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Protein

SH3 domain-binding glutamic acid-rich-like protein 3

Gene

Sh3bgrl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could act as a modulator of glutaredoxin biological activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein 3
Gene namesi
Name:Sh3bgrl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920973. Sh3bgrl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9392SH3 domain-binding glutamic acid-rich-like protein 3PRO_0000220750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VW3.
MaxQBiQ91VW3.
PaxDbiQ91VW3.
PRIDEiQ91VW3.

PTM databases

iPTMnetiQ91VW3.
PhosphoSiteiQ91VW3.

Expressioni

Gene expression databases

BgeeiQ91VW3.
ExpressionAtlasiQ91VW3. baseline and differential.
GenevisibleiQ91VW3. MM.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216213. 1 interaction.
IntActiQ91VW3. 3 interactions.
MINTiMINT-4134540.
STRINGi10090.ENSMUSP00000030651.

Structurei

Secondary structure

1
93
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Helixi15 – 3016Combined sources
Beta strandi36 – 394Combined sources
Turni40 – 423Combined sources
Helixi44 – 5310Combined sources
Beta strandi63 – 664Combined sources
Beta strandi69 – 735Combined sources
Helixi74 – 829Combined sources
Helixi86 – 894Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J0FNMR-A1-93[»]
1T1VX-ray1.60A/B1-93[»]
ProteinModelPortaliQ91VW3.
SMRiQ91VW3. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91VW3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 9392GlutaredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SH3BGR family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ91VW3.
OMAiYCGNYEM.
OrthoDBiEOG7GTT63.
PhylomeDBiQ91VW3.
TreeFamiTF105574.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRVYSTS VTGSREIKSQ QSEVTRILDG KRIQYQLVDI SQDNALRDEM
60 70 80 90
RTLAGNPKAT PPQIVNGNHY CGDYELFVEA VEQDTLQEFL KLA
Length:93
Mass (Da):10,477
Last modified:December 1, 2001 - v1
Checksum:iDB89688F0C5B82CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA. Translation: BAC25034.1.
BC008110 mRNA. Translation: AAH08110.1.
CCDSiCCDS38910.1.
RefSeqiNP_542126.1. NM_080559.1.
UniGeneiMm.22240.

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843.
GeneIDi73723.
KEGGimmu:73723.
UCSCiuc008vec.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003431 mRNA. Translation: BAC25034.1.
BC008110 mRNA. Translation: AAH08110.1.
CCDSiCCDS38910.1.
RefSeqiNP_542126.1. NM_080559.1.
UniGeneiMm.22240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J0FNMR-A1-93[»]
1T1VX-ray1.60A/B1-93[»]
ProteinModelPortaliQ91VW3.
SMRiQ91VW3. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216213. 1 interaction.
IntActiQ91VW3. 3 interactions.
MINTiMINT-4134540.
STRINGi10090.ENSMUSP00000030651.

PTM databases

iPTMnetiQ91VW3.
PhosphoSiteiQ91VW3.

Proteomic databases

EPDiQ91VW3.
MaxQBiQ91VW3.
PaxDbiQ91VW3.
PRIDEiQ91VW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030651; ENSMUSP00000030651; ENSMUSG00000028843.
GeneIDi73723.
KEGGimmu:73723.
UCSCiuc008vec.1. mouse.

Organism-specific databases

CTDi83442.
MGIiMGI:1920973. Sh3bgrl3.

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ91VW3.
OMAiYCGNYEM.
OrthoDBiEOG7GTT63.
PhylomeDBiQ91VW3.
TreeFamiTF105574.

Miscellaneous databases

EvolutionaryTraceiQ91VW3.
NextBioi338903.
PROiQ91VW3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VW3.
ExpressionAtlasiQ91VW3. baseline and differential.
GenevisibleiQ91VW3. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human homologue of the SH3BGR gene encodes a small protein similar to glutaredoxin 1 of Escherichia coli."
    Mazzocco M., Arrigo P., Egeo A., Maffei M., Vergano A., Di Lisi R., Ghiotto F., Ciccone E., Cinti R., Ravazzolo R., Scartezzini P.
    Biochem. Biophys. Res. Commun. 285:540-545(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 6-15; 285-302 AND 562-572, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Pancreas, Spleen and Testis.
  6. "Crystal structure of the glutaredoxin-like protein SH3BGRL3 at 1.6 Angstrom resolution."
    Nardini M., Mazzocco M., Massaro A., Maffei M., Vergano A., Donadini A., Scartezzini P., Bolognesi M.
    Biochem. Biophys. Res. Commun. 318:470-476(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS), SUBUNIT.
  7. "Solution structure of the SH3 domain binding glutamic acid-rich protein like 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (DEC-2003) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiSH3L3_MOUSE
AccessioniPrimary (citable) accession number: Q91VW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.