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Q91W27

- TIP39_MOUSE

UniProt

Q91W27 - TIP39_MOUSE

Protein

Tuberoinfundibular peptide of 39 residues

Gene

Pth2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.3 Publications

    GO - Molecular functioni

    1. receptor binding Source: MGI

    GO - Biological processi

    1. cAMP biosynthetic process Source: MGI
    2. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tuberoinfundibular peptide of 39 residues
    Short name:
    TIP39
    Alternative name(s):
    Parathyroid hormone 2
    Gene namesi
    Name:Pth2
    Synonyms:Tip39, Tipf39
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2152297. Pth2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Propeptidei31 – 5929By similarityPRO_0000045944Add
    BLAST
    Peptidei62 – 10039Tuberoinfundibular peptide of 39 residuesPRO_0000045945Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiQ91W27.
    PRIDEiQ91W27.

    Expressioni

    Tissue specificityi

    Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed in neurons of cerebral cortex and subcortical areas. Expressed in Purkinje cells of cerebellum.3 Publications

    Gene expression databases

    BgeeiQ91W27.
    CleanExiMM_PTH2.
    GenevestigatoriQ91W27.

    Interactioni

    Subunit structurei

    Ligand of high affinity for the PTH2 receptor (PTH2R).

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000041047.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the parathyroid hormone family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46945.
    GeneTreeiENSGT00410000026259.
    HOGENOMiHOG000154591.
    HOVERGENiHBG094047.
    InParanoidiQ91W27.
    OMAiSESAIVC.
    OrthoDBiEOG7MSMRW.
    PhylomeDBiQ91W27.
    TreeFamiTF353520.

    Family and domain databases

    InterProiIPR029396. TIP39.
    [Graphical view]
    PfamiPF14980. TIP39. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91W27-1 [UniParc]FASTAAdd to Basket

    « Hide

    METCQMSRSP RERLLLLLLL LLLVPWGTGP ASGVALPLAG VFSLRAPGRA    50
    WAGLGSPLSR RSLALADDAA FRERARLLAA LERRRWLDSY MQKLLLLDAP 100
    Length:100
    Mass (Da):11,022
    Last modified:December 1, 2001 - v1
    Checksum:iDC778742E13E0243
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921Q → H(PubMed:12559132)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF399674 mRNA. Translation: AAK84862.1.
    AY048587 mRNA. Translation: AAL06596.1.
    CCDSiCCDS21233.1.
    RefSeqiNP_444486.1. NM_053256.2.
    XP_006540625.1. XM_006540562.1.
    XP_006540626.1. XM_006540563.1.
    XP_006540627.1. XM_006540564.1.
    XP_006540628.1. XM_006540565.1.
    UniGeneiMm.207078.

    Genome annotation databases

    EnsembliENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300.
    GeneIDi114640.
    KEGGimmu:114640.
    UCSCiuc009gtz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF399674 mRNA. Translation: AAK84862.1 .
    AY048587 mRNA. Translation: AAL06596.1 .
    CCDSi CCDS21233.1.
    RefSeqi NP_444486.1. NM_053256.2.
    XP_006540625.1. XM_006540562.1.
    XP_006540626.1. XM_006540563.1.
    XP_006540627.1. XM_006540564.1.
    XP_006540628.1. XM_006540565.1.
    UniGenei Mm.207078.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000041047.

    Proteomic databases

    PaxDbi Q91W27.
    PRIDEi Q91W27.

    Protocols and materials databases

    DNASUi 114640.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042754 ; ENSMUSP00000041047 ; ENSMUSG00000038300 .
    GeneIDi 114640.
    KEGGi mmu:114640.
    UCSCi uc009gtz.1. mouse.

    Organism-specific databases

    CTDi 113091.
    MGIi MGI:2152297. Pth2.

    Phylogenomic databases

    eggNOGi NOG46945.
    GeneTreei ENSGT00410000026259.
    HOGENOMi HOG000154591.
    HOVERGENi HBG094047.
    InParanoidi Q91W27.
    OMAi SESAIVC.
    OrthoDBi EOG7MSMRW.
    PhylomeDBi Q91W27.
    TreeFami TF353520.

    Miscellaneous databases

    NextBioi 368587.
    PROi Q91W27.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91W27.
    CleanExi MM_PTH2.
    Genevestigatori Q91W27.

    Family and domain databases

    InterProi IPR029396. TIP39.
    [Graphical view ]
    Pfami PF14980. TIP39. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family."
      Hansen I.A., Jakob O., Wortmann S., Arzberger T., Allolio B., Blind E.
      J. Endocrinol. 174:95-102(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception."
      Dobolyi A., Ueda H., Uchida H., Palkovits M., Usdin T.B.
      Proc. Natl. Acad. Sci. U.S.A. 99:1651-1656(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
    3. "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor."
      Della Penna K., Kinose F., Sun H., Koblan K.S., Wang H.
      Neuropharmacology 44:141-153(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
      John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
      Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-90, FUNCTION, INTERACTION WITH PTH2R, TISSUE SPECIFICITY.
      Strain: Swiss Webster.
      Tissue: Brain.
    5. "Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39)."
      Hoare S.R.J., Usdin T.B.
      Peptides 23:989-998(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF TRUNCATED PEPTIDE.

    Entry informationi

    Entry nameiTIP39_MOUSE
    AccessioniPrimary (citable) accession number: Q91W27
    Secondary accession number(s): Q91ZA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The N-terminal truncation of tuberoinfundibular peptide of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity, then is a highly potent and selective antagonist for PTHR1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3