Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91W43

- GCSP_MOUSE

UniProt

Q91W43 - GCSP_MOUSE

Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

Gldc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) By similarity.By similarity

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Enzyme regulationi

    Stimulated by lipoic acid. Inhibited in presence of methylamine By similarity.By similarity

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: MGI
    2. lyase activity Source: InterPro
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P protein
    Glycine decarboxylase
    Glycine dehydrogenase (aminomethyl-transferring)
    Gene namesi
    Name:Gldc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1341155. Gldc.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionSequence AnalysisAdd
    BLAST
    Chaini36 – 1025990Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010741Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei452 – 4521N6-acetyllysine1 Publication
    Modified residuei519 – 5191N6-acetyllysine1 Publication
    Modified residuei653 – 6531N6-acetyllysine1 Publication
    Modified residuei669 – 6691N6-acetyllysine1 Publication
    Modified residuei759 – 7591N6-(pyridoxal phosphate)lysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ91W43.
    PaxDbiQ91W43.
    PRIDEiQ91W43.

    PTM databases

    PhosphoSiteiQ91W43.

    Expressioni

    Gene expression databases

    BgeeiQ91W43.
    CleanExiMM_GLDC.
    GenevestigatoriQ91W43.

    Interactioni

    Subunit structurei

    Interacts with GCSH By similarity. Homodimer. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH) By similarity.By similarity

    Protein-protein interaction databases

    BioGridi222425. 1 interaction.
    IntActiQ91W43. 1 interaction.
    MINTiMINT-1847717.
    STRINGi10090.ENSMUSP00000025778.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W43.
    SMRiQ91W43. Positions 51-1010.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1003.
    GeneTreeiENSGT00390000017970.
    HOGENOMiHOG000239369.
    HOVERGENiHBG005820.
    InParanoidiQ91W43.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG7FJGZQ.
    PhylomeDBiQ91W43.
    TreeFamiTF300678.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF01212. Beta_elim_lyase. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91W43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLCARAWGL RLGRGAGGGH RLARGTGLSW AQRSRDSSGG GGGGGGGDRG     50
    AAGASRLLER LLPRHDDFSR RHIGPGDKDR REMLQALGLA SIDELIEKTV 100
    PASIRLKRPL KMEDPICENE ILETLHAIAS KNQIWRSYIG MGYYNCSVPQ 150
    TILRNLLENS GWVTQYTPYQ PEVSQGRLES LLNYQTMVSD ITGLDMANAS 200
    LLDEATAAAE AMQLCHRHNK RKKFFVDPRC HPQTIAVVQT RAKYRGVLVE 250
    LKLPHEMDFS GKDVCGVLFQ YPDTEGKVED FTELVDRAHQ TGSLTCCATD 300
    LLALCILRPP GEFGVDIALG NSQRFGVPLG YGGPHAAFFA VKENLVRMMP 350
    GRMVGVTRDA TGKEVYRLAL QTREQHIRRD KATSNICTAQ ALLANMAAMF 400
    AIYHGSQGLK HIAKRVHNAT LILSEGLKRA GHQLQHDLFF DTLKVQCGCS 450
    VKEVLGRAAQ RQINFRLFDD GTLGISLDET VTEKDLDDLL WIFGCESSAE 500
    LVAEGMGEER RGLLGSSFKR TSPFLTHQVF NSYHSETNLV RYMKKLENKD 550
    ISLVHSMIPL GSCTMKLNSS SELAPITWRE FANIHPFVPL DQAQGYQQLF 600
    QGLEKDLCEI TGYDRVSFQP NSGAQGEYAG LATIRAYLDQ KGERHRTVCL 650
    IPKSAHGTNP ASAHMAGMKI QPVEVDRYGN IDVAHLKAMV DQHKENLAAI 700
    MITYPSTNGV FEENIGDVCA LIHQHGGQVY LDGANMNAQV GICRPGDFGS 750
    DVSHLNLHKT FCIPHGGGGP GMGPIGVKKH LSPFLPSHPV ISIKPTEGTW 800
    PVGTVSAAPW GSSSILPISW AYIKMMGGKG LKEATEIAIL NANYMAKRLE 850
    KHYRVLFRGA RGYVAHEFIL DTRPFKKSAN VEAVDVAKRL QDYGFHAPTM 900
    SWPVAGTLMI EPTESEDKAE LDRFCDAMIS IRQEIADIEE GRIDPRVNPL 950
    KMSPHSLTCV TSSCWDRPYS REVAAFPLPF VKPENKFWPT IARIDDIYGD 1000
    QHLVCTCPPM EVYESPFSEQ KRASS 1025
    Length:1,025
    Mass (Da):113,267
    Last modified:December 1, 2001 - v1
    Checksum:iBB4A1E3459FE3495
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC017135 mRNA. Translation: AAH17135.1.
    CCDSiCCDS37956.1.
    RefSeqiNP_613061.1. NM_138595.2.
    UniGeneiMm.274852.

    Genome annotation databases

    EnsembliENSMUST00000025778; ENSMUSP00000025778; ENSMUSG00000024827.
    GeneIDi104174.
    KEGGimmu:104174.
    UCSCiuc008hej.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC017135 mRNA. Translation: AAH17135.1 .
    CCDSi CCDS37956.1.
    RefSeqi NP_613061.1. NM_138595.2.
    UniGenei Mm.274852.

    3D structure databases

    ProteinModelPortali Q91W43.
    SMRi Q91W43. Positions 51-1010.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222425. 1 interaction.
    IntActi Q91W43. 1 interaction.
    MINTi MINT-1847717.
    STRINGi 10090.ENSMUSP00000025778.

    PTM databases

    PhosphoSitei Q91W43.

    Proteomic databases

    MaxQBi Q91W43.
    PaxDbi Q91W43.
    PRIDEi Q91W43.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025778 ; ENSMUSP00000025778 ; ENSMUSG00000024827 .
    GeneIDi 104174.
    KEGGi mmu:104174.
    UCSCi uc008hej.1. mouse.

    Organism-specific databases

    CTDi 2731.
    MGIi MGI:1341155. Gldc.

    Phylogenomic databases

    eggNOGi COG1003.
    GeneTreei ENSGT00390000017970.
    HOGENOMi HOG000239369.
    HOVERGENi HBG005820.
    InParanoidi Q91W43.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG7FJGZQ.
    PhylomeDBi Q91W43.
    TreeFami TF300678.

    Miscellaneous databases

    NextBioi 356668.
    PROi Q91W43.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91W43.
    CleanExi MM_GLDC.
    Genevestigatori Q91W43.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF01212. Beta_elim_lyase. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Retina.
    2. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 278-287; 606-615; 878-888 AND 933-942, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    3. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-452; LYS-519; LYS-653 AND LYS-669, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiGCSP_MOUSE
    AccessioniPrimary (citable) accession number: Q91W43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3