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Q91W39

- NCOA5_MOUSE

UniProt

Q91W39 - NCOA5_MOUSE

Protein

Nuclear receptor coactivator 5

Gene

Ncoa5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) By similarity.By similarity

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor coactivator 5
    Short name:
    NCoA-5
    Alternative name(s):
    Coactivator independent of AF-2
    Short name:
    CIA
    Gene namesi
    Name:Ncoa5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2385165. Ncoa5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Nuclear receptor coactivator 5PRO_0000094412Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei3 – 31PhosphothreonineBy similarity
    Modified residuei9 – 91PhosphoserineBy similarity
    Modified residuei29 – 291PhosphoserineBy similarity
    Modified residuei34 – 341PhosphoserineBy similarity
    Modified residuei126 – 1261PhosphoserineBy similarity
    Modified residuei151 – 1511PhosphoserineBy similarity
    Modified residuei378 – 3781PhosphoserineBy similarity
    Modified residuei381 – 3811PhosphoserineBy similarity
    Modified residuei395 – 3951PhosphoserineBy similarity
    Modified residuei398 – 3981PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ91W39.
    PaxDbiQ91W39.
    PRIDEiQ91W39.

    PTM databases

    PhosphoSiteiQ91W39.

    Expressioni

    Developmental stagei

    Expressed in many fetal tissues. High expression in fetal heart and kidney. Weak expression in fetal liver.1 Publication

    Gene expression databases

    BgeeiQ91W39.
    CleanExiMM_NCOA5.
    GenevestigatoriQ91W39.

    Interactioni

    Subunit structurei

    Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA By similarity.By similarity

    Protein-protein interaction databases

    BioGridi230788. 2 interactions.
    IntActiQ91W39. 2 interactions.
    MINTiMINT-4103204.
    STRINGi10090.ENSMUSP00000046388.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W39.
    SMRiQ91W39. Positions 197-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 158158Transcription repressionAdd
    BLAST
    Regioni458 – 579122Transcription activationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi345 – 3495LXXLL motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 196190Arg/Asp-rich (mixed charge)Add
    BLAST

    Domaini

    Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.By similarity

    Phylogenomic databases

    eggNOGiNOG147049.
    GeneTreeiENSGT00530000064134.
    HOGENOMiHOG000231008.
    HOVERGENiHBG052585.
    InParanoidiA2A5L2.
    OMAiGSARNMG.
    OrthoDBiEOG7GTT6B.
    PhylomeDBiQ91W39.
    TreeFamiTF324704.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    InterProiIPR004154. Anticodon-bd.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91W39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTAPSRPSP TRRDPYSFGD SRDTRRDRSP IRGSPRREPR DGRNGRDARD    50
    SRDIRDPRDL RDRRDSRDIR DHRDSRSVRE ARDLRDFRDF RDLRDSRDFR 100
    DHRDPVYDRY RDIRDSRDPL YRREGSYDRY LRVDDYCRRK DDSYFDRYRD 150
    SFDGRGPPGP ESQSRAKERL KREERRREEL YRRYFEEIQR RFDAERPVDC 200
    SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS 250
    PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKND 300
    CREKEREEIA RQAAKMANDA ILQERDRGGP EEGGRGGHPP AIQSLINLLA 350
    DNRYLTAEET DKIINYLRER KERLLRSSAD SLPGPISRQP LGAASGSSLK 400
    SQPSSQPLQS GQVLPSATPT PAAPPTSQQE LQAKILSLFN SGAVAANSSS 450
    ASPSVATGSS QNQNFSTAAN SQPQQRPQAS GNQPPNIVGQ AGSARNMGPR 500
    PGAPSQGLFG QPSSRLAPAS TMASQRPVSS TGINFDNPSV QKALDTLIQS 550
    GPALSHLVSQ TAAQVGRPQA PMGSYQRHY 579
    Length:579
    Mass (Da):65,319
    Last modified:December 1, 2001 - v1
    Checksum:i145A34199FB02D33
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591495 Genomic DNA. Translation: CAM26468.1.
    BC017152 mRNA. Translation: AAH17152.1.
    CCDSiCCDS17068.1.
    RefSeqiNP_659141.1. NM_144892.1.
    UniGeneiMm.233080.

    Genome annotation databases

    EnsembliENSMUST00000040381; ENSMUSP00000046388; ENSMUSG00000039804.
    GeneIDi228869.
    KEGGimmu:228869.
    UCSCiuc008nwv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591495 Genomic DNA. Translation: CAM26468.1 .
    BC017152 mRNA. Translation: AAH17152.1 .
    CCDSi CCDS17068.1.
    RefSeqi NP_659141.1. NM_144892.1.
    UniGenei Mm.233080.

    3D structure databases

    ProteinModelPortali Q91W39.
    SMRi Q91W39. Positions 197-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230788. 2 interactions.
    IntActi Q91W39. 2 interactions.
    MINTi MINT-4103204.
    STRINGi 10090.ENSMUSP00000046388.

    PTM databases

    PhosphoSitei Q91W39.

    Proteomic databases

    MaxQBi Q91W39.
    PaxDbi Q91W39.
    PRIDEi Q91W39.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040381 ; ENSMUSP00000046388 ; ENSMUSG00000039804 .
    GeneIDi 228869.
    KEGGi mmu:228869.
    UCSCi uc008nwv.1. mouse.

    Organism-specific databases

    CTDi 57727.
    MGIi MGI:2385165. Ncoa5.

    Phylogenomic databases

    eggNOGi NOG147049.
    GeneTreei ENSGT00530000064134.
    HOGENOMi HOG000231008.
    HOVERGENi HBG052585.
    InParanoidi A2A5L2.
    OMAi GSARNMG.
    OrthoDBi EOG7GTT6B.
    PhylomeDBi Q91W39.
    TreeFami TF324704.

    Miscellaneous databases

    ChiTaRSi NCOA5. mouse.
    NextBioi 379224.
    PROi Q91W39.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91W39.
    CleanExi MM_NCOA5.
    Genevestigatori Q91W39.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    InterProi IPR004154. Anticodon-bd.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Retina.
    3. "CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."
      Sauve F., McBroom L.D.B., Gallant J., Moraitis A.N., Labrie F., Giguere V.
      Mol. Cell. Biol. 21:343-353(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiNCOA5_MOUSE
    AccessioniPrimary (citable) accession number: Q91W39
    Secondary accession number(s): A2A5L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3