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Protein

Cold shock domain-containing protein E1

Gene

Csde1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock domain-containing protein E1
Gene namesi
Name:Csde1
Synonyms:D3Jfr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:92356 Csde1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003491 – 798Cold shock domain-containing protein E1Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81N6-acetyllysineBy similarity1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei123PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei514PhosphoserineBy similarity1
Modified residuei584PhosphoserineBy similarity1
Modified residuei761PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91W50
MaxQBiQ91W50
PaxDbiQ91W50
PRIDEiQ91W50

PTM databases

iPTMnetiQ91W50
PhosphoSitePlusiQ91W50

Expressioni

Gene expression databases

BgeeiENSMUSG00000068823
CleanExiMM_CSDE1
ExpressionAtlasiQ91W50 baseline and differential
GenevisibleiQ91W50 MM

Interactioni

Subunit structurei

Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent (By similarity).By similarity

Protein-protein interaction databases

BioGridi230878, 15 interactors
IntActiQ91W50, 11 interactors
MINTiQ91W50
STRINGi10090.ENSMUSP00000029446

Structurei

3D structure databases

ProteinModelPortaliQ91W50
SMRiQ91W50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 87CSD 1Add BLAST62
Domaini136 – 179CSD 2; truncatedAdd BLAST44
Domaini186 – 245CSD 3Add BLAST60
Domaini297 – 337CSD 4; truncatedAdd BLAST41
Domaini349 – 410CSD 5Add BLAST62
Domaini447 – 507CSD 6Add BLAST61
Domaini519 – 579CSD 7Add BLAST61
Domaini610 – 670CSD 8Add BLAST61
Domaini674 – 735CSD 9Add BLAST62

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF27 Eukaryota
ENOG410ZH8Y LUCA
GeneTreeiENSGT00390000016950
HOGENOMiHOG000013035
HOVERGENiHBG013042
InParanoidiQ91W50
OMAiRGPDNSK
OrthoDBiEOG091G053Z
PhylomeDBiQ91W50
TreeFamiTF324707

Family and domain databases

CDDicd04458 CSP_CDS, 2 hits
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
IPR024642 SUZ-C
PfamiView protein in Pfam
PF00313 CSD, 5 hits
PF12901 SUZ-C, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 5 hits
SUPFAMiSSF50249 SSF50249, 5 hits
PROSITEiView protein in PROSITE
PS00352 CSD_1, 4 hits
PS51857 CSD_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q91W50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDPNLLHN NGHNGYPNGT SAALRETGVI EKLLTSYGFI QCSERQARLF
60 70 80 90 100
FHCSQYNGNL QDLKVGDDVE FEVSSDRRTG KPIAIKLVKI KPEIHPEERM
110 120 130 140 150
NGQVVCAVPH NLESKSPAAP GQSPTGSVCY ERNGEVFYLT YTSEDVEGNV
160 170 180 190 200
QLETGDKINF VIDNNKHTGA VSARNIMLLK KKQARCQGVV CAMKEAFGFI
210 220 230 240 250
ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE VATDVRLLPQ
260 270 280 290 300
GTVIFEDISI EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG
310 320 330 340 350
DKDTKSKVTL LEGDHVRFNI STDRRDKLER ATNIEVLSNT FQFTNEAREM
360 370 380 390 400
GVIAAMRDGF GFIKCVDRDA RMFFHFSEIL DGNQLHIADE VEFTVVPDML
410 420 430 440 450
SAQRNHAIRI KKLPKGTVSF HSHSDHRFLG TVEKEATFSN PKTTSPNKGK
460 470 480 490 500
DKEAEDGIIA YDDCGVKLTI AFQAKDVEGS TSPQIGDKVE FSISDKQRPG
510 520 530 540 550
QQIATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK EIFFHYSEFS
560 570 580 590 600
GDVDSLELGD MVEYSLSKGK GNKVSAEKVN KAHSVNGITE EANPTIYSGK
610 620 630 640 650
VIRPLRGVDP TQIEYQGMIE IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE
660 670 680 690 700
SVKFQLCVLG QNAQTMAYNI TPLRRATVEC VKDQFGFINY EVGDSKKLFF
710 720 730 740 750
HVKEVQDGVE LQAGDEVEFS VILNQRTGKC SACNVWRVCE GPKAVAAPRP
760 770 780 790
DRLVNRLKNI TLDDASAPRL MVLRQPRGPD NSMGFGAERK IRQAGVID
Length:798
Mass (Da):88,791
Last modified:December 1, 2001 - v1
Checksum:i731065F734C60009
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016898 mRNA Translation: AAH16898.1
BC062097 mRNA Translation: AAH62097.1
CCDSiCCDS38569.1
RefSeqiNP_659150.1, NM_144901.4
XP_017175039.1, XM_017319550.1
UniGeneiMm.277713
Mm.442282

Genome annotation databases

EnsembliENSMUST00000029446; ENSMUSP00000029446; ENSMUSG00000068823
ENSMUST00000197827; ENSMUSP00000143503; ENSMUSG00000068823
GeneIDi229663
KEGGimmu:229663
UCSCiuc008qsg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCSDE1_MOUSE
AccessioniPrimary (citable) accession number: Q91W50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health