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Protein

Golgin subfamily A member 4

Gene

Golga4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 4
Alternative name(s):
tGolgin-1
Gene namesi
Name:Golga4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1859646. Golga4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22382238Golgin subfamily A member 4PRO_0000190060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei39 – 391PhosphothreonineCombined sources
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei93 – 931PhosphoserineBy similarity
Modified residuei100 – 1001PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91VW5.
MaxQBiQ91VW5.
PaxDbiQ91VW5.
PeptideAtlasiQ91VW5.
PRIDEiQ91VW5.

PTM databases

iPTMnetiQ91VW5.
PhosphoSiteiQ91VW5.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in oligodendrocyte precursors, particularly at a stage just prior to myelination.1 Publication

Gene expression databases

BgeeiQ91VW5.
CleanExiMM_GOLGA4.
GenevisibleiQ91VW5. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with GTP bound ARL1 (By similarity). Interacts with MACF1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207604. 1 interaction.
IntActiQ91VW5. 2 interactions.
MINTiMINT-1748581.
STRINGi10090.ENSMUSP00000081880.

Structurei

3D structure databases

ProteinModelPortaliQ91VW5.
SMRiQ91VW5. Positions 2180-2231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2178 – 222548GRIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 22471Interaction with MACF1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili156 – 21612006Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi335 – 1011677Glu-richAdd
BLAST
Compositional biasi1855 – 2107253Glu-richAdd
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEA5. Eukaryota.
ENOG410XQQG. LUCA.
GeneTreeiENSGT00730000111139.
HOGENOMiHOG000112753.
HOVERGENiHBG051754.
InParanoidiQ91VW5.
OMAiCKETIGS.
OrthoDBiEOG72C4ZF.
PhylomeDBiQ91VW5.
TreeFamiTF325082.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
SUPFAMiSSF101283. SSF101283. 1 hit.
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKLKQKIS EEQQQLQQAL APAQASSSSS TPTRTRSRTS SFTDQLDDVT
60 70 80 90 100
PNRENASTQA TKSPDGVSKD ESSPSQSGDT QTFAQKLQLR VPSMESLFRS
110 120 130 140 150
PIKESLFRSS KEPLVRTSSR ESLNQLDLDC SAAAFDPPSD MESEAEDAPW
160 170 180 190 200
NSDGLSREQL LQRLRRMERS LSSYRGKYSE LVTAFQTLQR EKKKLQGILS
210 220 230 240 250
QSQDKSLRRI SELREELQMD QQAKKHLQDE FDACLEEKDQ YISVLQTQVS
260 270 280 290 300
LLKQRLQNGP MNVDAPKPLP PGELQAEVHG DTEKMEGVGE PVGGGTSAKT
310 320 330 340 350
LEMLQQRVKR QENLLQRCKE TIGSHKEQCA LLLSEKEALQ EQLDERLQEL
360 370 380 390 400
EKMKELHMAE KTKLITQLRD AKNLIEQLEQ DKGMVITETK RQMLETLELK
410 420 430 440 450
EDEIAQLRSH IKQMTTQGEE LREQKEKSER AAFEELEKAL STAQKTEDAQ
460 470 480 490 500
RRMKMEMDEQ MKAVERASEE ERLRLQHELS RVRQEAASMA KKNSEEQVAA
