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Protein

Golgin subfamily A member 7

Gene

Golga7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 7
Gene namesi
Name:Golga7
ORF Names:MNCb-1213
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1931029 Golga7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139781 – 137Golgin subfamily A member 7Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi69S-palmitoyl cysteineBy similarity1
Lipidationi72S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ91W53
PaxDbiQ91W53
PeptideAtlasiQ91W53
PRIDEiQ91W53

PTM databases

iPTMnetiQ91W53
PhosphoSitePlusiQ91W53
SwissPalmiQ91W53

Expressioni

Gene expression databases

BgeeiENSMUSG00000015341
CleanExiMM_GOLGA7
GenevisibleiQ91W53 MM

Interactioni

Subunit structurei

Interacts with GOLGA3. Interacts with ZDHHC9 (By similarity).By similarity

Protein-protein interaction databases

BioGridi208294, 1 interactor
STRINGi10090.ENSMUSP00000062983

Family & Domainsi

Sequence similaritiesi

Belongs to the ERF4 family.Curated

Phylogenomic databases

eggNOGiKOG4069 Eukaryota
ENOG4111NS1 LUCA
GeneTreeiENSGT00390000000134
HOGENOMiHOG000010289
HOVERGENiHBG054534
InParanoidiQ91W53
OMAiDKIYAPR
OrthoDBiEOG091G0R12
PhylomeDBiQ91W53
TreeFamiTF313115

Family and domain databases

InterProiView protein in InterPro
IPR019383 Golgin_A_7/ERF4
PfamiView protein in Pfam
PF10256 Erf4, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91W53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQQAPVSG KVFIQRDYSS GTRCQFQTKF PAELENRIDR QQFEETVRTL
60 70 80 90 100
NNLYAEAEKL GGQSYLEGCL ACLTAYTIFL CMETHYEKVL KKVSKYIQEQ
110 120 130
NEKIYAPQGL LLTDPIERGL RVIEITIYED RGVSSGR
Length:137
Mass (Da):15,792
Last modified:December 1, 2001 - v1
Checksum:i00280547CA6702A3
GO
Isoform 2 (identifier: Q91W53-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-137: LKKVSKYIQE...YEDRGVSSGR → WLHLCSVKSL...IGQHVQVCLG

Note: No experimental confirmation available.
Show »
Length:153
Mass (Da):17,549
Checksum:iB8C069BA8D40FF31
GO

Sequence cautioni

The sequence BAA95052 differs from that shown. Reason: Frameshift at position 112.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01628190 – 137LKKVS…VSSGR → WLHLCSVKSLNTMKEDKSLH INSSFKLEKPLYNSDFVIAL TVQSTQKWVLSVCEIGQHVQ VCLG in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041568 mRNA Translation: BAA95052.1 Frameshift.
AK048175 mRNA Translation: BAC33266.1
AK077582 mRNA Translation: BAC36875.1
AK089856 mRNA Translation: BAC40977.1
AK150462 mRNA Translation: BAE29580.1
AK150696 mRNA Translation: BAE29775.1
AK151353 mRNA Translation: BAE30329.1
AK152520 mRNA Translation: BAE31280.1
AK152606 mRNA Translation: BAE31353.1
AK153213 mRNA Translation: BAE31811.1
AK158227 mRNA Translation: BAE34413.1
AK170129 mRNA Translation: BAE41583.1
BC058523 mRNA Translation: AAH58523.1
BC016894 mRNA Translation: AAH16894.1
BC103796 mRNA Translation: AAI03797.1
BC093518 mRNA Translation: AAH93518.1
CCDSiCCDS40297.1 [Q91W53-1]
RefSeqiNP_001035949.1, NM_001042484.1 [Q91W53-1]
NP_065610.2, NM_020585.2 [Q91W53-1]
UniGeneiMm.196269

Genome annotation databases

EnsembliENSMUST00000051094; ENSMUSP00000062983; ENSMUSG00000015341 [Q91W53-1]
ENSMUST00000121783; ENSMUSP00000112935; ENSMUSG00000015341 [Q91W53-1]
GeneIDi57437
KEGGimmu:57437
UCSCiuc009les.1 mouse [Q91W53-1]
uc009leu.1 mouse [Q91W53-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGOGA7_MOUSE
AccessioniPrimary (citable) accession number: Q91W53
Secondary accession number(s): Q8BN18, Q9JJE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health