Q91VY6 (CYTIP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytohesin-interacting protein

Alternative name(s):
Cytohesin-binding protein HE
Short name=Cbp HE
Pleckstrin homology Sec7 and coiled-coil domains-binding protein

Gene names

Name:	Cytip
Synonyms:	Pscdbp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm By similarity.
Subunit structure	Interacts with CYTH1 and SNX27 By similarity.
Subcellular location	Cytoplasm By similarity. Early endosome By similarity. Note: Recruited from the cytosol to endosomes by SNX27 By similarity.
Sequence similarities	Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Cytoplasm Endosome
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cell adhesion Inferred from electronic annotation. Source: Compara
Cellular_component	cell cortex Inferred from electronic annotation. Source: Compara early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Cytohesin-interacting protein		PRO_0000097062
Regions
	Domain	77 – 166	90	PDZ
	Region	166 – 188	23	Interaction with CYTH1 By similarity
	Coiled coil	165 – 188	24	Potential
	Compositional bias	241 – 323	83	Ser-rich
Experimental info
	Sequence conflict	6	1	F → Q in AAF04842. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q91VY6 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4C922BC8B96B11F7	FASTA	359	40,143
	10 20 30 40 50 60 MSLQRFLQRQ GSNGNLEYCA DSAYGSYSVL TGQLTMEDNR RIQVLADTVA TLPRGRKQLA 70 80 90 100 110 120 LARSSSLGDF SWSQRKVVTV EKQDNGTFGF EIQTYRLQNQ NICSSEVCTM ICKVQEDSPA 130 140 150 160 170 180 HCAGLQVGDI FANVNGVSTE GFTHKQVVDL IRSSGNLLTI ETLNGTMIHR RAELEAKLQT 190 200 210 220 230 240 LKQTLKKKWV ELRSLHLQEQ RLLHGDTANS PNLENMDLDE SSLFGNLLGP SPALLDRHRL 250 260 270 280 290 300 SSESSCKSWL SSLTVDSEDG YRSSMSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR 310 320 330 340 350 RNRSISVTSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR AVEEEESRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Bone marrow, Spleen and Thymus.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[4]	"Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins." Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S. J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
[5]	"A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer." Gorski K.S., Shin T., Crafton E., Otsuji M., Rattis F.M., Huang X., Kelleher E., Francisco L., Pardoll D., Tsuchiya H. Mol. Immunol. 40:35-47(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-359. Tissue: Bone marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK089364 mRNA. Translation: BAC40855.1. AK152784 mRNA. Translation: BAE31493.1. AK157859 mRNA. Translation: BAE34237.1. AK169575 mRNA. Translation: BAE41236.1. AK170544 mRNA. Translation: BAE41869.1. AK171467 mRNA. Translation: BAE42473.1. AK172071 mRNA. Translation: BAE42810.1. AL928564 Genomic DNA. Translation: CAM18785.1. BC007144 mRNA. Translation: AAH07144.1. AF374273 mRNA. Translation: AAL87039.1. AF192525 mRNA. Translation: AAF04842.1.
IPI	IPI00127446.
RefSeq	NP_631939.1. NM_139200.4.
UniGene	Mm.489718.
3D structure databases
ProteinModelPortal	Q91VY6.
SMR	Q91VY6. Positions 70-163.
ModBase	Search...
PTM databases
PhosphoSite	Q91VY6.
Proteomic databases
PRIDE	Q91VY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832.
GeneID	227929.
KEGG	mmu:227929.
UCSC	uc008jsi.1. mouse.
Organism-specific databases
CTD	9595.
MGI	MGI:2183535. Cytip.
Phylogenomic databases
eggNOG	NOG244814.
GeneTree	ENSGT00530000063734.
HOGENOM	HOG000231871.
HOVERGEN	HBG053061.
InParanoid	A2AS77.
OMA	TDDECFV.
OrthoDB	EOG4JQ3Z3.
Gene expression databases
ArrayExpress	Q91VY6.
Bgee	Q91VY6.
Genevestigator	Q91VY6.
GermOnline	ENSMUSG00000026832. Mus musculus.
Family and domain databases
InterPro	IPR001478. PDZ. [Graphical view]
Pfam	PF00595. PDZ. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CYTIP. mouse.
NextBio	378860.
SOURCE	Search...

Entry information

Entry name

CYTIP_MOUSE

Accession

Primary (citable) accession number: Q91VY6
Secondary accession number(s): A2AS77 , Q3TZH1, Q8R4T4, Q9QZA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program