510 520 530 540 550
LQKLHAEELA SKEQELSRRL EARERELQEQ MRIALEKSRS EYLKLTQEKE
560 570 580 590 600
QQESLALEEL ELQKKAILTE SENKLQELGQ EAEAYRTRIL ELETSLEKSL
610 620 630 640 650
QESKTQSEHL AVHLEAEKNK HNKELTALAE QHRTEVEGLQ QQQDSLWTER
660 670 680 690 700
LQSLSQQHQA AVEELREKYQ QEKDALLKEK ESLFQAHIQD MNEKTLEKLD
710 720 730 740 750
KKQMELESVS SELSEALRAR DQLAEELSVL RGDADKMKQA LEAELEEQRR
760 770 780 790 800
HHQREVGSIS EQQELTVRRA EKALKDELSR LGALLDERDE HLRERQARVQ
810 820 830 840 850
DLEAHLQKSA GELQQALAKL DLLHSEQSAA REQAGAYEEQ LAQMQQKVLD
860 870 880 890 900
LETEKSLLTK QVVEMETHKK HVCEELDAQR AQVQQLERQR SELEEKVRSL
910 920 930 940 950
AQLQDSQLKN STVEKEQARQ SLMEKENIIL QMREEQAKEI EILKQTLSSK
960 970 980 990 1000
EESISILHEE YETKFKNQEK RMEKIKQKAK EMQETKKKLL DQEAKLKKEL
1010 1020 1030 1040 1050
ENTVLELSQK EKQFNAQILE MAQANSAGIS DTVSRLEENQ RQQIESLTGA
1060 1070 1080 1090 1100
HQRKLDDVIE AWEKKLSQQA AELRDKHAEQ MEEKEQGLGE LRQKVRIVQS
1110 1120 1130 1140 1150
EKEELTKEVA RLKEAVSGQD VALAGLQGQL EQKSAVIVSL SERESQLQSQ
1160 1170 1180 1190 1200
VEKLEADLGC SLSEKLSLQE ELAELKLLAD KSQLRVSELT GQVQAAEKEL
1210 1220 1230 1240 1250
QSCKSLHELS KKSLEDKSLN LKSLLEELAS QLDSRCERTK ALLEAKTNEL
1260 1270 1280 1290 1300
VCTSRDKADA ILARLSQCQR HTATVGEALL RRMGQVSELE AQLTQLTEEQ
1310 1320 1330 1340 1350
RTLKSSFQQV TNQLEEKEKQ IKTMKADIEG LLTEKEALQQ EGGQQRQAAS
1360 1370 1380 1390 1400
EKESCITQLK KELAENINAV TLLREELSEK KSEIASLSKQ LSDLGAQLES
1410 1420 1430 1440 1450
SISPSDKAEA ISALSKQHEE QELQLQAQLQ ELSLKVDALS KEKMSALEQV
1460 1470 1480 1490 1500
DHWSNKFSEW KKKAQSRLAQ HQSTIKDLQA QLDVKATDAR EKEEQICLLK
1510 1520 1530 1540 1550
EDLDRQNKKF ECLKGEMEVR KSKMEKKECD LETALKTQTA RVVELEDCVT
1560 1570 1580 1590 1600
QRKKEVESLN ETLKNYNQQR DTEHSGLVQR LQHLEELGEE KDNKVREAEE
1610 1620 1630 1640 1650
TVLRLREHVS SLEAELGTVK KELEHVNSSV KSRDGELKAL EDKLELESAA
1660 1670 1680 1690 1700
KVELKRKAEQ KIAAIRKQLL SQMEEKTQRY AKDTENRLSE LSAQLKEREK
1710 1720 1730 1740 1750
QVHSLEDKLK NLESSPHPEV PAVSRSMQSV AASPEQEAPD SQDCTHKACK
1760 1770 1780 1790 1800
ERLCMLQRRL SEKEKLLRRL EQGEGEARPS QPEAQHRALS GKLDCTRARQ
1810 1820 1830 1840 1850
LEDHVLIGCL PEELEEKMKC SLIVSQPMGE ETGNNTGVKQ NWASVVDSVQ
1860 1870 1880 1890 1900
KTLQEKELTC QALEQRVKEL ESDLVRERGA HRLEVEKLTL KYEKSQSSQQ
1910 1920 1930 1940 1950
EMDGENKCVE VLEDRPEENS QSHEIQSNVG TVDGLRSDLE SKLTGAERDK
1960 1970 1980 1990 2000
QKLSKEVARL QKELRALRRE HQQELDILKR ECEQEAEEKL KQEQEDLELK
2010 2020 2030 2040 2050
HTSTLKQLMR EFNTQLAQKE QELERTVQET IDKAQEVEAE LLESHQEETQ
2060 2070 2080 2090 2100
QLHRKIAEKE DDLRRTARRY EEILDAREEE MTGKVTDLQT QLEELQKKYQ
2110 2120 2130 2140 2150
QRLEQEESTK DSVTILELQT QLAQKTTLIS DSKLKEQELR EQVHNLEDRL
2160 2170 2180 2190 2200
KRYEKNACAA TVGTPYKGGN LYHTEVSLFG EPTEFEYLRK VMFEYMMGRE
2210 2220 2230
TKTMAKVITT VLKFPDDQAQ KILEREDARL MSWLRTSS
Length:2,238
Mass (Da):257,564
Last modified:July 3, 2003 - v2
Checksum:i494EA2C111F0165B
GO

