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Protein

SH3 domain-binding glutamic acid-rich-like protein 3

Gene

Sh3bgrl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could act as a modulator of glutaredoxin biological activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein 3
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920973. Sh3bgrl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002207502 – 93SH3 domain-binding glutamic acid-rich-like protein 3Add BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VW3.
MaxQBiQ91VW3.
PaxDbiQ91VW3.
PeptideAtlasiQ91VW3.
PRIDEiQ91VW3.

PTM databases

iPTMnetiQ91VW3.
PhosphoSitePlusiQ91VW3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028843.
ExpressionAtlasiQ91VW3. baseline and differential.
GenevisibleiQ91VW3. MM.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216213. 1 interactor.
IntActiQ91VW3. 3 interactors.
MINTiMINT-4134540.
STRINGi10090.ENSMUSP00000030651.

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi15 – 30Combined sources16
Beta strandi36 – 39Combined sources4
Turni40 – 42Combined sources3
Helixi44 – 53Combined sources10
Beta strandi63 – 66Combined sources4
Beta strandi69 – 73Combined sources5
Helixi74 – 82Combined sources9
Helixi86 – 89Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0FNMR-A1-93[»]
1T1VX-ray1.60A/B1-93[»]
ProteinModelPortaliQ91VW3.
SMRiQ91VW3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91VW3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93GlutaredoxinPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the SH3BGR family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ91VW3.
OMAiYCGNYEM.
OrthoDBiEOG091G10PC.
PhylomeDBiQ91VW3.
TreeFamiTF105574.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRVYSTS VTGSREIKSQ QSEVTRILDG KRIQYQLVDI SQDNALRDEM
60 70 80 90
RTLAGNPKAT PPQIVNGNHY CGDYELFVEA VEQDTLQEFL KLA
Length:93
Mass (Da):10,477
Last modified:December 1, 2001 - v1
Checksum:iDB89688F0C5B82CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA. Translation: BAC25034.1.
BC008110 mRNA. Translation: AAH08110.1.
CCDSiCCDS38910.1.
RefSeqiNP_542126.1. NM_080559.1.
UniGeneiMm.22240.

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843.
GeneIDi73723.
KEGGimmu:73723.
UCSCiuc008vec.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA. Translation: BAC25034.1.
BC008110 mRNA. Translation: AAH08110.1.
CCDSiCCDS38910.1.
RefSeqiNP_542126.1. NM_080559.1.
UniGeneiMm.22240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0FNMR-A1-93[»]
1T1VX-ray1.60A/B1-93[»]
ProteinModelPortaliQ91VW3.
SMRiQ91VW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216213. 1 interactor.
IntActiQ91VW3. 3 interactors.
MINTiMINT-4134540.
STRINGi10090.ENSMUSP00000030651.

PTM databases

iPTMnetiQ91VW3.
PhosphoSitePlusiQ91VW3.

Proteomic databases

EPDiQ91VW3.
MaxQBiQ91VW3.
PaxDbiQ91VW3.
PeptideAtlasiQ91VW3.
PRIDEiQ91VW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843.
GeneIDi73723.
KEGGimmu:73723.
UCSCiuc008vec.1. mouse.

Organism-specific databases

CTDi83442.
MGIiMGI:1920973. Sh3bgrl3.

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ91VW3.
OMAiYCGNYEM.
OrthoDBiEOG091G10PC.
PhylomeDBiQ91VW3.
TreeFamiTF105574.

Miscellaneous databases

EvolutionaryTraceiQ91VW3.
PROiQ91VW3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028843.
ExpressionAtlasiQ91VW3. baseline and differential.
GenevisibleiQ91VW3. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSH3L3_MOUSE
AccessioniPrimary (citable) accession number: Q91VW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.