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Q91VW5 (GOGA4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgin subfamily A member 4
Alternative name(s):
tGolgin-1
Gene names
Name:Golga4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length2238 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 By similarity.

Subunit structure

Homodimer. Interacts with GTP bound ARL1 By similarity. Interacts with MACF1 By similarity.

Subcellular location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus By similarity Ref.1.

Tissue specificity

Ubiquitous. Highly expressed in oligodendrocyte precursors, particularly at a stage just prior to myelination. Ref.1

Domain

Extended rod-like protein with coiled-coil domains.

Sequence similarities

Contains 1 GRIP domain.

Sequence caution

The sequence AAH37641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22382238Golgin subfamily A member 4
PRO_0000190060

Regions

Domain2178 – 222548GRIP
Region154 – 22471Interaction with MACF1 By similarity
Coiled coil156 – 21612006 Potential
Compositional bias335 – 1011677Glu-rich
Compositional bias1855 – 2107253Glu-rich

Amino acid modifications

Modified residue411Phosphoserine Ref.4
Modified residue931Phosphoserine By similarity
Modified residue1001Phosphoserine By similarity

Natural variations

Natural variant611T → R in strain: Czech II. Ref.2
Natural variant2801G → S in strain: Czech II. Ref.2
Natural variant2931G → E in strain: Czech II. Ref.2
Natural variant6381G → S in strain: Czech II. Ref.2
Natural variant8191K → T in strain: Czech II. Ref.2
Natural variant8291A → T in strain: Czech II. Ref.2
Natural variant8591T → A in strain: Czech II. Ref.2
Natural variant20651R → S in strain: C57BL/6.

Sequences

Sequence LengthMass (Da)Tools
Q91VW5 [UniParc].

Last modified July 3, 2003. Version 2.
Checksum: 494EA2C111F0165B

FASTA2,238257,564
        10         20         30         40         50         60 
MFKKLKQKIS EEQQQLQQAL APAQASSSSS TPTRTRSRTS SFTDQLDDVT PNRENASTQA 

        70         80         90        100        110        120 
TKSPDGVSKD ESSPSQSGDT QTFAQKLQLR VPSMESLFRS PIKESLFRSS KEPLVRTSSR 

       130        140        150        160        170        180 
ESLNQLDLDC SAAAFDPPSD MESEAEDAPW NSDGLSREQL LQRLRRMERS LSSYRGKYSE 

       190        200        210        220        230        240 
LVTAFQTLQR EKKKLQGILS QSQDKSLRRI SELREELQMD QQAKKHLQDE FDACLEEKDQ 

       250        260        270        280        290        300 
YISVLQTQVS LLKQRLQNGP MNVDAPKPLP PGELQAEVHG DTEKMEGVGE PVGGGTSAKT 

       310        320        330        340        350        360 
LEMLQQRVKR QENLLQRCKE TIGSHKEQCA LLLSEKEALQ EQLDERLQEL EKMKELHMAE 

       370        380        390        400        410        420 
KTKLITQLRD AKNLIEQLEQ DKGMVITETK RQMLETLELK EDEIAQLRSH IKQMTTQGEE 

       430        440        450        460        470        480 
LREQKEKSER AAFEELEKAL STAQKTEDAQ RRMKMEMDEQ MKAVERASEE ERLRLQHELS 

       490        500        510        520        530        540 
RVRQEAASMA KKNSEEQVAA LQKLHAEELA SKEQELSRRL EARERELQEQ MRIALEKSRS 

       550        560        570        580        590        600 
EYLKLTQEKE QQESLALEEL ELQKKAILTE SENKLQELGQ EAEAYRTRIL ELETSLEKSL 

       610        620        630        640        650        660 
QESKTQSEHL AVHLEAEKNK HNKELTALAE QHRTEVEGLQ QQQDSLWTER LQSLSQQHQA 

       670        680        690        700        710        720 
AVEELREKYQ QEKDALLKEK ESLFQAHIQD MNEKTLEKLD KKQMELESVS SELSEALRAR 

       730        740        750        760        770        780 
DQLAEELSVL RGDADKMKQA LEAELEEQRR HHQREVGSIS EQQELTVRRA EKALKDELSR 

       790        800        810        820        830        840 
LGALLDERDE HLRERQARVQ DLEAHLQKSA GELQQALAKL DLLHSEQSAA REQAGAYEEQ 

       850        860        870        880        890        900 
LAQMQQKVLD LETEKSLLTK QVVEMETHKK HVCEELDAQR AQVQQLERQR SELEEKVRSL 

       910        920        930        940        950        960 
AQLQDSQLKN STVEKEQARQ SLMEKENIIL QMREEQAKEI EILKQTLSSK EESISILHEE 

       970        980        990       1000       1010       1020 
YETKFKNQEK RMEKIKQKAK EMQETKKKLL DQEAKLKKEL ENTVLELSQK EKQFNAQILE 

      1030       1040       1050       1060       1070       1080 
MAQANSAGIS DTVSRLEENQ RQQIESLTGA HQRKLDDVIE AWEKKLSQQA AELRDKHAEQ 

      1090       1100       1110       1120       1130       1140 
MEEKEQGLGE LRQKVRIVQS EKEELTKEVA RLKEAVSGQD VALAGLQGQL EQKSAVIVSL 

      1150       1160       1170       1180       1190       1200 
SERESQLQSQ VEKLEADLGC SLSEKLSLQE ELAELKLLAD KSQLRVSELT GQVQAAEKEL 

      1210       1220       1230       1240       1250       1260 
QSCKSLHELS KKSLEDKSLN LKSLLEELAS QLDSRCERTK ALLEAKTNEL VCTSRDKADA 

