Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91W29

- COX42_MOUSE

UniProt

Q91W29 - COX42_MOUSE

Protein

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Gene

Cox4i2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: MGI

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase subunit IV isoform 2
    Short name:
    COX IV-2
    Gene namesi
    Name:Cox4i2
    Synonyms:Cox4b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2135755. Cox4i2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: MGI
    2. mitochondrial respiratory chain complex IV Source: MGI
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 172Cytochrome c oxidase subunit 4 isoform 2, mitochondrialPRO_0000006090
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 55Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ91W29.
    PRIDEiQ91W29.

    Expressioni

    Gene expression databases

    BgeeiQ91W29.
    CleanExiMM_COX4I2.
    GenevestigatoriQ91W29.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4997865.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91W29.
    SMRiQ91W29. Positions 35-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase IV family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG328739.
    GeneTreeiENSGT00390000002407.
    HOGENOMiHOG000231486.
    HOVERGENiHBG051087.
    InParanoidiQ91W29.
    KOiK02263.
    OMAiLVIWWQR.
    OrthoDBiEOG7BKCWF.
    PhylomeDBiQ91W29.
    TreeFamiTF105061.

    Family and domain databases

    Gene3Di1.10.442.10. 1 hit.
    InterProiIPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view]
    PfamiPF02936. COX4. 1 hit.
    [Graphical view]
    PRINTSiPR01873. CYTCOXIDASE4.
    SUPFAMiSSF81406. SSF81406. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91W29-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSRAARSLV MRTGLRTRGT GTHSPGDAAG SQRRMTPYVD CYAQRSYPMP    50
    DEPFCTELSE EQRALKEKEK GSWTQLSQAE KVALYRLQFH ETFAEMNHRS 100
    NEWKTVMGCV FFFIGFTALV IWWQRVYVFP KKVVTLTEER KAQQLQRLLD 150
    MKSNPIQGLA AHWDYEKKEW KK 172
    Length:172
    Mass (Da):20,206
    Last modified:December 1, 2001 - v1
    Checksum:iA2395EF4FD68CEA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271382 mRNA. Translation: AAK49433.1.
    BC049623 mRNA. Translation: AAH49623.1.
    CCDSiCCDS16898.1.
    RefSeqiNP_444321.1. NM_053091.2.
    UniGeneiMm.196668.

    Genome annotation databases

    EnsembliENSMUST00000010020; ENSMUSP00000010020; ENSMUSG00000009876.
    ENSMUST00000109821; ENSMUSP00000105446; ENSMUSG00000009876.
    GeneIDi84682.
    KEGGimmu:84682.
    UCSCiuc008ngg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271382 mRNA. Translation: AAK49433.1 .
    BC049623 mRNA. Translation: AAH49623.1 .
    CCDSi CCDS16898.1.
    RefSeqi NP_444321.1. NM_053091.2.
    UniGenei Mm.196668.

    3D structure databases

    ProteinModelPortali Q91W29.
    SMRi Q91W29. Positions 35-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997865.

    Proteomic databases

    PaxDbi Q91W29.
    PRIDEi Q91W29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000010020 ; ENSMUSP00000010020 ; ENSMUSG00000009876 .
    ENSMUST00000109821 ; ENSMUSP00000105446 ; ENSMUSG00000009876 .
    GeneIDi 84682.
    KEGGi mmu:84682.
    UCSCi uc008ngg.1. mouse.

    Organism-specific databases

    CTDi 84701.
    MGIi MGI:2135755. Cox4i2.

    Phylogenomic databases

    eggNOGi NOG328739.
    GeneTreei ENSGT00390000002407.
    HOGENOMi HOG000231486.
    HOVERGENi HBG051087.
    InParanoidi Q91W29.
    KOi K02263.
    OMAi LVIWWQR.
    OrthoDBi EOG7BKCWF.
    PhylomeDBi Q91W29.
    TreeFami TF105061.

    Miscellaneous databases

    NextBioi 350931.
    PROi Q91W29.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91W29.
    CleanExi MM_COX4I2.
    Genevestigatori Q91W29.

    Family and domain databases

    Gene3Di 1.10.442.10. 1 hit.
    InterProi IPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view ]
    Pfami PF02936. COX4. 1 hit.
    [Graphical view ]
    PRINTSi PR01873. CYTCOXIDASE4.
    SUPFAMi SSF81406. SSF81406. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian subunit IV isoforms of cytochrome c oxidase."
      Huettemann M., Kadenbach B., Grossman L.I.
      Gene 267:111-123(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCOX42_MOUSE
    AccessioniPrimary (citable) accession number: Q91W29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3