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Protein

SH3 domain-binding glutamic acid-rich-like protein 3

Gene

Sh3bgrl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could act as a modulator of glutaredoxin biological activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein 3
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920973. Sh3bgrl3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002207502 – 93SH3 domain-binding glutamic acid-rich-like protein 3Add BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VW3.
MaxQBiQ91VW3.
PaxDbiQ91VW3.
PeptideAtlasiQ91VW3.
PRIDEiQ91VW3.

PTM databases

iPTMnetiQ91VW3.
PhosphoSitePlusiQ91VW3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028843.
ExpressionAtlasiQ91VW3. baseline and differential.
GenevisibleiQ91VW3. MM.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216213. 1 interactor.
IntActiQ91VW3. 3 interactors.
MINTiMINT-4134540.
STRINGi10090.ENSMUSP00000030651.

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi15 – 30Combined sources16
Beta strandi36 – 39Combined sources4
Turni40 – 42Combined sources3
Helixi44 – 53Combined sources10
Beta strandi63 – 66Combined sources4
Beta strandi69 – 73Combined sources5
Helixi74 – 82Combined sources9
Helixi86 – 89Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0FNMR-A1-93[»]
1T1VX-ray1.60A/B1-93[»]
ProteinModelPortaliQ91VW3.
SMRiQ91VW3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91VW3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93GlutaredoxinPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ91VW3.
OMAiYCGNYEM.
OrthoDBiEOG091G10PC.
PhylomeDBiQ91VW3.
TreeFamiTF105574.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiView protein in InterPro
IPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF04908. SH3BGR. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51354. GLUTAREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRVYSTS VTGSREIKSQ QSEVTRILDG KRIQYQLVDI SQDNALRDEM
60 70 80 90
RTLAGNPKAT PPQIVNGNHY CGDYELFVEA VEQDTLQEFL KLA
Length:93
Mass (Da):10,477
Last modified:December 1, 2001 - v1
Checksum:iDB89688F0C5B82CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA. Translation: BAC25034.1.
BC008110 mRNA. Translation: AAH08110.1.
CCDSiCCDS38910.1.
RefSeqiNP_542126.1. NM_080559.1.
UniGeneiMm.22240.

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843.
GeneIDi73723.
KEGGimmu:73723.
UCSCiuc008vec.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA. Translation: BAC25034.1.
BC008110 mRNA. Translation: AAH08110.1.
CCDSiCCDS38910.1.
RefSeqiNP_542126.1. NM_080559.1.
UniGeneiMm.22240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0FNMR-A1-93[»]
1T1VX-ray1.60A/B1-93[»]
ProteinModelPortaliQ91VW3.
SMRiQ91VW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216213. 1 interactor.
IntActiQ91VW3. 3 interactors.
MINTiMINT-4134540.
STRINGi10090.ENSMUSP00000030651.

PTM databases

iPTMnetiQ91VW3.
PhosphoSitePlusiQ91VW3.

Proteomic databases

EPDiQ91VW3.
MaxQBiQ91VW3.
PaxDbiQ91VW3.
PeptideAtlasiQ91VW3.
PRIDEiQ91VW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843.
GeneIDi73723.
KEGGimmu:73723.
UCSCiuc008vec.1. mouse.

Organism-specific databases

CTDi83442.
MGIiMGI:1920973. Sh3bgrl3.

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ91VW3.
OMAiYCGNYEM.
OrthoDBiEOG091G10PC.
PhylomeDBiQ91VW3.
TreeFamiTF105574.

Miscellaneous databases

EvolutionaryTraceiQ91VW3.
PROiPR:Q91VW3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028843.
ExpressionAtlasiQ91VW3. baseline and differential.
GenevisibleiQ91VW3. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiView protein in InterPro
IPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF04908. SH3BGR. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51354. GLUTAREDOXIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSH3L3_MOUSE
AccessioniPrimary (citable) accession number: Q91VW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: March 15, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.