      1270       1280       1290       1300       1310       1320 
ILARLSQCQR HTATVGEALL RRMGQVSELE AQLTQLTEEQ RTLKSSFQQV TNQLEEKEKQ 

      1330       1340       1350       1360       1370       1380 
IKTMKADIEG LLTEKEALQQ EGGQQRQAAS EKESCITQLK KELAENINAV TLLREELSEK 

      1390       1400       1410       1420       1430       1440 
KSEIASLSKQ LSDLGAQLES SISPSDKAEA ISALSKQHEE QELQLQAQLQ ELSLKVDALS 

      1450       1460       1470       1480       1490       1500 
KEKMSALEQV DHWSNKFSEW KKKAQSRLAQ HQSTIKDLQA QLDVKATDAR EKEEQICLLK 

      1510       1520       1530       1540       1550       1560 
EDLDRQNKKF ECLKGEMEVR KSKMEKKECD LETALKTQTA RVVELEDCVT QRKKEVESLN 

      1570       1580       1590       1600       1610       1620 
ETLKNYNQQR DTEHSGLVQR LQHLEELGEE KDNKVREAEE TVLRLREHVS SLEAELGTVK 

      1630       1640       1650       1660       1670       1680 
KELEHVNSSV KSRDGELKAL EDKLELESAA KVELKRKAEQ KIAAIRKQLL SQMEEKTQRY 

      1690       1700       1710       1720       1730       1740 
AKDTENRLSE LSAQLKEREK QVHSLEDKLK NLESSPHPEV PAVSRSMQSV AASPEQEAPD 

      1750       1760       1770       1780       1790       1800 
SQDCTHKACK ERLCMLQRRL SEKEKLLRRL EQGEGEARPS QPEAQHRALS GKLDCTRARQ 

      1810       1820       1830       1840       1850       1860 
LEDHVLIGCL PEELEEKMKC SLIVSQPMGE ETGNNTGVKQ NWASVVDSVQ KTLQEKELTC 

      1870       1880       1890       1900       1910       1920 
QALEQRVKEL ESDLVRERGA HRLEVEKLTL KYEKSQSSQQ EMDGENKCVE VLEDRPEENS 

      1930       1940       1950       1960       1970       1980 
QSHEIQSNVG TVDGLRSDLE SKLTGAERDK QKLSKEVARL QKELRALRRE HQQELDILKR 

      1990       2000       2010       2020       2030       2040 
ECEQEAEEKL KQEQEDLELK HTSTLKQLMR EFNTQLAQKE QELERTVQET IDKAQEVEAE 

      2050       2060       2070       2080       2090       2100 
LLESHQEETQ QLHRKIAEKE DDLRRTARRY EEILDAREEE MTGKVTDLQT QLEELQKKYQ 

      2110       2120       2130       2140       2150       2160 
QRLEQEESTK DSVTILELQT QLAQKTTLIS DSKLKEQELR EQVHNLEDRL KRYEKNACAA 

      2170       2180       2190       2200       2210       2220 
TVGTPYKGGN LYHTEVSLFG EPTEFEYLRK VMFEYMMGRE TKTMAKVITT VLKFPDDQAQ 

      2230 
KILEREDARL MSWLRTSS

« Hide

References

« Hide 'large scale' references
[1]"Characterization of mouse tGolgin-1 (golgin-245/trans-Golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development."
Cowan D.A., Gay D., Bieler B.M., Zhao H., Yoshino A., Davis J.G., Tomayko M.M., Murali R., Greene M.I., Marks M.S.
DNA Cell Biol. 21:505-517(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-980 AND 991-2231, VARIANTS ARG-61; SER-280; GLU-293; SER-638; THR-819; THR-829 AND ALA-859.
Strain: C57BL/6 and Czech II.
Tissue: Brain and Mammary tumor.
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1840-1856, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF051357 mRNA. Translation: AAC05573.2.
BC007485 mRNA. Translation: AAH07485.1.
BC037641 mRNA. Translation: AAH37641.1. Different initiation.
BC053000 mRNA. Translation: AAH53000.1.
IPIIPI00138860.
PIRT14265.
RefSeqNP_061218.2. NM_018748.3.
UniGeneMm.10409.

3D structure databases

ProteinModelPortalQ91VW5.
SMRQ91VW5. Positions 2180-2231.
ModBaseSearch...

Protein-protein interaction databases

IntActQ91VW5. 1 interaction.
STRING10090.ENSMUSP00000081880.

PTM databases

PhosphoSiteQ91VW5.

Proteomic databases

PaxDbQ91VW5.
PRIDEQ91VW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084820; ENSMUSP00000081880; ENSMUSG00000038708.
GeneID54214.
KEGGmmu:54214.
UCSCuc009rzs.1. mouse.

Organism-specific databases

CTD2803.
MGIMGI:1859646. Golga4.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00700000104373.
HOGENOMHOG000112753.
HOVERGENHBG051754.
InParanoidQ91VW5.
OMADTLETRS.
OrthoDBEOG4QRH34.

Gene expression databases

ArrayExpressQ91VW5.
BgeeQ91VW5.
CleanExMM_GOLGA4.
GenevestigatorQ91VW5.
GermOnlineENSMUSG00000038708. Mus musculus.

Family and domain databases

Gene3D1.10.220.60. 1 hit.
InterProIPR000237. GRIP.
[Graphical view]
PfamPF01465. GRIP. 1 hit.
[Graphical view]
SMARTSM00755. Grip. 1 hit.
[Graphical view]
SUPFAMSSF101283. GRIP. 1 hit.
PROSITEPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311074.
SOURCESearch...

Entry information

Entry nameGOGA4_MOUSE
AccessionPrimary (citable) accession number: Q91VW5
Secondary accession number(s): O70365, Q8CGH6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: April 3, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents