Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat-containing protein 26

Gene

Lrrc26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 26
Alternative name(s):
BK channel auxiliary gamma subunit LRRC26
Gene namesi
Name:Lrrc26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385129. Lrrc26.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 261ExtracellularSequence analysisAdd BLAST235
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 331CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000030936127 – 331Leucine-rich repeat-containing protein 26Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 49Sequence analysis
Disulfide bondi47 ↔ 57Sequence analysis
Disulfide bondi205 ↔ 231Sequence analysis
Disulfide bondi207 ↔ 253Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91W20.
PRIDEiQ91W20.

PTM databases

iPTMnetiQ91W20.
PhosphoSitePlusiQ91W20.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026961.
CleanExiMM_LRRC26.
GenevisibleiQ91W20. MM.

Interactioni

Subunit structurei

Interacts with KCNMA1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028337.

Structurei

3D structure databases

ProteinModelPortaliQ91W20.
SMRiQ91W20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 71LRRNTAdd BLAST38
Repeati72 – 93LRR 1Add BLAST22
Repeati96 – 117LRR 2Add BLAST22
Repeati120 – 141LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati168 – 191LRR 5Add BLAST24
Domaini201 – 255LRRCTAdd BLAST55

Domaini

The transmembrane domain is necessary for interaction with KCNMA1.By similarity

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000113367.
HOVERGENiHBG096585.
InParanoidiQ91W20.
OMAiDAAFSHC.
OrthoDBiEOG091G0G9Q.
PhylomeDBiQ91W20.
TreeFamiTF334689.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91W20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSFFSRLP PQLSLLLLLS LRRVWTQEDI GTAPSKSPVA PECPEACSCS
60 70 80 90 100
LGGKANCSAL ALPAVPADLS WQVRSLLLDH NRVSALPPGA FANAGALLYL
110 120 130 140 150
DLRENRLRSV HARAFWGLGV LQWLDLSSNQ LETLPPGTFA PLRALSFLSL
160 170 180 190 200
AGNRLALLEP SILGPLPLLR VLSLQDNSLS AIEAGLLNNL PALDVLRLHG
210 220 230 240 250
NPWTCNCALR PLCTWLRKHP RPASETETLL CVSPRLQTLS LLTAFPDAAF
260 270 280 290 300
KQCTQSLAAR DLAVVYALGP VSFLASLAIC LALGSVLTAC GARRRRRRRT
310 320 330
TVRHLLRRQL DPEGPPSLED AGSPVTAAIQ A
Length:331
Mass (Da):35,696
Last modified:December 1, 2001 - v1
Checksum:i81659EA77EDC3430
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330Q → R in BAE23492 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137758 mRNA. Translation: BAE23492.1.
AK142669 mRNA. Translation: BAE25154.1.
AL732309 Genomic DNA. Translation: CAM14683.1.
BC024531 mRNA. Translation: AAH24531.1.
BC024539 mRNA. Translation: AAH24539.1.
BC004853 mRNA. Translation: AAH04853.1.
CCDSiCCDS15763.1.
RefSeqiNP_666229.1. NM_146117.2.
UniGeneiMm.275228.

Genome annotation databases

EnsembliENSMUST00000028337; ENSMUSP00000028337; ENSMUSG00000026961.
GeneIDi227618.
KEGGimmu:227618.
UCSCiuc008irg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137758 mRNA. Translation: BAE23492.1.
AK142669 mRNA. Translation: BAE25154.1.
AL732309 Genomic DNA. Translation: CAM14683.1.
BC024531 mRNA. Translation: AAH24531.1.
BC024539 mRNA. Translation: AAH24539.1.
BC004853 mRNA. Translation: AAH04853.1.
CCDSiCCDS15763.1.
RefSeqiNP_666229.1. NM_146117.2.
UniGeneiMm.275228.

3D structure databases

ProteinModelPortaliQ91W20.
SMRiQ91W20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028337.

PTM databases

iPTMnetiQ91W20.
PhosphoSitePlusiQ91W20.

Proteomic databases

PaxDbiQ91W20.
PRIDEiQ91W20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028337; ENSMUSP00000028337; ENSMUSG00000026961.
GeneIDi227618.
KEGGimmu:227618.
UCSCiuc008irg.2. mouse.

Organism-specific databases

CTDi389816.
MGIiMGI:2385129. Lrrc26.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000113367.
HOVERGENiHBG096585.
InParanoidiQ91W20.
OMAiDAAFSHC.
OrthoDBiEOG091G0G9Q.
PhylomeDBiQ91W20.
TreeFamiTF334689.

Miscellaneous databases

PROiQ91W20.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026961.
CleanExiMM_LRRC26.
GenevisibleiQ91W20. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC26_MOUSE
AccessioniPrimary (citable) accession number: Q91W20
Secondary accession number(s): Q3UUY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.