Reviewed, UniProtKB/Swiss-Prot Q91W63 (NRK1_MOUSE)

Names and origin

Protein names

Recommended name:
    Nicotinamide riboside kinase 1
      Short name=NmR-K 1
      Short name=NRK 1
    EC=2.7.1.22
Alternative name(s):
    Ribosylnicotinamide kinase 1
      Short name=RNK 1
    Nicotinic acid riboside kinase 1
    EC=2.7.1.n4
    Ribosylnicotinic acid kinase 1

Gene names

Name:

Nrk1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN) By similarity.
Catalytic activity	ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide. ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the uridine kinase family. NRK subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribosylnicotinamide kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	Nicotinamide riboside kinase 1		PRO_0000215892
Regions
	Nucleotide binding	10 – 18	9	ATP By similarity
	Nucleotide binding	172 – 174	3	ATP By similarity
Sites
	Active site	36	1	Proton acceptor By similarity
	Metal binding	17	1	Magnesium By similarity
	Metal binding	36	1	Magnesium By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	128	1	ATP By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	132	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91W63-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F54B182A85797764	FASTA	195	22,303
	10 20 30 40 50 60 MKRFVIGIGG VTNGGKTTLA KSLQKHLPNC SVISQDDFFK PESEIDIDEN GFLQYDVLEA 70 80 90 100 110 120 LNMEKMMSAV SCWMENPGSS AGPAALESAQ GVPILIIEGF LLFNYKPLDT IWNRSYFLTV 130 140 150 160 170 180 PYEECKRRRS TRVYEPPDPP GYFDGHVWPM YLKHRQEMSS ITWDIVYLDG TRSEEDLFSQ 190 VYEDVKQELE KQNGL

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Thymus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK050579 mRNA. Translation: BAC34328.1. AK169962 mRNA. Translation: BAE41485.1. BC016495 mRNA. Translation: AAH16495.1.
IPI	IPI00127357.
RefSeq	NP_663472.1.
UniGene	Mm.211595
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q91W63.
Proteomic databases
PRIDE	Q91W63.
Genome annotation databases
Ensembl	ENSMUST00000042392; ENSMUSP00000037198; ENSMUSG00000037847; Mus musculus. [Genome view]
GeneID	225994.
KEGG	mmu:225994.
NMPDR	fig|10090.3.peg.4824.
UCSC	uc008gxt.1. mouse.
Organism-specific databases
MGI	MGI:2147434. BC016495.
Phylogenomic databases
HOGENOM	Q91W63.
HOVERGEN	Q91W63.
OMA	WNRSYFL.
Gene expression databases
ArrayExpress	Q91W63.
Bgee	Q91W63.
CleanEx	MM_BC016495.
Genevestigator	Q91W63.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	377899.
SOURCE	Search...

Entry information

Entry name

NRK1_MOUSE

Accession

Primary (citable) accession number: Q91W63
Secondary accession number(s): Q3TDW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)