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Q91VY6 (CYTIP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytohesin-interacting protein
Alternative name(s):
Cytohesin-binding protein HE
Short name=Cbp HE
Pleckstrin homology Sec7 and coiled-coil domains-binding protein
Gene names
Name:Cytip
Synonyms:Pscdbp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm By similarity.

Subunit structure

Interacts with CYTH1 and SNX27 By similarity.

Subcellular location

Cytoplasm By similarity. Early endosome By similarity. Note: Recruited from the cytosol to endosomes by SNX27 By similarity.

Sequence similarities

Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Endosome
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: Ensembl

early endosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Cytohesin-interacting protein
PRO_0000097062

Regions

Domain77 – 16690PDZ
Region166 – 18823Interaction with CYTH1 By similarity
Coiled coil165 – 18824 Potential
Compositional bias241 – 32383Ser-rich

Experimental info

Sequence conflict61F → Q in AAF04842. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q91VY6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4C922BC8B96B11F7

FASTA35940,143
        10         20         30         40         50         60 
MSLQRFLQRQ GSNGNLEYCA DSAYGSYSVL TGQLTMEDNR RIQVLADTVA TLPRGRKQLA 

        70         80         90        100        110        120 
LARSSSLGDF SWSQRKVVTV EKQDNGTFGF EIQTYRLQNQ NICSSEVCTM ICKVQEDSPA 

       130        140        150        160        170        180 
HCAGLQVGDI FANVNGVSTE GFTHKQVVDL IRSSGNLLTI ETLNGTMIHR RAELEAKLQT 

       190        200        210        220        230        240 
LKQTLKKKWV ELRSLHLQEQ RLLHGDTANS PNLENMDLDE SSLFGNLLGP SPALLDRHRL 

       250        260        270        280        290        300 
SSESSCKSWL SSLTVDSEDG YRSSMSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR 

       310        320        330        340        350 
RNRSISVTSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR AVEEEESRF 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Bone marrow, Spleen and Thymus.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
[5]"A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer."
Gorski K.S., Shin T., Crafton E., Otsuji M., Rattis F.M., Huang X., Kelleher E., Francisco L., Pardoll D., Tsuchiya H.
Mol. Immunol. 40:35-47(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-359.
Tissue: Bone marrow.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK089364 mRNA. Translation: BAC40855.1.
AK152784 mRNA. Translation: BAE31493.1.
AK157859 mRNA. Translation: BAE34237.1.
AK169575 mRNA. Translation: BAE41236.1.
AK170544 mRNA. Translation: BAE41869.1.
AK171467 mRNA. Translation: BAE42473.1.
AK172071 mRNA. Translation: BAE42810.1.
AL928564 Genomic DNA. Translation: CAM18785.1.
BC007144 mRNA. Translation: AAH07144.1.
AF374273 mRNA. Translation: AAL87039.1.
AF192525 mRNA. Translation: AAF04842.1.
RefSeqNP_631939.1. NM_139200.4.
XP_006498075.1. XM_006498012.1.
XP_006498076.1. XM_006498013.1.
UniGeneMm.273905.

3D structure databases

ProteinModelPortalQ91VY6.
SMRQ91VY6. Positions 70-163.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91VY6.

Proteomic databases

PRIDEQ91VY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832.
GeneID227929.
KEGGmmu:227929.
UCSCuc008jsi.1. mouse.

Organism-specific databases

CTD9595.
MGIMGI:2183535. Cytip.

Phylogenomic databases

eggNOGNOG244814.
GeneTreeENSGT00530000063734.
HOGENOMHOG000231871.
HOVERGENHBG053061.
InParanoidA2AS77.
OMAEMCTLIC.
OrthoDBEOG72NRQP.
PhylomeDBQ91VY6.
TreeFamTF316315.

Gene expression databases

ArrayExpressQ91VY6.
BgeeQ91VY6.
GenevestigatorQ91VY6.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR001478. PDZ.
[Graphical view]
PfamPF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCYTIP. mouse.
NextBio378860.
PROQ91VY6.
SOURCESearch...

Entry information

Entry nameCYTIP_MOUSE
AccessionPrimary (citable) accession number: Q91VY6
Secondary accession number(s): A2AS77 expand/collapse secondary AC list , Q3TZH1, Q8R4T4, Q9QZA9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot