Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cold shock domain-containing protein E1

Gene

Csde1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock domain-containing protein E1
Gene namesi
Name:Csde1
Synonyms:D3Jfr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:92356. Csde1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 798798Cold shock domain-containing protein E1PRO_0000100349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811N6-acetyllysineBy similarity
Cross-linki91 – 91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei514 – 5141PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91W50.
MaxQBiQ91W50.
PaxDbiQ91W50.
PRIDEiQ91W50.

PTM databases

iPTMnetiQ91W50.
PhosphoSiteiQ91W50.

Expressioni

Gene expression databases

BgeeiQ91W50.
CleanExiMM_CSDE1.
ExpressionAtlasiQ91W50. baseline and differential.
GenevisibleiQ91W50. MM.

Interactioni

Subunit structurei

Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent (By similarity).By similarity

Protein-protein interaction databases

BioGridi230878. 14 interactions.
IntActiQ91W50. 11 interactions.
MINTiMINT-4121285.
STRINGi10090.ENSMUSP00000029446.

Structurei

3D structure databases

ProteinModelPortaliQ91W50.
SMRiQ91W50. Positions 16-90, 172-259, 345-424, 456-581, 673-744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8762CSD 1Add
BLAST
Domaini136 – 17944CSD 2; truncatedAdd
BLAST
Domaini186 – 24560CSD 3Add
BLAST
Domaini297 – 33741CSD 4; truncatedAdd
BLAST
Domaini349 – 41062CSD 5Add
BLAST
Domaini447 – 50761CSD 6Add
BLAST
Domaini519 – 57961CSD 7Add
BLAST
Domaini610 – 67061CSD 8Add
BLAST
Domaini674 – 73562CSD 9Add
BLAST

Sequence similaritiesi

Contains 9 CSD (cold-shock) domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF27. Eukaryota.
ENOG410ZH8Y. LUCA.
GeneTreeiENSGT00390000016950.
HOGENOMiHOG000013035.
HOVERGENiHBG013042.
InParanoidiQ91W50.
OMAiLFFHMSE.
OrthoDBiEOG725DGS.
PhylomeDBiQ91W50.
TreeFamiTF324707.

Family and domain databases

Gene3Di2.40.50.140. 6 hits.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR024642. SUZ-C.
[Graphical view]
PfamiPF00313. CSD. 5 hits.
PF12901. SUZ-C. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 5 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 5 hits.
PROSITEiPS00352. COLD_SHOCK. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91W50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDPNLLHN NGHNGYPNGT SAALRETGVI EKLLTSYGFI QCSERQARLF
60 70 80 90 100
FHCSQYNGNL QDLKVGDDVE FEVSSDRRTG KPIAIKLVKI KPEIHPEERM
110 120 130 140 150
NGQVVCAVPH NLESKSPAAP GQSPTGSVCY ERNGEVFYLT YTSEDVEGNV
160 170 180 190 200
QLETGDKINF VIDNNKHTGA VSARNIMLLK KKQARCQGVV CAMKEAFGFI
210 220 230 240 250
ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE VATDVRLLPQ
260 270 280 290 300
GTVIFEDISI EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG
310 320 330 340 350
DKDTKSKVTL LEGDHVRFNI STDRRDKLER ATNIEVLSNT FQFTNEAREM
360 370 380 390 400
GVIAAMRDGF GFIKCVDRDA RMFFHFSEIL DGNQLHIADE VEFTVVPDML
410 420 430 440 450
SAQRNHAIRI KKLPKGTVSF HSHSDHRFLG TVEKEATFSN PKTTSPNKGK
460 470 480 490 500
DKEAEDGIIA YDDCGVKLTI AFQAKDVEGS TSPQIGDKVE FSISDKQRPG
510 520 530 540 550
QQIATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK EIFFHYSEFS
560 570 580 590 600
GDVDSLELGD MVEYSLSKGK GNKVSAEKVN KAHSVNGITE EANPTIYSGK
610 620 630 640 650
VIRPLRGVDP TQIEYQGMIE IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE
660 670 680 690 700
SVKFQLCVLG QNAQTMAYNI TPLRRATVEC VKDQFGFINY EVGDSKKLFF
710 720 730 740 750
HVKEVQDGVE LQAGDEVEFS VILNQRTGKC SACNVWRVCE GPKAVAAPRP
760 770 780 790
DRLVNRLKNI TLDDASAPRL MVLRQPRGPD NSMGFGAERK IRQAGVID
Length:798
Mass (Da):88,791
Last modified:December 1, 2001 - v1
Checksum:i731065F734C60009
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016898 mRNA. Translation: AAH16898.1.
BC062097 mRNA. Translation: AAH62097.1.
CCDSiCCDS38569.1.
RefSeqiNP_659150.1. NM_144901.4.
UniGeneiMm.277713.
Mm.442282.

Genome annotation databases

EnsembliENSMUST00000029446; ENSMUSP00000029446; ENSMUSG00000068823.
ENSMUST00000197827; ENSMUSP00000143503; ENSMUSG00000068823.
GeneIDi229663.
KEGGimmu:229663.
UCSCiuc008qsg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016898 mRNA. Translation: AAH16898.1.
BC062097 mRNA. Translation: AAH62097.1.
CCDSiCCDS38569.1.
RefSeqiNP_659150.1. NM_144901.4.
UniGeneiMm.277713.
Mm.442282.

3D structure databases

ProteinModelPortaliQ91W50.
SMRiQ91W50. Positions 16-90, 172-259, 345-424, 456-581, 673-744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230878. 14 interactions.
IntActiQ91W50. 11 interactions.
MINTiMINT-4121285.
STRINGi10090.ENSMUSP00000029446.

PTM databases

iPTMnetiQ91W50.
PhosphoSiteiQ91W50.

Proteomic databases

EPDiQ91W50.
MaxQBiQ91W50.
PaxDbiQ91W50.
PRIDEiQ91W50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029446; ENSMUSP00000029446; ENSMUSG00000068823.
ENSMUST00000197827; ENSMUSP00000143503; ENSMUSG00000068823.
GeneIDi229663.
KEGGimmu:229663.
UCSCiuc008qsg.2. mouse.

Organism-specific databases

CTDi7812.
MGIiMGI:92356. Csde1.

Phylogenomic databases

eggNOGiENOG410IF27. Eukaryota.
ENOG410ZH8Y. LUCA.
GeneTreeiENSGT00390000016950.
HOGENOMiHOG000013035.
HOVERGENiHBG013042.
InParanoidiQ91W50.
OMAiLFFHMSE.
OrthoDBiEOG725DGS.
PhylomeDBiQ91W50.
TreeFamiTF324707.

Miscellaneous databases

ChiTaRSiCsde1. mouse.
PROiQ91W50.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W50.
CleanExiMM_CSDE1.
ExpressionAtlasiQ91W50. baseline and differential.
GenevisibleiQ91W50. MM.

Family and domain databases

Gene3Di2.40.50.140. 6 hits.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR024642. SUZ-C.
[Graphical view]
PfamiPF00313. CSD. 5 hits.
PF12901. SUZ-C. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 5 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 5 hits.
PROSITEiPS00352. COLD_SHOCK. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Colon.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCSDE1_MOUSE
AccessioniPrimary (citable) accession number: Q91W50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.