Sequence cautioni

The sequence AAH37641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611T → R in strain: Czech II. 1 Publication
Natural varianti280 – 2801G → S in strain: Czech II. 1 Publication
Natural varianti293 – 2931G → E in strain: Czech II. 1 Publication
Natural varianti638 – 6381G → S in strain: Czech II. 1 Publication
Natural varianti819 – 8191K → T in strain: Czech II. 1 Publication
Natural varianti829 – 8291A → T in strain: Czech II. 1 Publication
Natural varianti859 – 8591T → A in strain: Czech II. 1 Publication
Natural varianti2065 – 20651R → S in strain: C57BL/6.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051357 mRNA. Translation: AAC05573.2.
BC007485 mRNA. Translation: AAH07485.1.
BC037641 mRNA. Translation: AAH37641.1. Different initiation.
BC053000 mRNA. Translation: AAH53000.1.
CCDSiCCDS40801.1.
PIRiT14265.
RefSeqiNP_061218.2. NM_018748.3.
UniGeneiMm.10409.

Genome annotation databases

EnsembliENSMUST00000084820; ENSMUSP00000081880; ENSMUSG00000038708.
GeneIDi54214.
KEGGimmu:54214.
UCSCiuc009rzs.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051357 mRNA. Translation: AAC05573.2.
BC007485 mRNA. Translation: AAH07485.1.
BC037641 mRNA. Translation: AAH37641.1. Different initiation.
BC053000 mRNA. Translation: AAH53000.1.
CCDSiCCDS40801.1.
PIRiT14265.
RefSeqiNP_061218.2. NM_018748.3.
UniGeneiMm.10409.

3D structure databases

ProteinModelPortaliQ91VW5.
SMRiQ91VW5. Positions 2180-2231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207604. 1 interaction.
IntActiQ91VW5. 2 interactions.
MINTiMINT-1748581.
STRINGi10090.ENSMUSP00000081880.

PTM databases

iPTMnetiQ91VW5.
PhosphoSiteiQ91VW5.

Proteomic databases

EPDiQ91VW5.
MaxQBiQ91VW5.
PaxDbiQ91VW5.
PeptideAtlasiQ91VW5.
PRIDEiQ91VW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084820; ENSMUSP00000081880; ENSMUSG00000038708.
GeneIDi54214.
KEGGimmu:54214.
UCSCiuc009rzs.1. mouse.

Organism-specific databases

CTDi2803.
MGIiMGI:1859646. Golga4.

Phylogenomic databases

eggNOGiENOG410IEA5. Eukaryota.
ENOG410XQQG. LUCA.
GeneTreeiENSGT00730000111139.
HOGENOMiHOG000112753.
HOVERGENiHBG051754.
InParanoidiQ91VW5.
OMAiCKETIGS.
OrthoDBiEOG72C4ZF.
PhylomeDBiQ91VW5.
TreeFamiTF325082.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ91VW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VW5.
CleanExiMM_GOLGA4.
GenevisibleiQ91VW5. MM.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
SUPFAMiSSF101283. SSF101283. 1 hit.
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of mouse tGolgin-1 (golgin-245/trans-Golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development."
    Cowan D.A., Gay D., Bieler B.M., Zhao H., Yoshino A., Davis J.G., Tomayko M.M., Murali R., Greene M.I., Marks M.S.
    DNA Cell Biol. 21:505-517(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-980 AND 991-2231, VARIANTS ARG-61; SER-280; GLU-293; SER-638; THR-819; THR-829 AND ALA-859.
    Strain: C57BL/6J and Czech II.
    Tissue: Brain and Mammary tumor.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1840-1856, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiGOGA4_MOUSE
AccessioniPrimary (citable) accession number: Q91VW5
Secondary accession number(s): O70365, Q8CGH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.