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Protein

Nuclear receptor coactivator 5

Gene

Ncoa5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) (By similarity).By similarity

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. poly(A) RNA binding Source: MGI

GO - Biological processi

  1. glucose homeostasis Source: MGI
  2. negative regulation of insulin receptor signaling pathway Source: MGI
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 5
Short name:
NCoA-5
Alternative name(s):
Coactivator independent of AF-2
Short name:
CIA
Gene namesi
Name:Ncoa5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2385165. Ncoa5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: MGI
  2. extracellular space Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Nuclear receptor coactivator 5PRO_0000094412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei3 – 31PhosphothreonineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei29 – 291PhosphoserineBy similarity
Modified residuei34 – 341PhosphoserineBy similarity
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei395 – 3951PhosphoserineBy similarity
Modified residuei398 – 3981PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91W39.
PaxDbiQ91W39.
PRIDEiQ91W39.

PTM databases

PhosphoSiteiQ91W39.

Expressioni

Developmental stagei

Expressed in many fetal tissues. High expression in fetal heart and kidney. Weak expression in fetal liver.1 Publication

Gene expression databases

BgeeiQ91W39.
CleanExiMM_NCOA5.
ExpressionAtlasiQ91W39. baseline and differential.
GenevestigatoriQ91W39.

Interactioni

Subunit structurei

Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA (By similarity).By similarity

Protein-protein interaction databases

BioGridi230788. 2 interactions.
IntActiQ91W39. 2 interactions.
MINTiMINT-4103204.
STRINGi10090.ENSMUSP00000046388.

Structurei

3D structure databases

ProteinModelPortaliQ91W39.
SMRiQ91W39. Positions 197-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 158158Transcription repressionAdd
BLAST
Regioni458 – 579122Transcription activationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi345 – 3495LXXLL motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 196190Arg/Asp-rich (mixed charge)Add
BLAST

Domaini

Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.By similarity

Phylogenomic databases

eggNOGiNOG147049.
GeneTreeiENSGT00530000064134.
HOGENOMiHOG000231008.
HOVERGENiHBG052585.
InParanoidiQ91W39.
OMAiGSARNMG.
OrthoDBiEOG7GTT6B.
PhylomeDBiQ91W39.
TreeFamiTF324704.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91W39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTAPSRPSP TRRDPYSFGD SRDTRRDRSP IRGSPRREPR DGRNGRDARD
60 70 80 90 100
SRDIRDPRDL RDRRDSRDIR DHRDSRSVRE ARDLRDFRDF RDLRDSRDFR
110 120 130 140 150
DHRDPVYDRY RDIRDSRDPL YRREGSYDRY LRVDDYCRRK DDSYFDRYRD
160 170 180 190 200
SFDGRGPPGP ESQSRAKERL KREERRREEL YRRYFEEIQR RFDAERPVDC
210 220 230 240 250
SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS
260 270 280 290 300
PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKND
310 320 330 340 350
CREKEREEIA RQAAKMANDA ILQERDRGGP EEGGRGGHPP AIQSLINLLA
360 370 380 390 400
DNRYLTAEET DKIINYLRER KERLLRSSAD SLPGPISRQP LGAASGSSLK
410 420 430 440 450
SQPSSQPLQS GQVLPSATPT PAAPPTSQQE LQAKILSLFN SGAVAANSSS
460 470 480 490 500
ASPSVATGSS QNQNFSTAAN SQPQQRPQAS GNQPPNIVGQ AGSARNMGPR
510 520 530 540 550
PGAPSQGLFG QPSSRLAPAS TMASQRPVSS TGINFDNPSV QKALDTLIQS
560 570
GPALSHLVSQ TAAQVGRPQA PMGSYQRHY
Length:579
Mass (Da):65,319
Last modified:December 1, 2001 - v1
Checksum:i145A34199FB02D33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591495 Genomic DNA. Translation: CAM26468.1.
BC017152 mRNA. Translation: AAH17152.1.
CCDSiCCDS17068.1.
RefSeqiNP_659141.1. NM_144892.1.
UniGeneiMm.233080.

Genome annotation databases

EnsembliENSMUST00000040381; ENSMUSP00000046388; ENSMUSG00000039804.
GeneIDi228869.
KEGGimmu:228869.
UCSCiuc008nwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591495 Genomic DNA. Translation: CAM26468.1.
BC017152 mRNA. Translation: AAH17152.1.
CCDSiCCDS17068.1.
RefSeqiNP_659141.1. NM_144892.1.
UniGeneiMm.233080.

3D structure databases

ProteinModelPortaliQ91W39.
SMRiQ91W39. Positions 197-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230788. 2 interactions.
IntActiQ91W39. 2 interactions.
MINTiMINT-4103204.
STRINGi10090.ENSMUSP00000046388.

PTM databases

PhosphoSiteiQ91W39.

Proteomic databases

MaxQBiQ91W39.
PaxDbiQ91W39.
PRIDEiQ91W39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040381; ENSMUSP00000046388; ENSMUSG00000039804.
GeneIDi228869.
KEGGimmu:228869.
UCSCiuc008nwv.1. mouse.

Organism-specific databases

CTDi57727.
MGIiMGI:2385165. Ncoa5.

Phylogenomic databases

eggNOGiNOG147049.
GeneTreeiENSGT00530000064134.
HOGENOMiHOG000231008.
HOVERGENiHBG052585.
InParanoidiQ91W39.
OMAiGSARNMG.
OrthoDBiEOG7GTT6B.
PhylomeDBiQ91W39.
TreeFamiTF324704.

Miscellaneous databases

ChiTaRSiNcoa5. mouse.
NextBioi379224.
PROiQ91W39.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W39.
CleanExiMM_NCOA5.
ExpressionAtlasiQ91W39. baseline and differential.
GenevestigatoriQ91W39.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Retina.
  3. "CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."
    Sauve F., McBroom L.D.B., Gallant J., Moraitis A.N., Labrie F., Giguere V.
    Mol. Cell. Biol. 21:343-353(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiNCOA5_MOUSE
AccessioniPrimary (citable) accession number: Q91W39
Secondary accession number(s): A2A5L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.