BLAST

Proteomic databases

MaxQBiQ91W64.
PaxDbiQ91W64.
PRIDEiQ91W64.

PTM databases

PhosphoSiteiQ91W64.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiQ91W64.
ExpressionAtlasiQ91W64. baseline and differential.
GenevestigatoriQ91W64.

Interactioni

Protein-protein interaction databases

IntActiQ91W64. 2 interactions.
MINTiMINT-1863855.

Structurei

3D structure databases

ProteinModelPortaliQ91W64.
SMRiQ91W64. Positions 28-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ91W64.
KOiK07413.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ91W64.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W64-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALFIFLGIW LSCFLFLFLW NQHRGRGKLP PGPTPLPIVG NILQVDVKNI
60 70 80 90 100
SKSMGMLAKK YGPVFTVYLG MKPTVVLHGY KAMKEALIDQ GDEFSDKTDS
110 120 130 140 150
SLLSRTSQGL GIVFSNGETW KQTRRFSLMV LRSMGMGKKT IEDRIQEEIL
160 170 180 190 200
YMLDALRKTN GSPCDPSFLL ACVPCNVIST VIFQHRFDYN DQTFQDFMEN
210 220 230 240 250
FHRKIEILAS PWSQLCSAYP ILYYLPGIHN RFLKDVTQQK KFILEEINRH
260 270 280 290 300
QKSLDLSNPQ DFIDYFLIKM EKEKHNQKSE FTMDNLVVSI GDLFGAGTET
310 320 330 340 350
TSSTVKYGLL LLLKYPEVTA KIQEEIAHVI GRHRRPTMQD RNHMPYTDAV
360 370 380 390 400
LHEIQRYIDF VPIPSPRKTT QDVEFRGYHI PKGTSVMACL TSVLNDDKEF
410 420 430 440 450
PNPEKFDPGH FLDEKGNFKK SDYFVAFSAG RRACIGEGLA RMEMFLILTN
460 470 480
ILQHFTLKPL VKPEDIDTKP VQTGLLHVPP PFELCFIPV
Length:489
Mass (Da):56,020
Last modified:December 6, 2005 - v2
Checksum:i90973D9B05964B1B
GO

Sequence cautioni

The sequence AAH25822.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461D → Y in AAP55509. 1 PublicationCurated
Sequence conflicti46 – 461D → Y in AAH16494. (PubMed:15489334)Curated
Sequence conflicti130 – 1301V → A in AAP55509. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227736 mRNA. Translation: AAP55509.1.
BC016494 mRNA. Translation: AAH16494.1.
BC022151 mRNA. Translation: AAH22151.1.
BC023894 mRNA. Translation: AAH23894.2.
BC025822 mRNA. Translation: AAH25822.1. Different initiation.
BC034831 mRNA. Translation: AAH34831.1.
CCDSiCCDS37976.1.
RefSeqiNP_663474.2. NM_145499.2.
UniGeneiMm.29119.

Genome annotation databases

EnsembliENSMUST00000051846; ENSMUSP00000060584; ENSMUSG00000060613.
GeneIDi226105.
KEGGimmu:226105.
UCSCiuc008hkj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227736 mRNA. Translation: AAP55509.1.
BC016494 mRNA. Translation: AAH16494.1.
BC022151 mRNA. Translation: AAH22151.1.
BC023894 mRNA. Translation: AAH23894.2.
BC025822 mRNA. Translation: AAH25822.1. Different initiation.
BC034831 mRNA. Translation: AAH34831.1.
CCDSiCCDS37976.1.
RefSeqiNP_663474.2. NM_145499.2.
UniGeneiMm.29119.

3D structure databases

ProteinModelPortaliQ91W64.
SMRiQ91W64. Positions 28-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91W64. 2 interactions.
MINTiMINT-1863855.

PTM databases

PhosphoSiteiQ91W64.

Proteomic databases

MaxQBiQ91W64.
PaxDbiQ91W64.
PRIDEiQ91W64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051846; ENSMUSP00000060584; ENSMUSG00000060613.
GeneIDi226105.
KEGGimmu:226105.
UCSCiuc008hkj.2. mouse.

Organism-specific databases

CTDi226105.
MGIiMGI:2385878. Cyp2c70.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ91W64.
KOiK07413.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ91W64.
TreeFamiTF352043.

Miscellaneous databases

ChiTaRSiCyp2c70. mouse.
NextBioi377994.
PROiQ91W64.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W64.
ExpressionAtlasiQ91W64. baseline and differential.
GenevestigatoriQ91W64.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and characterization of four novel mouse cytochrome P450 (CYP) genes (CYP2C65, CYP2C66, CYP2C53 and CYP2C70)."
    Zhao Y., Wang H., Goldstein J.A., Zeldin D.C.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiCP270_MOUSE
AccessioniPrimary (citable) accession number: Q91W64
Secondary accession number(s): Q5GLY9
, Q80VW0, Q8R120, Q8VC00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: February 4, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.