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Protein

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Gene

Cox4i2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 2
Short name:
COX IV-2
Gene namesi
Name:Cox4i2
Synonyms:Cox4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2135755. Cox4i2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial membrane Source: MGI
  • mitochondrial respiratory chain complex IV Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 172Cytochrome c oxidase subunit 4 isoform 2, mitochondrialPRO_0000006090
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 55Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91W29.
PRIDEiQ91W29.

Expressioni

Gene expression databases

BgeeiQ91W29.
CleanExiMM_COX4I2.
GenevisibleiQ91W29. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997865.
STRINGi10090.ENSMUSP00000010020.

Structurei

3D structure databases

ProteinModelPortaliQ91W29.
SMRiQ91W29. Positions 35-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG328739.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiQ91W29.
KOiK02263.
OMAiLVIWWQR.
OrthoDBiEOG7BKCWF.
PhylomeDBiQ91W29.
TreeFamiTF105061.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRAARSLV MRTGLRTRGT GTHSPGDAAG SQRRMTPYVD CYAQRSYPMP
60 70 80 90 100
DEPFCTELSE EQRALKEKEK GSWTQLSQAE KVALYRLQFH ETFAEMNHRS
110 120 130 140 150
NEWKTVMGCV FFFIGFTALV IWWQRVYVFP KKVVTLTEER KAQQLQRLLD
160 170
MKSNPIQGLA AHWDYEKKEW KK
Length:172
Mass (Da):20,206
Last modified:December 1, 2001 - v1
Checksum:iA2395EF4FD68CEA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271382 mRNA. Translation: AAK49433.1.
BC049623 mRNA. Translation: AAH49623.1.
CCDSiCCDS16898.1.
RefSeqiNP_444321.1. NM_053091.2.
UniGeneiMm.196668.

Genome annotation databases

EnsembliENSMUST00000010020; ENSMUSP00000010020; ENSMUSG00000009876.
ENSMUST00000109821; ENSMUSP00000105446; ENSMUSG00000009876.
GeneIDi84682.
KEGGimmu:84682.
UCSCiuc008ngg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271382 mRNA. Translation: AAK49433.1.
BC049623 mRNA. Translation: AAH49623.1.
CCDSiCCDS16898.1.
RefSeqiNP_444321.1. NM_053091.2.
UniGeneiMm.196668.

3D structure databases

ProteinModelPortaliQ91W29.
SMRiQ91W29. Positions 35-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997865.
STRINGi10090.ENSMUSP00000010020.

Proteomic databases

PaxDbiQ91W29.
PRIDEiQ91W29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010020; ENSMUSP00000010020; ENSMUSG00000009876.
ENSMUST00000109821; ENSMUSP00000105446; ENSMUSG00000009876.
GeneIDi84682.
KEGGimmu:84682.
UCSCiuc008ngg.1. mouse.

Organism-specific databases

CTDi84701.
MGIiMGI:2135755. Cox4i2.

Phylogenomic databases

eggNOGiNOG328739.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiQ91W29.
KOiK02263.
OMAiLVIWWQR.
OrthoDBiEOG7BKCWF.
PhylomeDBiQ91W29.
TreeFamiTF105061.

Miscellaneous databases

NextBioi350931.
PROiQ91W29.
SOURCEiSearch...

Gene expression databases

BgeeiQ91W29.
CleanExiMM_COX4I2.
GenevisibleiQ91W29. MM.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian subunit IV isoforms of cytochrome c oxidase."
    Huettemann M., Kadenbach B., Grossman L.I.
    Gene 267:111-123(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCOX42_MOUSE
AccessioniPrimary (citable) accession number: Q91W29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.