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Protein

Zinc finger protein with KRAB and SCAN domains 3

Gene

Zkscan3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri313 – 335C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processAutophagy, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 3
Alternative name(s):
SCAN-KRAB-zinc finger protein
Zinc finger protein 306
Zinc finger protein 307
Zinc finger protein 47 homolog
Short name:
Zf47
Short name:
Zfp-47
Gene namesi
Name:Zkscan3
Synonyms:Skz1, Zfp306, Zfp307, Zfp47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919989 Zkscan3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003948611 – 553Zinc finger protein with KRAB and SCAN domains 3Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei136PhosphothreonineCombined sources1
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei206PhosphothreonineBy similarity1
Modified residuei223PhosphoserineCombined sources1
Modified residuei448PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ91VW9
PaxDbiQ91VW9
PRIDEiQ91VW9

PTM databases

iPTMnetiQ91VW9
PhosphoSitePlusiQ91VW9

Expressioni

Tissue specificityi

Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068424

Structurei

3D structure databases

ProteinModelPortaliQ91VW9
SMRiQ91VW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini213 – 273KRABAdd BLAST61

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri313 – 335C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ91VW9
KOiK09229
PhylomeDBiQ91VW9
TreeFamiTF350830

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

Q91VW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARESRESTT LDSHSAEDQM ELLVIKVEQE ESSPLAEETS WLGSPGPDRS
60 70 80 90 100
RQRFRAFRYP EAAGPRQALS RLRELCRQWL RPDMHSKEQI LELLVLEQFL
110 120 130 140 150
TILPGELQAW VREQHPDSGE EVVALLEYLD RQLDDTPPQV PDDDDGQELL
160 170 180 190 200
CSKAVLLTSA QGSESSQMEP VEPLLKQESL GSLPSEVRVT HVGHCGEDGV
210 220 230 240 250
TATRLTSELQ GLLKMEDVAP VLSPRWTEQD SSQMNLYKDG MQEHSGSLVS
260 270 280 290 300
LDQDMQTKVR DLPRAEEYRD QKPEQTVCFL GEDTVPIPTG AEASEQEGKL
310 320 330 340 350
QAAQKSATGT RRFYCRECGK SFAQSSGLSK HKRIHTGLKP YECEECGKAF
360 370 380 390 400
IGSSALIIHQ RVHTGEKPYE CEECGKAFSH SSDLIKHQRT HTGEKPYECD
410 420 430 440 450
DCGKTFTQSC SLLEHHRIHT GEKPYQCNMC PKAFRRSSHL LRHQRTHTGD
460 470 480 490 500
KDFFVPEPYW ESQSRVESHW ENIETPVSYQ CNDCERSFSR ITSLIEHQKV
510 520 530 540 550
HTGEKPFECQ TCGKGFTRPS YLIQHQRRHT GKKTSVTVTP AVHSEVGVQL

SLN
Length:553
Mass (Da):62,642
Last modified:December 1, 2001 - v1
Checksum:i53B41483D21AC3C8
GO

Sequence cautioni

The sequence AAG00602 differs from that shown. Reason: Frameshift at positions 421 and 432.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → A in BAC27333 (PubMed:16141072).Curated1
Sequence conflicti32S → A in BAE20446 (PubMed:16141072).Curated1
Sequence conflicti62A → T in AAG00602 (PubMed:11342224).Curated1
Sequence conflicti67Q → R in BAE20446 (PubMed:16141072).Curated1
Sequence conflicti538V → M in AAG00602 (PubMed:11342224).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291722 mRNA Translation: AAG00602.1 Frameshift.
AK028902 mRNA Translation: BAE20446.1
AK031286 mRNA Translation: BAC27333.1
CH466561 Genomic DNA Translation: EDL32657.1
CH466561 Genomic DNA Translation: EDL32658.1
CH466561 Genomic DNA Translation: EDL32661.1
BC007473 mRNA Translation: AAH07473.1
CCDSiCCDS26274.1
RefSeqiNP_001139250.1, NM_001145778.1
NP_076174.3, NM_023685.4
XP_006516852.1, XM_006516789.3
XP_006516853.1, XM_006516790.3
UniGeneiMm.296071

Genome annotation databases

GeneIDi72739
KEGGimmu:72739
UCSCiuc007pqg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZKSC3_MOUSE
AccessioniPrimary (citable) accession number: Q91VW9
Secondary accession number(s): Q3V3Z2, Q8CD81, Q9ESY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health