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Protein

Neurexophilin-3

Gene

Nxph3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins.

GO - Molecular functioni

  • receptor binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-3
Gene namesi
Name:Nxph3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1336188. Nxph3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 252230Neurexophilin-3PRO_0000020066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91VX5.
PaxDbiQ91VX5.
PRIDEiQ91VX5.

PTM databases

PhosphoSiteiQ91VX5.

Expressioni

Tissue specificityi

Highest level in brain, present also in lung, kidney and testis.1 Publication

Gene expression databases

BgeeiQ91VX5.
CleanExiMM_NXPH3.
ExpressionAtlasiQ91VX5. baseline and differential.
GenevisibleiQ91VX5. MM.

Interactioni

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

IntActiQ91VX5. 1 interaction.
STRINGi10090.ENSMUSP00000058254.

Structurei

3D structure databases

ProteinModelPortaliQ91VX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 7553IIAdd
BLAST
Regioni76 – 15782IIIAdd
BLAST
Regioni158 – 1669IV (linker domain)
Regioni167 – 25286V (Cys-rich)Add
BLAST

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4V. Eukaryota.
ENOG410Y975. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiQ91VX5.
KOiK16658.
OMAiDHESQPR.
OrthoDBiEOG7K0ZCR.
PhylomeDBiQ91VX5.
TreeFamiTF333047.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPEHDDHEG QPRPRVPRKR
60 70 80 90 100
GHISPKSRPL ANSTLLGLLA PPGEVWGVLG QPPNRPKQSP LPSTKVKKIF
110 120 130 140 150
GWGDFYSNIK TVALNLLVTG KIVDHGNGTF SVHFRHNATG QGNISISLVP
160 170 180 190 200
PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE KVERGRRTSL CTHDPAKICS
210 220 230 240 250
RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY NYHSDTPYYP

SG
Length:252
Mass (Da):28,183
Last modified:December 1, 2001 - v1
Checksum:iA770645706435A7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007167 mRNA. Translation: AAH07167.1.
CCDSiCCDS25278.1.
RefSeqiNP_570928.1. NM_130858.3.
UniGeneiMm.22970.

Genome annotation databases

EnsembliENSMUST00000058866; ENSMUSP00000058254; ENSMUSG00000046719.
GeneIDi104079.
KEGGimmu:104079.
UCSCiuc007lal.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007167 mRNA. Translation: AAH07167.1.
CCDSiCCDS25278.1.
RefSeqiNP_570928.1. NM_130858.3.
UniGeneiMm.22970.

3D structure databases

ProteinModelPortaliQ91VX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VX5. 1 interaction.
STRINGi10090.ENSMUSP00000058254.

PTM databases

PhosphoSiteiQ91VX5.

Proteomic databases

MaxQBiQ91VX5.
PaxDbiQ91VX5.
PRIDEiQ91VX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058866; ENSMUSP00000058254; ENSMUSG00000046719.
GeneIDi104079.
KEGGimmu:104079.
UCSCiuc007lal.1. mouse.

Organism-specific databases

CTDi11248.
MGIiMGI:1336188. Nxph3.

Phylogenomic databases

eggNOGiENOG410IK4V. Eukaryota.
ENOG410Y975. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiQ91VX5.
KOiK16658.
OMAiDHESQPR.
OrthoDBiEOG7K0ZCR.
PhylomeDBiQ91VX5.
TreeFamiTF333047.

Miscellaneous databases

NextBioi356473.
PROiQ91VX5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VX5.
CleanExiMM_NXPH3.
ExpressionAtlasiQ91VX5. baseline and differential.
GenevisibleiQ91VX5. MM.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. "Neurexophilins form a conserved family of neuropeptide-like glycoproteins."
    Missler M., Suedhof T.C.
    J. Neurosci. 18:3630-3638(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNXPH3_MOUSE
AccessioniPrimary (citable) accession number: Q91VX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.