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Q91W27 (TIP39_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tuberoinfundibular peptide of 39 residues

Short name=TIP39
Alternative name(s):
Parathyroid hormone 2
Gene names
Name:Pth2
Synonyms:Tip39, Tipf39
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Ref.2 Ref.4 Ref.5

Subunit structure

Ligand of high affinity for the PTH2 receptor (PTH2R).

Subcellular location

Secreted.

Tissue specificity

Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed in neurons of cerebral cortex and subcortical areas. Expressed in Purkinje cells of cerebellum. Ref.1 Ref.2 Ref.4

Miscellaneous

The N-terminal truncation of tuberoinfundibular peptide of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity, then is a highly potent and selective antagonist for PTHR1.

Sequence similarities

Belongs to the parathyroid hormone family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionNeuropeptide
   PTMCleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcAMP biosynthetic process

Traceable author statement Ref.2. Source: MGI

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionreceptor binding

Traceable author statement Ref.2. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Propeptide31 – 5929 By similarity
PRO_0000045944
Peptide62 – 10039Tuberoinfundibular peptide of 39 residues
PRO_0000045945

Experimental info

Sequence conflict921Q → H Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q91W27 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: DC778742E13E0243

FASTA10011,022
        10         20         30         40         50         60 
METCQMSRSP RERLLLLLLL LLLVPWGTGP ASGVALPLAG VFSLRAPGRA WAGLGSPLSR 

        70         80         90        100 
RSLALADDAA FRERARLLAA LERRRWLDSY MQKLLLLDAP 

« Hide

References

[1]"Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family."
Hansen I.A., Jakob O., Wortmann S., Arzberger T., Allolio B., Blind E.
J. Endocrinol. 174:95-102(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception."
Dobolyi A., Ueda H., Uchida H., Palkovits M., Usdin T.B.
Proc. Natl. Acad. Sci. U.S.A. 99:1651-1656(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
[3]"Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor."
Della Penna K., Kinose F., Sun H., Koblan K.S., Wang H.
Neuropharmacology 44:141-153(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-90, FUNCTION, INTERACTION WITH PTH2R, TISSUE SPECIFICITY.
Strain: Swiss Webster.
Tissue: Brain.
[5]"Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39)."
Hoare S.R.J., Usdin T.B.
Peptides 23:989-998(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF TRUNCATED PEPTIDE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF399674 mRNA. Translation: AAK84862.1.
AY048587 mRNA. Translation: AAL06596.1.
RefSeqNP_444486.1. NM_053256.2.
XP_006540625.1. XM_006540562.1.
XP_006540626.1. XM_006540563.1.
XP_006540627.1. XM_006540564.1.
XP_006540628.1. XM_006540565.1.
UniGeneMm.207078.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000041047.

Proteomic databases

PaxDbQ91W27.
PRIDEQ91W27.

Protocols and materials databases

DNASU114640.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300.
GeneID114640.
KEGGmmu:114640.
UCSCuc009gtz.1. mouse.

Organism-specific databases

CTD113091.
MGIMGI:2152297. Pth2.

Phylogenomic databases

eggNOGNOG46945.
GeneTreeENSGT00410000026259.
HOGENOMHOG000154591.
HOVERGENHBG094047.
InParanoidQ91W27.
OMAYMHKLLV.
OrthoDBEOG7MSMRW.
PhylomeDBQ91W27.
TreeFamTF353520.

Gene expression databases

BgeeQ91W27.
CleanExMM_PTH2.
GenevestigatorQ91W27.

Family and domain databases

ProtoNetSearch...

Other

NextBio368587.
PROQ91W27.
SOURCESearch...

Entry information

Entry nameTIP39_MOUSE
AccessionPrimary (citable) accession number: Q91W27
Secondary accession number(s): Q91ZA0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot