SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91W43

- GCSP_MOUSE

UniProt

Q91W43 - GCSP_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glycine dehydrogenase (decarboxylating), mitochondrial
Gene
Gldc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Enzyme regulationi

Stimulated by lipoic acid. Inhibited in presence of methylamine By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: MGI
  2. lyase activity Source: InterPro
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:Gldc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1341155. Gldc.

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535Mitochondrion Reviewed prediction
Add
BLAST
Chaini36 – 1025990Glycine dehydrogenase (decarboxylating), mitochondrialUniRule annotation
PRO_0000010741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521N6-acetyllysine1 Publication
Modified residuei519 – 5191N6-acetyllysine1 Publication
Modified residuei653 – 6531N6-acetyllysine1 Publication
Modified residuei669 – 6691N6-acetyllysine1 Publication
Modified residuei759 – 7591N6-(pyridoxal phosphate)lysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ91W43.
PaxDbiQ91W43.
PRIDEiQ91W43.

PTM databases

PhosphoSiteiQ91W43.

Expressioni

Gene expression databases

BgeeiQ91W43.
CleanExiMM_GLDC.
GenevestigatoriQ91W43.

Interactioni

Subunit structurei

Interacts with GCSH By similarity. Homodimer. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH) By similarity.UniRule annotation

Protein-protein interaction databases

BioGridi222425. 1 interaction.
IntActiQ91W43. 1 interaction.
MINTiMINT-1847717.
STRINGi10090.ENSMUSP00000025778.

Structurei

3D structure databases

ProteinModelPortaliQ91W43.
SMRiQ91W43. Positions 51-1010.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
GeneTreeiENSGT00390000017970.
HOGENOMiHOG000239369.
HOVERGENiHBG005820.
InParanoidiQ91W43.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG7FJGZQ.
PhylomeDBiQ91W43.
TreeFamiTF300678.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W43-1 [UniParc]FASTAAdd to Basket

« Hide

MQLCARAWGL RLGRGAGGGH RLARGTGLSW AQRSRDSSGG GGGGGGGDRG     50
AAGASRLLER LLPRHDDFSR RHIGPGDKDR REMLQALGLA SIDELIEKTV 100
PASIRLKRPL KMEDPICENE ILETLHAIAS KNQIWRSYIG MGYYNCSVPQ 150
TILRNLLENS GWVTQYTPYQ PEVSQGRLES LLNYQTMVSD ITGLDMANAS 200
LLDEATAAAE AMQLCHRHNK RKKFFVDPRC HPQTIAVVQT RAKYRGVLVE 250
LKLPHEMDFS GKDVCGVLFQ YPDTEGKVED FTELVDRAHQ TGSLTCCATD 300
LLALCILRPP GEFGVDIALG NSQRFGVPLG YGGPHAAFFA VKENLVRMMP 350
GRMVGVTRDA TGKEVYRLAL QTREQHIRRD KATSNICTAQ ALLANMAAMF 400
AIYHGSQGLK HIAKRVHNAT LILSEGLKRA GHQLQHDLFF DTLKVQCGCS 450
VKEVLGRAAQ RQINFRLFDD GTLGISLDET VTEKDLDDLL WIFGCESSAE 500
LVAEGMGEER RGLLGSSFKR TSPFLTHQVF NSYHSETNLV RYMKKLENKD 550
ISLVHSMIPL GSCTMKLNSS SELAPITWRE FANIHPFVPL DQAQGYQQLF 600
QGLEKDLCEI TGYDRVSFQP NSGAQGEYAG LATIRAYLDQ KGERHRTVCL 650
IPKSAHGTNP ASAHMAGMKI QPVEVDRYGN IDVAHLKAMV DQHKENLAAI 700
MITYPSTNGV FEENIGDVCA LIHQHGGQVY LDGANMNAQV GICRPGDFGS 750
DVSHLNLHKT FCIPHGGGGP GMGPIGVKKH LSPFLPSHPV ISIKPTEGTW 800
PVGTVSAAPW GSSSILPISW AYIKMMGGKG LKEATEIAIL NANYMAKRLE 850
KHYRVLFRGA RGYVAHEFIL DTRPFKKSAN VEAVDVAKRL QDYGFHAPTM 900
SWPVAGTLMI EPTESEDKAE LDRFCDAMIS IRQEIADIEE GRIDPRVNPL 950
KMSPHSLTCV TSSCWDRPYS REVAAFPLPF VKPENKFWPT IARIDDIYGD 1000
QHLVCTCPPM EVYESPFSEQ KRASS 1025
Length:1,025
Mass (Da):113,267
Last modified:December 1, 2001 - v1
Checksum:iBB4A1E3459FE3495
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC017135 mRNA. Translation: AAH17135.1.
CCDSiCCDS37956.1.
RefSeqiNP_613061.1. NM_138595.2.
UniGeneiMm.274852.

Genome annotation databases

EnsembliENSMUST00000025778; ENSMUSP00000025778; ENSMUSG00000024827.
GeneIDi104174.
KEGGimmu:104174.
UCSCiuc008hej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC017135 mRNA. Translation: AAH17135.1 .
CCDSi CCDS37956.1.
RefSeqi NP_613061.1. NM_138595.2.
UniGenei Mm.274852.

3D structure databases

ProteinModelPortali Q91W43.
SMRi Q91W43. Positions 51-1010.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222425. 1 interaction.
IntActi Q91W43. 1 interaction.
MINTi MINT-1847717.
STRINGi 10090.ENSMUSP00000025778.

PTM databases

PhosphoSitei Q91W43.

Proteomic databases

MaxQBi Q91W43.
PaxDbi Q91W43.
PRIDEi Q91W43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025778 ; ENSMUSP00000025778 ; ENSMUSG00000024827 .
GeneIDi 104174.
KEGGi mmu:104174.
UCSCi uc008hej.1. mouse.

Organism-specific databases

CTDi 2731.
MGIi MGI:1341155. Gldc.

Phylogenomic databases

eggNOGi COG1003.
GeneTreei ENSGT00390000017970.
HOGENOMi HOG000239369.
HOVERGENi HBG005820.
InParanoidi Q91W43.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG7FJGZQ.
PhylomeDBi Q91W43.
TreeFami TF300678.

Miscellaneous databases

NextBioi 356668.
PROi Q91W43.
SOURCEi Search...

Gene expression databases

Bgeei Q91W43.
CleanExi MM_GLDC.
Genevestigatori Q91W43.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Retina.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 278-287; 606-615; 878-888 AND 933-942, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-452; LYS-519; LYS-653 AND LYS-669, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGCSP_MOUSE
AccessioniPrimary (citable) accession number: Q91W43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi