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Protein

Zinc transporter ZIP8

Gene

Slc39a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.8. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP8
Alternative name(s):
Solute carrier family 39 member 8
Zrt- and Irt-like protein 8
Short name:
ZIP-8
Gene namesi
Name:Slc39a8
Synonyms:Zip8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914797. Slc39a8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 23HelicalSequence analysisAdd BLAST17
Topological domaini24 – 132CytoplasmicSequence analysisAdd BLAST109
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 160ExtracellularSequence analysis7
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 191CytoplasmicSequence analysis10
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 304ExtracellularSequence analysisAdd BLAST92
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 367CytoplasmicSequence analysisAdd BLAST42
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 390ExtracellularSequence analysis2
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 431CytoplasmicSequence analysisAdd BLAST20
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 462ExtracellularSequence analysis10

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • organelle membrane Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127081 – 462Zinc transporter ZIP8Add BLAST462

Proteomic databases

PaxDbiQ91W10.
PeptideAtlasiQ91W10.
PRIDEiQ91W10.

PTM databases

PhosphoSitePlusiQ91W10.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053897.
GenevisibleiQ91W10. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029810.

Structurei

3D structure databases

ProteinModelPortaliQ91W10.
SMRiQ91W10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi345 – 350XEXPHE-motifBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 13Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ91W10.
KOiK14714.
OMAiFFVERVL.
OrthoDBiEOG091G064Y.
PhylomeDBiQ91W10.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91W10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPGRAVAGL LLLAATSLGH PSEGPELAFS EDVLSVFGAN RSLSAAQLGR
60 70 80 90 100
LLERLGAASQ QGALDLGQLH FNQCLSAEDI FSLHGFSNVT QITSSNFSAI
110 120 130 140 150
CPAILQQLNF HPCEDLRKHN AKPSLSEVWG YGFLSVTIIN LASLLGLILT
160 170 180 190 200
PLIKKSYFPK ILTYFVGLAI GTLFSNAIFQ LIPEAFGFNP KIDNYVEKAV
210 220 230 240 250
AVFGGFYMLF FVERTLKMLL KTYGQNDHTH FRNDDFGSKE KTHQPKTLPL
260 270 280 290 300
PAVNGVTCYA NPAVTEPNGH IHFDTVSVVS LQDGKTEPSS CTCLKGPKLS
310 320 330 340 350
EIGTIAWMIT LCDALHNFID GLAIGASCTL SLLQGLSTSI AILCEEFPHE
360 370 380 390 400
LGDFVILLNA GMSTRQALLF NFLSACSCYV GLAFGILVGN NFAPNIIFAL
410 420 430 440 450
AGGMFLYISL ADMFPEMNDM LREKVTGRQT DFTFFMIQNA GMLTGFTAIL
460
LITLYAGDIE LQ
Length:462
Mass (Da):50,082
Last modified:December 1, 2001 - v1
Checksum:i52EBA157C295411C
GO
Isoform 2 (identifier: Q91W10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-341: DGKTEPSSCT...LLQGLSTSIA → VCPADCTFLL...LSLWMLRPTK
     342-462: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):37,465
Checksum:i90633BFE59004E51
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94S → R in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti98S → C in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti104I → M in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti108L → V in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti113C → W in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti116L → V in BAC40727 (PubMed:16141072).Curated1
Sequence conflicti316H → Y in BAB30465 (PubMed:16141072).Curated1
Sequence conflicti371N → S in BAB29610 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029886283 – 341DGKTE…STSIA → VCPADCTFLLIFCVIFTIKV AGNAGSQYFKCSHVKPAHLH RRSHFTFFLLSLWMLRPTK in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_029887342 – 462Missing in isoform 2. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014895 mRNA. Translation: BAB29610.1.
AK016853 mRNA. Translation: BAB30465.1.
AK085740 mRNA. Translation: BAC39526.1.
AK089060 mRNA. Translation: BAC40727.1.
BC006731 mRNA. Translation: AAH06731.1.
CCDSiCCDS17859.1. [Q91W10-1]
RefSeqiNP_001128621.1. NM_001135149.1. [Q91W10-1]
NP_001128622.1. NM_001135150.1. [Q91W10-1]
NP_080504.3. NM_026228.5. [Q91W10-1]
XP_006501997.1. XM_006501934.2. [Q91W10-1]
UniGeneiMm.30239.
Mm.491277.

Genome annotation databases

EnsembliENSMUST00000029810; ENSMUSP00000029810; ENSMUSG00000053897. [Q91W10-1]
ENSMUST00000081978; ENSMUSP00000080640; ENSMUSG00000053897. [Q91W10-1]
ENSMUST00000167390; ENSMUSP00000128245; ENSMUSG00000053897. [Q91W10-1]
ENSMUST00000180196; ENSMUSP00000136634; ENSMUSG00000053897. [Q91W10-1]
GeneIDi67547.
KEGGimmu:67547.
UCSCiuc008rlz.3. mouse. [Q91W10-1]
uc008rma.2. mouse. [Q91W10-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014895 mRNA. Translation: BAB29610.1.
AK016853 mRNA. Translation: BAB30465.1.
AK085740 mRNA. Translation: BAC39526.1.
AK089060 mRNA. Translation: BAC40727.1.
BC006731 mRNA. Translation: AAH06731.1.
CCDSiCCDS17859.1. [Q91W10-1]
RefSeqiNP_001128621.1. NM_001135149.1. [Q91W10-1]
NP_001128622.1. NM_001135150.1. [Q91W10-1]
NP_080504.3. NM_026228.5. [Q91W10-1]
XP_006501997.1. XM_006501934.2. [Q91W10-1]
UniGeneiMm.30239.
Mm.491277.

3D structure databases

ProteinModelPortaliQ91W10.
SMRiQ91W10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029810.

Protein family/group databases

TCDBi2.A.5.4.8. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSitePlusiQ91W10.

Proteomic databases

PaxDbiQ91W10.
PeptideAtlasiQ91W10.
PRIDEiQ91W10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029810; ENSMUSP00000029810; ENSMUSG00000053897. [Q91W10-1]
ENSMUST00000081978; ENSMUSP00000080640; ENSMUSG00000053897. [Q91W10-1]
ENSMUST00000167390; ENSMUSP00000128245; ENSMUSG00000053897. [Q91W10-1]
ENSMUST00000180196; ENSMUSP00000136634; ENSMUSG00000053897. [Q91W10-1]
GeneIDi67547.
KEGGimmu:67547.
UCSCiuc008rlz.3. mouse. [Q91W10-1]
uc008rma.2. mouse. [Q91W10-2]

Organism-specific databases

CTDi64116.
MGIiMGI:1914797. Slc39a8.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ91W10.
KOiK14714.
OMAiFFVERVL.
OrthoDBiEOG091G064Y.
PhylomeDBiQ91W10.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

PROiQ91W10.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053897.
GenevisibleiQ91W10. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A8_MOUSE
AccessioniPrimary (citable) accession number: Q91W10
Secondary accession number(s): Q8BTQ3
, Q8BUD6, Q9D426, Q9D5V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.