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Q91W29

- COX42_MOUSE

UniProt

Q91W29 - COX42_MOUSE

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Protein

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Gene

Cox4i2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: MGI

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 2
Short name:
COX IV-2
Gene namesi
Name:Cox4i2
Synonyms:Cox4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2135755. Cox4i2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: MGI
  2. mitochondrial respiratory chain complex IV Source: MGI
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 172Cytochrome c oxidase subunit 4 isoform 2, mitochondrialPRO_0000006090
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 55Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91W29.
PRIDEiQ91W29.

Expressioni

Gene expression databases

BgeeiQ91W29.
CleanExiMM_COX4I2.
GenevestigatoriQ91W29.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997865.

Structurei

3D structure databases

ProteinModelPortaliQ91W29.
SMRiQ91W29. Positions 35-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG328739.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiQ91W29.
KOiK02263.
OMAiLVIWWQR.
OrthoDBiEOG7BKCWF.
PhylomeDBiQ91W29.
TreeFamiTF105061.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSRAARSLV MRTGLRTRGT GTHSPGDAAG SQRRMTPYVD CYAQRSYPMP
60 70 80 90 100
DEPFCTELSE EQRALKEKEK GSWTQLSQAE KVALYRLQFH ETFAEMNHRS
110 120 130 140 150
NEWKTVMGCV FFFIGFTALV IWWQRVYVFP KKVVTLTEER KAQQLQRLLD
160 170
MKSNPIQGLA AHWDYEKKEW KK
Length:172
Mass (Da):20,206
Last modified:December 1, 2001 - v1
Checksum:iA2395EF4FD68CEA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271382 mRNA. Translation: AAK49433.1.
BC049623 mRNA. Translation: AAH49623.1.
CCDSiCCDS16898.1.
RefSeqiNP_444321.1. NM_053091.2.
UniGeneiMm.196668.

Genome annotation databases

EnsembliENSMUST00000010020; ENSMUSP00000010020; ENSMUSG00000009876.
ENSMUST00000109821; ENSMUSP00000105446; ENSMUSG00000009876.
GeneIDi84682.
KEGGimmu:84682.
UCSCiuc008ngg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271382 mRNA. Translation: AAK49433.1 .
BC049623 mRNA. Translation: AAH49623.1 .
CCDSi CCDS16898.1.
RefSeqi NP_444321.1. NM_053091.2.
UniGenei Mm.196668.

3D structure databases

ProteinModelPortali Q91W29.
SMRi Q91W29. Positions 35-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997865.

Proteomic databases

PaxDbi Q91W29.
PRIDEi Q91W29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000010020 ; ENSMUSP00000010020 ; ENSMUSG00000009876 .
ENSMUST00000109821 ; ENSMUSP00000105446 ; ENSMUSG00000009876 .
GeneIDi 84682.
KEGGi mmu:84682.
UCSCi uc008ngg.1. mouse.

Organism-specific databases

CTDi 84701.
MGIi MGI:2135755. Cox4i2.

Phylogenomic databases

eggNOGi NOG328739.
GeneTreei ENSGT00390000002407.
HOGENOMi HOG000231486.
HOVERGENi HBG051087.
InParanoidi Q91W29.
KOi K02263.
OMAi LVIWWQR.
OrthoDBi EOG7BKCWF.
PhylomeDBi Q91W29.
TreeFami TF105061.

Miscellaneous databases

NextBioi 350931.
PROi Q91W29.
SOURCEi Search...

Gene expression databases

Bgeei Q91W29.
CleanExi MM_COX4I2.
Genevestigatori Q91W29.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian subunit IV isoforms of cytochrome c oxidase."
    Huettemann M., Kadenbach B., Grossman L.I.
    Gene 267:111-123(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCOX42_MOUSE
AccessioniPrimary (citable) accession number: Q91W29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3