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Q91VY6

- CYTIP_MOUSE

UniProt

Q91VY6 - CYTIP_MOUSE

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Protein

Cytohesin-interacting protein

Gene
Cytip, Pscdbp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm By similarity.

GO - Biological processi

  1. regulation of cell adhesion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-interacting protein
Alternative name(s):
Cytohesin-binding protein HE
Short name:
Cbp HE
Pleckstrin homology Sec7 and coiled-coil domains-binding protein
Gene namesi
Name:Cytip
Synonyms:Pscdbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2183535. Cytip.

Subcellular locationi

Cytoplasm By similarity. Early endosome By similarity
Note: Recruited from the cytosol to endosomes by SNX27 By similarity.

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. early endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Cytohesin-interacting proteinPRO_0000097062Add
BLAST

Proteomic databases

PRIDEiQ91VY6.

PTM databases

PhosphoSiteiQ91VY6.

Expressioni

Gene expression databases

ArrayExpressiQ91VY6.
BgeeiQ91VY6.
GenevestigatoriQ91VY6.

Interactioni

Subunit structurei

Interacts with CYTH1 and SNX27 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ91VY6.
SMRiQ91VY6. Positions 70-163.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 16690PDZAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 18823Interaction with CYTH1 By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili165 – 18824 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi241 – 32383Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG244814.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiA2AS77.
OMAiEMCTLIC.
OrthoDBiEOG72NRQP.
PhylomeDBiQ91VY6.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VY6-1 [UniParc]FASTAAdd to Basket

« Hide

MSLQRFLQRQ GSNGNLEYCA DSAYGSYSVL TGQLTMEDNR RIQVLADTVA    50
TLPRGRKQLA LARSSSLGDF SWSQRKVVTV EKQDNGTFGF EIQTYRLQNQ 100
NICSSEVCTM ICKVQEDSPA HCAGLQVGDI FANVNGVSTE GFTHKQVVDL 150
IRSSGNLLTI ETLNGTMIHR RAELEAKLQT LKQTLKKKWV ELRSLHLQEQ 200
RLLHGDTANS PNLENMDLDE SSLFGNLLGP SPALLDRHRL SSESSCKSWL 250
SSLTVDSEDG YRSSMSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR 300
RNRSISVTSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR 350
AVEEEESRF 359
Length:359
Mass (Da):40,143
Last modified:December 1, 2001 - v1
Checksum:i4C922BC8B96B11F7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61F → Q in AAF04842. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK089364 mRNA. Translation: BAC40855.1.
AK152784 mRNA. Translation: BAE31493.1.
AK157859 mRNA. Translation: BAE34237.1.
AK169575 mRNA. Translation: BAE41236.1.
AK170544 mRNA. Translation: BAE41869.1.
AK171467 mRNA. Translation: BAE42473.1.
AK172071 mRNA. Translation: BAE42810.1.
AL928564 Genomic DNA. Translation: CAM18785.1.
BC007144 mRNA. Translation: AAH07144.1.
AF374273 mRNA. Translation: AAL87039.1.
AF192525 mRNA. Translation: AAF04842.1.
CCDSiCCDS16048.1.
RefSeqiNP_631939.1. NM_139200.4.
XP_006498075.1. XM_006498012.1.
XP_006498076.1. XM_006498013.1.
UniGeneiMm.273905.

Genome annotation databases

EnsembliENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832.
GeneIDi227929.
KEGGimmu:227929.
UCSCiuc008jsi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK089364 mRNA. Translation: BAC40855.1 .
AK152784 mRNA. Translation: BAE31493.1 .
AK157859 mRNA. Translation: BAE34237.1 .
AK169575 mRNA. Translation: BAE41236.1 .
AK170544 mRNA. Translation: BAE41869.1 .
AK171467 mRNA. Translation: BAE42473.1 .
AK172071 mRNA. Translation: BAE42810.1 .
AL928564 Genomic DNA. Translation: CAM18785.1 .
BC007144 mRNA. Translation: AAH07144.1 .
AF374273 mRNA. Translation: AAL87039.1 .
AF192525 mRNA. Translation: AAF04842.1 .
CCDSi CCDS16048.1.
RefSeqi NP_631939.1. NM_139200.4.
XP_006498075.1. XM_006498012.1.
XP_006498076.1. XM_006498013.1.
UniGenei Mm.273905.

3D structure databases

ProteinModelPortali Q91VY6.
SMRi Q91VY6. Positions 70-163.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91VY6.

Proteomic databases

PRIDEi Q91VY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028175 ; ENSMUSP00000028175 ; ENSMUSG00000026832 .
GeneIDi 227929.
KEGGi mmu:227929.
UCSCi uc008jsi.1. mouse.

Organism-specific databases

CTDi 9595.
MGIi MGI:2183535. Cytip.

Phylogenomic databases

eggNOGi NOG244814.
GeneTreei ENSGT00530000063734.
HOGENOMi HOG000231871.
HOVERGENi HBG053061.
InParanoidi A2AS77.
OMAi EMCTLIC.
OrthoDBi EOG72NRQP.
PhylomeDBi Q91VY6.
TreeFami TF316315.

Miscellaneous databases

ChiTaRSi CYTIP. mouse.
NextBioi 378860.
PROi Q91VY6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91VY6.
Bgeei Q91VY6.
Genevestigatori Q91VY6.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Spleen and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
    Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
    J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
  5. "A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer."
    Gorski K.S., Shin T., Crafton E., Otsuji M., Rattis F.M., Huang X., Kelleher E., Francisco L., Pardoll D., Tsuchiya H.
    Mol. Immunol. 40:35-47(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-359.
    Tissue: Bone marrow.

Entry informationi

Entry nameiCYTIP_MOUSE
AccessioniPrimary (citable) accession number: Q91VY6
Secondary accession number(s): A2AS77
, Q3TZH1, Q8R4T4, Q9QZA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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