Q91VX5 (NXPH3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurexophilin-3

Gene names

Name:

Nxph3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins.
Subcellular location	Secreted Potential.
Tissue specificity	Highest level in brain, present also in lung, kidney and testis. Ref.2
Post-translational modification	May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells By similarity.
Sequence similarities	Belongs to the neurexophilin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 252	230	Neurexophilin-3		PRO_0000020066
Regions
	Region	23 – 75	53	II
	Region	76 – 157	82	III
	Region	158 – 166	9	IV (linker domain)
	Region	167 – 252	86	V (Cys-rich)
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	137	1	N-linked (GlcNAc...) Potential
	Glycosylation	143	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q91VX5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A770645706435A7C	FASTA	252	28,183
	10 20 30 40 50 60 MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPEHDDHEG QPRPRVPRKR GHISPKSRPL 70 80 90 100 110 120 ANSTLLGLLA PPGEVWGVLG QPPNRPKQSP LPSTKVKKIF GWGDFYSNIK TVALNLLVTG 130 140 150 160 170 180 KIVDHGNGTF SVHFRHNATG QGNISISLVP PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE 190 200 210 220 230 240 KVERGRRTSL CTHDPAKICS RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY 250 NYHSDTPYYP SG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[2]	"Neurexophilins form a conserved family of neuropeptide-like glycoproteins." Missler M., Suedhof T.C. J. Neurosci. 18:3630-3638(1998) [PubMed: 9570794] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC007167 mRNA. Translation: AAH07167.1.
IPI	IPI00127400.
RefSeq	NP_570928.1. NM_130858.3.
UniGene	Mm.22970.
3D structure databases
ProteinModelPortal	Q91VX5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q91VX5. 1 interaction.
STRING	Q91VX5.
PTM databases
PhosphoSite	Q91VX5.
Proteomic databases
PRIDE	Q91VX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000058866; ENSMUSP00000058254; ENSMUSG00000046719.
GeneID	104079.
KEGG	mmu:104079.
Organism-specific databases
CTD	11248.
MGI	MGI:1336188. Nxph3.
Phylogenomic databases
eggNOG	roNOG11490.
GeneTree	ENSGT00390000015950.
HOGENOM	HBG714165.
HOVERGEN	HBG052706.
InParanoid	Q91VX5.
OMA	FRHNATG.
OrthoDB	EOG4XSKQJ.
PhylomeDB	Q91VX5.
Gene expression databases
ArrayExpress	Q91VX5.
Bgee	Q91VX5.
CleanEx	MM_NXPH3.
Genevestigator	Q91VX5.
GermOnline	ENSMUSG00000046719. Mus musculus.
Family and domain databases
InterPro	IPR010450. Neurexophilin. [Graphical view]
PANTHER	PTHR17103. Neurexophilin. 1 hit.
PIRSF	PIRSF038019. Neurexophilin. 1 hit.
ProtoNet	Search...
Other
NextBio	356473.
SOURCE	Search...

Entry information

Entry name

NXPH3_MOUSE

Accession

Primary (citable) accession number: Q91VX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	December 1, 2001
Last modified:	September 21, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program