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Q91W39 (NCOA5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor coactivator 5

Short name=NCoA-5
Alternative name(s):
Coactivator independent of AF-2
Short name=CIA
Gene names
Name:Ncoa5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) By similarity.

Subunit structure

Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA By similarity.

Subcellular location

Nucleus By similarity.

Developmental stage

Expressed in many fetal tissues. High expression in fetal heart and kidney. Weak expression in fetal liver. Ref.3

Domain

Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors By similarity.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionRepressor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 579579Nuclear receptor coactivator 5
PRO_0000094412

Regions

Region1 – 158158Transcription repression
Region458 – 579122Transcription activation
Motif345 – 3495LXXLL motif
Compositional bias7 – 196190Arg/Asp-rich (mixed charge)

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue31Phosphothreonine By similarity
Modified residue91Phosphoserine By similarity
Modified residue291Phosphoserine By similarity
Modified residue341Phosphoserine By similarity
Modified residue1261Phosphoserine By similarity
Modified residue1511Phosphoserine By similarity
Modified residue3781Phosphoserine By similarity
Modified residue3811Phosphoserine By similarity
Modified residue3951Phosphoserine By similarity
Modified residue3981Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91W39 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 145A34199FB02D33

FASTA57965,319
        10         20         30         40         50         60 
MNTAPSRPSP TRRDPYSFGD SRDTRRDRSP IRGSPRREPR DGRNGRDARD SRDIRDPRDL 

        70         80         90        100        110        120 
RDRRDSRDIR DHRDSRSVRE ARDLRDFRDF RDLRDSRDFR DHRDPVYDRY RDIRDSRDPL 

       130        140        150        160        170        180 
YRREGSYDRY LRVDDYCRRK DDSYFDRYRD SFDGRGPPGP ESQSRAKERL KREERRREEL 

       190        200        210        220        230        240 
YRRYFEEIQR RFDAERPVDC SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ 

       250        260        270        280        290        300 
ALEDVSRGGS PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKND 

       310        320        330        340        350        360 
CREKEREEIA RQAAKMANDA ILQERDRGGP EEGGRGGHPP AIQSLINLLA DNRYLTAEET 

       370        380        390        400        410        420 
DKIINYLRER KERLLRSSAD SLPGPISRQP LGAASGSSLK SQPSSQPLQS GQVLPSATPT 

       430        440        450        460        470        480 
PAAPPTSQQE LQAKILSLFN SGAVAANSSS ASPSVATGSS QNQNFSTAAN SQPQQRPQAS 

       490        500        510        520        530        540 
GNQPPNIVGQ AGSARNMGPR PGAPSQGLFG QPSSRLAPAS TMASQRPVSS TGINFDNPSV 

       550        560        570 
QKALDTLIQS GPALSHLVSQ TAAQVGRPQA PMGSYQRHY 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Retina.
[3]"CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."
Sauve F., McBroom L.D.B., Gallant J., Moraitis A.N., Labrie F., Giguere V.
Mol. Cell. Biol. 21:343-353(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591495 Genomic DNA. Translation: CAM26468.1.
BC017152 mRNA. Translation: AAH17152.1.
RefSeqNP_659141.1. NM_144892.1.
UniGeneMm.233080.

3D structure databases

ProteinModelPortalQ91W39.
SMRQ91W39. Positions 197-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid230788. 1 interaction.
IntActQ91W39. 2 interactions.
MINTMINT-4103204.
STRING10090.ENSMUSP00000046388.

PTM databases

PhosphoSiteQ91W39.

Proteomic databases

PaxDbQ91W39.
PRIDEQ91W39.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040381; ENSMUSP00000046388; ENSMUSG00000039804.
GeneID228869.
KEGGmmu:228869.
UCSCuc008nwv.1. mouse.

Organism-specific databases

CTD57727.
MGIMGI:2385165. Ncoa5.

Phylogenomic databases

eggNOGNOG147049.
GeneTreeENSGT00530000064134.
HOGENOMHOG000231008.
HOVERGENHBG052585.
InParanoidA2A5L2.
OMAGSARNMG.
OrthoDBEOG7GTT6B.
PhylomeDBQ91W39.
TreeFamTF324704.

Gene expression databases

BgeeQ91W39.
CleanExMM_NCOA5.
GenevestigatorQ91W39.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
InterProIPR004154. Anticodon-bd.
[Graphical view]
SUPFAMSSF52954. SSF52954. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNCOA5. mouse.
NextBio379224.
PROQ91W39.
SOURCESearch...

Entry information

Entry nameNCOA5_MOUSE
AccessionPrimary (citable) accession number: Q91W39
Secondary accession number(s): A2A5L2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot