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Q91W39

- NCOA5_MOUSE

UniProt

Q91W39 - NCOA5_MOUSE

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Protein

Nuclear receptor coactivator 5

Gene
Ncoa5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) By similarity.

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 5
Short name:
NCoA-5
Alternative name(s):
Coactivator independent of AF-2
Short name:
CIA
Gene namesi
Name:Ncoa5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2385165. Ncoa5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Nuclear receptor coactivator 5PRO_0000094412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei3 – 31Phosphothreonine By similarity
Modified residuei9 – 91Phosphoserine By similarity
Modified residuei29 – 291Phosphoserine By similarity
Modified residuei34 – 341Phosphoserine By similarity
Modified residuei126 – 1261Phosphoserine By similarity
Modified residuei151 – 1511Phosphoserine By similarity
Modified residuei378 – 3781Phosphoserine By similarity
Modified residuei381 – 3811Phosphoserine By similarity
Modified residuei395 – 3951Phosphoserine By similarity
Modified residuei398 – 3981Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91W39.
PaxDbiQ91W39.
PRIDEiQ91W39.

PTM databases

PhosphoSiteiQ91W39.

Expressioni

Developmental stagei

Expressed in many fetal tissues. High expression in fetal heart and kidney. Weak expression in fetal liver.1 Publication

Gene expression databases

BgeeiQ91W39.
CleanExiMM_NCOA5.
GenevestigatoriQ91W39.

Interactioni

Subunit structurei

Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA By similarity.

Protein-protein interaction databases

BioGridi230788. 2 interactions.
IntActiQ91W39. 2 interactions.
MINTiMINT-4103204.
STRINGi10090.ENSMUSP00000046388.

Structurei

3D structure databases

ProteinModelPortaliQ91W39.
SMRiQ91W39. Positions 197-314.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 158158Transcription repressionAdd
BLAST
Regioni458 – 579122Transcription activationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi345 – 3495LXXLL motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 196190Arg/Asp-rich (mixed charge)Add
BLAST

Domaini

Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors (By similarity).

Phylogenomic databases

eggNOGiNOG147049.
GeneTreeiENSGT00530000064134.
HOGENOMiHOG000231008.
HOVERGENiHBG052585.
InParanoidiA2A5L2.
OMAiGSARNMG.
OrthoDBiEOG7GTT6B.
PhylomeDBiQ91W39.
TreeFamiTF324704.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91W39-1 [UniParc]FASTAAdd to Basket

« Hide

MNTAPSRPSP TRRDPYSFGD SRDTRRDRSP IRGSPRREPR DGRNGRDARD    50
SRDIRDPRDL RDRRDSRDIR DHRDSRSVRE ARDLRDFRDF RDLRDSRDFR 100
DHRDPVYDRY RDIRDSRDPL YRREGSYDRY LRVDDYCRRK DDSYFDRYRD 150
SFDGRGPPGP ESQSRAKERL KREERRREEL YRRYFEEIQR RFDAERPVDC 200
SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS 250
PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKND 300
CREKEREEIA RQAAKMANDA ILQERDRGGP EEGGRGGHPP AIQSLINLLA 350
DNRYLTAEET DKIINYLRER KERLLRSSAD SLPGPISRQP LGAASGSSLK 400
SQPSSQPLQS GQVLPSATPT PAAPPTSQQE LQAKILSLFN SGAVAANSSS 450
ASPSVATGSS QNQNFSTAAN SQPQQRPQAS GNQPPNIVGQ AGSARNMGPR 500
PGAPSQGLFG QPSSRLAPAS TMASQRPVSS TGINFDNPSV QKALDTLIQS 550
GPALSHLVSQ TAAQVGRPQA PMGSYQRHY 579
Length:579
Mass (Da):65,319
Last modified:December 1, 2001 - v1
Checksum:i145A34199FB02D33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591495 Genomic DNA. Translation: CAM26468.1.
BC017152 mRNA. Translation: AAH17152.1.
CCDSiCCDS17068.1.
RefSeqiNP_659141.1. NM_144892.1.
UniGeneiMm.233080.

Genome annotation databases

EnsembliENSMUST00000040381; ENSMUSP00000046388; ENSMUSG00000039804.
GeneIDi228869.
KEGGimmu:228869.
UCSCiuc008nwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591495 Genomic DNA. Translation: CAM26468.1 .
BC017152 mRNA. Translation: AAH17152.1 .
CCDSi CCDS17068.1.
RefSeqi NP_659141.1. NM_144892.1.
UniGenei Mm.233080.

3D structure databases

ProteinModelPortali Q91W39.
SMRi Q91W39. Positions 197-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230788. 2 interactions.
IntActi Q91W39. 2 interactions.
MINTi MINT-4103204.
STRINGi 10090.ENSMUSP00000046388.

PTM databases

PhosphoSitei Q91W39.

Proteomic databases

MaxQBi Q91W39.
PaxDbi Q91W39.
PRIDEi Q91W39.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040381 ; ENSMUSP00000046388 ; ENSMUSG00000039804 .
GeneIDi 228869.
KEGGi mmu:228869.
UCSCi uc008nwv.1. mouse.

Organism-specific databases

CTDi 57727.
MGIi MGI:2385165. Ncoa5.

Phylogenomic databases

eggNOGi NOG147049.
GeneTreei ENSGT00530000064134.
HOGENOMi HOG000231008.
HOVERGENi HBG052585.
InParanoidi A2A5L2.
OMAi GSARNMG.
OrthoDBi EOG7GTT6B.
PhylomeDBi Q91W39.
TreeFami TF324704.

Miscellaneous databases

ChiTaRSi NCOA5. mouse.
NextBioi 379224.
PROi Q91W39.
SOURCEi Search...

Gene expression databases

Bgeei Q91W39.
CleanExi MM_NCOA5.
Genevestigatori Q91W39.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
InterProi IPR004154. Anticodon-bd.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Retina.
  3. "CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."
    Sauve F., McBroom L.D.B., Gallant J., Moraitis A.N., Labrie F., Giguere V.
    Mol. Cell. Biol. 21:343-353(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiNCOA5_MOUSE
AccessioniPrimary (citable) accession number: Q91W39
Secondary accession number(s): A2A5L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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