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Protein

Golgin subfamily A member 7

Gene

Golga7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 7
Gene namesi
Name:Golga7
ORF Names:MNCb-1213
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1931029. Golga7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Golgin subfamily A member 7PRO_0000213978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi69 – 691S-palmitoyl cysteineBy similarity
Lipidationi72 – 721S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ91W53.
MaxQBiQ91W53.
PaxDbiQ91W53.
PeptideAtlasiQ91W53.
PRIDEiQ91W53.

PTM databases

iPTMnetiQ91W53.
PhosphoSiteiQ91W53.
SwissPalmiQ91W53.

Expressioni

Gene expression databases

BgeeiQ91W53.
CleanExiMM_GOLGA7.
GenevisibleiQ91W53. MM.

Interactioni

Subunit structurei

Interacts with GOLGA3. Interacts with ZDHHC9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062983.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERF4 family.Curated

Phylogenomic databases

eggNOGiKOG4069. Eukaryota.
ENOG4111NS1. LUCA.
GeneTreeiENSGT00390000000134.
HOGENOMiHOG000010289.
HOVERGENiHBG054534.
InParanoidiQ91W53.
OMAiNERVYNP.
OrthoDBiEOG7KQ23H.
PhylomeDBiQ91W53.
TreeFamiTF313115.

Family and domain databases

InterProiIPR019383. Golgin_A_7/ERF4.
[Graphical view]
PfamiPF10256. Erf4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91W53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQQAPVSG KVFIQRDYSS GTRCQFQTKF PAELENRIDR QQFEETVRTL
60 70 80 90 100
NNLYAEAEKL GGQSYLEGCL ACLTAYTIFL CMETHYEKVL KKVSKYIQEQ
110 120 130
NEKIYAPQGL LLTDPIERGL RVIEITIYED RGVSSGR
Length:137
Mass (Da):15,792
Last modified:December 1, 2001 - v1
Checksum:i00280547CA6702A3
GO
Isoform 2 (identifier: Q91W53-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-137: LKKVSKYIQE...YEDRGVSSGR → WLHLCSVKSL...IGQHVQVCLG

Note: No experimental confirmation available.
Show »
Length:153
Mass (Da):17,549
Checksum:iB8C069BA8D40FF31
GO

Sequence cautioni

The sequence BAA95052.1 differs from that shown. Reason: Frameshift at position 112. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 13748LKKVS…VSSGR → WLHLCSVKSLNTMKEDKSLH INSSFKLEKPLYNSDFVIAL TVQSTQKWVLSVCEIGQHVQ VCLG in isoform 2. 1 PublicationVSP_016281Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041568 mRNA. Translation: BAA95052.1. Frameshift.
AK048175 mRNA. Translation: BAC33266.1.
AK077582 mRNA. Translation: BAC36875.1.
AK089856 mRNA. Translation: BAC40977.1.
AK150462 mRNA. Translation: BAE29580.1.
AK150696 mRNA. Translation: BAE29775.1.
AK151353 mRNA. Translation: BAE30329.1.
AK152520 mRNA. Translation: BAE31280.1.
AK152606 mRNA. Translation: BAE31353.1.
AK153213 mRNA. Translation: BAE31811.1.
AK158227 mRNA. Translation: BAE34413.1.
AK170129 mRNA. Translation: BAE41583.1.
BC058523 mRNA. Translation: AAH58523.1.
BC016894 mRNA. Translation: AAH16894.1.
BC103796 mRNA. Translation: AAI03797.1.
BC093518 mRNA. Translation: AAH93518.1.
CCDSiCCDS40297.1. [Q91W53-1]
RefSeqiNP_001035949.1. NM_001042484.1. [Q91W53-1]
NP_065610.2. NM_020585.2. [Q91W53-1]
UniGeneiMm.196269.

Genome annotation databases

EnsembliENSMUST00000051094; ENSMUSP00000062983; ENSMUSG00000015341. [Q91W53-1]
ENSMUST00000121783; ENSMUSP00000112935; ENSMUSG00000015341. [Q91W53-1]
GeneIDi57437.
KEGGimmu:57437.
UCSCiuc009les.1. mouse. [Q91W53-1]
uc009leu.1. mouse. [Q91W53-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041568 mRNA. Translation: BAA95052.1. Frameshift.
AK048175 mRNA. Translation: BAC33266.1.
AK077582 mRNA. Translation: BAC36875.1.
AK089856 mRNA. Translation: BAC40977.1.
AK150462 mRNA. Translation: BAE29580.1.
AK150696 mRNA. Translation: BAE29775.1.
AK151353 mRNA. Translation: BAE30329.1.
AK152520 mRNA. Translation: BAE31280.1.
AK152606 mRNA. Translation: BAE31353.1.
AK153213 mRNA. Translation: BAE31811.1.
AK158227 mRNA. Translation: BAE34413.1.
AK170129 mRNA. Translation: BAE41583.1.
BC058523 mRNA. Translation: AAH58523.1.
BC016894 mRNA. Translation: AAH16894.1.
BC103796 mRNA. Translation: AAI03797.1.
BC093518 mRNA. Translation: AAH93518.1.
CCDSiCCDS40297.1. [Q91W53-1]
RefSeqiNP_001035949.1. NM_001042484.1. [Q91W53-1]
NP_065610.2. NM_020585.2. [Q91W53-1]
UniGeneiMm.196269.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062983.

PTM databases

iPTMnetiQ91W53.
PhosphoSiteiQ91W53.
SwissPalmiQ91W53.

Proteomic databases

EPDiQ91W53.
MaxQBiQ91W53.
PaxDbiQ91W53.
PeptideAtlasiQ91W53.
PRIDEiQ91W53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051094; ENSMUSP00000062983; ENSMUSG00000015341. [Q91W53-1]
ENSMUST00000121783; ENSMUSP00000112935; ENSMUSG00000015341. [Q91W53-1]
GeneIDi57437.
KEGGimmu:57437.
UCSCiuc009les.1. mouse. [Q91W53-1]
uc009leu.1. mouse. [Q91W53-2]

Organism-specific databases

CTDi51125.
MGIiMGI:1931029. Golga7.

Phylogenomic databases

eggNOGiKOG4069. Eukaryota.
ENOG4111NS1. LUCA.
GeneTreeiENSGT00390000000134.
HOGENOMiHOG000010289.
HOVERGENiHBG054534.
InParanoidiQ91W53.
OMAiNERVYNP.
OrthoDBiEOG7KQ23H.
PhylomeDBiQ91W53.
TreeFamiTF313115.

Miscellaneous databases

ChiTaRSiGolga7. mouse.
PROiQ91W53.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W53.
CleanExiMM_GOLGA7.
GenevisibleiQ91W53. MM.

Family and domain databases

InterProiIPR019383. Golgin_A_7/ERF4.
[Graphical view]
PfamiPF10256. Erf4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Embryo, Head, Inner ear and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain, Colon, Limb and Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Liver, Lung and Testis.

Entry informationi

Entry nameiGOGA7_MOUSE
AccessioniPrimary (citable) accession number: Q91W53
Secondary accession number(s): Q8BN18, Q9JJE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.