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Protein

RNA-binding motif, single-stranded-interacting protein 1

Gene

Rbms1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 1
Alternative name(s):
Single-stranded DNA-binding protein MSSP-1
Gene namesi
Name:Rbms1
Synonyms:Mssp, Mssp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1861774. Rbms1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817991 – 403RNA-binding motif, single-stranded-interacting protein 1Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91W59.
PeptideAtlasiQ91W59.
PRIDEiQ91W59.

PTM databases

iPTMnetiQ91W59.
PhosphoSitePlusiQ91W59.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in all tissues except testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000026970.
ExpressionAtlasiQ91W59. baseline and differential.
GenevisibleiQ91W59. MM.

Interactioni

Protein-protein interaction databases

BioGridi208206. 1 interactor.
STRINGi10090.ENSMUSP00000131306.

Structurei

3D structure databases

ProteinModelPortaliQ91W59.
SMRiQ91W59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 135RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini141 – 226RRM 2PROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4733. Eukaryota.
ENOG410XRB5. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000008467.
HOVERGENiHBG053108.
InParanoidiQ91W59.
PhylomeDBiQ91W59.
TreeFamiTF314644.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91W59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKVWKQQMY PQYATYYYPQ YLQAKQSLVP AHPMAPPSPS TTSSNNNSSS
60 70 80 90 100
SSNSGWDQLS KTNLYIRGLP PNTTDQDLVK LCQPYGKIVS TKAILDKATN
110 120 130 140 150
KCKGYGFVDF DSPAAAQKAV SALKANGVQA QMAKQQEQDP TNLYISNLPL
160 170 180 190 200
SMDEQELENM LKPFGQVIST RVLRDSSGAS RGVGFARMES TEKCEAVIGH
210 220 230 240 250
FNGKFIKTPP GVSAPTEPLL CKFADGGQKK RQNPNKYIPN GRPWPRDGEA
260 270 280 290 300
GMTLTYDPTT AALHNGFYPS PYSIATNRMI TQTSLTPYIA SPVSAYQVQS
310 320 330 340 350
PSWMQPQPYI LQHPGAVLTP SMEHTMSLQP ASMISPLAQQ MSHLSLGSTG
360 370 380 390 400
TYMPATSAMQ GAYLPQYTHM QTAAVPVEEA SGQQQVAVET SNDHSPYTFP

PNK
Length:403
Mass (Da):43,991
Last modified:December 1, 2001 - v1
Checksum:i68B8AC5816834726
GO
Isoform 2 (identifier: Q91W59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:370
Mass (Da):40,001
Checksum:i62C4BEFC8757B700
GO
Isoform 3 (identifier: Q91W59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     298-298: V → VAKETRENKYRGSAIKV

Show »
Length:386
Mass (Da):41,833
Checksum:i950F2C5A56A5C850
GO

Sequence cautioni

The sequence AAH16501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158E → K in BAE22471 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0119311 – 33Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_011932298V → VAKETRENKYRGSAIKV in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026582 Genomic DNA. Translation: BAA77264.1.
AB026569 mRNA. Translation: BAA77262.1.
AK135280 mRNA. Translation: BAE22471.1.
AK147109 mRNA. Translation: BAE27681.1.
AL928581, AL929012 Genomic DNA. Translation: CAM20660.1.
AL929012, AL928581 Genomic DNA. Translation: CAM25422.1.
BC016501 mRNA. Translation: AAH16501.2. Different initiation.
BC056609 mRNA. Translation: AAH56609.1.
BC057866 mRNA. Translation: AAH57866.1.
CCDSiCCDS50591.1. [Q91W59-1]
RefSeqiNP_001135403.1. NM_001141931.1.
NP_064692.2. NM_020296.2. [Q91W59-1]
UniGeneiMm.259667.
Mm.482338.

Genome annotation databases

EnsembliENSMUST00000028347; ENSMUSP00000028347; ENSMUSG00000026970. [Q91W59-1]
ENSMUST00000112509; ENSMUSP00000108128; ENSMUSG00000026970. [Q91W59-3]
GeneIDi56878.
KEGGimmu:56878.
UCSCiuc008juq.2. mouse. [Q91W59-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026582 Genomic DNA. Translation: BAA77264.1.
AB026569 mRNA. Translation: BAA77262.1.
AK135280 mRNA. Translation: BAE22471.1.
AK147109 mRNA. Translation: BAE27681.1.
AL928581, AL929012 Genomic DNA. Translation: CAM20660.1.
AL929012, AL928581 Genomic DNA. Translation: CAM25422.1.
BC016501 mRNA. Translation: AAH16501.2. Different initiation.
BC056609 mRNA. Translation: AAH56609.1.
BC057866 mRNA. Translation: AAH57866.1.
CCDSiCCDS50591.1. [Q91W59-1]
RefSeqiNP_001135403.1. NM_001141931.1.
NP_064692.2. NM_020296.2. [Q91W59-1]
UniGeneiMm.259667.
Mm.482338.

3D structure databases

ProteinModelPortaliQ91W59.
SMRiQ91W59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208206. 1 interactor.
STRINGi10090.ENSMUSP00000131306.

PTM databases

iPTMnetiQ91W59.
PhosphoSitePlusiQ91W59.

Proteomic databases

PaxDbiQ91W59.
PeptideAtlasiQ91W59.
PRIDEiQ91W59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028347; ENSMUSP00000028347; ENSMUSG00000026970. [Q91W59-1]
ENSMUST00000112509; ENSMUSP00000108128; ENSMUSG00000026970. [Q91W59-3]
GeneIDi56878.
KEGGimmu:56878.
UCSCiuc008juq.2. mouse. [Q91W59-1]

Organism-specific databases

CTDi5937.
MGIiMGI:1861774. Rbms1.

Phylogenomic databases

eggNOGiKOG4733. Eukaryota.
ENOG410XRB5. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000008467.
HOVERGENiHBG053108.
InParanoidiQ91W59.
PhylomeDBiQ91W59.
TreeFamiTF314644.

Miscellaneous databases

ChiTaRSiRbms1. mouse.
PROiQ91W59.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026970.
ExpressionAtlasiQ91W59. baseline and differential.
GenevisibleiQ91W59. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBMS1_MOUSE
AccessioniPrimary (citable) accession number: Q91W59
Secondary accession number(s): Q3UI25
, Q3UXU2, Q6PEU6, Q6PHC2, Q9WTK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.