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Protein

Cytohesin-interacting protein

Gene

Cytip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-interacting protein
Alternative name(s):
Cytohesin-binding protein HE
Short name:
Cbp HE
Pleckstrin homology Sec7 and coiled-coil domains-binding protein
Gene namesi
Name:Cytip
Synonyms:Pscdbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2183535. Cytip.

Subcellular locationi

  • Cytoplasm By similarity
  • Early endosome By similarity

  • Note: Recruited from the cytosol to endosomes by SNX27.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Cytohesin-interacting proteinPRO_0000097062Add
BLAST

Proteomic databases

PRIDEiQ91VY6.

PTM databases

PhosphoSiteiQ91VY6.

Expressioni

Gene expression databases

BgeeiQ91VY6.
ExpressionAtlasiQ91VY6. baseline and differential.
GenevisibleiQ91VY6. MM.

Interactioni

Subunit structurei

Interacts with CYTH1 and SNX27.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028175.

Structurei

3D structure databases

ProteinModelPortaliQ91VY6.
SMRiQ91VY6. Positions 70-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 16690PDZPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 18823Interaction with CYTH1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili165 – 18824Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi241 – 32383Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG244814.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ91VY6.
OMAiEMCTLIC.
OrthoDBiEOG72NRQP.
PhylomeDBiQ91VY6.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQRFLQRQ GSNGNLEYCA DSAYGSYSVL TGQLTMEDNR RIQVLADTVA
60 70 80 90 100
TLPRGRKQLA LARSSSLGDF SWSQRKVVTV EKQDNGTFGF EIQTYRLQNQ
110 120 130 140 150
NICSSEVCTM ICKVQEDSPA HCAGLQVGDI FANVNGVSTE GFTHKQVVDL
160 170 180 190 200
IRSSGNLLTI ETLNGTMIHR RAELEAKLQT LKQTLKKKWV ELRSLHLQEQ
210 220 230 240 250
RLLHGDTANS PNLENMDLDE SSLFGNLLGP SPALLDRHRL SSESSCKSWL
260 270 280 290 300
SSLTVDSEDG YRSSMSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR
310 320 330 340 350
RNRSISVTSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR

AVEEEESRF
Length:359
Mass (Da):40,143
Last modified:December 1, 2001 - v1
Checksum:i4C922BC8B96B11F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61F → Q in AAF04842 (PubMed:12909129).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089364 mRNA. Translation: BAC40855.1.
AK152784 mRNA. Translation: BAE31493.1.
AK157859 mRNA. Translation: BAE34237.1.
AK169575 mRNA. Translation: BAE41236.1.
AK170544 mRNA. Translation: BAE41869.1.
AK171467 mRNA. Translation: BAE42473.1.
AK172071 mRNA. Translation: BAE42810.1.
AL928564 Genomic DNA. Translation: CAM18785.1.
BC007144 mRNA. Translation: AAH07144.1.
AF374273 mRNA. Translation: AAL87039.1.
AF192525 mRNA. Translation: AAF04842.1.
CCDSiCCDS16048.1.
RefSeqiNP_631939.1. NM_139200.4.
XP_006498075.1. XM_006498012.2.
XP_006498076.1. XM_006498013.2.
UniGeneiMm.273905.

Genome annotation databases

EnsembliENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832.
GeneIDi227929.
KEGGimmu:227929.
UCSCiuc008jsi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089364 mRNA. Translation: BAC40855.1.
AK152784 mRNA. Translation: BAE31493.1.
AK157859 mRNA. Translation: BAE34237.1.
AK169575 mRNA. Translation: BAE41236.1.
AK170544 mRNA. Translation: BAE41869.1.
AK171467 mRNA. Translation: BAE42473.1.
AK172071 mRNA. Translation: BAE42810.1.
AL928564 Genomic DNA. Translation: CAM18785.1.
BC007144 mRNA. Translation: AAH07144.1.
AF374273 mRNA. Translation: AAL87039.1.
AF192525 mRNA. Translation: AAF04842.1.
CCDSiCCDS16048.1.
RefSeqiNP_631939.1. NM_139200.4.
XP_006498075.1. XM_006498012.2.
XP_006498076.1. XM_006498013.2.
UniGeneiMm.273905.

3D structure databases

ProteinModelPortaliQ91VY6.
SMRiQ91VY6. Positions 70-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028175.

PTM databases

PhosphoSiteiQ91VY6.

Proteomic databases

PRIDEiQ91VY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832.
GeneIDi227929.
KEGGimmu:227929.
UCSCiuc008jsi.1. mouse.

Organism-specific databases

CTDi9595.
MGIiMGI:2183535. Cytip.

Phylogenomic databases

eggNOGiNOG244814.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ91VY6.
OMAiEMCTLIC.
OrthoDBiEOG72NRQP.
PhylomeDBiQ91VY6.
TreeFamiTF316315.

Miscellaneous databases

ChiTaRSiCytip. mouse.
NextBioi378860.
PROiQ91VY6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VY6.
ExpressionAtlasiQ91VY6. baseline and differential.
GenevisibleiQ91VY6. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Spleen and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
    Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
    J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
  5. "A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer."
    Gorski K.S., Shin T., Crafton E., Otsuji M., Rattis F.M., Huang X., Kelleher E., Francisco L., Pardoll D., Tsuchiya H.
    Mol. Immunol. 40:35-47(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-359.
    Tissue: Bone marrow.

Entry informationi

Entry nameiCYTIP_MOUSE
AccessioniPrimary (citable) accession number: Q91VY6
Secondary accession number(s): A2AS77
, Q3TZH1, Q8R4T4, Q9QZA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.