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Protein

Tuberoinfundibular peptide of 39 residues

Gene

Pth2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.3 Publications

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

  • cAMP biosynthetic process Source: MGI
  • neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Tuberoinfundibular peptide of 39 residues
Short name:
TIP39
Alternative name(s):
Parathyroid hormone 2
Gene namesi
Name:Pth2
Synonyms:Tip39, Tipf39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2152297. Pth2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Propeptidei31 – 5929By similarityPRO_0000045944Add
BLAST
Peptidei62 – 10039Tuberoinfundibular peptide of 39 residuesPRO_0000045945Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ91W27.
PRIDEiQ91W27.

PTM databases

PhosphoSiteiQ91W27.

Expressioni

Tissue specificityi

Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed in neurons of cerebral cortex and subcortical areas. Expressed in Purkinje cells of cerebellum.3 Publications

Gene expression databases

BgeeiENSMUSG00000038300.
CleanExiMM_PTH2.
GenevisibleiQ91W27. MM.

Interactioni

Subunit structurei

Ligand of high affinity for the PTH2 receptor (PTH2R).

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041047.

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J15Z. Eukaryota.
ENOG410Y2YH. LUCA.
GeneTreeiENSGT00410000026259.
HOGENOMiHOG000154591.
HOVERGENiHBG094047.
InParanoidiQ91W27.
OMAiYMHKLLV.
OrthoDBiEOG091G16L2.
PhylomeDBiQ91W27.
TreeFamiTF353520.

Family and domain databases

InterProiIPR029396. TIP39.
[Graphical view]
PfamiPF14980. TIP39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METCQMSRSP RERLLLLLLL LLLVPWGTGP ASGVALPLAG VFSLRAPGRA
60 70 80 90 100
WAGLGSPLSR RSLALADDAA FRERARLLAA LERRRWLDSY MQKLLLLDAP
Length:100
Mass (Da):11,022
Last modified:December 1, 2001 - v1
Checksum:iDC778742E13E0243
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921Q → H (PubMed:12559132).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399674 mRNA. Translation: AAK84862.1.
AY048587 mRNA. Translation: AAL06596.1.
CCDSiCCDS21233.1.
RefSeqiNP_444486.1. NM_053256.2.
XP_006540625.1. XM_006540562.1.
XP_006540626.1. XM_006540563.1.
XP_006540627.1. XM_006540564.2.
XP_006540628.1. XM_006540565.2.
XP_011249080.1. XM_011250778.1.
UniGeneiMm.207078.

Genome annotation databases

EnsembliENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300.
GeneIDi114640.
KEGGimmu:114640.
UCSCiuc009gtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399674 mRNA. Translation: AAK84862.1.
AY048587 mRNA. Translation: AAL06596.1.
CCDSiCCDS21233.1.
RefSeqiNP_444486.1. NM_053256.2.
XP_006540625.1. XM_006540562.1.
XP_006540626.1. XM_006540563.1.
XP_006540627.1. XM_006540564.2.
XP_006540628.1. XM_006540565.2.
XP_011249080.1. XM_011250778.1.
UniGeneiMm.207078.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041047.

PTM databases

PhosphoSiteiQ91W27.

Proteomic databases

PaxDbiQ91W27.
PRIDEiQ91W27.

Protocols and materials databases

DNASUi114640.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300.
GeneIDi114640.
KEGGimmu:114640.
UCSCiuc009gtz.1. mouse.

Organism-specific databases

CTDi113091.
MGIiMGI:2152297. Pth2.

Phylogenomic databases

eggNOGiENOG410J15Z. Eukaryota.
ENOG410Y2YH. LUCA.
GeneTreeiENSGT00410000026259.
HOGENOMiHOG000154591.
HOVERGENiHBG094047.
InParanoidiQ91W27.
OMAiYMHKLLV.
OrthoDBiEOG091G16L2.
PhylomeDBiQ91W27.
TreeFamiTF353520.

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ91W27.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038300.
CleanExiMM_PTH2.
GenevisibleiQ91W27. MM.

Family and domain databases

InterProiIPR029396. TIP39.
[Graphical view]
PfamiPF14980. TIP39. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIP39_MOUSE
AccessioniPrimary (citable) accession number: Q91W27
Secondary accession number(s): Q91ZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The N-terminal truncation of tuberoinfundibular peptide of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity, then is a highly potent and selective antagonist for PTHR1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.