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Q91W27

- TIP39_MOUSE

UniProt

Q91W27 - TIP39_MOUSE

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Protein

Tuberoinfundibular peptide of 39 residues

Gene

Pth2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.3 Publications

GO - Molecular functioni

  1. receptor binding Source: MGI

GO - Biological processi

  1. cAMP biosynthetic process Source: MGI
  2. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Tuberoinfundibular peptide of 39 residues
Short name:
TIP39
Alternative name(s):
Parathyroid hormone 2
Gene namesi
Name:Pth2
Synonyms:Tip39, Tipf39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2152297. Pth2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Propeptidei31 – 5929By similarityPRO_0000045944Add
BLAST
Peptidei62 – 10039Tuberoinfundibular peptide of 39 residuesPRO_0000045945Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ91W27.
PRIDEiQ91W27.

Expressioni

Tissue specificityi

Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed in neurons of cerebral cortex and subcortical areas. Expressed in Purkinje cells of cerebellum.3 Publications

Gene expression databases

BgeeiQ91W27.
CleanExiMM_PTH2.
GenevestigatoriQ91W27.

Interactioni

Subunit structurei

Ligand of high affinity for the PTH2 receptor (PTH2R).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041047.

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46945.
GeneTreeiENSGT00410000026259.
HOGENOMiHOG000154591.
HOVERGENiHBG094047.
InParanoidiQ91W27.
OMAiSESAIVC.
OrthoDBiEOG7MSMRW.
PhylomeDBiQ91W27.
TreeFamiTF353520.

Family and domain databases

InterProiIPR029396. TIP39.
[Graphical view]
PfamiPF14980. TIP39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METCQMSRSP RERLLLLLLL LLLVPWGTGP ASGVALPLAG VFSLRAPGRA
60 70 80 90 100
WAGLGSPLSR RSLALADDAA FRERARLLAA LERRRWLDSY MQKLLLLDAP
Length:100
Mass (Da):11,022
Last modified:December 1, 2001 - v1
Checksum:iDC778742E13E0243
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921Q → H(PubMed:12559132)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF399674 mRNA. Translation: AAK84862.1.
AY048587 mRNA. Translation: AAL06596.1.
CCDSiCCDS21233.1.
RefSeqiNP_444486.1. NM_053256.2.
XP_006540625.1. XM_006540562.1.
XP_006540626.1. XM_006540563.1.
XP_006540627.1. XM_006540564.1.
XP_006540628.1. XM_006540565.1.
UniGeneiMm.207078.

Genome annotation databases

EnsembliENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300.
GeneIDi114640.
KEGGimmu:114640.
UCSCiuc009gtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF399674 mRNA. Translation: AAK84862.1 .
AY048587 mRNA. Translation: AAL06596.1 .
CCDSi CCDS21233.1.
RefSeqi NP_444486.1. NM_053256.2.
XP_006540625.1. XM_006540562.1.
XP_006540626.1. XM_006540563.1.
XP_006540627.1. XM_006540564.1.
XP_006540628.1. XM_006540565.1.
UniGenei Mm.207078.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000041047.

Proteomic databases

PaxDbi Q91W27.
PRIDEi Q91W27.

Protocols and materials databases

DNASUi 114640.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042754 ; ENSMUSP00000041047 ; ENSMUSG00000038300 .
GeneIDi 114640.
KEGGi mmu:114640.
UCSCi uc009gtz.1. mouse.

Organism-specific databases

CTDi 113091.
MGIi MGI:2152297. Pth2.

Phylogenomic databases

eggNOGi NOG46945.
GeneTreei ENSGT00410000026259.
HOGENOMi HOG000154591.
HOVERGENi HBG094047.
InParanoidi Q91W27.
OMAi SESAIVC.
OrthoDBi EOG7MSMRW.
PhylomeDBi Q91W27.
TreeFami TF353520.

Miscellaneous databases

NextBioi 368587.
PROi Q91W27.
SOURCEi Search...

Gene expression databases

Bgeei Q91W27.
CleanExi MM_PTH2.
Genevestigatori Q91W27.

Family and domain databases

InterProi IPR029396. TIP39.
[Graphical view ]
Pfami PF14980. TIP39. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family."
    Hansen I.A., Jakob O., Wortmann S., Arzberger T., Allolio B., Blind E.
    J. Endocrinol. 174:95-102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception."
    Dobolyi A., Ueda H., Uchida H., Palkovits M., Usdin T.B.
    Proc. Natl. Acad. Sci. U.S.A. 99:1651-1656(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
  3. "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor."
    Della Penna K., Kinose F., Sun H., Koblan K.S., Wang H.
    Neuropharmacology 44:141-153(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
    John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
    Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-90, FUNCTION, INTERACTION WITH PTH2R, TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Brain.
  5. "Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39)."
    Hoare S.R.J., Usdin T.B.
    Peptides 23:989-998(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF TRUNCATED PEPTIDE.

Entry informationi

Entry nameiTIP39_MOUSE
AccessioniPrimary (citable) accession number: Q91W27
Secondary accession number(s): Q91ZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The N-terminal truncation of tuberoinfundibular peptide of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity, then is a highly potent and selective antagonist for PTHR1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3