Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91W43

- GCSP_MOUSE

UniProt

Q91W43 - GCSP_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

Gldc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity).By similarity

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

Pyridoxal phosphate.By similarity

Enzyme regulationi

Stimulated by lipoic acid. Inhibited in presence of methylamine (By similarity).By similarity

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: MGI
  2. lyase activity Source: InterPro
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:Gldc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1341155. Gldc.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionSequence AnalysisAdd
BLAST
Chaini36 – 1025990Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521N6-acetyllysine1 Publication
Modified residuei519 – 5191N6-acetyllysine1 Publication
Modified residuei653 – 6531N6-acetyllysine1 Publication
Modified residuei669 – 6691N6-acetyllysine1 Publication
Modified residuei759 – 7591N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ91W43.
PaxDbiQ91W43.
PRIDEiQ91W43.

PTM databases

PhosphoSiteiQ91W43.

Expressioni

Gene expression databases

BgeeiQ91W43.
CleanExiMM_GLDC.
GenevestigatoriQ91W43.

Interactioni

Subunit structurei

Interacts with GCSH (By similarity). Homodimer. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH) (By similarity).By similarity

Protein-protein interaction databases

BioGridi222425. 1 interaction.
IntActiQ91W43. 1 interaction.
MINTiMINT-1847717.
STRINGi10090.ENSMUSP00000025778.

Structurei

3D structure databases

ProteinModelPortaliQ91W43.
SMRiQ91W43. Positions 51-1010.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
GeneTreeiENSGT00390000017970.
HOGENOMiHOG000239369.
HOVERGENiHBG005820.
InParanoidiQ91W43.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG7FJGZQ.
PhylomeDBiQ91W43.
TreeFamiTF300678.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLCARAWGL RLGRGAGGGH RLARGTGLSW AQRSRDSSGG GGGGGGGDRG
60 70 80 90 100
AAGASRLLER LLPRHDDFSR RHIGPGDKDR REMLQALGLA SIDELIEKTV
110 120 130 140 150
PASIRLKRPL KMEDPICENE ILETLHAIAS KNQIWRSYIG MGYYNCSVPQ
160 170 180 190 200
TILRNLLENS GWVTQYTPYQ PEVSQGRLES LLNYQTMVSD ITGLDMANAS
210 220 230 240 250
LLDEATAAAE AMQLCHRHNK RKKFFVDPRC HPQTIAVVQT RAKYRGVLVE
260 270 280 290 300
LKLPHEMDFS GKDVCGVLFQ YPDTEGKVED FTELVDRAHQ TGSLTCCATD
310 320 330 340 350
LLALCILRPP GEFGVDIALG NSQRFGVPLG YGGPHAAFFA VKENLVRMMP
360 370 380 390 400
GRMVGVTRDA TGKEVYRLAL QTREQHIRRD KATSNICTAQ ALLANMAAMF
410 420 430 440 450
AIYHGSQGLK HIAKRVHNAT LILSEGLKRA GHQLQHDLFF DTLKVQCGCS
460 470 480 490 500
VKEVLGRAAQ RQINFRLFDD GTLGISLDET VTEKDLDDLL WIFGCESSAE
510 520 530 540 550
LVAEGMGEER RGLLGSSFKR TSPFLTHQVF NSYHSETNLV RYMKKLENKD
560 570 580 590 600
ISLVHSMIPL GSCTMKLNSS SELAPITWRE FANIHPFVPL DQAQGYQQLF
610 620 630 640 650
QGLEKDLCEI TGYDRVSFQP NSGAQGEYAG LATIRAYLDQ KGERHRTVCL
660 670 680 690 700
IPKSAHGTNP ASAHMAGMKI QPVEVDRYGN IDVAHLKAMV DQHKENLAAI
710 720 730 740 750
MITYPSTNGV FEENIGDVCA LIHQHGGQVY LDGANMNAQV GICRPGDFGS
760 770 780 790 800
DVSHLNLHKT FCIPHGGGGP GMGPIGVKKH LSPFLPSHPV ISIKPTEGTW
810 820 830 840 850
PVGTVSAAPW GSSSILPISW AYIKMMGGKG LKEATEIAIL NANYMAKRLE
860 870 880 890 900
KHYRVLFRGA RGYVAHEFIL DTRPFKKSAN VEAVDVAKRL QDYGFHAPTM
910 920 930 940 950
SWPVAGTLMI EPTESEDKAE LDRFCDAMIS IRQEIADIEE GRIDPRVNPL
960 970 980 990 1000
KMSPHSLTCV TSSCWDRPYS REVAAFPLPF VKPENKFWPT IARIDDIYGD
1010 1020
QHLVCTCPPM EVYESPFSEQ KRASS
Length:1,025
Mass (Da):113,267
Last modified:December 1, 2001 - v1
Checksum:iBB4A1E3459FE3495
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC017135 mRNA. Translation: AAH17135.1.
CCDSiCCDS37956.1.
RefSeqiNP_613061.1. NM_138595.2.
UniGeneiMm.274852.

Genome annotation databases

EnsembliENSMUST00000025778; ENSMUSP00000025778; ENSMUSG00000024827.
GeneIDi104174.
KEGGimmu:104174.
UCSCiuc008hej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC017135 mRNA. Translation: AAH17135.1 .
CCDSi CCDS37956.1.
RefSeqi NP_613061.1. NM_138595.2.
UniGenei Mm.274852.

3D structure databases

ProteinModelPortali Q91W43.
SMRi Q91W43. Positions 51-1010.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222425. 1 interaction.
IntActi Q91W43. 1 interaction.
MINTi MINT-1847717.
STRINGi 10090.ENSMUSP00000025778.

PTM databases

PhosphoSitei Q91W43.

Proteomic databases

MaxQBi Q91W43.
PaxDbi Q91W43.
PRIDEi Q91W43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025778 ; ENSMUSP00000025778 ; ENSMUSG00000024827 .
GeneIDi 104174.
KEGGi mmu:104174.
UCSCi uc008hej.1. mouse.

Organism-specific databases

CTDi 2731.
MGIi MGI:1341155. Gldc.

Phylogenomic databases

eggNOGi COG1003.
GeneTreei ENSGT00390000017970.
HOGENOMi HOG000239369.
HOVERGENi HBG005820.
InParanoidi Q91W43.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG7FJGZQ.
PhylomeDBi Q91W43.
TreeFami TF300678.

Miscellaneous databases

NextBioi 356668.
PROi Q91W43.
SOURCEi Search...

Gene expression databases

Bgeei Q91W43.
CleanExi MM_GLDC.
Genevestigatori Q91W43.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Retina.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 278-287; 606-615; 878-888 AND 933-942, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-452; LYS-519; LYS-653 AND LYS-669, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGCSP_MOUSE
AccessioniPrimary (citable) accession number: Q91W43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3