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Q91VY6

- CYTIP_MOUSE

UniProt

Q91VY6 - CYTIP_MOUSE

Protein

Cytohesin-interacting protein

Gene

Cytip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.By similarity

    GO - Biological processi

    1. regulation of cell adhesion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytohesin-interacting protein
    Alternative name(s):
    Cytohesin-binding protein HE
    Short name:
    Cbp HE
    Pleckstrin homology Sec7 and coiled-coil domains-binding protein
    Gene namesi
    Name:Cytip
    Synonyms:Pscdbp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2183535. Cytip.

    Subcellular locationi

    Cytoplasm By similarity. Early endosome By similarity
    Note: Recruited from the cytosol to endosomes by SNX27.By similarity

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. early endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Cytohesin-interacting proteinPRO_0000097062Add
    BLAST

    Proteomic databases

    PRIDEiQ91VY6.

    PTM databases

    PhosphoSiteiQ91VY6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91VY6.
    BgeeiQ91VY6.
    GenevestigatoriQ91VY6.

    Interactioni

    Subunit structurei

    Interacts with CYTH1 and SNX27.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91VY6.
    SMRiQ91VY6. Positions 70-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini77 – 16690PDZPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni166 – 18823Interaction with CYTH1By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili165 – 18824Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi241 – 32383Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG244814.
    GeneTreeiENSGT00530000063734.
    HOGENOMiHOG000231871.
    HOVERGENiHBG053061.
    InParanoidiA2AS77.
    OMAiEMCTLIC.
    OrthoDBiEOG72NRQP.
    PhylomeDBiQ91VY6.
    TreeFamiTF316315.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91VY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLQRFLQRQ GSNGNLEYCA DSAYGSYSVL TGQLTMEDNR RIQVLADTVA    50
    TLPRGRKQLA LARSSSLGDF SWSQRKVVTV EKQDNGTFGF EIQTYRLQNQ 100
    NICSSEVCTM ICKVQEDSPA HCAGLQVGDI FANVNGVSTE GFTHKQVVDL 150
    IRSSGNLLTI ETLNGTMIHR RAELEAKLQT LKQTLKKKWV ELRSLHLQEQ 200
    RLLHGDTANS PNLENMDLDE SSLFGNLLGP SPALLDRHRL SSESSCKSWL 250
    SSLTVDSEDG YRSSMSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR 300
    RNRSISVTSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR 350
    AVEEEESRF 359
    Length:359
    Mass (Da):40,143
    Last modified:December 1, 2001 - v1
    Checksum:i4C922BC8B96B11F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61F → Q in AAF04842. (PubMed:12909129)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK089364 mRNA. Translation: BAC40855.1.
    AK152784 mRNA. Translation: BAE31493.1.
    AK157859 mRNA. Translation: BAE34237.1.
    AK169575 mRNA. Translation: BAE41236.1.
    AK170544 mRNA. Translation: BAE41869.1.
    AK171467 mRNA. Translation: BAE42473.1.
    AK172071 mRNA. Translation: BAE42810.1.
    AL928564 Genomic DNA. Translation: CAM18785.1.
    BC007144 mRNA. Translation: AAH07144.1.
    AF374273 mRNA. Translation: AAL87039.1.
    AF192525 mRNA. Translation: AAF04842.1.
    CCDSiCCDS16048.1.
    RefSeqiNP_631939.1. NM_139200.4.
    XP_006498075.1. XM_006498012.1.
    XP_006498076.1. XM_006498013.1.
    UniGeneiMm.273905.

    Genome annotation databases

    EnsembliENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832.
    GeneIDi227929.
    KEGGimmu:227929.
    UCSCiuc008jsi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK089364 mRNA. Translation: BAC40855.1 .
    AK152784 mRNA. Translation: BAE31493.1 .
    AK157859 mRNA. Translation: BAE34237.1 .
    AK169575 mRNA. Translation: BAE41236.1 .
    AK170544 mRNA. Translation: BAE41869.1 .
    AK171467 mRNA. Translation: BAE42473.1 .
    AK172071 mRNA. Translation: BAE42810.1 .
    AL928564 Genomic DNA. Translation: CAM18785.1 .
    BC007144 mRNA. Translation: AAH07144.1 .
    AF374273 mRNA. Translation: AAL87039.1 .
    AF192525 mRNA. Translation: AAF04842.1 .
    CCDSi CCDS16048.1.
    RefSeqi NP_631939.1. NM_139200.4.
    XP_006498075.1. XM_006498012.1.
    XP_006498076.1. XM_006498013.1.
    UniGenei Mm.273905.

    3D structure databases

    ProteinModelPortali Q91VY6.
    SMRi Q91VY6. Positions 70-163.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91VY6.

    Proteomic databases

    PRIDEi Q91VY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028175 ; ENSMUSP00000028175 ; ENSMUSG00000026832 .
    GeneIDi 227929.
    KEGGi mmu:227929.
    UCSCi uc008jsi.1. mouse.

    Organism-specific databases

    CTDi 9595.
    MGIi MGI:2183535. Cytip.

    Phylogenomic databases

    eggNOGi NOG244814.
    GeneTreei ENSGT00530000063734.
    HOGENOMi HOG000231871.
    HOVERGENi HBG053061.
    InParanoidi A2AS77.
    OMAi EMCTLIC.
    OrthoDBi EOG72NRQP.
    PhylomeDBi Q91VY6.
    TreeFami TF316315.

    Miscellaneous databases

    ChiTaRSi CYTIP. mouse.
    NextBioi 378860.
    PROi Q91VY6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91VY6.
    Bgeei Q91VY6.
    Genevestigatori Q91VY6.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Spleen and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
      Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
      J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
    5. "A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer."
      Gorski K.S., Shin T., Crafton E., Otsuji M., Rattis F.M., Huang X., Kelleher E., Francisco L., Pardoll D., Tsuchiya H.
      Mol. Immunol. 40:35-47(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-359.
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiCYTIP_MOUSE
    AccessioniPrimary (citable) accession number: Q91VY6
    Secondary accession number(s): A2AS77
    , Q3TZH1, Q8R4T4, Q9QZA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3